Breast Cancer: Triple Negative

Breast Cancer: Triple Negative

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Article Count - 13
Cumulative Knowledge - 61

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What is Cumulative Knowledge?

Cumulative Knowledge is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.

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Quick Summary: 6 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Blueberry	4	2	Log in \| Sign up
Bee Propolis	2	1	Log in \| Sign up
Caffeic acid phenethyl ester	2	1	Log in \| Sign up
Curcumin	2	2	Log in \| Sign up
Flavonoids	2	1	Log in \| Sign up
Polyphenols	2	1	Log in \| Sign up

Quick Summary: 3 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Fructose	10	1	Log in \| Sign up
High Fructose Corn Syrup	10	1	Log in \| Sign up
Oral Contraceptives	10	1	Log in \| Sign up

Quick Summary: 2 associated Problematic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Radiotherapy	20	2	Log in \| Sign up
Chemotherapy	10	1	Log in \| Sign up

View the Evidence: Ailments

Fructose consumption may worsen the condition of breast cancer patients.

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Pubmed Data : Int J Oncol. 2010 Sep;37(3):615-22. PMID: 20664930

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Bone Metastasis : CK(19) : AC(8), Breast Cancer: Invasive Lobular Carcinoma (ILC) : CK(51) : AC(4), Breast Cancer: Metastatic : CK(82) : AC(33), Breast Cancer: Prevention : CK(525) : AC(73), Breast Cancer: Recovery : CK(110) : AC(11), Breast Cancer: Triple Negative : CK(61) : AC(13)

Problem Substances : Fructose : CK(356) : AC(103), High Fructose Corn Syrup : CK(67) : AC(10)

Oral contraceptive use>or =1 year was associated with a 2.5-fold increased risk for triple-negative breast cancer.

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Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1157-66. Epub 2009 Mar 31. PMID: 19336554

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Triple Negative : CK(61) : AC(13), Cancer Metastasis : CK(272) : AC(135)

Problem Substances : Oral Contraceptives : CK(287) : AC(24)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Radiation and chemotherapy may increase tumour-initiating cell activity in triple-negative breast cancer.

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Pubmed Data : Expert Rev Mol Med. 2010;12:e22. Epub 2010 Jul 26. PMID: 20653987

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38), Radiotherapy : CK(342) : AC(55)

Radiotherapy in women undergoing breast conservation treatment with triple-negative results in poorer outcomes.

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Pubmed Data : JPEN J Parenter Enteral Nutr. 2006 Jan-Feb;30(1):10-5. PMID: 19433390

Article Published Date : Jan 01, 2006

Study Type : Human Study

Additional Links

Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Triple Negative : CK(61) : AC(13)

Anti Therapeutic Actions : Radiotherapy : CK(342) : AC(55)

The prevalence of BRCA mutations in an unselected population of triple-negative breast cancer is 10.6%..

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Pubmed Data : Cancer. 2012 Jun 1 ;118(11):2787-95. Epub 2011 Oct 5. PMID: 22614657

Article Published Date : May 31, 2012

Study Type : Human Study

Additional Links

Diseases : BRCA1/BRCA2: Prevalence : CK(50) : AC(5), Breast Cancer: Triple Negative : CK(61) : AC(13)

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.

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Pubmed Data : Cancer Res. 2010 May 1;70(9):3594-605. Epub 2010 Apr 13. PMID: 20388778

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Substances : Blueberry : CK(140) : AC(39), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Metastatic : CK(82) : AC(33), Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)

Additional Keywords : Plant Extracts : CK(3616) : AC(1226)

Blueberry supresses the growth and metastasis of triple negative breast tumors in animals.

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Pubmed Data : J Nutr. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21880954

Article Published Date : Aug 31, 2011

Study Type : Animal Study

Additional Links

Substances : Blueberry : CK(140) : AC(39)

Diseases : Breast Cancer: Metastatic : CK(82) : AC(33), Breast Cancer: Triple Negative : CK(61) : AC(13), Cancer Metastasis : CK(272) : AC(135)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Chemopreventive : CK(1528) : AC(382)

Propolis contains a compound which inhibits triple negative breast cancer in the animal model.

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Pubmed Data : Cancer Lett. 2011 Sep 1;308(1):43-53. Epub 2011 May 13. PMID: 21570765

Article Published Date : Sep 01, 2011

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(220) : AC(83), Caffeic acid phenethyl ester : CK(15) : AC(8)

Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Apoptotic : CK(1535) : AC(1155), Cell cycle arrest : CK(390) : AC(319), NF-kappaB Inhibitor : CK(595) : AC(401)

Breast cancer stem cells are resistant to conventional hyperthermia.

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Pubmed Data : Biomaterials. 2012 Apr ;33(10):2961-70. Epub 2012 Jan 14. PMID: 22245557

Article Published Date : Apr 01, 2012

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13), Breast Cancer Stem Cells : CK(11) : AC(1), Cancer Stem Cells : CK(988) : AC(42)

Curcumin induces apoptosis of triple-negative breast cancer cells.

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Pubmed Data : Mol Med Report. 2012 Sep 26. Epub 2012 Sep 26. PMID: 23023821

Article Published Date : Sep 25, 2012

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : apoptosis, Epidermal growth factor receptor (EGFR) inhibitor : CK(27) : AC(22)

Curcumin induces DNA damage in triple negative breast cancer cells.

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Pubmed Data : Breast Cancer (Auckl). 2010;4:1-3. Epub 2010 Feb 16. PMID: 20697527

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13)

Curcumin induces programmed cell death in triple negative breast cancer cell lines.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Breast Cancer. 2009 Sep 2;3:61-75. PMID: 19809577

Article Published Date : Sep 02, 2009

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2923) : AC(1482)

Diseases : Breast Cancer : CK(2361) : AC(621), Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155)

Genistein inhibits triple-negative breast cancer cell growth.

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Pubmed Data : Int J Mol Med. 2012 Aug ;30(2):337-43. Epub 2012 May 9. PMID: 22580499

Article Published Date : Jul 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Genistein : CK(450) : AC(174)

Diseases : Breast Cancer: Triple Negative : CK(61) : AC(13)

Pharmacological Actions : Apoptotic : CK(1535) : AC(1155), Bcl-2 protein down-regulation : CK(49) : AC(38), Bcl-xL down-regulation : CK(1) : AC(1), Chemopreventive : CK(1528) : AC(382), NF-kappaB Inhibitor : CK(595) : AC(401)

Health Guide: Breast Cancer

Related Blogs

Research: Curcumin Is A Triple Negative Breast Cancer Killer

Written by Sayer Ji, Founder

A new study from Zheijian Provincial People's Hospital in Zheijiang, China indicates that a compound in turmeric known as curcumin, which gives the spice its characteristic saffron-like color, is capable of inducing cell death within triple negative breast cancer cells.

Do Blueberries Hold The Key To Defeating Cancer?

Written by Margie King, Health Coach

Investigators at the University of Alabama at Birmingham, studying the link between disease and nutrition, believe that eating just one cup of blueberries every day prevents cell damage linked to cancer.

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