Autoimmune Diseases

Autoimmune Diseases

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View the Evidence: Ailments

Curcumin may support the regeneration of articular cartilage.

Pubmed Data : Arthritis Res Ther. 2010;12(4):R127. Epub 2010 Jul 1. PMID: 20594343
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cartilage Diseases : CK(5) : AC(5), Osteoarthritis : CK(615) : AC(91), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Apoptotic : CK(1489) : AC(1114), Interleukin-1 beta downregulation : CK(177) : AC(70), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin prevents human dendritic cell response to immune stimulants, indicating it may have value as an immunosuppresant.

Pubmed Data : Biochem Biophys Res Commun. 2008 Sep 26;374(3):431-6. Epub 2008 Jul 17. PMID: 18639521
Article Published Date : Sep 26, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions : Immunosuppressive Agents : CK(26) : AC(19)

Curcumin's blood sugar lowering effect may be due to its inhibitory effect on hepatic gluconeogenesis.

Pubmed Data : Biochem Biophys Res Commun. 2009 Oct 16;388(2):377-82. Epub 2009 Aug 8. PMID: 19665995
Article Published Date : Oct 16, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Pharmacological Actions : AMP-activated protein kinase modulation : CK(2) : AC(2), Gluconeogenesis Inhibitor : CK(20) : AC(14)
Additional Keywords : Metformin Alternatives : CK(19) : AC(6), Natural Substances Versus Drugs : CK(988) : AC(165)

Destruction and/or replacement of probiotic bacteria with pathogenic ones may be contribute to the development of autoimmune diseases.

Pubmed Data : Med Hypotheses. 2008;70(3):657-60. Epub 2007 Aug 27. PMID: 17720327
Article Published Date : Jan 01, 2008
Study Type : Commentary
Additional Links
Substances : Probiotics : CK(2468) : AC(245)
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Dysbiosis : CK(123) : AC(30)

Diarrhoea due to coeliac disease may be mistakenly diagnosed as 'diabetic diarrhoea."

Pubmed Data : Q J Med. 1978 Jan ;47(185):89-100. PMID: 674552
Article Published Date : Jan 01, 1978
Study Type : Review
Additional Links
Diseases : Celiac Disease : CK(1527) : AC(215)
Problem Substances : Gluten : CK(1755) : AC(144)

Dietary antigen similar to gluten in celiac disease suspected as trigger of T1D

Pubmed Data : Cold Spring Harb Perspect Med. 2012 Jul ;2(7):a007690. PMID: 22762021
Article Published Date : Jun 30, 2012
Study Type : Review
Additional Links
Diseases : Celiac Disease : CK(1527) : AC(215), Diabetes Mellitus: Type 1 : CK(1107) : AC(218)

Do dietary lectins cause disease?

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ. 1999 Apr 17 ;318(7190):1023-4. PMID: 10205084
Article Published Date : Apr 16, 1999
Study Type : Review
Additional Links
Diseases : Rheumatoid Arthritis : CK(424) : AC(64)
Additional Keywords : Lectins : CK(58) : AC(36)
Problem Substances : Wheat Germ Agglutinin (WGA) : CK(821) : AC(39)

Early introduction of gluten-free diet and lifelong adherence decreases risk of CD related autoimmune complications.

Pubmed Data : Endokrynol Pol. 2012 ;63(3):240-9. PMID: 22744631
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Celiac Disease : CK(1527) : AC(215)
Therapeutic Actions : Dietary Modification: Wheat/Gluten Free : CK(259) : AC(29)

EGCG, a green tea polyphenol, induces programmed cell death in rheumatoid arthritis synovial fibroblasts.

Pubmed Data : Am J Surg. 2010 Jul 7. Epub 2010 Jul 7. PMID: 19404960
Article Published Date : Jul 07, 2010
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Rheumatoid Arthritis : CK(424) : AC(64)

EGCG, a green tea polyphenol, may play a role in regulating inflammation and bone destruction in RA patients.

Pubmed Data : Gastroenterology. 2007 May;132(5):1925-36. Epub 2007 Feb 21. PMID: 18496696
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Environmental exposure to pesticides, industrial chemicals and infections may trigger autoimmune thyroiditis.

Pubmed Data : J Autoimmun. 2009 Nov-Dec;33(3-4):183-9. Epub 2009 Oct 9. PMID: 19818584
Article Published Date : Nov 01, 2009
Study Type : Review
Additional Links
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Autoimmune Thyroiditis : CK(134) : AC(17), Bacterial Infections and Mycoses : CK(127) : AC(51)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)
Problem Substances : Crude Oil/Petroleum : CK(273) : AC(34), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(699) : AC(70), Polychlorinated biphenyls (PCBs) : CK(179) : AC(24), Polycyclic aromatic hydrocarbon : CK(13) : AC(4)

EPA may have a positive immunomodulatory role through the induction of regulatory T cells in autoimmune conditions.

Pubmed Data : J Neurosci Res. 2004 May 1;76(3):397-405. PMID: 21182821
Article Published Date : May 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Immune Dysregulation: TH1/TH2 imbalance : CK(146) : AC(36), Immune Function: TH2 dominance : CK(2) : AC(2)
Pharmacological Actions : Immunomodulatory : CK(536) : AC(142)

Epicatechin flavanoid compound cause beta cell regeneration. - Article 2

Pubmed Data : Diabetes. 1984 Mar;33(3):291-6. PMID: 6365662
Article Published Date : Mar 01, 1984
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids : CK(909) : AC(289)
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218)
Pharmacological Actions : Insulin-releasing : CK(26) : AC(15)
Additional Keywords : Beta Cell Regeneration : CK(60) : AC(24)

Essential fatty acid supplementation may be beneficial in treating Sjogren's syndrome.

Pubmed Data : Med Hypotheses. 1984 Jul;14(3):233-47. PMID: 6088955
Article Published Date : Jul 01, 1984
Study Type : Commentary
Additional Links
Substances : Essential Fatty Acids : CK(88) : AC(12)
Diseases : Sjogren's Syndrome : CK(81) : AC(14)

Estradiol may play a role in the neuroprotection of spinal astrocytes in amyotrophic lateral sclerosis patients.

Pubmed Data : Neurobiol Dis. 2005 Nov;20(2):461-70. PMID: 15893467
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2)) : CK(21) : AC(14)
Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Pharmacological Actions : Estrogen Receptor Modulators : CK(28) : AC(19), Neuroprotective Agents : CK(962) : AC(480)

Estradiol protects spinal motor neurons from excitotoxic insults in vitro, and may have application as a treatment for ALS.

Pubmed Data : Neuroreport. 2000 Nov 9;11(16):3493-7. PMID: 11095506
Article Published Date : Nov 09, 2000
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2)) : CK(21) : AC(14)
Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Estrogen may have therapeutic value in the treatment of amyotrophic lateral sclerosis and spinal cord injury.

Pubmed Data : J Endocrinol. 2011 Feb;208(2):171-82. Epub 2010 Nov 10. PMID: 21068071
Article Published Date : Feb 01, 2011
Study Type : In Vitro Study
Additional Links
Substances : Estradiol (E(2)) : CK(21) : AC(14)
Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Spinal Cord Injuries : CK(98) : AC(28)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Evidence: DQ9-restricted gluten-specific T cells in HLA-DQ9 confers risk to celiac disease

Pubmed Data : Hum Immunol. 2012 Apr ;73(4):376-81. Epub 2012 Jan 31. PMID: 22342873
Article Published Date : Mar 31, 2012
Study Type : Review
Additional Links
Diseases : Celiac Disease : CK(1527) : AC(215)
Additional Keywords : DR9DQ9 haplotype

Folic acid protects motor neurons against the increased homocysteine, inflammation and programmed cell death.

Pubmed Data : Neuropharmacology. 2008 Jun;54(7):1112-9. Epub 2008 Mar 16. PMID: 18436268
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Bcl-2 protein down-regulation : CK(49) : AC(38), Neuroprotective Agents : CK(962) : AC(480), Nitric Oxide Inhibitor : CK(108) : AC(57), Superoxide Dismutase Up-regulation : CK(131) : AC(42), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Food processing by selected sourdough lactobacilli and fungal proteases to create detoxified wheat flour may be considered an efficient approach to eliminate gluten toxicity.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Appl Environ Microbiol. 2007 Jul ;73(14):4499-507. Epub 2007 May 18. PMID: 17513580
Article Published Date : Jun 30, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Celiac Disease : CK(1527) : AC(215), Gluten Sensitivity : CK(2477) : AC(270)
Additional Keywords : sourdough process
Problem Substances : Gluten : CK(1755) : AC(144)

Fumonisins in gluten-free products and their potential impact on chronic conditions, T2D and cardiovascular diseases

Pubmed Data : Mol Nutr Food Res. 2012 Apr ;56(4):632-40. PMID: 22495987
Article Published Date : Mar 31, 2012
Study Type : Review
Additional Links
Substances : Grains: All : CK(3) : AC(1)
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Celiac Disease : CK(1527) : AC(215), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Therapeutic Actions : Dietary Modification: Paleolithic/Stone Age Diet : CK(63) : AC(7)
Additional Keywords : Calcium Deficiency, Folate, Iron Deficiency
Problem Substances : Fumonisin : CK(25) : AC(6)

Gallic acid preserves beta cell function and exhibits insulin-secreting action.

Pubmed Data : Phytother Res. 2009 Jul 16. PMID: 19610036
Article Published Date : Jul 16, 2009
Study Type : In Vitro Study
Additional Links
Substances : Gallic Acid : CK(26) : AC(13)
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218)
Pharmacological Actions : Insulin-releasing : CK(26) : AC(15)
Additional Keywords : Beta Cell Regeneration : CK(60) : AC(24)

Related Blogs

Wheat: 200 Clinically Confirmed Reasons Not To Eat It
Written by Sayer Ji, Founder
Whereas conventional screenings for wheat allergies or celiac disease consider intolerance exceedingly rare, an accumulating body of clinical research now links wheat consumption with over 200 health problems. Could this be why millions of American consumers are now expressing their wholesale rejection of this "king of grains"?

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