Blood Sugar Problems

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View the Evidence: Ailments

There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.

Pubmed Data : Diabetes Care. 2010 Jun;33(6):1224-9. Epub 2010 Mar 9. PMID: 20215447
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Mortality: All-Cause : CK(644) : AC(55)
Problem Substances : Glipizide : CK(64) : AC(6), Glyburide : CK(50) : AC(4)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Among patients with impaired glucose tolerance or type 2 diabetes, rosiglitazone use for at least 12 months is associated with a significantly increased risk of myocardial infarction and heart failure.

Pubmed Data : JAMA. 2007 Sep 12;298(10):1189-95. PMID: 17848653
Article Published Date : Sep 12, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Heart Failure : CK(711) : AC(97), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Rosiglitazone (trade name Avandia) : CK(106) : AC(15)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Antidepressant users have a moderately elevated risk of type 2 diabetes mellitus compared with non-users, even after adjustment for BMI.

Pubmed Data : Diabetologia. 2011 Aug 3. Epub 2011 Aug 3. PMID: 21811871
Article Published Date : Aug 03, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8)
Problem Substances : Antidepressants : CK(245) : AC(33)

Aspirin does not prevent cardiovascular events in diabetes mellitus.

Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Problem Substances : Aspirin : CK(471) : AC(64)

Chocolate consumption is associated with a substantial reduction in the risk of cardiometabolic disorders.

Pubmed Data : BMJ. 2011 ;343:d4488. Epub 2011 Aug 26. PMID: 21875885
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Chocolate : CK(243) : AC(32)
Diseases : Blood Sugar Problems : CK(4280) : AC(727), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122), Stroke : CK(540) : AC(47)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Chronic exposure to organochlorine compounds may contribute to type 2 diabetes and thyroid diseases.

Pubmed Data : Ann Ig. 2010 May-Jun;22(3):185-98. PMID: 20677670
Article Published Date : May 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Organochlorine pesticides : CK(260) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Cinnamon extract and/or cinnamon improves fasting blood sugar in people with type 2 diabetes or prediabetes.

Pubmed Data : J Med Food. 2011 Sep ;14(9):884-9. Epub 2011 Apr 11. PMID: 21480806
Article Published Date : Sep 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Cinnamon : CK(135) : AC(61)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59)
Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.

Pubmed Data : J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20. PMID: 19381015
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Dyslipidemias : CK(176) : AC(33), Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1869) : AC(275)
Problem Substances : Fructose : CK(356) : AC(103)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Consumption of trans-fatty acids from partially hydrogenated oils adversely affects multiple cardiovascular risk factors and contributes significantly to increased risk of oronary heart disease events.

Pubmed Data : Eur J Clin Nutr. 2009 May;63 Suppl 2:S5-21. PMID: 19424218
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173), Inflammation : CK(1077) : AC(363), Insulin Resistance : CK(1034) : AC(221), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Countries with higher availability of HFCS have a higher prevalence of type 2 diabetes independent of obesity.

Pubmed Data : Glob Public Health. 2012 Nov 27. Epub 2012 Nov 27. PMID: 23181629
Article Published Date : Nov 26, 2012
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8)
Problem Substances : High Fructose Corn Syrup : CK(67) : AC(10)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Dietary consumption of Echinacea by mice afflicted with autoimmune (type I) diabetes results in long-lasting immunostimulation of NK cells only and no indication of increased autoimmunity.

Pubmed Data : Autoimmunity. 2005 Sep;38(6):453-61. PMID: 16278152
Article Published Date : Sep 01, 2005
Study Type : Meta Analysis
Additional Links
Substances : Echinacea : CK(469) : AC(88)
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Low Immune Function: Natural Killer Cells : CK(108) : AC(21)
Pharmacological Actions : Immunostimulatory : CK(143) : AC(33)

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744
Article Published Date : Jun 22, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.

Pubmed Data : Diabetes Res Clin Pract. 2008 Dec;82(3):391-5. Epub 2008 Oct 21. PMID: 18945509
Article Published Date : Dec 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Drug: Metformin : CK(195) : AC(23)
Problem Substances : Glibenclamide : CK(122) : AC(3), Glipizide : CK(64) : AC(6)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Intensive glucose lowering treatment increases all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes.

Pubmed Data : BMJ. 2011 ;343:d4169. Epub 2011 Jul 26. PMID: 21791495
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Anti-diabetic drugs : CK(22) : AC(2)

Meta-analysis: Chocolate, cocoa and flavan-3-ols improve insulin resistance, reduces serum insulin levels, and parameters associated with cardiovascular disease risk.

Pubmed Data : Am J Clin Nutr. 2012 Feb 1. Epub 2012 Feb 1. PMID: 22301923
Article Published Date : Feb 01, 2012
Study Type : Meta Analysis
Additional Links
Substances : Chocolate : CK(243) : AC(32), Cocoa : CK(243) : AC(32), Flavan-3-ols : CK(20) : AC(1)
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Hypertension : CK(2783) : AC(271), Insulin: Elevated : CK(186) : AC(41), Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions : Hypotensive : CK(383) : AC(53)

Prolonged TV viewing is associated with increased risk of type 2 diabetes, cardiovascular disease, and all-cause mortality.

Pubmed Data : JAMA. 2011 Jun 15;305(23):2448-55. PMID: 21673296
Article Published Date : Jun 15, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Mortality: All-Cause : CK(644) : AC(55)
Anti Therapeutic Actions : Television Viewing : CK(60) : AC(4)

Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes.

Pubmed Data : N Engl J Med. 2007 Jun 14;356(24):2457-71. Epub 2007 May 21. PMID: 17517853
Article Published Date : Jun 14, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Rosiglitazone (trade name Avandia) : CK(106) : AC(15)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Simvastatin contributes to insulin resistance in non-diabetic patients.

Pubmed Data : Diabetes Res Clin Pract. 2010 Jan ;87(1):98-107. Epub 2009 Nov 12. PMID: 19913318
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59), Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations.

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated : CK(26) : AC(4), Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Elevated: ALT : CK(23) : AC(2), Elevated: Creatinine Kinase : CK(33) : AC(3), GGT : CK(73) : AC(10)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Statin drugs increase the risk of diabetes.

Pubmed Data : Curr Opin Cardiol. 2011 Jul;26(4):342-7. PMID: 21499090
Article Published Date : Jul 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Drug-Induced Toxicity : CK(560) : AC(78), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Related Blogs

Insulin Doubles Death Rate in Type 2 Diabetics: Study
Written by Heidi Stevenson
A new study clearly documents that the standard treatment for type 2 diabetes is a killer, resulting in more than double the deaths. The treatment justification has always been based on irrelevant criteria - just as it is with most pharmaceutical treatments.

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