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Blood-Brain-Barrier Disorders
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Additional Topics Details for this Page
Article Count
- 15
Cumulative Knowledge
- 25
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View the Evidence: Ailments
Berberine attenuates experimental autoimmune encephalomyelitis in mice.
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(10):e13489. Epub 2010 Oct 19. PMID:
20976070
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Berberine : CK(156) : AC(75)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Brain Inflammation : CK(79) : AC(35)
,
Multiple Sclerosis : CK(716) : AC(133)
Pharmacological Actions
:
Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
,
Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)
Cocaine-induced blood-brain-barrier disruption may precipitate brain pathology.
Click here to read the entire abstract
Pubmed Data
: Int Rev Neurobiol. 2009;88:297-334. PMID:
19897082
Article Published Date
: Jan 01, 2009
Study Type
: Animal Study
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Cocaine Toxicity : CK(19) : AC(5)
Curcumin has a neuroprotective effect on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Click here to read the entire abstract
Pubmed Data
: Chemotherapy. 2010;56(1):60-5. Epub 2010 Mar 19. PMID:
17303117
Article Published Date
: Jan 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Brain Ischemia : CK(94) : AC(38)
,
Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
Pharmacological Actions
:
Neuroprotective Agents : CK(962) : AC(480)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Duodenal and portal glucose changes shown to regulate eating behaviour via brain area modulations
Click here to read the entire abstract
Pubmed Data
: J Neuroendocrinol. 2012 Apr 4. Epub 2012 Apr 4. PMID:
22487360
Article Published Date
: Apr 03, 2012
Study Type
: Animal Study
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Eating Disorders : CK(23) : AC(3)
,
Gut Brain Axis: Imbalance : CK(22) : AC(9)
Pharmacological Actions
:
Brain-derived neurotrophic factor modulator : CK(4) : AC(1)
Additional Keywords
:
Caudate
,
Orbitofrontal Cortex
,
Prepyriform
,
Putamen
Problem Substances
:
Glucose : CK(8) : AC(5)
Magnesium sulfate attenuates increased blood-brain barrier permeability during insulin-induced hypoglycemia in rats.
Click here to read the entire abstract
Pubmed Data
: Can J Physiol Pharmacol. 2001 Sep;79(9):793-8. PMID:
11599780
Article Published Date
: Sep 01, 2001
Study Type
: Animal Study
Additional Links
Substances
:
Magnesium : CK(826) : AC(120)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Hyperinsulinism : CK(1182) : AC(41)
,
Hypoglycemia : CK(274) : AC(21)
Polystyrene nanoparticles are capable of entering through the blood-brain-barrier in an animal model of brain ischemia and perfusion.
Click here to read the entire abstract
Pubmed Data
: Anal Chem. 2004 Aug 1 ;76(15):4465-71. PMID:
15283589
Article Published Date
: Aug 01, 2004
Study Type
: Animal Study
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
Anti Therapeutic Actions
:
Nanotechnology : CK(67) : AC(28)
Problem Substances
:
Polystyrene nanoparticles : CK(16) : AC(2)
Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier.
Click here to read the entire abstract
Pubmed Data
: J Nutr. 2010 Dec;140(12):2187-92. Epub 2010 Oct 27. PMID:
20980646
Article Published Date
: Dec 01, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Cholesterol: Oxidation : CK(457) : AC(98)
,
Endothelial Dysfunction : CK(897) : AC(173)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords
:
Stilbenes : CK(402) : AC(242)
Sesamol improves blood-brain-barrier function in diabetic rats.
Click here to read the entire abstract
Pubmed Data
: Exp Brain Res. 2009 Jul ;197(1):23-34. Epub 2009 Jun 30. PMID:
19565232
Article Published Date
: Jul 01, 2009
Study Type
: Transgenic Animal Study
Additional Links
Substances
:
Sesamol : CK(79) : AC(30)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Diabetes: Cognitive Dysfunction : CK(35) : AC(12)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
Some statin drugs are may cause neurological problems due to their ability to cross the blood-brain barrier.
Click here to read the entire abstract
Pubmed Data
: Pharm Res. 1994 Feb ;11(2):305-11. PMID:
8165193
Article Published Date
: Feb 01, 1994
Study Type
: Animal Study
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Sulforaphane improves cognitive function administered following traumatic brain injury.
Click here to read the entire abstract
Pubmed Data
: Neurosci Lett. 2009 Aug 28;460(2):103-7. Epub 2009 Apr 15. PMID:
19515491
Article Published Date
: Aug 28, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Sulforaphane : CK(520) : AC(171)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Brain Damage : CK(89) : AC(41)
,
Brain Injury: Traumatic : CK(68) : AC(21)
,
Cognitive Decline/Dysfunction : CK(522) : AC(87)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Neuroprotective Agents : CK(962) : AC(480)
Epstein-Barr virus can infect human Blood-Brain-Barrier cells contributing to multiple sclerosis pathogenesis.
Click here to read the entire abstract
Pubmed Data
: J Neuroimmunol. 2011 Jan;230(1-2):173-7. Epub 2010 Sep 9. PMID:
20826008
Article Published Date
: Jan 01, 2011
Study Type
: Review
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Epstein-Barr Virus Infections : CK(100) : AC(43)
,
Multiple Sclerosis : CK(716) : AC(133)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
Problem Substances
:
Epstein-Barr Virus : CK(12) : AC(2)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Resveratrol attenuates oxidized LDL-evoked adverse changes in cerebrovascular endothelial cells.
Click here to read the entire abstract
Pubmed Data
: J Cereb Blood Flow Metab. 2011 Mar;31(3):842-54. Epub 2010 Oct 13. PMID:
20940732
Article Published Date
: Mar 01, 2011
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Cholesterol: Oxidation : CK(457) : AC(98)
Pharmacological Actions
:
Neuroprotective Agents : CK(962) : AC(480)
Sulforaphane may have a therapeutic role to play in brain cancer.
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2008 Jun;52(6):692-700. PMID:
18435488
Article Published Date
: Jun 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane : CK(520) : AC(171)
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
,
Brain Cancer : CK(231) : AC(88)
Pharmacological Actions
:
Anticarcinogenic Agents : CK(521) : AC(275)
,
Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
,
Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)
Wheat germ agglutinin (WGA) enhances the passage of native horseradish peroxidase enzyme (HRP) approximately 10 times more rapidly than HRP alone.
Click here to read the entire abstract
Pubmed Data
: J Neurochem. 1994 Jun;62(6):2404-19. PMID:
7514652
Article Published Date
: Jun 01, 1994
Study Type
: In Vitro Study
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
Problem Substances
:
Lectins : CK(35) : AC(27)
,
Wheat Germ Agglutinin (WGA) : CK(821) : AC(39)
Wheat germ agglutinin (WGA) enters through the blood-brain-barrier through adsorptive endocytosis.
Click here to read the entire abstract
Pubmed Data
: Proc Natl Acad Sci U S A. 1988 Jan;85(2):632-6. PMID:
2448779
Article Published Date
: Jan 01, 1988
Study Type
: In Vitro Study
Additional Links
Diseases
:
Blood-Brain-Barrier Disorders : CK(25) : AC(15)
Problem Substances
:
Lectins : CK(35) : AC(27)
,
Wheat Germ Agglutinin (WGA) : CK(821) : AC(39)
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