Cancers: Radiation-Resistant

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View the Evidence: Ailments

"Stem cells: their role in breast cancer development and resistance to treatment."

Pubmed Data : Curr Pharm Biotechnol. 2011 Feb 1 ;12(2):196-205. PMID: 21044007
Article Published Date : Jan 31, 2011
Study Type : Review
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer Stem Cells : CK(11) : AC(1), Cancers: Drug Resistant : CK(225) : AC(147), Cancers: Radiation-Resistant : CK(7) : AC(1)

2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant breast cancer cells through multiple mechanisms.

Pubmed Data : Int J Radiat Oncol Biol Phys. 2011 May 1 ;80(1):231-9. Epub 2011 Mar 9. PMID: 21392897
Article Published Date : Apr 30, 2011
Study Type : In Vitro Study
Additional Links
Substances : 2-Methoxyestradiol : CK(1) : AC(1)
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer: Conventional Treatment : CK(14) : AC(1), Cancers: Radiation-Resistant : CK(7) : AC(1), DNA damage : CK(711) : AC(293), Radiation Induced Illness : CK(1018) : AC(249)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), Bcl-2 protein down-regulation : CK(49) : AC(38), Cell cycle arrest : CK(390) : AC(319), Radiosensitizer : CK(50) : AC(29)

Radiotherapy may confer greater aggressiveness to breast cancer stem cells, resulting in recurrence.

Pubmed Data : Oncogene. 2012 Feb 13. Epub 2012 Feb 13. PMID: 22330142
Article Published Date : Feb 12, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Breast Cancer Stem Cells : CK(11) : AC(1), Cancer Stem Cells : CK(988) : AC(42), Cancers: Radiation-Induced : CK(3) : AC(1), Cancers: Radiation-Resistant : CK(7) : AC(1)
Anti Therapeutic Actions : Radiotherapy : CK(342) : AC(55)
Adverse Pharmacological Actions : Tumorigenic : CK(12) : AC(8)

Radiotherapy may result in the enrichment of highly malingant cancer stem cells in breast cancer patients.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Transl Oncol. 2011 Aug ;4(4):227-33. Epub 2011 Aug 1. PMID: 21804918
Article Published Date : Jul 31, 2011
Study Type : Review
Additional Links
Diseases : Breast Cancer Stem Cells : CK(11) : AC(1), Cancer Stem Cells : CK(988) : AC(42), Cancers: Radiation-Induced : CK(3) : AC(1), Cancers: Radiation-Resistant : CK(7) : AC(1)
Anti Therapeutic Actions : Radiotherapy : CK(342) : AC(55)
Adverse Pharmacological Actions : Tumorigenic : CK(12) : AC(8)

Recurrence at secondary locations, often years after removal of the primary tumor, accounts for most of the mortality associated with solid tumors; most current anticancer regimens select for cells with mesenchymal and CSC properties.

Pubmed Data : Front Biosci (Elite Ed). 2012 ;4:1528-41. Epub 2012 Jan 1. PMID: 22201973
Article Published Date : Dec 31, 2011
Study Type : Review
Additional Links
Diseases : Cancer Stem Cells : CK(988) : AC(42), Cancers: Drug Resistant : CK(225) : AC(147), Cancers: Multi-Drug Resistant : CK(92) : AC(73), Cancers: Radiation-Resistant : CK(7) : AC(1)
Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38), Radiotherapy : CK(342) : AC(55), Surgical Procedures : CK(103) : AC(9)

Review: Radiation resistance in breast cancer.

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Breast Cancer Res. 2010 ;12(2):105. Epub 2010 Apr 7. PMID: 20377923
Article Published Date : Dec 31, 2009
Study Type : Review
Additional Links
Diseases : Breast Cancer : CK(2354) : AC(621), Breast Cancer Stem Cells : CK(11) : AC(1), Cancer Stem Cells : CK(988) : AC(42), Cancers: Radiation-Resistant : CK(7) : AC(1)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Cell cycle arrest : CK(390) : AC(319), Proteasome Inhibitors : CK(41) : AC(27)
Additional Keywords : Cancer Stem Cells : CK(30) : AC(24)
Anti Therapeutic Actions : Radiotherapy : CK(342) : AC(55)

Vitamin K2-derived compounds inhibit growth in radioresistant cancer cells.

Pubmed Data : Kobe J Med Sci. 2010 ;56(2):E38-49. Epub 2010 Sep 28. PMID: 21063145
Article Published Date : Dec 31, 2009
Study Type : In Vitro Study
Additional Links
Substances : Vitamin K2 : CK(277) : AC(32)
Diseases : Cancers: Radiation-Resistant : CK(7) : AC(1)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), NF-kappaB Inhibitor : CK(595) : AC(401), Radiosensitizer : CK(50) : AC(29)

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