Chemically-Induced Liver Damage

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View the Evidence: Ailments

The use of statins for LDL suppression is associated with increased risk for cancer.

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869), Chemically-Induced Liver Damage : CK(475) : AC(175), High Cholesterol : CK(1718) : AC(198), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Atorvastatin-induced acute pancreatitis has been reported.

Pubmed Data : J Pharmacol Pharmacother. 2011 Jan ;2(1):40-2. PMID: 21701646
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Pancreatitis : CK(164) : AC(40), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Autoimmune hepatitis associated with atorvastatin use has been reported.

Pubmed Data : Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804
Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis: Autoimmune : CK(41) : AC(8), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran

Pubmed Data : Z Gastroenterol. 2009 Sep;47(9):807-13. Epub 2009 Sep 11. PMID: 19750427
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175)
Problem Substances : Tylenol : CK(125) : AC(13)

Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study.

Pubmed Data : CMAJ. 2012 Aug 13. Epub 2012 Aug 13. PMID: 22891208
Article Published Date : Aug 12, 2012
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175)
Problem Substances : Fluoroquinolone Antibiotic : CK(82) : AC(11)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Fluvastatin has been linked to adverse hepatic reactions.

Pubmed Data : Drug Saf. 2006 ;29(12):1163-72. PMID: 17147462
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Isoniazid has been associated with grade 3 or 4 liver failure in 1.4%-5.2% of patients being treated for latent tuberculosis infection.

Pubmed Data : Clin Infect Dis. 2009 Dec 15;49(12):1883-9. PMID: 19911936
Article Published Date : Dec 15, 2009
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Damage: Drug-Induced : CK(46) : AC(10), Tuberculosis : CK(255) : AC(44)
Problem Substances : Isoniazid : CK(111) : AC(12)

Isoniazid treatment in latent tuberculosis infection may be associated with moderate-to-severe liver damage without symptoms.

Pubmed Data : Chest. 2005 Jul;128(1):116-23. PMID: 16002924
Article Published Date : Jul 01, 2005
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Damage: Drug-Induced : CK(46) : AC(10), Tuberculosis : CK(255) : AC(44)
Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)
Problem Substances : Isoniazid : CK(111) : AC(12)

Liver failure and damage are rare but severe unintended consequences of statin drug use.

Pubmed Data : J Hepatol. 2011 Aug 31. Epub 2011 Aug 31. PMID: 21889469
Article Published Date : Aug 31, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Damage : CK(597) : AC(213), Liver Disease : CK(112) : AC(31), Liver Failure: Drug Induced : CK(23) : AC(3), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Severe liver toxicity requiring discontinuation occurs in 5% of simvastatin-treated patients and 4.5% of pravastatin-treated patients.

Pubmed Data : Minerva Gastroenterol Dietol. 1992 Jan-Mar;38(1):41-4. PMID: 1520752
Article Published Date : Jan 01, 1992
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Severe, even fatal liver injuries have resulted as a consequence of isoniazid treatment in individuals with latent tuberculosis.

Pubmed Data : MMWR Morb Mortal Wkly Rep. 2010 Mar 5;59(8):224-9. PMID: 20203555
Article Published Date : Mar 05, 2010
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Liver Damage: Drug-Induced : CK(46) : AC(10), Tuberculosis : CK(255) : AC(44)
Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)
Problem Substances : Isoniazid : CK(111) : AC(12)

Tamoxifen treatment for breast cancer may result in fatty liver.

Pubmed Data : Oncol Rep. 2000 Nov-Dec;7(6):1299-304. PMID: 11032933
Article Published Date : Nov 01, 2000
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Fatty Liver : CK(493) : AC(122)
Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug: Doxorubicin : CK(141) : AC(55), Drug: Tamoxifen : CK(380) : AC(57)
Problem Substances : Tamoxifen : CK(319) : AC(39)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.

Pubmed Data : BMJ. 2010;340:c2197. Epub 2010 May 20. PMID: 20488911
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Cataract : CK(182) : AC(55), Chemically-Induced Liver Damage : CK(475) : AC(175), Esophageal Cancer : CK(328) : AC(55), Kidney Failure : CK(668) : AC(41), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Fluvastatin : CK(75) : AC(15), Pravastatin : CK(239) : AC(40), Rosuvastatin : CK(68) : AC(16), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

A case of hepatitis caused by simvastatin has been reported.

Pubmed Data : Gastroenterol Clin Biol. 1991 ;15(1):94-5. PMID: 2010080
Article Published Date : Jan 01, 1991
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis : CK(64) : AC(23), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Lovastatin : CK(265) : AC(67), Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis associated with atorvastatin use has been reported.

Pubmed Data : Gastroenterol Hepatol. 2006 Jan ;29(1):21-4. PMID: 16393626
Article Published Date : Jan 01, 2006
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis associated with pravastatin has been reported.

Pubmed Data : Am J Gastroenterol. 1999 May ;94(5):1388-90. PMID: 10235223
Article Published Date : May 01, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), GGT : CK(73) : AC(10), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis induced by cerivastatin has been reported.

Pubmed Data : Med Clin (Barc). 2002 May 18 ;118(18):717. PMID: 12042141
Article Published Date : May 18, 2002
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Cerivastatin : CK(10) : AC(4), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute cholestatic hepatitis induced by fenofibrate has been reported.

Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016
Article Published Date : Oct 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Toxicity : CK(560) : AC(78), Hepatitis : CK(64) : AC(23)
Problem Substances : Fenofibrates : CK(133) : AC(19)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Acute exposure to CS tear gas has been reported to cause several health problems in an individual.

Pubmed Data : Schweiz Med Wochenschr. 1981 Dec 26 ;111(52):2056-60. PMID: 6800031
Article Published Date : Dec 26, 1981
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Heart Failure : CK(711) : AC(97), Liver Damage : CK(597) : AC(213), Pneumonia : CK(330) : AC(40)
Problem Substances : 2-chlorobenzylidene malononitrile (CS) : CK(15) : AC(3)

Acute hepatitis induced by lovastatin has been reported.

Pubmed Data : Dig Dis Sci. 1994 Sep ;39(9):2032-3. PMID: 8082513
Article Published Date : Sep 01, 1994
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), GGT : CK(73) : AC(10), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Atorvastatin has been reported to have caused severe acute hepatitis with symptomatic cholestasis for more than 3 months and bile duct injury.

Pubmed Data : Acta Gastroenterol Belg. 2008 Jul-Sep;71(3):318-20. PMID: 19198578
Article Published Date : Jul 01, 2008
Study Type : Human: Case Report
Additional Links
Diseases : Bile Duct Injury : CK(6) : AC(2), Chemically-Induced Liver Damage : CK(475) : AC(175), Cholestasis : CK(274) : AC(30), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Atorvastatin-induced cholestatic hepatitis in a young woman with systemic lupus erythematosus has been reported.

Pubmed Data : Arch Intern Med. 1999 Aug 9-23;159(15):1811-2. PMID: 10448788
Article Published Date : Aug 09, 1999
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis: Cholestatic : CK(28) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Cholestatic jaundice induced by atorvastatin has been observed.

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Pubmed Data : Isr Med Assoc J. 2009 Jul ;11(7):440-1. PMID: 19911499
Article Published Date : Jul 01, 2009
Study Type : Human: Case Report
Additional Links
Diseases : Autoimmune Diseases : CK(5317) : AC(779), Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis: Cholestatic : CK(28) : AC(10), Jaundice : CK(11) : AC(4)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Hepatitis associated with treatment with lovastatin has been reported.

Pubmed Data : Gastroenterol Hepatol. 1998 Mar ;21(3):127-8. PMID: 9607293
Article Published Date : Mar 01, 1998
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis : CK(64) : AC(23), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Liver fibrosis has been attributed to lipid lowering medications.

Pubmed Data : J Intern Med. 2001 Sep ;250(3):249-54. PMID: 11555130
Article Published Date : Sep 01, 2001
Study Type : Human: Case Report
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Hepatitis : CK(64) : AC(23), Liver Cirrhosis : CK(216) : AC(32), Liver Fibrosis : CK(341) : AC(74)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

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