Cardiovascular Diseases

Cardiovascular Diseases

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View the Evidence: Ailments

There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.

Pubmed Data : Diabetes Care. 2010 Jun;33(6):1224-9. Epub 2010 Mar 9. PMID: 20215447
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Mortality: All-Cause : CK(644) : AC(55)
Problem Substances : Glipizide : CK(64) : AC(6), Glyburide : CK(50) : AC(4)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Among patients with impaired glucose tolerance or type 2 diabetes, rosiglitazone use for at least 12 months is associated with a significantly increased risk of myocardial infarction and heart failure.

Pubmed Data : JAMA. 2007 Sep 12;298(10):1189-95. PMID: 17848653
Article Published Date : Sep 12, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Heart Failure : CK(711) : AC(97), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Rosiglitazone (trade name Avandia) : CK(106) : AC(15)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

An omega-6 fatty acid rich diet may be associated with higher rates of coronary heart disease and cardiac mortality.

Pubmed Data : Br J Nutr. 2010 Dec;104(11):1586-600. PMID: 21118617
Article Published Date : Dec 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Omega-6 Fatty Acids: Excess/Disproportionate to Omega-3's : CK(36) : AC(3)

Aspirin does not prevent cardiovascular events in diabetes mellitus.

Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Problem Substances : Aspirin : CK(471) : AC(64)

Being in the lowest quartile of vitamin D levels is associated with a 26% increased rate of all-cause mortality

Pubmed Data : Arch Intern Med. 2008 Aug 11;168(15):1629-37. PMID: 18695076
Article Published Date : Aug 11, 2008
Study Type : Meta Analysis
Additional Links
Substances : Vitamin D : CK(1682) : AC(238)
Diseases : Cardiac Mortality : CK(703) : AC(67), Mortality: All-Cause : CK(644) : AC(55), Vitamin D Deficiency : CK(495) : AC(45)

Calcium supplements with or without vitamin D increase the risk of cardiovascular events.

Pubmed Data : BMJ. 2011;342:d2040. Epub 2011 Apr 19. PMID: 21505219
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117), Stroke : CK(540) : AC(47)
Problem Substances : Calcium Carbonate : CK(176) : AC(19)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Cardiac mortality is associated with low levels of omega-3 and omega-6 fatty acids in the heart of cadavers with a history of coronary heart disease.

Pubmed Data : Nutr Res. 2009 Oct;29(10):696-704. PMID: 19917448
Article Published Date : Oct 01, 2009
Study Type : Meta Analysis
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319), Omega-6 Fatty Acids : CK(30) : AC(2)
Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Cardiovascular risks are significantly lower in individuals who excrete higher levels of magnesium and taurine, indicating their protective roles.

Pubmed Data : J Biomed Sci. 2010;17 Suppl 1:S21. Epub 2010 Aug 24. PMID: 20804596
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Substances : Magnesium : CK(826) : AC(120), Taurine : CK(145) : AC(33)
Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Chocolate consumption is associated with a substantial reduction in the risk of cardiometabolic disorders.

Pubmed Data : BMJ. 2011 ;343:d4488. Epub 2011 Aug 26. PMID: 21875885
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Chocolate : CK(243) : AC(32)
Diseases : Blood Sugar Problems : CK(4050) : AC(693), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122), Stroke : CK(540) : AC(47)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Consuming small quantities of fish is associated with a reduction in coronary heart disease.

Pubmed Data : Am J Prev Med. 2005 Nov;29(4):335-46. PMID: 16242600
Article Published Date : Nov 01, 2005
Study Type : Meta Analysis
Additional Links
Substances : Fish : CK(241) : AC(21), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)

Consumption of trans-fatty acids from partially hydrogenated oils adversely affects multiple cardiovascular risk factors and contributes significantly to increased risk of oronary heart disease events.

Pubmed Data : Eur J Clin Nutr. 2009 May;63 Suppl 2:S5-21. PMID: 19424218
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173), Inflammation : CK(1077) : AC(363), Insulin Resistance : CK(1034) : AC(221), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

CoQ(10) may improve the ejection fraction in patients with congestive heart failure.

Pubmed Data : Am J Clin Nutr. 2012 Dec 5. Epub 2012 Dec 5. PMID: 23221577
Article Published Date : Dec 04, 2012
Study Type : Meta Analysis
Additional Links
Substances : Coenzyme Q10 : CK(667) : AC(104)
Diseases : Congestive Heart Failure : CK(256) : AC(30), Heart Failure : CK(711) : AC(97)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196), Cardiotonic Agents : CK(46) : AC(7)

Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with myocardial infarction.

Pubmed Data : Ann Med. 2009;41(4):301-10. PMID: 19148838
Article Published Date : Jan 01, 2009
Study Type : Meta Analysis
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Cardiac Arrest : CK(40) : AC(2), Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Doubling global vitamin D levels could significantly reduce mortality.

Pubmed Data : Eur J Clin Nutr. 2011 Jul 6. Epub 2011 Jul 6. PMID: 21731036
Article Published Date : Jul 06, 2011
Study Type : Meta Analysis
Additional Links
Substances : Vitamin D : CK(1682) : AC(238)
Diseases : African-American Specific Deficiencies/Diseases : CK(200) : AC(19), Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Mortality: All-Cause : CK(644) : AC(55), Respiratory Diseases : CK(174) : AC(29), Tuberculosis : CK(255) : AC(44), Vitamin D Deficiency : CK(495) : AC(45)
Therapeutic Actions : Sunlight exposure : CK(432) : AC(39)

Exposure to isoflavone-containing soy products may improve endothelial function.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Aug 14. Epub 2010 Aug 14. PMID: 20709515
Article Published Date : Aug 14, 2010
Study Type : Meta Analysis
Additional Links
Substances : Isoflavones : CK(627) : AC(124), phytoestrogens : CK(699) : AC(210), Soy : CK(1672) : AC(347), Soy Protein : CK(2307) : AC(56)
Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173)

Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.

Pubmed Data : Circulation. 2003 Apr 15;107(14):1852-7. Epub 2003 Mar 31. PMID: 12668520
Article Published Date : Apr 15, 2003
Study Type : Meta Analysis
Additional Links
Substances : Fish : CK(241) : AC(21), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Mortality: All-Cause : CK(644) : AC(55)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

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