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Article Count - 39
Cumulative Knowledge - 83

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Quick Summary: Current access displays 2 out of 18 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Curcumin	4	4	Log in \| Sign up
Resveratrol	4	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 3 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Forteo	14	3	Log in \| Sign up
Simian virus 40 (SV40)	1	1	Log in \| Sign up

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View the Evidence: Ailments

Hyperbaric oxygen therapy may be an appropriate therapeutic regimen for the treatment of patients with osteosarcoma.

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Pubmed Data : Oncol Rep. 2009 Nov;22(5):1045-50. PMID: 19787219

Article Published Date : Nov 01, 2009

Study Type : Human Study

Additional Links

Diseases : Osteosarcoma : CK(80) : AC(39)

Therapeutic Actions : Hyperbaric Treatment : CK(297) : AC(32)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Radiotherapy may result in a wide range of destructive effects in the skeletal system.

Click here to read the entire abstract

Pubmed Data : Radiographics. 1998 Sep-Oct;18(5):1125-36; quiz 1242-3. PMID: 9747611

Article Published Date : Sep 01, 1998

Study Type : Human Study

Additional Links

Diseases : Bone Cancer : CK(65) : AC(39), Osteopenia : CK(207) : AC(41)

Additional Keywords : Radiation-Induced High Bone Density : CK(10) : AC(1)

Anti Therapeutic Actions : Radiotherapy : CK(342) : AC(55)

Several cases of osteosarcoma induced by Forteo (teriparatide) have been identified.

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Pubmed Data : Osteoporos Int. 2009 Jul 14. Epub 2009 Jul 14. PMID: 19597911

Article Published Date : Jul 14, 2009

Study Type : Human Study

Additional Links

Diseases : Osteosarcoma : CK(80) : AC(39)

Problem Substances : Forteo : CK(16) : AC(4)

SV40 is associated significantly with brain tumors, bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma.

Click here to read the entire abstract

Pubmed Data : Am J Med. 2003 Jun 1 ;114(8):675-84. PMID: 12798456

Article Published Date : Jun 01, 2003

Study Type : Human Study

Additional Links

Diseases : Bone Cancer : CK(65) : AC(39), Brain Cancer : CK(231) : AC(88), Mesothelioma : CK(30) : AC(10), Non-Hodgkin Lymphoma : CK(525) : AC(67), Simian virus 40 (SV40) : CK(7) : AC(5), Tumors : CK(197) : AC(110)

Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

SV40-like sequences are commonly found in human mesotheliomas and osteosarcomas.

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Pubmed Data : Dev Biol Stand. 1998 ;94:33-40. PMID: 9776223

Article Published Date : Jan 01, 1998

Study Type : Human In Vitro

Additional Links

Diseases : Mesothelioma : CK(30) : AC(10), Osteosarcoma : CK(80) : AC(39), Simian virus 40 (SV40) : CK(7) : AC(5)

Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Forteo (teriparatide) is associated with bone cancer in rats.

Click here to read the entire abstract

Pubmed Data : Toxicol Pathol. 2004 Jul-Aug;32(4):426-38. PMID: 15204966

Article Published Date : Jul 01, 2004

Study Type : Animal Study

Additional Links

Diseases : Osteosarcoma : CK(80) : AC(39)

Problem Substances : Forteo : CK(16) : AC(4)

Forteo is associated with bone cancer in rats.

Click here to read the entire abstract

Pubmed Data : Toxicol Pathol. 2002 May-Jun;30(3):312-21. PMID: 12051548

Article Published Date : May 01, 2002

Study Type : Animal Study

Additional Links

Diseases : Osteosarcoma : CK(80) : AC(39)

Problem Substances : Forteo : CK(16) : AC(4)

Kaempferol induces programmed cell death in human osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Mol Nutr Food Res. 2010 Nov;54(11):1585-95. PMID: 20564475

Article Published Date : Nov 01, 2010

Study Type : Animal Study

Additional Links

Substances : Kaempferol : CK(27) : AC(22)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Simian virus 40 can induce cancers in hamsters

Click here to read the entire abstract

Pubmed Data : Dev Biol Stand. 1998 ;94:273-9. PMID: 9776247

Article Published Date : Jan 01, 1998

Study Type : Animal Study

Additional Links

Diseases : Lymphoma : CK(209) : AC(69), Mesothelioma : CK(30) : AC(10), Osteosarcoma : CK(80) : AC(39), Simian virus 40 (SV40) : CK(7) : AC(5)

Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo.

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Pubmed Data : Oncol Rep. 2007 Nov;18(5):1263-8. PMID: 17914583

Article Published Date : Nov 01, 2007

Study Type : Animal Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

"Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway."

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Pubmed Data : Oncol Rep. 2013 Feb ;29(2):571-8. Epub 2012 Dec 4. PMID: 23232982

Article Published Date : Jan 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone : CK(3) : AC(1)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), NF-kappaB Inhibitor : CK(595) : AC(401)

"Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8."

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cell Biol. 2012 ;13(1):24. Epub 2012 Sep 26. PMID: 23013480

Article Published Date : Dec 31, 2011

Study Type : In Vitro Study

Additional Links

Substances : Genistein : CK(450) : AC(174)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Cell Differentiation Inducer : CK(6) : AC(5)

A garlic derivative has significant anti-proliferative activity against osteosarcoma cells.

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Pubmed Data : Anticancer Drugs. 2009 Sep;20(8):702-12. PMID: 19550292

Article Published Date : Sep 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Garlic : CK(485) : AC(160)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Berberine induces cell cycle arrest and programmed cell death in human osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2009 Mar 9;662(1-2):75-83. Epub 2008 Dec 31. PMID: 19159633

Article Published Date : Mar 09, 2009

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Cancer risk associated with simian virus 40 contaminated polio vaccine.

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 1999 May-Jun;19(3B):2173-80. PMID: 10472327

Article Published Date : Apr 30, 1999

Study Type : Viral

Additional Links

Diseases : Cancers: All : CK(9062) : AC(2869), Ependymoma : CK(1) : AC(1), Mesothelioma : CK(30) : AC(10), Osteosarcoma : CK(80) : AC(39)

Additional Keywords : Vaccine Contamination : CK(5) : AC(1)

Problem Substances : Simian virus 40 (SV40) : CK(84) : AC(16)

Curcumin demonstrates cytotoxic effects on seven osteosarcoma cell lines

Click here to read the entire abstract

Pubmed Data : Invest New Drugs. 2008 Aug;26(4):289-97. Epub 2007 Dec 11. PMID: 18071634

Article Published Date : Aug 01, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Bone Cancer : CK(65) : AC(39), Osteosarcoma : CK(80) : AC(39)

Curcumin has antitumor activity against human osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Invest New Drugs. 2010 Dec;28(6):766-82. PMID: 19730790

Article Published Date : Dec 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Anti-Tumor : CK(69) : AC(44)

Curcumin induces cell cycle arrest and programmed cell death in human osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Anticancer Res. 2009 Dec;29(12):5039-44. PMID: 20044614

Article Published Date : Dec 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Cell cycle arrest : CK(390) : AC(319)

Curcumin may play a therapeutic role in diseases of the bone associated with osteoclastogenesis and bone lysis.

Click here to read the entire abstract

Pubmed Data : J Cancer Res Clin Oncol. 2009 Feb;135(2):173-9. Epub 2008 Sep 3. PMID: 18766375

Article Published Date : Feb 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)

Curcumin reverse multidrug resistance of osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 21434326

Article Published Date : Jan 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Cancers: Multi-Drug Resistant : CK(92) : AC(73), Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Chemosensitizer : CK(197) : AC(159)

Additional Keywords : Drug: Adriamycin : CK(5) : AC(4), Drug Synergy : CK(327) : AC(147)

Depleted uranium is capable of transforming human bone cells into expressing a tumorous phenotype.

Click here to read the entire abstract

Pubmed Data : Environ Health Perspect. 1998 Aug;106(8):465-71. PMID: 9681973

Article Published Date : Aug 01, 1998

Study Type : In Vitro Study

Additional Links

Diseases : Bone Cancer : CK(65) : AC(39)

Problem Substances : Uranium: Depleted : CK(22) : AC(11)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

EGCG induces programmed cell death and inhibits proliferation in human osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Inflamm Bowel Dis. 2000 May;6(2):77-84. PMID: 16756080

Article Published Date : May 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(403) : AC(130)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Flavonoids purified from Rhus verniciflua Stokes (Sumac) actively inhibit cell growth and induce apoptosis in human osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Biochim Biophys Acta. 2005 Nov 30;1726(3):309-16. Epub 2005 Sep 15. PMID: 16213662

Article Published Date : Nov 30, 2005

Study Type : In Vitro Study

Additional Links

Substances : Flavonoids : CK(909) : AC(289)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Anticarcinogenic Agents : CK(521) : AC(275), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Genistein enhances the anti-cancer activity of gemcitabine in osteosarcoma cells.

Click here to read the entire abstract

Pubmed Data : Anticancer Drugs. 2010 Mar;21(3):288-96. PMID: 20038829

Article Published Date : Mar 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Genistein : CK(450) : AC(174)

Diseases : Osteosarcoma : CK(80) : AC(39)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Chemosensitizer : CK(197) : AC(159), NF-kappaB Inhibitor : CK(595) : AC(401)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

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