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4 Substances Researched for Bone Diseases
NameACCKFocus
Cryptoxanthin12Locked
Palm Tree12Locked
Tocotrienols12Locked
Vitamin C11Locked
3 Problem Substances Researched for Bone Diseases
NameACCKFocus
Aromatase Inhibitor Drugs110Locked
Letrozole (trade name Femera)110Locked
Tamoxifen12Locked
1 Problematic Actions Researched for Bone Diseases
NameACCKFocus
Radiotherapy11Locked

View the Evidence:
31 Abstracts with Bone Diseases Research

[+]

Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults.Apr 30, 2017

Pubmed Data : Osteoporos Int. 2017 May 1. Epub 2017 May 1. PMID: 28462469
Article Published Date : Apr 30, 2017
Study Type : Human Study
Additional Links
Substances : Yoghurt
Diseases : Aging, Bone Diseases
Pharmacological Actions : Osteoprotective
Additional Keywords : Aging, Bone Diseases, Osteoprotective, Yoghurt
[+]

Long-term proton pump inhibitors use is associated with risk of bone complications.Feb 28, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Tunis Med. 2018 Mar ;96(3):193-197. PMID: 30325487
Article Published Date : Feb 28, 2018
Study Type : Human Study
Additional Links
Diseases : Bone Diseases, Osteoporosis
Additional Keywords : Increased Risk
Problem Substances : Proton-Pump Inhibitors
[+]

Peripubertal aromatase inhibition in male rats has adverse long-term effects on bone strength and growth and induces prostatic hyperplasia.Oct 01, 2010

Pubmed Data : J Endocrinol. 2010 Oct;207(1):27-34. Epub 2010 Jul 30. PMID: 20675302
Article Published Date : Oct 01, 2010
Study Type : Human Study
Additional Links
Diseases : Bone Diseases, Children: Impaired Growth, Drug-Induced Toxicity , Prostatic Hyperplasia: Benign
Problem Substances : Aromatase Inhibitor Drugs, Letrozole (trade name Femera)
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

This study indicates that daily consumption of 6 g/d of flaxseed oil may reduce bone resorption in hemodialysis patients.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Iran J Kidney Dis. 2018 07 ;12(4):215-222. PMID: 30087216
Article Published Date : Dec 31, 2017
Study Type : Human Study
Additional Links
Substances : Flaxseed
Diseases : Bone Diseases, Hemodialysis
Pharmacological Actions : Osteoprotective
[+]

Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway.Apr 14, 2016

Pubmed Data : Biochem Pharmacol. 2016 Apr 15 ;106:82-93. Epub 2016 Mar 3. PMID: 26947453
Article Published Date : Apr 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Isoliquiritigenin
Diseases : Bone Diseases, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Arctigenin is a promising candidate for the treatment of osteoclast-related osteolytic diseases caused by excessive osteoclast formation.Oct 13, 2018

Pubmed Data : J Cell Biochem. 2018 Oct 14. Epub 2018 Oct 14. PMID: 30317692
Article Published Date : Oct 13, 2018
Study Type : Animal Study
Additional Links
Substances : Arctigenin
Diseases : Bone Diseases, Titanium Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Berberine can be a potential therapeutic agent for osteoclast-related bone diseases.Mar 03, 2019

Pubmed Data : Am J Chin Med. 2019 Mar 4:1-17. Epub 2019 Mar 4. PMID: 30827151
Article Published Date : Mar 03, 2019
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Berberine
Diseases : Bone Diseases, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Osteoprotective
[+]

Better measurement of bone mechanical properties were observed for boron supplementation.Dec 31, 2005

Pubmed Data : Biofactors. 2006 ;28(3-4):195-201. PMID: 17473380
Article Published Date : Dec 31, 2005
Study Type : Animal Study
Additional Links
Substances : Boron
Diseases : Bone Diseases
Pharmacological Actions : Osteoprotective
[+]

Blackcurrant supplementation improves trabecular bone mass in young but not aged mice.Nov 04, 2018

Pubmed Data : Nutrients. 2018 Nov 5 ;10(11). Epub 2018 Nov 5. PMID: 30400569
Article Published Date : Nov 04, 2018
Study Type : Animal Study
Additional Links
Substances : Black Currant
Diseases : Bone Diseases
Pharmacological Actions : Osteoprotective
[+]

Boron preserves bone mass in rats that have been exposed to intense exercise.Dec 31, 2001

Pubmed Data : J Clin Densitom. 2002 ;5(2):187-92. PMID: 12110762
Article Published Date : Dec 31, 2001
Study Type : Animal Study
Additional Links
Substances : Boron
Diseases : Bone Diseases
Therapeutic Actions : Exercise: Aerobic
Pharmacological Actions : Osteoprotective
[+]

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis.Sep 30, 2017

Pubmed Data : J Mol Med (Berl). 2017 Oct ;95(10):1065-1076. Epub 2017 Jul 4. PMID: 28674855
Article Published Date : Sep 30, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Carnosic Acid
Diseases : Bone Diseases
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Osteoprotective
Additional Keywords : Anti-Inflammatory Agents, Antioxidants, Bone Diseases, Carnosic Acid, NF-kappaB Inhibitor, Osteoprotective
[+]

Effects of nutritional deficiency of boron on the bones of the appendicular skeleton of mice.Sep 03, 2018

Pubmed Data : Biol Trace Elem Res. 2018 Sep 4. Epub 2018 Sep 4. PMID: 30182352
Article Published Date : Sep 03, 2018
Study Type : Animal Study
Additional Links
Substances : Boron
Diseases : Bone Diseases, Boron Deficiency
[+]

Fermented rooibos may have a beneficial effect on bone health.May 22, 2018

Pubmed Data : Food Funct. 2018 May 23. Epub 2018 May 23. PMID: 29790498
Article Published Date : May 22, 2018
Study Type : Animal Study
Additional Links
Substances : Rooibos
Diseases : Bone Diseases, Osteoporosis
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Osteoprotective
[+]

Herbacetin has potential for use as a therapeutic agent in disorders associated with bone loss.Apr 14, 2016

Pubmed Data : Eur J Pharmacol. 2016 Apr 15 ;777:17-25. Epub 2016 Feb 26. PMID: 26923730
Article Published Date : Apr 14, 2016
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Flavonoids, Flaxseed
Diseases : Bone Diseases, Inflammation, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Parthenolide has potential therapeutic value for bone destructive disorders that are associated with increased bone resorption.Jul 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMB Rep. 2014 Aug ;47(8):451-6. PMID: 24314143
Article Published Date : Jul 31, 2014
Study Type : Animal Study
Additional Links
Substances : Parthenolide
Diseases : Bone Diseases, Osteoarthrosis
Pharmacological Actions : Osteoprotective
[+]

Supplementation with β-cryptoxanthin would be beneficial for prophylaxis and for therapy of metabolic bone diseases associated with abnormal osteoclast activation.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pharmacol Sci. 2015 Sep ;129(1):72-7. Epub 2015 Aug 22. PMID: 26342276
Article Published Date : Aug 31, 2015
Study Type : Animal Study
Additional Links
Substances : Cryptoxanthin
Diseases : Bone Diseases, Bone Diseases: Over-Active Osteoclasts
Additional Keywords : Supplementation
[+]

Tamoxifen impairs both longitudinal and cortical bone growth in young male rats.Aug 01, 2008

Pubmed Data : J Bone Miner Res. 2008 Aug;23(8):1267-77. PMID: 18348701
Article Published Date : Aug 01, 2008
Study Type : Animal Study
Additional Links
Diseases : Bone Diseases
Additional Keywords : Drug: Tamoxifen
Problem Substances : Tamoxifen
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Tetramethylpyrazine eliminates the senescent phenotype of bone marrow mesenchymal stromal.May 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Aging Cell. 2018 Jun ;17(3):e12741. Epub 2018 Feb 28. PMID: 29488314
Article Published Date : May 31, 2018
Study Type : Animal Study
Additional Links
Substances : Ligustrazine
Diseases : Aging, Bone Diseases
[+]

Tocotrienols are more effective than d-alpha tocopherol in protecting the bone from free radical damage.Mar 31, 2005

Pubmed Data : N Engl J Med. 2005 Mar 31;352(13):1293-304. Epub 2005 Mar 7. PMID: 18598299
Article Published Date : Mar 31, 2005
Study Type : Animal Study
Additional Links
Substances : Palm Tree, Tocotrienols
Diseases : Bone Diseases
Pharmacological Actions : Antioxidants
[+]

20(R)-ginsenoside Rh2 is a selective osteoclastgenesis inhibitor without any cytotoxicity.Jun 14, 2009

Pubmed Data : Bioorg Med Chem Lett. 2009 Jun 15 ;19(12):3320-3. Epub 2009 Apr 18. PMID: 19428246
Article Published Date : Jun 14, 2009
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Bone Diseases
Pharmacological Actions : Osteoprotective
[+]

Boron deficiency has been correlated with low immune function and high incidence of osteoporosis.Nov 30, 2018

Pubmed Data : J Trace Elem Med Biol. 2018 Dec ;50:296-304. Epub 2018 Jul 24. PMID: 30262295
Article Published Date : Nov 30, 2018
Study Type : Review
Additional Links
Substances : Boron
Diseases : Bone Diseases, Boron Deficiency , Osteoporosis
Additional Keywords : Risk Factors
[+]

Cafestol may be a novel agent for bone diseases.Jun 30, 2015

Pubmed Data : Biofactors. 2015 Jul-Aug;41(4):222-31. Epub 2015 Jul 7. PMID: 26154488
Article Published Date : Jun 30, 2015
Study Type : In Vitro Study
Additional Links
Substances : Cafestol, Kahweol
Diseases : Bone Diseases, Osteoarthritis
Pharmacological Actions : MicroRNA modulator, NF-kappaB Inhibitor, Nrf2 activation, Osteogenic, Osteoprotective
Additional Keywords : Dose Response
[+]

Cannabinoids and bone regeneration.Jan 30, 2019

Pubmed Data : Drug Metab Rev. 2019 Jan 31:1-20. Epub 2019 Jan 31. PMID: 30702341
Article Published Date : Jan 30, 2019
Study Type : Review
Additional Links
Substances : Cannabinoids
Diseases : Bone Diseases
Pharmacological Actions : Osteoprotective
Additional Keywords : Bone Regeneration
[+]

Harmine has bone anabolic effects and may be useful for the treatment of bone-decreasing diseases and bone regeneration.Jun 02, 2011

Pubmed Data : Biochem Biophys Res Commun. 2011 Jun 3 ;409(2):260-5. Epub 2011 May 6. PMID: 21570953
Article Published Date : Jun 02, 2011
Study Type : In Vitro Study
Additional Links
Substances : Psychedelics:All
Diseases : Bone Diseases
Pharmacological Actions : MicroRNA modulator, Osteoprotective
[+]

Isoquercitrin is a natural potential osteoinductive compound and might be valuable for the prevention or treatment of bone disorders.Jun 17, 2018

Pubmed Data : Connect Tissue Res. 2018 Jun 18:1-11. Epub 2018 Jun 18. PMID: 29852784
Article Published Date : Jun 17, 2018
Study Type : In Vitro Study
Additional Links
Substances : Isoquercitrin
Diseases : Bone Diseases, Osteoporosis
Pharmacological Actions : Osteoprotective
[+]

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation.Jul 31, 2017

Pubmed Data : Mol Med Rep. 2017 Aug ;16(2):1328-1332. Epub 2017 Jun 12. PMID: 28627701
Article Published Date : Jul 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Mangiferin
Diseases : Bone Diseases, Osteoarthritis
[+]

Quercetin may be a potential drug for preventing abnormal human bone loss induced by LPS in bacteria-induced bone diseases.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Physiol Biochem. 2017 ;43(4):1547-1561. Epub 2017 Oct 16. PMID: 29035884
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Quercetin
Diseases : Bone Diseases, Lipopolysaccharide-Induced Toxicity
Pharmacological Actions : Anti-Apoptotic, Osteoprotective
[+]

Radiotherapy may have a wide range of serious adverse effects in skeletal system.Jan 01, 1985

Pubmed Data : Crit Rev Diagn Imaging. 1985;23(3):235-67. PMID: 3891233
Article Published Date : Jan 01, 1985
Study Type : Commentary
Additional Links
Diseases : Bone Diseases, Sarcoma
Anti Therapeutic Actions : Radiotherapy
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These results revealed that Chrysanthemum indicum extract could have a potential therapeutic role in bone-related disorders.Dec 31, 2013

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2014 ;2014:176049. Epub 2014 Oct 28. PMID: 25530776
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Chrysanthemum Indicum
Diseases : Bone Diseases
Pharmacological Actions : Osteoprotective
[+]

This review examines the functional importance of vitamin C as it relates to the development and maintenance of bone tissues. Sep 10, 2015

Pubmed Data : J Bone Miner Res. 2015 Sep 11. Epub 2015 Sep 11. PMID: 26358868
Article Published Date : Sep 10, 2015
Study Type : Review
Additional Links
Substances : Vitamin C
Diseases : Bone Diseases, Bone Fractures, Osteoporosis
Additional Keywords : Epigenetic Modification, Gene Expression Regulation
[+]

Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss.Oct 03, 2018

Pubmed Data : FASEB J. 2018 Oct 4:fj201800920R. Epub 2018 Oct 4. PMID: 30285579
Article Published Date : Oct 03, 2018
Study Type : In Vitro Study
Additional Links
Substances : Tomatidine
Diseases : Bone Diseases, Osteoporosis
Pharmacological Actions : Osteoprotective

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