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Chemotherapy-Induced Toxicity: Cisplatin

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Article Count - 66
Cumulative Knowledge - 181

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Quick Summary: Current access displays 2 out of 51 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Acetyl-l-carnitine	20	2	Log in \| Sign up
Curcumin	16	11	Log in \| Sign up

Quick Summary: 2 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Cisplatin	5	3	Log in \| Sign up
Nicotine	2	2	Log in \| Sign up

Quick Summary: 1 associated Problematic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Chemotherapy	20	2	Log in \| Sign up

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View the Evidence: Ailments

Acetyl L-carnitine treatment improves symptoms of chemotherapy induced neuropathy.

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Pubmed Data : Eur J Cancer. 2005 Aug;41(12):1746-50. PMID: 16039110

Article Published Date : Aug 01, 2005

Study Type : Human Study

Additional Links

Substances : Acetyl-l-carnitine : CK(672) : AC(38)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Neuropathic Pain : CK(157) : AC(24)

Acetyl-L-carnitine appears to be an effective and well-tolerated agent for the treatment of chemotherapy-induced peripheral neuropathy.

Click here to read the entire abstract

Pubmed Data : Tumori. 2005 Mar-Apr;91(2):135-8. PMID: 15948540

Article Published Date : Mar 01, 2005

Study Type : Human Study

Additional Links

Substances : Acetyl-l-carnitine : CK(672) : AC(38)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Neuropathic Pain : CK(157) : AC(24)

Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)

Alpha lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.

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Pubmed Data : Exp Neurol. 2008 Dec;214(2):276-84. Epub 2008 Sep 9. PMID: 18809400

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(384) : AC(82)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Chemotherapy-Induced Toxicity: Paclitaxel : CK(32) : AC(4), Chemotherapy-Induced Toxicity: Peripheral Neuropathy : CK(250) : AC(5)

Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Bi-weekly administration of paclitaxel and cisplatin in patients with advanced esophageal cancer results in amedian survival for all patients of 9 months.

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Pubmed Data : Br J Cancer. 2002 Mar 4;86(5):669-73. PMID: 11875723

Article Published Date : Mar 04, 2002

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Esophageal Cancer : CK(328) : AC(55)

Additional Keywords : Drug: Cisplatin : CK(31) : AC(11), Drug: Paclitaxel : CK(36) : AC(13)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Caffeine potentiates chemotherapy for metastatic osteosarcoma.

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Pubmed Data : J Orthop Sci. 2009 Sep;14(5):556-65. Epub 2009 Oct 3. PMID: 19802667

Article Published Date : Sep 01, 2009

Study Type : Human Study

Additional Links

Substances : Caffeine : CK(109) : AC(18)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Chemosensitizer : CK(197) : AC(159)

Additional Keywords : Drug: Doxorubicin : CK(141) : AC(55), Drug Synergy : CK(327) : AC(147)

Chemotherapy used in advanced gastric or gastroesophageal adenocarcinoma results in an overall median survival time of between 7-9 months.

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Pubmed Data : J Clin Oncol. 2010 Mar 20;28(9):1547-53. Epub 2010 Feb 16. PMID: 20159816

Article Published Date : Mar 20, 2010

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Esophageal Cancer : CK(328) : AC(55), Gastric Cancer : CK(373) : AC(111)

Additional Keywords : Chemotherapy : CK(20) : AC(2), Drug: 5-flourouracil : CK(88) : AC(22)

Anti Therapeutic Actions : Chemotherapy : CK(257) : AC(38)

Oral glutamine supplementation protects lymphocytes and attenuates gut permeability in patients with esophageal cancer during radiochemotherapy.

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Pubmed Data : Ann Surg. 1998 Apr;227(4):485-91. PMID: 9563534

Article Published Date : Apr 01, 1998

Study Type : Human Study

Additional Links

Substances : Glutamine : CK(98) : AC(19)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Esophageal Cancer : CK(328) : AC(55), Radiation Induced Illness : CK(1018) : AC(249)

Additional Keywords : Drug: 5-flourouracil : CK(88) : AC(22), Drug Side Effect Attenuation : CK(252) : AC(49)

"Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice."

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Pubmed Data : J Biosci Bioeng. 2012 Dec 12. Epub 2012 Dec 12. PMID: 23245727

Article Published Date : Dec 11, 2012

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Chemotherapy-Induced Toxicity: Kidney : CK(8) : AC(4)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)

A combination of Bacopa, Amla (E. officinalis), Licorice (G. glabra), Indian mango (M. indica) and Clove (S. aromaticum) protect against experimentally-induced cardiac and renal damage.

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Pubmed Data : Phytother Res. 2005 Mar;19(3):216-21. PMID: 15934019

Article Published Date : Mar 01, 2005

Study Type : Animal Study

Additional Links

Substances : Amla Fruit : CK(51) : AC(28), Bacopa : CK(47) : AC(18), Clove : CK(92) : AC(46), Licorice : CK(257) : AC(81), Mango : CK(60) : AC(34)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Myocardial Infarction : CK(2632) : AC(117)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

A compound in ginger known as 6-Gingerol prevents cisplatin-induced acute renal failure in rats.

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Pubmed Data : J Agric Food Chem. 2005 Apr 6;53(7):2446-50. PMID: 16971750

Article Published Date : Apr 06, 2005

Study Type : Animal Study

Additional Links

Substances : Catechols : CK(14) : AC(12), Ginger : CK(310) : AC(89)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Renoprotective : CK(191) : AC(90)

A compound in mangosteen prevents cisplatin-induced toxicity to the kidneys of rats.

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Pubmed Data : Chem Biol Interact. 2010 Oct 6;188(1):144-50. PMID: 20603111

Article Published Date : Oct 06, 2010

Study Type : Animal Study

Additional Links

Substances : Mangosteen : CK(42) : AC(20)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Additional Keywords : Drug Side Effect Attenuation : CK(252) : AC(49)

AHCC attenuates cisplatin (chemotherapy) induced side effects in tumor-bearing mice.

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Pubmed Data : Toxicol Appl Pharmacol. 2007 Jul 15;222(2):152-8. Epub 2007 Apr 20. PMID: 17555784

Article Published Date : Jul 15, 2007

Study Type : Animal Study

Additional Links

Substances : AHCC : CK(48) : AC(17)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Tumors : CK(197) : AC(110)

Alpha lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation.

Click here to read the entire abstract

Pubmed Data : Nephrol Dial Transplant. 2009 Oct;24(10):3012-20. Epub 2009 May 27. PMID: 19474282

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(384) : AC(82)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Ascorbic acid and vitamin E protect against cisplatin induced kidney injury in mice.

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Pubmed Data : Clin Chim Acta. 2007 Jan;375(1-2):82-6. Epub 2006 Jun 14. PMID: 16889761

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Brassica rapa (Mustard Greens) have a protective effect on cisplatin-induced nephrotoxicity in cells and rats.

Click here to read the entire abstract

Pubmed Data : Biol Pharm Bull. 2006 Dec;29(12):2436-41. PMID: 17142978

Article Published Date : Dec 01, 2006

Study Type : Animal Study

Additional Links

Substances : Mustard Greens : CK(39) : AC(12)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Antineoplastic Agents : CK(69) : AC(28), Plant Extracts : CK(3572) : AC(1216)

Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice.

Click here to read the entire abstract

Pubmed Data : Toxicology. 2010 Jul-Aug;274(1-3):49-56. Epub 2010 May 25. PMID: 20510337

Article Published Date : Jul 01, 2010

Study Type : Animal Study

Additional Links

Substances : Coenzyme Q10 : CK(667) : AC(104)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin has a synergistic effect with cisplatin against fibrosarcoma.

Click here to read the entire abstract

Pubmed Data : Pharmacol Res. 1999 Mar;39(3):175-9. PMID: 10094841

Article Published Date : Mar 01, 1999

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Fibrosarcoma : CK(10) : AC(7)

Pharmacological Actions : Chemosensitizer : CK(197) : AC(159)

Additional Keywords : Drug Synergy : CK(327) : AC(147)

Curcumin inhibits lung cancer cell metastasis.

Click here to read the entire abstract

Pubmed Data : Clin Exp Metastasis. 2000;18(7):539-45. PMID: 11688958

Article Published Date : Jan 01, 2000

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Cancer Metastasis : CK(272) : AC(135), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Lung Cancer : CK(496) : AC(198)

Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775)

Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.

Click here to read the entire abstract

Pubmed Data : J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039

Article Published Date : Dec 12, 2007

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Inflammation : CK(1077) : AC(363), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Renoprotective : CK(191) : AC(90), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin prevents cisplatin-induced chromosomal abberations in rat bone marrow cells.

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2000 Feb 16;465(1-2):131-7. PMID: 10708978

Article Published Date : Feb 16, 2000

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy Induced Myelotoxicity : CK(48) : AC(13), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Genoprotective : CK(116) : AC(48)

Curcumin protects against cisplatin-induced oxidative injury in rat testis.

Click here to read the entire abstract

Pubmed Data : Hum Reprod. 2009 Jul;24(7):1717-25. Epub 2009 Mar 11. PMID: 19279034

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Chemotherapy-Induced Toxicity : CK(704) : AC(184), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), NF-kappaB Inhibitor : CK(595) : AC(401)

Additional Keywords : Drug: Cisplatin : CK(31) : AC(11)

D-methionine provides excellent protection from cisplatin ototoxicity in the rat.

Click here to read the entire abstract

Pubmed Data : Vasc Med. 2003 May;8(2):77-81. PMID: 8951454

Article Published Date : May 01, 2003

Study Type : Animal Study

Additional Links

Substances : Methionine : CK(52) : AC(12)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496)

Dietary flaxseed oil supplementation ameliorates cisplatin-induced intestinal damage.

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2012 Jul 2. Epub 2012 Jul 2. PMID: 22751286

Article Published Date : Jul 01, 2012

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Problem Substances : Cisplatin : CK(24) : AC(7)

Ellagic acid protects against cisplatin-induced kidney injury and oxidative stress in rats.

Click here to read the entire abstract

Pubmed Data : Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):121-6. PMID: 17244261

Article Published Date : Feb 01, 2007

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid : CK(77) : AC(40)

Diseases : Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66)

Flaxseed oil protects against cisplatin-induced hepatotoxicity.

Click here to read the entire abstract

Pubmed Data : Hum Exp Toxicol. 2012 Apr ;31(4):364-75. Epub 2012 Jan 16. PMID: 22249395

Article Published Date : Mar 31, 2012

Study Type : Animal Study

Additional Links

Substances : Flaxseed : CK(275) : AC(57)

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Chemotherapy-Induced Toxicity: Cisplatin : CK(172) : AC(66), Lipid Peroxidation : CK(403) : AC(127)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antioxidants : CK(3653) : AC(1318), Hepatoprotective : CK(557) : AC(272)

Problem Substances : Cisplatin : CK(24) : AC(7)

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