Chemotherapy-Induced Toxicity: Cyclophosphamide

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22 Substances Researched for Chemotherapy-Induced Toxicity: Cyclophosphamide
NameACCKFocus
Melatonin212Locked
Chokeberry110Locked
Vitamin D110Locked
Curcumin58Locked
Anthocyanins24Locked
Astaxanthin24Locked
Blueberry24Locked
Achiote12Locked
Apricot Kernel12Locked
Arginine12Locked
Bitter Apple12Locked
Buckwheat12Locked
Clove12Locked
Coconut Oil12Locked
Gallic Acid12Locked
Garlic12Locked
Indian Mulberry12Locked
Lycopene12Locked
Moringa oleifera12Locked
Taurine12Locked
Thymoquinone12Locked
Water: Deuterium Depleted12Locked
1 Problem Substances Researched for Chemotherapy-Induced Toxicity: Cyclophosphamide
NameACCKFocus
Cyclophosphamide48Locked
2 Problematic Actions Researched for Chemotherapy-Induced Toxicity: Cyclophosphamide
NameACCKFocus
Chemotherapy110Locked
Radiotherapy110Locked
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Chemotherapy-Induced Toxicity: Cyclophosphamide is a Sub of the following Topic

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72 Abstracts with Chemotherapy-Induced Toxicity: Cyclophosphamide Research

[+]

Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma. Dec 31, 2012

Pubmed Data : Mol Cell Biochem. 2013 Jan ;372(1-2):47-55. Epub 2012 Sep 5. PMID: 22949034
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Substances : Chokeberry
Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Doxorubicin
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Superoxide Dismutase Up-regulation
Additional Keywords : Drug: Doxorubicin, Plant Extracts
[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005
Article Published Date : Dec 31, 2012
Study Type : Human Study
Additional Links
Substances : Melatonin, Vitamin D
Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide
Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome
[+]

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukemia: Acute myelogenous leukemia (AML) , Lymphoma, Myelodysplastic Syndrome, Radiation Induced Illness
Additional Keywords : Iatrogenic Disease
Anti Therapeutic Actions : Chemotherapy, Radiotherapy
[+]

Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis.Mar 22, 2018

Pubmed Data : Pediatr Transplant. 2018 Mar 23:e13171. Epub 2018 Mar 23. PMID: 29569791
Article Published Date : Mar 22, 2018
Study Type : Human: Case Report
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Therapeutic Actions : Hyperbaric Treatment
Pharmacological Actions : Chemoprotective Agents
[+]

20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.Jan 31, 2008

Pubmed Data : Arch Toxicol. 2008 Feb ;82(2):117-23. Epub 2007 Jun 28. PMID: 17598087
Article Published Date : Jan 31, 2008
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

Pubmed Data : Indian J Pharmacol. 2017 Jan-Feb;49(1):65-70. PMID: 28458425
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Curcumin, Piperine
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

A diet supplemented with whole Chlorella vulgaris has beneficial effects on cyclophosphamide induced immunosuppression.Jul 05, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Jul 6 ;9(7). Epub 2017 Jul 6. PMID: 28684674
Article Published Date : Jul 05, 2017
Study Type : Animal Study
Additional Links
Substances : Chlorella (Algae)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Immunomodulatory
[+]

A enriched extract of blueberry anthocyanins protected against cyclophosphamide induced lung damage.Oct 15, 2014

Pubmed Data : Chem Biol Interact. 2014 Oct 16 ;222C:106-111. Epub 2014 Oct 16. PMID: 25451569
Article Published Date : Oct 15, 2014
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Blueberry
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants
Additional Keywords : Dose Response
[+]

Administration of M. vulgare extract was found to be beneficial by attenuating cyclophosphamide-induced liver damage.Mar 31, 2016

Pubmed Data : Can J Physiol Pharmacol. 2016 Apr ;94(4):441-7. Epub 2015 Oct 28. PMID: 26886858
Article Published Date : Mar 31, 2016
Study Type : Animal Study
Additional Links
Substances : Horehound
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Alleviation of cyclophosphamide-induced hemorrhagic cystitis by dietary pomegranate.May 03, 2018

Pubmed Data : J Pediatr Hematol Oncol. 2018 May 4. Epub 2018 May 4. PMID: 29734214
Article Published Date : May 03, 2018
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis: Hemorrhagic
Pharmacological Actions : Chemoprotective Agents
[+]

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Rep. 2017 ;4:226-233. Epub 2017 May 11. PMID: 28959643
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Horsetail
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
[+]

An enriched blueberry anthocyanin extract attenuated the cyclophosphamide induced cardiac injury.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(7):e0127813. Epub 2015 Jul 2. PMID: 26133371
Article Published Date : Dec 31, 2014
Study Type : Animal Study
Additional Links
Substances : Anthocyanins, Blueberry
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective
Additional Keywords : Significant Treatment Outcome
[+]

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

Pubmed Data : J Ethnopharmacol. 2016 Apr 22 ;182:101-9. Epub 2016 Feb 10. PMID: 26875643
Article Published Date : Apr 21, 2016
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents, Fertility Agents: Male
Additional Keywords : Plant Extracts
Problem Substances : Cyclophosphamide
[+]

An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

Pubmed Data : J Ethnopharmacol. 2018 Apr 6 ;215:191-198. Epub 2018 Jan 9. PMID: 29325915
Article Published Date : Apr 05, 2018
Study Type : Animal Study
Additional Links
Substances : Purslane
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antispasmodic, Immunomodulatory
Problem Substances : Cyclophosphamide
[+]

Annato seed extracts could prevent oxidative stress that is occasioned by cyclophosphamide administration.Feb 28, 2011

Pubmed Data : Exp Toxicol Pathol. 2011 Mar ;63(3):257-62. PMID: 20137904
Article Published Date : Feb 28, 2011
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Achiote
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemopreventive
Additional Keywords : Plant Extracts
[+]

Apricot Kernel Oil Ameliorates Cyclophosphamide-Associated Immunosuppression in Rats.Jun 03, 2016

Pubmed Data : Lipids. 2016 Jun 4. Epub 2016 Jun 4. PMID: 27262314
Article Published Date : Jun 03, 2016
Study Type : Animal Study
Additional Links
Substances : Apricot Kernel
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Problem Substances : Cyclophosphamide
[+]

Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat.Feb 01, 2010

Pubmed Data : Mutat Res. 2010 Feb ;696(1):69-80. Epub 2009 Dec 28. PMID: 20038455
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Liver Damage, Oxidative Stress
Pharmacological Actions : Chemopreventive, Tumor Suppressor Protein p53 Upregulation
[+]

Astaxanthin protects against cyclophosphamide-induced oxidative stress and DNA damage.Aug 14, 2009

Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):398-406. Epub 2009 Apr 2. PMID: 19539803
Article Published Date : Aug 14, 2009
Study Type : Animal Study
Additional Links
Substances : Astaxanthin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation
[+]

Bitter apple pretreatment attenuates cyclophosphamide-induced oxidative stress and the subsequent DNA damage in mice.Dec 31, 2012

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2013 ;2013:980480. Epub 2013 Nov 7. PMID: 24324391
Article Published Date : Dec 31, 2012
Study Type : Animal Study
Additional Links
Substances : Bitter Apple
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Additional Keywords : Plant Extracts
[+]

Camel milk may have an immunopotentiating role in diseases or conditions associated with leukopenia or drug-induced toxicities.Aug 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Health Sci (Qassim). 2017 Sep-Oct;11(4):18-22. PMID: 29085263
Article Published Date : Aug 31, 2017
Study Type : Animal Study
Additional Links
Substances : Camel Milk
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukopenia
Pharmacological Actions : Chemoprotective Agents
[+]

Carvacrol attenuates cyclophosphamide-induced oxidative stress in rat kidney.Feb 02, 2017

Pubmed Data : Can J Physiol Pharmacol. 2017 Feb 3. Epub 2017 Feb 3. PMID: 28177660
Article Published Date : Feb 02, 2017
Study Type : Animal Study
Additional Links
Substances : Carvacrol
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells.Mar 31, 2005

Pubmed Data : J Pharm Pharmacol. 2005 Apr ;57(4):505-9. PMID: 15831212
Article Published Date : Mar 31, 2005
Study Type : Animal Study
Additional Links
Substances : Bitter Orange
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antimutagenic Agents, Antioxidants, Chemoprotective Agents
Additional Keywords : Plant Extracts
[+]

Clove postively modulates humoral and cell-mediated immune responses and prevents cyclophosphamide-induced immunosuppression in mice. Jul 01, 2009

Pubmed Data : J Pharm Pharmacol. 2009 Jul;61(7):961-7. PMID: 19589240
Article Published Date : Jul 01, 2009
Study Type : Animal Study
Additional Links
Substances : Clove
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Additional Keywords : Drug Side Effect Attenuation
[+]

Combined extracts of pumpkin seed and ginger might be used as a protective agent against cyclophosphamide induced reproductive toxicity.Aug 31, 2016

Pubmed Data : Anat Sci Int. 2016 Sep ;91(4):382-90. Epub 2015 Dec 29. PMID: 26714700
Article Published Date : Aug 31, 2016
Study Type : Animal Study
Additional Links
Substances : Ginger, Pumpkin Seeds
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Plant Extracts
[+]

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Pubmed Data : Zhong Yao Cai. 2014 Oct ;37(10):1833-6. PMID: 25895394
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Corn Silk
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Chemotherapeutic Agent: Cyclophosphamide, Natural Substance/Drug Synergy, Polysaccharides
[+]

Curcumin inhibits lipid peroxidation and cholesterol levels in mice.Oct 01, 1992

Pubmed Data : Indian J Physiol Pharmacol. 1992 Oct;36(4):239-43. PMID: 1291474
Article Published Date : Oct 01, 1992
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation
Pharmacological Actions : Hepatoprotective
[+]

Curcumin protects against cyclophosphamide-induced haemorrhagic cystitis.Apr 16, 2004

Pubmed Data : Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PMID: 19413659
Article Published Date : Apr 16, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin
Diseases : Bladder Dysfunction , Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis, Interstitial Cystitis
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs.Oct 01, 2009

Pubmed Data : Amino Acids. 2009 Oct;37(4):643-51. Epub 2008 Sep 28. PMID: 18821052
Article Published Date : Oct 01, 2009
Study Type : Animal Study
Additional Links
Substances : Arginine
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Immunostimulatory
[+]

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity.Jul 31, 2013

Pubmed Data : Food Chem Toxicol. 2013 Aug ;58:210-9. Epub 2013 Apr 17. PMID: 23603381
Article Published Date : Jul 31, 2013
Study Type : Animal Study
Additional Links
Substances : Ellagic Acid
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Bleomycin
Pharmacological Actions : Chemoprotective Agents
[+]

Fermented red ginseng alleviates cyclophosphamide-induced immunosuppression.Dec 31, 2017

Pubmed Data : Am J Chin Med. 2018 ;46(8):1879-1897. Epub 2018 Dec 6. PMID: 30518233
Article Published Date : Dec 31, 2017
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Fermented Foods and Beverages, Ginseng (Korean)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Colitis
Pharmacological Actions : Chemoprotective Agents, Immunomodulatory
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Gallic acid can modify the reproductive toxicity of cyclophosphamide.Mar 17, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Urol J. 2019 Mar 18. Epub 2019 Mar 18. PMID: 30882156
Article Published Date : Mar 17, 2019
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants
[+]

Gallic acid has the capacity to protect against reproductive toxicity induced by cyclophosphamide.Jul 28, 2015

Pubmed Data : Andrologia. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26223283
Article Published Date : Jul 28, 2015
Study Type : Animal Study
Additional Links
Substances : Gallic Acid
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Garlic extracts have immunomodulatory and antioxidant effects and has the ability to diminish the alterations induced by cyclophosphamide.Apr 02, 2019

Pubmed Data : Environ Sci Pollut Res Int. 2019 Apr 3. Epub 2019 Apr 3. PMID: 30945076
Article Published Date : Apr 02, 2019
Study Type : Insect Study
Additional Links
Substances : Garlic
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Immunomodulatory
Additional Keywords : Plant Extracts
[+]

Gene expression signatures that predict radiation exposure in mice and humans.Mar 31, 2007

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS Med. 2007 Apr ;4(4):e106. PMID: 17407386
Article Published Date : Mar 31, 2007
Study Type : Animal Study
Additional Links
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Radiation Induced Illness
[+]

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Pubmed Data : Chin Med J (Engl). 2007 Apr 5 ;120(7):584-8. PMID: 17442207
Article Published Date : Apr 04, 2007
Study Type : Animal Study
Additional Links
Substances : Ginsenosides
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Ovarian Cancer
Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors
Additional Keywords : Natural Substance/Drug Synergy
[+]

H. sabdariffa L. presented a protective effect to cyclophosphamide induced damage to DNA.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : ScientificWorldJournal. 2017 ;2017:9392532. Epub 2017 Jan 19. PMID: 28197528
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Hibiscus sabdariffa
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Obesity
Pharmacological Actions : Antimutagenic Agents, Chemoprotective Agents
Problem Substances : Monosodium Glutamate (MSG)
[+]

Hepatoprotective effects of zataria multiflora ethanolic extract on liver toxicity induced by cyclophosphamide.Mar 31, 2015

Pubmed Data : Drug Res (Stuttg). 2015 Apr ;65(4):169-75. Epub 2014 Apr 2. PMID: 24696425
Article Published Date : Mar 31, 2015
Study Type : Animal Study
Additional Links
Substances : Zataria multiflora
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Hesperidin opposes the negative impact of cyclophosphamide on mice kidneys.Mar 19, 2019

Pubmed Data : Drug Chem Toxicol. 2019 Mar 20:1-6. Epub 2019 Mar 20. PMID: 30889984
Article Published Date : Mar 19, 2019
Study Type : Animal Study
Additional Links
Substances : Hesperidin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

Immune-enhancing effect of nanometric Lactobacillus plantarum nF1 in a mouse model of cyclophosphamide-induced immunosuppression.Nov 14, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Microbiol Biotechnol. 2017 Nov 15. Epub 2017 Nov 15. PMID: 29141128
Article Published Date : Nov 14, 2017
Study Type : Animal Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Immunomodulatory
[+]

In this study deuterium depleted water led to a statistically significant increased survival rate compared with control groups fed with normal distilled water after irradiation, 61% versus 25%.Jun 30, 1999

Pubmed Data : Rom J Physiol. 1999 Jul-Dec;36(3-4):205-18. PMID: 11797936
Article Published Date : Jun 30, 1999
Study Type : Animal Study
Additional Links
Substances : Water: Deuterium Depleted
Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemotherapeutic, Immunostimulatory, Radioprotective
Problem Substances : Cyclophosphamide
[+]

L. plantarum KLDS1.0318 could be of significant advantage to mitigate the harmful effects of cyclophosphamide.Dec 31, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Microbiol. 2019 ;10:731. Epub 2019 Apr 12. PMID: 31031723
Article Published Date : Dec 31, 2018
Study Type : Animal Study
Additional Links
Substances : Lactobacillus plantarum
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents, Gastroprotective
[+]

Morinda officinalis extract can repair cytoxan-induced damage to rat spermatogenesis.Apr 30, 2015

Pubmed Data : Zhonghua Nan Ke Xue. 2015 May ;21(5):436-42. PMID: 26117943
Article Published Date : Apr 30, 2015
Study Type : Animal Study
Additional Links
Substances : Indian Mulberry
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
[+]

Moringa leaves play an important role in ameliorating and protecting the bladder from CP toxicity.Jan 31, 2015

Pubmed Data : Tissue Cell. 2015 Feb ;47(1):94-104. Epub 2014 Dec 23. PMID: 25595312
Article Published Date : Jan 31, 2015
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
[+]

Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity.May 14, 2018

Pubmed Data : Environ Sci Pollut Res Int. 2018 May 15. Epub 2018 May 15. PMID: 29766429
Article Published Date : May 14, 2018
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Anti-Inflammatory Agents, Chemoprotective Agents, Cyclooxygenase 2 Inhibitors, Hepatoprotective, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Renoprotective
[+]

Nigella sativa oil and thymoquinone have protective effects against toxicity induced by the anticancer drug cyclophosphamide.Dec 31, 2009

Pubmed Data : Br J Biomed Sci. 2010 ;67(1):20-8. PMID: 20373678
Article Published Date : Dec 31, 2009
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed), Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Nigella sativa oil can protect against Cyclophosphamide-induced DNA damage and hepatotoxicity.Mar 31, 2017

Pubmed Data : Nutr Cancer. 2017 Apr ;69(3):498-504. Epub 2017 Feb 17. PMID: 28287318
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Nigella sativa (aka Black Seed)
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective
[+]

Omega-3 fatty acids modulate cyclophosphamide induced markers of immunosuppression and oxidative stress in pigs.Feb 24, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2019 Feb 25 ;9(1):2684. Epub 2019 Feb 25. PMID: 30804435
Article Published Date : Feb 24, 2019
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Immunomodulatory
Problem Substances : Cyclophosphamide
[+]

Pumpkin seed extract might be used as protective agent against cyclophosphamide induced reproductive toxicity.Sep 30, 2014

Pubmed Data : Andrologia. 2014 Oct ;46(8):927-35. Epub 2013 Oct 11. PMID: 24124763
Article Published Date : Sep 30, 2014
Study Type : Animal Study
Additional Links
Substances : Pumpkin Seeds
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID: 27310207
Article Published Date : Jun 30, 2016
Study Type : Animal Study
Additional Links
Substances : Punicalagin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Hepatoprotective
[+]

Resveratrol may confer multi-organ protection against cyclophosphamide toxicity via antioxidant and anti-inflammatory mechanisms.May 01, 2017

Pubmed Data : Immunopharmacol Immunotoxicol. 2017 May 2:1-8. Epub 2017 May 2. PMID: 28463035
Article Published Date : May 01, 2017
Study Type : Animal Study
Additional Links
Substances : Resveratrol
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Royal jelly provided biochemical and histo-pathological improvement in cyclophosphamide induced prostatic tissue toxicity.Mar 20, 2017

Pubmed Data : Biomed Pharmacother. 2017 Mar 21 ;90:15-23. Epub 2017 Mar 21. PMID: 28340377
Article Published Date : Mar 20, 2017
Study Type : Animal Study
Additional Links
Substances : Royal Jelly
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Saffron, garlic and curcumin protect against yclophosphamide induced genotoxicity in mice.Jan 01, 2004

Pubmed Data : Asia Pac J Clin Nutr. 2004;13(3):292-4. PMID: 15331343
Article Published Date : Jan 01, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin, Garlic
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antimutagenic Agents, Genoprotective
Additional Keywords : Plant Extracts
[+]

Supplementation of diet with lycopene and melatonin provided antioxidant defense with strong protective activity against cyclophosphamide induced cytotoxicity.Jun 30, 2014

Pubmed Data : Toxicol Ind Health. 2014 Jul ;30(6):570-5. Epub 2012 Sep 28. PMID: 23024110
Article Published Date : Jun 30, 2014
Study Type : Animal Study
Additional Links
Substances : Lycopene, Melatonin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents
Additional Keywords : Natural Substance Synergy
[+]

Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.Jul 14, 2015

Pubmed Data : Phytomedicine. 2015 Jul 15 ;22(7-8):730-6. Epub 2015 May 23. PMID: 26141759
Article Published Date : Jul 14, 2015
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Buckwheat
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer
Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemoprotective Agents, Tumor Suppressor Protein p53 Upregulation
Problem Substances : Cyclophosphamide
[+]

Taurine is suggested to be a potential candidate to ameliorate cyclophosphamide induced cardiorenal toxicity.Jul 17, 2015

Pubmed Data : Can J Physiol Pharmacol. 2015 Jul 18:1-9. Epub 2015 Jul 18. PMID: 26695545
Article Published Date : Jul 17, 2015
Study Type : Animal Study
Additional Links
Substances : Taurine
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Malondialdehyde Down-regulation, Renoprotective
[+]

The immunomodulatory activity of litchi pulp polysaccharides was accompanied with its antioxidant activity.Oct 31, 2016

Pubmed Data : Int J Biol Macromol. 2016 Nov ;92:1067-1073. Epub 2016 Aug 8. PMID: 27514443
Article Published Date : Oct 31, 2016
Study Type : Animal Study
Additional Links
Substances : Lychee
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents, Immunomodulatory, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.May 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Ayurveda Integr Med. 2017 Apr - Jun;8(2):62-67. Epub 2017 Jun 10. PMID: 28610894
Article Published Date : May 31, 2017
Study Type : Animal Study
Additional Links
Substances : Mangiferin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cardioprotective, Chemoprotective Agents
[+]

The present study reveals the protective role of M. koenigii extract against cyclophosphamide induced nephrotoxicity.Jul 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2017 Aug ;10(8):808-812. Epub 2017 Aug 24. PMID: 28942830
Article Published Date : Jul 31, 2017
Study Type : Animal Study
Additional Links
Substances : Curry Leaves
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Chemoprotective Agents, Renoprotective
[+]

The results of our study confirmed the antioxidant effects of spirulina against cyclophosphamide induced adverse effects in testicular tissue.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Vet Res Forum. 2018 ;9(1):35-41. Epub 2018 Mar 15. PMID: 29719662
Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : Spirulina
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

The results reveal that Zataria multiflora protects lung tissues from cyclophosphamide-induced toxicity.Sep 21, 2018

Pubmed Data : Chin J Integr Med. 2018 Sep 22. Epub 2018 Sep 22. PMID: 30242592
Article Published Date : Sep 21, 2018
Study Type : Animal Study
Additional Links
Substances : Zataria multiflora
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Thymoquinone can reduce the level of bilirubin in systemic circulation in disease conditions that lead to hyperbilirubinemia and liver toxicity.Jun 01, 2016

Pubmed Data : Biochimie. 2016 Jun 2. Epub 2016 Jun 2. PMID: 27265787
Article Published Date : Jun 01, 2016
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Hyperbilirubinemia: Hereditary
Pharmacological Actions : Hepatoprotective
[+]

Thymoquinone supplementation attenuates cyclophosphamide induced cardiotoxicity.Apr 30, 2011

Pubmed Data : J Biochem Mol Toxicol. 2011 May-Jun;25(3):135-42. Epub 2010 Oct 18. PMID: 20957680
Article Published Date : Apr 30, 2011
Study Type : Animal Study
Additional Links
Substances : Thymoquinone
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.Mar 23, 2015

Pubmed Data : Hum Exp Toxicol. 2015 Mar 24. Epub 2015 Mar 24. PMID: 25805601
Article Published Date : Mar 23, 2015
Study Type : Animal Study
Additional Links
Substances : Coconut Oil
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Cytoprotective, Superoxide Dismutase Up-regulation
[+]

Vitamin C can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model.Mar 31, 2017

Pubmed Data : J Adv Pharm Technol Res. 2017 Apr-Jun;8(2):73-79. PMID: 28516060
Article Published Date : Mar 31, 2017
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Cytoprotective
Problem Substances : Cyclophosphamide
[+]

Watercress has promising properties to be used as health promoter or protective agent against oxidative damage.Dec 31, 2016

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Medicina (B Aires). 2017 ;77(3):201-206. PMID: 28643677
Article Published Date : Dec 31, 2016
Study Type : Animal Study
Additional Links
Substances : Watercress
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents
[+]

Chemoprotective effects of Zataria multiflora against genotoxicity induced by cyclophosphamide in mice bone marrow cells.May 31, 2010

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Integr Cancer Ther. 2010 Jun ;9(2):219-23. Epub 2010 Mar 31. PMID: 20356951
Article Published Date : May 31, 2010
Study Type : In Vitro Study
Additional Links
Substances : Zataria multiflora
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antimutagenic Agents, Antioxidants, Chemoprotective Agents
Additional Keywords : Plant Extracts
[+]

Curcumin has antimutagenic activity. Jun 01, 2008

Pubmed Data : Int J Antimicrob Agents. 2008 Jun;31(6):572-6. Epub 2008 Apr 28. PMID: 10682600
Article Published Date : Jun 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage
Pharmacological Actions : Antimutagenic Agents, Genoprotective
[+]

Curcumin has antimutagenic potential. Mar 25, 2002

Pubmed Data : Mutat Res. 2002 Mar 25;515(1-2):197-202. PMID: 11909768
Article Published Date : Mar 25, 2002
Study Type : In Vitro Study
Additional Links
Substances : Curcumin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage
Pharmacological Actions : Antimutagenic Agents, Genoprotective
[+]

Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.Nov 30, 1990

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Jpn J Pharmacol. 1990 Dec ;54(4):447-54. PMID: 2087006
Article Published Date : Nov 30, 1990
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Immunomodulatory
[+]

Immunostimulatory polysaccharide isolated from the leaves of Diospyros kaki Thumb modulate macrophage via TLR2.Jul 31, 2015

Pubmed Data : Int J Biol Macromol. 2015 Aug ;79:971-82. Epub 2015 Jun 17. PMID: 26093315
Article Published Date : Jul 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Persimmon
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide
Pharmacological Actions : Immunostimulatory
[+]

The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity.Jul 31, 2018

Pubmed Data : Int Immunopharmacol. 2018 Aug ;61:29-36. Epub 2018 May 23. PMID: 29800788
Article Published Date : Jul 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Oleuropein, Quercetin
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemoprotective Agents
[+]

This study clearly demonstrated the potentiality of sesamol against cyclophosphamide induced organ toxicity and oxidative stress.Dec 31, 2013

Pubmed Data : Anticancer Agents Med Chem. 2014 ;14(7):975-83. PMID: 24372526
Article Published Date : Dec 31, 2013
Study Type : In Vitro Study
Additional Links
Substances : Sesamol
Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Inflammation, Lipid Peroxidation, Oxidative Stress
Pharmacological Actions : Antioxidants, Chemoprotective Agents

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