Brain Inflammation

Name	AC	CK
Curcumin	20	31
Alpha-Lipoic Acid	2	11
Resveratrol	8	11
Cannabinoids	7	10
Frankincense	1	10
Melatonin	5	9
Silibinin	3	6
Apigenin	4	5
Bee Venom	3	5
Cannabidiol	3	5
EGCG (Epigallocatechin gallate)	4	5
Flavonoids	4	5
Ginger	3	5
6-Shogaol	2	4
Berberine	2	4
Ginkgo biloba	2	4
Huperzine	3	4
Luteolin	3	4
Ume (Japanese apricot)	2	4
Blueberry	2	3
Catechols	2	3
Arctigenin	1	2
Arginine	1	2
Astaxanthin	1	2
Bacopa	2	2
Baicalein	1	2
Bamboo	1	2
Bee Pollen	1	2
Berries: All	1	2
Burdock	1	2
Chinese Skullcap	1	2
Choline	1	2
Citrus Peel	1	2
Coconut Oil	1	2
Delta-tetrahydrocannabinol (THC)	2	2
EPA (Eicosapentaenoic Acid)	1	2
Endocannabinoids	1	2
Fermented Foods and Beverages	1	2
Gardenia	1	2
Garlic	2	2
Ginsenosides	1	2
Glucosamine	1	2
Gotu Kola	1	2
Grape Seed Extract	1	2
Hesperidin	1	2
Lactobacillus probiotics	1	2
Lithium	1	2
Magnesium	1	2
Naringenin	1	2
Neem	1	2
Nobiletin	1	2
Olive Oil	1	2
Peony	1	2
Piperine	1	2
Polyphenols	2	2
Reishi Mushroom	1	2
Rutin	1	2
St. Johns Wort	1	2
Sulforaphane	1	2
Sweet Potato: Purple	1	2
Tangeretin	1	2
Vitamin C	1	2
Walnut	1	2
Acacia catechu	1	1
Achillea fragrantissima	1	1
Agrimony	1	1
Butterbur	1	1
Cannabinoids: Synthetic	1	1
Cannabis	1	1
Chrysin	1	1
Cordyceps sinensis	1	1
Cysteine (see N-Acetylcysteine)	1	1
DHA (Docosahexaenoic Acid)	1	1
Dandelion	1	1
Elderberry	1	1
Fisetin	1	1
Fucoidan	1	1
Goji	1	1
Green Tea	1	1
Knema laurina	1	1
Maple Syrup	1	1
Persimmon	1	1
Pomegranate	1	1
Pycnogenol (Pine Bark)	1	1
Quercetin	1	1
Red Wine Extract	1	1
Rice Bran	1	1
Spirulina	1	1
Thymoquinone	1	1
Toona sinensis	1	1
Turmeric	1	1
Turmerones	1	1
Vitamin D	1	1
Wine	1	1

Name	AC	CK
Aluminum	4	14
Butyrophilin	1	10
Chlamydia Pneumoniae	1	10
Cow Milk	1	10
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	1	10
Streptococcal M Protein	1	10
Aspartame	1	2
Fluoride	1	2
Glyphosate formulations	1	2
High Fructose Corn Syrup	1	2
Nanoparticles	1	2
Roundup (herbicide)	1	2
Simvastatin	1	2
Sodium Fluoride	1	2

Name	AC	CK
Exercise	3	4
Exercise: Endurance	1	2
Laser Treatment: Low-Level	1	2

Name	AC	CK
Nanotechnology	1	2
Vaccination: HPV (Gardisil)	1	2
Vaccination: All	1	1
Vaccination: Yellow Fever	1	1

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Boswellic acids could be used to reduce peritumoral edema associated with primary and secondary brain tumors.Dec 14, 2011

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Pubmed Data : J Pharm Biomed Anal. 2011 Dec 15 ;56(5):998-1005. Epub 2011 Jul 29. PMID: 21855244

Article Published Date : Dec 14, 2011

Study Type : Human Study

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : J HIV AIDS. 2016 May ;2(3). Epub 2016 May 11. PMID: 27398410

Article Published Date : Apr 30, 2016

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Brain Inflammation , HIV Infections

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Plant Extracts

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Bee pollen can be used safely to ameliorate oxidative stress, neuroinflammation, poor detoxification, and abnormal gut microbiota.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Complement Altern Med. 2016 ;16(1):120. Epub 2016 Apr 23. PMID: 27107819

Pubmed Data : J Parasitol. 2016 Aug 11. Epub 2016 Aug 11. PMID: 27513205

Article Published Date : Aug 10, 2016

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Brain Inflammation , Toxoplasma gondii Infection

Additional Keywords : Increased Risk

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Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Click here to read the entire abstract

Pubmed Data : Inflammopharmacology. 2016 Nov 16. Epub 2016 Nov 16. PMID: 27853890

Article Published Date : Nov 15, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Brain Inflammation , Parkinson's Disease

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Anti-Inflammatory Agents, Brain Inflammation, CURCUMIN, Interleukin-1 beta downregulation, Natural Substance Synergy, Parkinson's disease, Piperine

[+]

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

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Pubmed Data : Pharmacology. 2016 Jan 30 ;97(3-4):151-160. Epub 2016 Jan 30. PMID: 26828892

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Pubmed Data : Biomed Pharmacother. 2016 Dec 22 ;86:441-449. Epub 2016 Dec 22. PMID: 28012923

Article Published Date : Dec 21, 2016

Study Type : Animal Study

Additional Links

Substances : Rosemary, Rosmarinic acid

Diseases : Brain Inflammation , Neuropathic Pain

Pharmacological Actions : Anti-Inflammatory Agents, Cyclooxygenase 2 Inhibitors, Interleukin-1 beta downregulation, Matrix metalloproteinase-2 (MMP-2) inhibitor, Nitric Oxide Inhibitor, Prostaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

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F. mume is a potentially valuable drug or nutraceutical for the treatment of vascular dementia.Jan 31, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

[+]

MECHANISMS UNDERLYING THE NEUROTOXICITY INDUCED BY GLYPHOSATE-BASED HERBICIDE IN IMMATURE RAT HIPPOCAMPUS: INVOLVEMENT OF GLUTAMATE EXCITOTOXICITY.Mar 13, 2014

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Pubmed Data : Toxicology. 2014 Mar 14. Epub 2014 Mar 14. PMID: 24636977

Article Published Date : Mar 13, 2014

Study Type : Animal Study

Additional Links

Diseases : Alzheimer's Disease, Brain Inflammation , Neurotoxicity, Parkinson's Disease, Parkinsonism

Problem Substances : Glyphosate formulations, Roundup (herbicide)

Adverse Pharmacological Actions : Excitotoxic, Neurotoxic

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Melatonin attenuates sepsis induced brain injury via activation SIRT1 signaling activation.Jun 09, 2015

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Pubmed Data : J Pineal Res. 2015 Jun 10. Epub 2015 Jun 10. PMID: 26094939

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Cell Mol Immunol. 2015 Nov 9. Epub 2015 Nov 9. PMID: 26549801

Pubmed Data : Inflammation. 2016 Feb ;39(1):405-12. PMID: 26490968

Article Published Date : Jan 31, 2016

Study Type : Animal Study

Additional Links

Diseases : Brain Inflammation , Hyperalgesia, Toxoplasma gondii Infection

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Tangerine peel possesses potent anti-neuroinflammatory capacity which is attributed to the collective effect of hesperidin, nobiletin, and tangeretin.Aug 31, 2014

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Pubmed Data : Food Chem Toxicol. 2014 Sep ;71:176-82. Epub 2014 Jun 20. PMID: 24955543

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Pubmed Data : Sci Rep. 2017 Apr 10 ;7:45693. Epub 2017 Apr 10. PMID: 28393871

Article Published Date : Apr 09, 2017

Study Type : Animal Study

Additional Links

Diseases : Aggression, Brain Inflammation

Additional Keywords : Increased Risk

Problem Substances : Sugar Sweetened Beverages

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Treatment with bee venom phospholipase A2 attenuated learning and memory deficits exerted anti-neuroinflammation effects in 3xTg-AD mice.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : PLoS One. 2015 ;10(3):e0120203. Epub 2015 Mar 19. PMID: 25789481

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Ginger

Diseases : Brain Inflammation , Central Nervous System Diseases, Cerebral Ischemia

Pharmacological Actions : Anti-Inflammatory Agents, Neuroprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Paradols

[+]

A Cordyceps sinensis extract reduced the amount of hypoxia-induced inflammatory cytokines and transcription factors on par with the normoxic control.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Stem Cell Res Ther. 2014 ;5(6):127. Epub 2014 Nov 17. PMID: 25688994

Article Published Date : Dec 31, 2013

Study Type : Review

Additional Links

Substances : Turmeric, Turmerones

Diseases : Brain Inflammation , Neurodegenerative Diseases, Stroke: Attenuation/Recovery

Pharmacological Actions : Neuroprotective Agents

Additional Keywords : Neural Stem Cell

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Ashwagandha may prove to be a potential therapeutic candidate for the suppression of neuroinflammation.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neuroinflammation. 2016 ;13(1):193. Epub 2016 Aug 22. PMID: 27550017

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Pubmed Data : Planta Med. 2005 Jan;71(1):12-9. PMID: 15678367

Article Published Date : Jan 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Butterbur

Diseases : Brain: Microglial Activation, Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Cyclooxygenase 1 Inhibitor, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Postaglandin PGE2 downregulation

Additional Keywords : Plant Extracts

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Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants.Jul 06, 1998

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Extracts of Toona sinensis leaves could be used in the treatment of neurodegenerative diseases by inhibition of inflammatory mediator production in activated microglia.Jan 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Kaohsiung J Med Sci. 2014 Feb ;30(2):73-81. Epub 2013 Nov 1. PMID: 24444536

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Neuroinflammation. 2017 Mar 24 ;14(1):63. Epub 2017 Mar 24. PMID: 28340576

Article Published Date : Mar 23, 2017

Study Type : In Vitro Study

Additional Links

Substances : Reishi Mushroom

Diseases : Brain Inflammation , Lipopolysaccharide-Induced Toxicity

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Polysaccharides

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Reducing neuroinflammation might be beneficial for patients with depression. Sep 29, 2015

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Pubmed Data : Neuromolecular Med. 2016 Sep ;18(3):474-82. Epub 2016 Jun 4. PMID: 27263111

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Pubmed Data : Brain Res Bull. 2016 Mar 26 ;125:19-29. Epub 2016 Mar 26. PMID: 27021169

Pubmed Data : Neurochem Res. 2016 Jul 14. Epub 2016 Jul 14. PMID: 27418278

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View the Evidence: 183 Abstracts with Brain Inflammation Research

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Boswellic acids could be used to reduce peritumoral edema associated with primary and secondary brain tumors.Dec 14, 2011

Inflammation may influence glutamate metabolism to alter behaviour, leading to depressive symptoms.Nov 09, 2016

Lipoic acid down-regulates inflammation in multiple sclerosis patients.Jan 01, 2010

Milk and bacterial proteins may produce neuron-specific antigens in children with autism. Aug 01, 2002

The results suggest that aluminum-induced CRP may in part contribute to a pathophysiological state associated with a chronic systemic inflammation of the human vasculature.Jul 31, 2015

This demonstrates the broad neuroprotective action of apigenin against AD pathogenesis in a human disease model.Dec 31, 2015

6-Shogaol exerts neuroprotective effects on dopaminergic neurons in vitro and in vivo parkinson's disease models.Aug 31, 2013

6-shogaol may play a role in inhibiting glial cell activation and reducing memory impairment in animal models of dementia. Jun 19, 2014

A combination of ginger and peony root may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.Nov 29, 2015

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.Feb 06, 2017

A Spirulina diet given to lactating mothers can protect against neuroinflammation and decreased antioxidant defence in brain of suckling pups.Aug 28, 2016

Administering curcumin may alleviate cerebral inflammation resulting from intracerebral hemorrhage.Mar 25, 2016

Administration of synthetic 2-AG to mice after CHI led to significant reduction of brain oedema, better clinical recovery, reduced infarct volume and reduced hippocampal cell death compared with controls.Oct 03, 2001

Aluminium, fluoride and a combination of aluminium-fluoride treatments caused an increase in brain lipid peroxidation products and reactive oxygen species formation.Feb 28, 2015

Aluminum can induce neuroinflammation and could lead to learning and memory deficits.Apr 30, 2016

Apigenin restored immune function and decreased neuroinflammation in an experimental autoimmune encephalomyelitis model. Jun 03, 2015

Arctigenin may have anti-inflammatory and immunosuppressive properties via inhibiting Th17 cells.Oct 05, 2015

Ashwagandha may serve as an effective dietary supplement for management of sleep deprivation induced stress and associated functional impairments.Dec 20, 2016

Ashwagandha treatment reversed the cytoplasmic mislocalization of hTDP-43 in spinal motor neurons and in brain.Dec 06, 2016

Astaxanthin had an anti-depressant effect on diabetic mice.Dec 21, 2016

Astaxanthin suppresses the neurological disorders induced by the K+ channel blocker kaliotoxin.Apr 05, 2016

Baicalein is a promising novel analgesic agent for cancer-induced bone pain.Dec 31, 2014

Bamboo extracts could be useful in treating HIV driven brain inflammation. Apr 30, 2016

Bee pollen can be used safely to ameliorate oxidative stress, neuroinflammation, poor detoxification, and abnormal gut microbiota.Dec 31, 2015

Bee venom could be considered a potential therapeutic or preventive agent for PD and other neuroinflammatory associated disorders.Jul 27, 2016

Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process.Jan 02, 2017

Berberine attenuates experimental autoimmune encephalomyelitis in mice.Jan 01, 2010

Berberine could alleviate postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice.Jun 30, 2016

Blueberry attenuates microglial activation in the brain suggesting it may attenuate age-induced inflammation. Dec 14, 2009

Cannabidiol may have potential as a preventative treatment for Alzheimer's disease.Dec 31, 2013

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.Apr 30, 2009

Cannabinoids may have therapeutic value in neurodegenerative conditions by preventing and/or reducing neuroinflammation. Feb 22, 2007

Chronic consumption of alcohol in combination with energy drinks causes an inflammatory response and oxidative stress.Dec 31, 2015

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation. Aug 31, 2012

Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation.Aug 01, 2007

Chronic T. gondii infection promotes neuroinflammation through cytokine networks and induces pathological progression of Alzheimer's disease.Aug 10, 2016

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.Nov 15, 2016

Curcumin and piperine showed strong antioxidant and protective effect against QA-induced behavioural and neurological alteration.Jan 29, 2016

Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.Aug 07, 2015

Curcumin is effective in attenuating glial activation and ameliorates cognitive deficits in chronic epilepsy.Jul 15, 2015

Curcumin may be beneficial in the treatment of acute stress induced anxiety and enhancement of memory function.May 31, 2015

Curcumin protects pre-oligodendrocytes from activated microglia, indicating it may play a role in protecting against preterm periventricular leukomalacia (PVL).Jun 21, 2010

Curcumin treatment attenuates ischemic stroke-induced brain injury via activation of SIRT1.Nov 26, 2015

Curcumin treatment significantly improved the neurological status evaluated during 2 weeks after brain injury.Aug 31, 2013

Dietary choline supplementation improves behavioral, histological, and neurochemical outcomes in a rat model of traumatic brain injury.Aug 01, 2008

Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway.Dec 31, 2012

EGCG has a beneficial effect on impaired adult neurogenesis caused by lipopolysaccharide induced neuro-inflammation.Dec 31, 2015

Electroacupuncture pre-treatment alleviates sepsis-induced brain injury by inhibition of microglial activation and attenuation of inflammation.Oct 18, 2016

Endurance exercise may exert neuroprotective effects by mitigating the production of pro-inflammatory cytokines.Mar 15, 2016

EPA and GLA attenuate interleukin-1 beta-induced brain inflammation in rats. May 01, 2008

Exercise three times a week was effective at reversing serum and brain RANTES and MCP-1 expression to the levels of controls.Dec 31, 2015

Extracts of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain.Dec 21, 2016

F. mume is a potentially valuable drug or nutraceutical for the treatment of vascular dementia.Jan 31, 2016

F. mume is potentially an effective therapeutic for the treatment of vascular dementia.Dec 31, 2014

Fermentation enhances Ginkgo biloba protective role on gamma-irradiation induced inflammatory gene expression and stress hormones in rat brain.Mar 03, 2016

Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions.Jul 15, 2016

Genipin, a compound found within gardenia fruit, inhibits microglial activation in a mouse model of brain inflammation. Feb 01, 2010

Genistein supplementation alleviated neuroinflammation and peripheral and brain insulin resistance.Oct 30, 2016

Ginger inhibits micoglial cell activiation associated with brain inflammation. Jun 01, 2009

Ginkgo biloba extract has specific neuroprotective effects that may be useful for the treatment of chronic cerebral hypoperfusion.Nov 14, 2016

Ginkgo biloba extract improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse.Jul 31, 2016

Ginsenoside has an anti-neuroinflammation effect in a rat model of Alzheimer disease.Jan 03, 2011

Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury.Nov 15, 2010

Gotu Kola protected against sleep deprivation-induced anxiety-like behaviour, oxidative damage and neuroinflammation in mice.Feb 04, 2016

Gut bacteria regulate movement disorders in mice and suggest that alterations in the human microbiome represent a risk factor for PD.Nov 30, 2016

Hesperidin could reduce the incidence and severity of Multiple sclerosis.Nov 25, 2016

HFCS-55, negatively impacts hippocampal function, metabolic outcomes, and neuroinflammation when consumed in excess during the adolescent period of development.Jan 31, 2015

Hippocampal derangements triggered by high fat-high fructose diet feeding were effectively curtailed by apigenin.Feb 22, 2017

Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.Mar 01, 2010

Hyperbaric oxygen therapy treatment may ameliorate TBI-induced depression-like behaviour in rats by attenuating neuro-inflammation.Jan 04, 2017

L-arginine causes amelioration of cerebrovascular dysfunction and brain inflammation during experimental heatstroke.Feb 01, 2008

Long-term resveratrol treatment confers neuroprotection against cerebral vascular dysfunction during nutrient stress.Apr 08, 2016

Brain Inflammation

View the Evidence:
183 Abstracts with Brain Inflammation Research