Breast Cancer: HER-2 Overexpressed

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10 Substances Researched for Breast Cancer: HER-2 Overexpressed

Name	AC	CK
Cucurbitacin B	1	2
Apigenin	1	1
Berberine	1	1
Bioflavonoids	1	1
Erucin	1	1
Naringenin	1	1
Olive Oil	1	1
Polyphenols	1	1
Sulforaphane	1	1
Vitamin E: Gamma-tocotrienol	1	1

Research Articles 9
Cumulative Knowledge Score 14
Overall Research Rating GOOD

View the Evidence:
9 Abstracts with Breast Cancer: HER-2 Overexpressed Research

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Cucurbitacin B administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%.Apr 14, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2014 Apr 15 ;5(7):1812-28. PMID: 24729020

Article Published Date : Apr 14, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed, Breast Cancer: Triple Negative

Pharmacological Actions : Antiproliferative , Apoptotic, Epidermal growth factor receptor (EGFR) inhibitor

Additional Keywords : Dose Response

[+]

Curcumin exhibits potential utility in the treatment of HER-2 overexpressed breast cancer. Jan 01, 2012

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Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:486568. Epub 2011 Jun 6. PMID: 21876713

Article Published Date : Jan 01, 2012

Study Type : Transgenic Animal Study

Additional Links

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Chemopreventive, HER-2 oncoprotein down-regulation, NF-kappaB Inhibitor

[+]

Apigenin was found to be an effective phytoestrogen that strongly inhibited the growth of breast cancer cells, including HER2-positive ones.Jun 30, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Naturae. 2015 Jul-Sep;7(3):133-9. PMID: 26483970

Article Published Date : Jun 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Apigenin

Diseases : Breast Cancer, Breast Cancer: estrogen receptor alpha-positive, Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Antiproliferative , Cytotoxic

[+]

Combined treatment induced apoptosis more efficiently than either agent alone; however the most effective was a combination of lapatinib with erucin.Jul 01, 2015

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Pubmed Data : Nutr Cancer. 2015 Jul 2:1-11. Epub 2015 Jul 2. PMID: 26134366

Article Published Date : Jul 01, 2015

Study Type : In Vitro Study

Additional Links

Substances : Erucin, Sulforaphane

Diseases : Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Drug: Allopurinol, Isothiocyanates, Natural Substance/Drug Synergy

[+]

Extra-virgin olive oil polyphenols induced strong tumoricidal effects by selectively triggering apoptotic cell death in HER2-positive cells.Dec 31, 2008

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Pubmed Data : Int J Oncol. 2009 Jan ;34(1):43-51. PMID: 19082476

Article Published Date : Dec 31, 2008

Study Type : In Vitro Study

Additional Links

Substances : Olive Oil, Polyphenols

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Anti-metastatic, Anti-Tumor, Apoptotic

Additional Keywords : Plant Oils, Selective Cytotoxicity

[+]

Gamma-tocotrienol is a promising natural drug for future breast cancer therapy.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMC Cancer. 2015 ;15:609. Epub 2015 Aug 28. PMID: 26315028

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Vitamin E: Gamma-tocotrienol

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed, Cervical Cancer, Colon Cancer

Pharmacological Actions : Antioxidants, Apoptotic

Additional Keywords : Cancer Stem Cells, Gene Expression Regulation

[+]

Hesperetin and Naringenin sensitize HER2 positive cancer cells to death.Jul 19, 2016

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Pubmed Data : Life Sci. 2016 Jul 20. Epub 2016 Jul 20. PMID: 27449398

Article Published Date : Jul 19, 2016

Study Type : In Vitro Study

Additional Links

Substances : Bioflavonoids, Naringenin

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed

Pharmacological Actions : Apoptotic, Chemosensitizer

[+]

These finding provides a novel strategy of using berberine to overcome lapatinib resistance.Jul 13, 2016

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Pubmed Data : Cancer Biol Ther. 2016 Jul 14:0. Epub 2016 Jul 14. PMID: 27416292

Article Published Date : Jul 13, 2016

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed, Cancers: Drug Resistant

Pharmacological Actions : Apoptotic

[+]

These results show an association between elevated CB2 expression in HER2+ breast tumors and poor patient prognosis.May 31, 2015

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Pubmed Data : J Natl Cancer Inst. 2015 Jun ;107(6):djv077. Epub 2015 Apr 8. PMID: 25855725

Article Published Date : May 31, 2015

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer, Breast Cancer: HER-2 Overexpressed

Additional Keywords : Cannabinoid Receptors

Research Articles 9
Cumulative Knowledge Score 14
Overall Research Rating GOOD

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Focus Your Research

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View the Evidence: 9 Abstracts with Breast Cancer: HER-2 Overexpressed Research

Limited to Members Only

Currently Available Sorting Options

Cucurbitacin B administration inhibited MDA-MB-231 orthotopic tumors by 55%, and 4T-1 tumors by 40%.Apr 14, 2014

Curcumin exhibits potential utility in the treatment of HER-2 overexpressed breast cancer. Jan 01, 2012

Apigenin was found to be an effective phytoestrogen that strongly inhibited the growth of breast cancer cells, including HER2-positive ones.Jun 30, 2015

Combined treatment induced apoptosis more efficiently than either agent alone; however the most effective was a combination of lapatinib with erucin.Jul 01, 2015

Extra-virgin olive oil polyphenols induced strong tumoricidal effects by selectively triggering apoptotic cell death in HER2-positive cells.Dec 31, 2008

Gamma-tocotrienol is a promising natural drug for future breast cancer therapy.Dec 31, 2014

Hesperetin and Naringenin sensitize HER2 positive cancer cells to death.Jul 19, 2016

These finding provides a novel strategy of using berberine to overcome lapatinib resistance.Jul 13, 2016

These results show an association between elevated CB2 expression in HER2+ breast tumors and poor patient prognosis.May 31, 2015

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Breast Cancer: HER-2 Overexpressed

View the Evidence:
9 Abstracts with Breast Cancer: HER-2 Overexpressed Research