Chemotherapy-Induced Toxicity: Cyclophosphamide

Name	AC	CK
Melatonin	2	12
Chokeberry	1	10
Vitamin D	1	10
Curcumin	5	8
Anthocyanins	2	4
Astaxanthin	2	4
Blueberry	2	4
Achiote	1	2
Apricot Kernel	1	2
Arginine	1	2
Bitter Apple	1	2
Buckwheat	1	2
Clove	1	2
Coconut Oil	1	2
Gallic Acid	1	2
Garlic	1	2
Indian Mulberry	1	2
Lycopene	1	2
Moringa oleifera	1	2
Taurine	1	2
Thymoquinone	1	2
Water: Deuterium Depleted	1	2

Name	AC	CK	Focus
Cyclophosphamide	4	8

Name	AC	CK	Focus
Chemotherapy	1	10
Radiotherapy	1	10

[+]

Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma. Dec 31, 2012

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Pubmed Data : Mol Cell Biochem. 2013 Jan ;372(1-2):47-55. Epub 2012 Sep 5. PMID: 22949034

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Chokeberry

Diseases : Breast Cancer, Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Doxorubicin

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Superoxide Dismutase Up-regulation

Additional Keywords : Drug: Doxorubicin, Plant Extracts

[+]

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Click here to read the entire abstract

Pubmed Data : Neuro Endocrinol Lett. 2013 ;34(7):660-8. PMID: 24464005

Article Published Date : Dec 31, 2012

Study Type : Human Study

Additional Links

Substances : Melatonin, Vitamin D

Diseases : Breast Cancer, Breast Cancer: Metastatic, Chemotherapy-Induced Toxicity: Cyclophosphamide

Additional Keywords : Natural Substance/Drug Synergy, Significant Treatment Outcome

[+]

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

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Pubmed Data : J Med Food. 2005 Fall;8(3):382-5. PMID: 3857944

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukemia: Acute myelogenous leukemia (AML) , Lymphoma, Myelodysplastic Syndrome, Radiation Induced Illness

Additional Keywords : Iatrogenic Disease

Anti Therapeutic Actions : Chemotherapy, Radiotherapy

[+]

Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis.Mar 22, 2018

Click here to read the entire abstract

Pubmed Data : Pediatr Transplant. 2018 Mar 23:e13171. Epub 2018 Mar 23. PMID: 29569791

Article Published Date : Mar 22, 2018

Study Type : Human: Case Report

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Therapeutic Actions : Hyperbaric Treatment

Pharmacological Actions : Chemoprotective Agents

[+]

20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.Jan 31, 2008

Click here to read the entire abstract

Pubmed Data : Arch Toxicol. 2008 Feb ;82(2):117-23. Epub 2007 Jun 28. PMID: 17598087

Article Published Date : Jan 31, 2008

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Anti-Apoptotic, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

[+]

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

Click here to read the entire abstract

Pubmed Data : Indian J Pharmacol. 2017 Jan-Feb;49(1):65-70. PMID: 28458425

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Curcumin, Piperine

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

A diet supplemented with whole Chlorella vulgaris has beneficial effects on cyclophosphamide induced immunosuppression.Jul 05, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Nutrients. 2017 Jul 6 ;9(7). Epub 2017 Jul 6. PMID: 28684674

Article Published Date : Jul 05, 2017

Study Type : Animal Study

Additional Links

Substances : Chlorella (Algae)

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Immunomodulatory

[+]

A enriched extract of blueberry anthocyanins protected against cyclophosphamide induced lung damage.Oct 15, 2014

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Pubmed Data : Chem Biol Interact. 2014 Oct 16 ;222C:106-111. Epub 2014 Oct 16. PMID: 25451569

Article Published Date : Oct 15, 2014

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Blueberry

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

Additional Keywords : Dose Response

[+]

Administration of M. vulgare extract was found to be beneficial by attenuating cyclophosphamide-induced liver damage.Mar 31, 2016

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2016 Apr ;94(4):441-7. Epub 2015 Oct 28. PMID: 26886858

Article Published Date : Mar 31, 2016

Study Type : Animal Study

Additional Links

Substances : Horehound

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Alleviation of cyclophosphamide-induced hemorrhagic cystitis by dietary pomegranate.May 03, 2018

Click here to read the entire abstract

Pubmed Data : J Pediatr Hematol Oncol. 2018 May 4. Epub 2018 May 4. PMID: 29734214

Article Published Date : May 03, 2018

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis: Hemorrhagic

Pharmacological Actions : Chemoprotective Agents

[+]

An enriched blueberry anthocyanin extract attenuated the cyclophosphamide induced cardiac injury.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(7):e0127813. Epub 2015 Jul 2. PMID: 26133371

Article Published Date : Dec 31, 2014

Study Type : Animal Study

Additional Links

Substances : Anthocyanins, Blueberry

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Cardioprotective

Additional Keywords : Significant Treatment Outcome

[+]

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2016 Apr 22 ;182:101-9. Epub 2016 Feb 10. PMID: 26875643

Article Published Date : Apr 21, 2016

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Fertility Agents: Male

Additional Keywords : Plant Extracts

Problem Substances : Cyclophosphamide

[+]

An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2018 Apr 6 ;215:191-198. Epub 2018 Jan 9. PMID: 29325915

Article Published Date : Apr 05, 2018

Study Type : Animal Study

Additional Links

Substances : Purslane

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antispasmodic, Immunomodulatory

Problem Substances : Cyclophosphamide

[+]

Annato seed extracts could prevent oxidative stress that is occasioned by cyclophosphamide administration.Feb 28, 2011

Click here to read the entire abstract

Pubmed Data : Exp Toxicol Pathol. 2011 Mar ;63(3):257-62. PMID: 20137904

Article Published Date : Feb 28, 2011

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Achiote

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemopreventive

Additional Keywords : Plant Extracts

[+]

Apricot Kernel Oil Ameliorates Cyclophosphamide-Associated Immunosuppression in Rats.Jun 03, 2016

Click here to read the entire abstract

Pubmed Data : Lipids. 2016 Jun 4. Epub 2016 Jun 4. PMID: 27262314

Article Published Date : Jun 03, 2016

Study Type : Animal Study

Additional Links

Substances : Apricot Kernel

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Problem Substances : Cyclophosphamide

[+]

Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat.Feb 01, 2010

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2010 Feb ;696(1):69-80. Epub 2009 Dec 28. PMID: 20038455

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Liver Damage, Oxidative Stress

Pharmacological Actions : Chemopreventive, Tumor Suppressor Protein p53 Upregulation

[+]

Astaxanthin protects against cyclophosphamide-induced oxidative stress and DNA damage.Aug 14, 2009

Click here to read the entire abstract

Pubmed Data : Chem Biol Interact. 2009 Aug 14;180(3):398-406. Epub 2009 Apr 2. PMID: 19539803

Article Published Date : Aug 14, 2009

Study Type : Animal Study

Additional Links

Substances : Astaxanthin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation

[+]

Bitter apple pretreatment attenuates cyclophosphamide-induced oxidative stress and the subsequent DNA damage in mice.Dec 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ScientificWorldJournal. 2013 ;2013:980480. Epub 2013 Nov 7. PMID: 24324391

Article Published Date : Dec 31, 2012

Study Type : Animal Study

Additional Links

Substances : Bitter Apple

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation

Pharmacological Actions : Antioxidants, Chemoprotective Agents

Additional Keywords : Plant Extracts

[+]

Camel milk may have an immunopotentiating role in diseases or conditions associated with leukopenia or drug-induced toxicities.Aug 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Health Sci (Qassim). 2017 Sep-Oct;11(4):18-22. PMID: 29085263

Article Published Date : Aug 31, 2017

Study Type : Animal Study

Additional Links

Substances : Camel Milk

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Leukopenia

Pharmacological Actions : Chemoprotective Agents

[+]

Carvacrol attenuates cyclophosphamide-induced oxidative stress in rat kidney.Feb 02, 2017

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2017 Feb 3. Epub 2017 Feb 3. PMID: 28177660

Article Published Date : Feb 02, 2017

Study Type : Animal Study

Additional Links

Substances : Carvacrol

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells.Mar 31, 2005

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2005 Apr ;57(4):505-9. PMID: 15831212

Article Published Date : Mar 31, 2005

Study Type : Animal Study

Additional Links

Substances : Bitter Orange

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antimutagenic Agents, Antioxidants, Chemoprotective Agents

Additional Keywords : Plant Extracts

[+]

Clove postively modulates humoral and cell-mediated immune responses and prevents cyclophosphamide-induced immunosuppression in mice. Jul 01, 2009

Click here to read the entire abstract

Pubmed Data : J Pharm Pharmacol. 2009 Jul;61(7):961-7. PMID: 19589240

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Clove

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Additional Keywords : Drug Side Effect Attenuation

[+]

Combined extracts of pumpkin seed and ginger might be used as a protective agent against cyclophosphamide induced reproductive toxicity.Aug 31, 2016

Click here to read the entire abstract

Pubmed Data : Anat Sci Int. 2016 Sep ;91(4):382-90. Epub 2015 Dec 29. PMID: 26714700

Article Published Date : Aug 31, 2016

Study Type : Animal Study

Additional Links

Substances : Ginger, Pumpkin Seeds

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Plant Extracts

[+]

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Zhong Yao Cai. 2014 Oct ;37(10):1833-6. PMID: 25895394

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Corn Silk

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Chemotherapeutic Agent: Cyclophosphamide, Natural Substance/Drug Synergy, Polysaccharides

[+]

Curcumin inhibits lipid peroxidation and cholesterol levels in mice.Oct 01, 1992

Click here to read the entire abstract

Pubmed Data : Indian J Physiol Pharmacol. 1992 Oct;36(4):239-43. PMID: 1291474

Article Published Date : Oct 01, 1992

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Lipid Peroxidation

Pharmacological Actions : Hepatoprotective

[+]

Curcumin protects against cyclophosphamide-induced haemorrhagic cystitis.Apr 16, 2004

Click here to read the entire abstract

Pubmed Data : Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PMID: 19413659

Article Published Date : Apr 16, 2004

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Bladder Dysfunction , Chemotherapy-Induced Toxicity: Cyclophosphamide, Cystitis, Interstitial Cystitis

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs.Oct 01, 2009

Click here to read the entire abstract

Pubmed Data : Amino Acids. 2009 Oct;37(4):643-51. Epub 2008 Sep 28. PMID: 18821052

Article Published Date : Oct 01, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Immunostimulatory

[+]

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity.Jul 31, 2013

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2013 Aug ;58:210-9. Epub 2013 Apr 17. PMID: 23603381

Article Published Date : Jul 31, 2013

Study Type : Animal Study

Additional Links

Substances : Ellagic Acid

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Chemotherapy-Induced Toxicity: Bleomycin

Pharmacological Actions : Chemoprotective Agents

[+]

Gallic acid has the capacity to protect against reproductive toxicity induced by cyclophosphamide.Jul 28, 2015

Click here to read the entire abstract

Pubmed Data : Andrologia. 2015 Jul 29. Epub 2015 Jul 29. PMID: 26223283

Article Published Date : Jul 28, 2015

Study Type : Animal Study

Additional Links

Substances : Gallic Acid

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Gene expression signatures that predict radiation exposure in mice and humans.Mar 31, 2007

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS Med. 2007 Apr ;4(4):e106. PMID: 17407386

Article Published Date : Mar 31, 2007

Study Type : Animal Study

Additional Links

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Radiation Induced Illness

[+]

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

Click here to read the entire abstract

Pubmed Data : Chin Med J (Engl). 2007 Apr 5 ;120(7):584-8. PMID: 17442207

Article Published Date : Apr 04, 2007

Study Type : Animal Study

Additional Links

Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Ovarian Cancer

Pharmacological Actions : Angiogenesis Inhibitors, Antiproliferative , Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Natural Substance/Drug Synergy

[+]

H. sabdariffa L. presented a protective effect to cyclophosphamide induced damage to DNA.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : ScientificWorldJournal. 2017 ;2017:9392532. Epub 2017 Jan 19. PMID: 28197528

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Hibiscus sabdariffa

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage, Obesity

Pharmacological Actions : Antimutagenic Agents, Chemoprotective Agents

Problem Substances : Monosodium Glutamate (MSG)

[+]

Immune-enhancing effect of nanometric Lactobacillus plantarum nF1 in a mouse model of cyclophosphamide-induced immunosuppression.Nov 14, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Microbiol Biotechnol. 2017 Nov 15. Epub 2017 Nov 15. PMID: 29141128

Article Published Date : Nov 14, 2017

Study Type : Animal Study

Additional Links

Substances : Lactobacillus plantarum

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Immunomodulatory

[+]

In this study deuterium depleted water led to a statistically significant increased survival rate compared with control groups fed with normal distilled water after irradiation, 61% versus 25%.Jun 30, 1999

Click here to read the entire abstract

Pubmed Data : Rom J Physiol. 1999 Jul-Dec;36(3-4):205-18. PMID: 11797936

Article Published Date : Jun 30, 1999

Study Type : Animal Study

Additional Links

Substances : Water: Deuterium Depleted

Diseases : Chemotherapy and Radiation Toxicity, Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemotherapeutic, Immunostimulatory, Radioprotective

Problem Substances : Cyclophosphamide

[+]

Morinda officinalis extract can repair cytoxan-induced damage to rat spermatogenesis.Apr 30, 2015

Click here to read the entire abstract

Pubmed Data : Zhonghua Nan Ke Xue. 2015 May ;21(5):436-42. PMID: 26117943

Article Published Date : Apr 30, 2015

Study Type : Animal Study

Additional Links

Substances : Indian Mulberry

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents

[+]

Moringa leaves play an important role in ameliorating and protecting the bladder from CP toxicity.Jan 31, 2015

Click here to read the entire abstract

Pubmed Data : Tissue Cell. 2015 Feb ;47(1):94-104. Epub 2014 Dec 23. PMID: 25595312

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Moringa oleifera

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents

[+]

Nigella sativa oil and thymoquinone have protective effects against toxicity induced by the anticancer drug cyclophosphamide.Dec 31, 2009

Click here to read the entire abstract

Pubmed Data : Br J Biomed Sci. 2010 ;67(1):20-8. PMID: 20373678

Article Published Date : Dec 31, 2009

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed), Thymoquinone

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Nigella sativa oil can protect against Cyclophosphamide-induced DNA damage and hepatotoxicity.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2017 Apr ;69(3):498-504. Epub 2017 Feb 17. PMID: 28287318

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed)

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective

[+]

Pumpkin seed extract might be used as protective agent against cyclophosphamide induced reproductive toxicity.Sep 30, 2014

Click here to read the entire abstract

Pubmed Data : Andrologia. 2014 Oct ;46(8):927-35. Epub 2013 Oct 11. PMID: 24124763

Article Published Date : Sep 30, 2014

Study Type : Animal Study

Additional Links

Substances : Pumpkin Seeds

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : Environ Toxicol Pharmacol. 2016 Jul ;45:158-62. Epub 2016 Aug 1. PMID: 27310207

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Punicalagin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cyclooxygenase 2 Inhibitors, Hepatoprotective

[+]

Resveratrol may confer multi-organ protection against cyclophosphamide toxicity via antioxidant and anti-inflammatory mechanisms.May 01, 2017

Click here to read the entire abstract

Pubmed Data : Immunopharmacol Immunotoxicol. 2017 May 2:1-8. Epub 2017 May 2. PMID: 28463035

Article Published Date : May 01, 2017

Study Type : Animal Study

Additional Links

Substances : Resveratrol

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Royal jelly provided biochemical and histo-pathological improvement in cyclophosphamide induced prostatic tissue toxicity.Mar 20, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Mar 21 ;90:15-23. Epub 2017 Mar 21. PMID: 28340377

Article Published Date : Mar 20, 2017

Study Type : Animal Study

Additional Links

Substances : Royal Jelly

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Saffron, garlic and curcumin protect against yclophosphamide induced genotoxicity in mice.Jan 01, 2004

Click here to read the entire abstract

Pubmed Data : Asia Pac J Clin Nutr. 2004;13(3):292-4. PMID: 15331343

Article Published Date : Jan 01, 2004

Study Type : Animal Study

Additional Links

Substances : Curcumin, Garlic

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antimutagenic Agents, Genoprotective

Additional Keywords : Plant Extracts

[+]

Supplementation of diet with lycopene and melatonin provided antioxidant defense with strong protective activity against cyclophosphamide induced cytotoxicity.Jun 30, 2014

Click here to read the entire abstract

Pubmed Data : Toxicol Ind Health. 2014 Jul ;30(6):570-5. Epub 2012 Sep 28. PMID: 23024110

Article Published Date : Jun 30, 2014

Study Type : Animal Study

Additional Links

Substances : Lycopene, Melatonin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents

Additional Keywords : Natural Substance Synergy

[+]

Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.Jul 14, 2015

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2015 Jul 15 ;22(7-8):730-6. Epub 2015 May 23. PMID: 26141759

Article Published Date : Jul 14, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Buckwheat

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Liver Cancer

Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Chemoprotective Agents, Tumor Suppressor Protein p53 Upregulation

Problem Substances : Cyclophosphamide

[+]

Taurine is suggested to be a potential candidate to ameliorate cyclophosphamide induced cardiorenal toxicity.Jul 17, 2015

Click here to read the entire abstract

Pubmed Data : Can J Physiol Pharmacol. 2015 Jul 18:1-9. Epub 2015 Jul 18. PMID: 26695545

Article Published Date : Jul 17, 2015

Study Type : Animal Study

Additional Links

Substances : Taurine

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Malondialdehyde Down-regulation, Renoprotective

[+]

The immunomodulatory activity of litchi pulp polysaccharides was accompanied with its antioxidant activity.Oct 31, 2016

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2016 Nov ;92:1067-1073. Epub 2016 Aug 8. PMID: 27514443

Article Published Date : Oct 31, 2016

Study Type : Animal Study

Additional Links

Substances : Lychee

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents, Immunomodulatory, Interleukin-6 Downregulation, Malondialdehyde Down-regulation, Superoxide Dismutase Up-regulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.May 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Ayurveda Integr Med. 2017 Apr - Jun;8(2):62-67. Epub 2017 Jun 10. PMID: 28610894

Article Published Date : May 31, 2017

Study Type : Animal Study

Additional Links

Substances : Mangiferin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cardioprotective, Chemoprotective Agents

[+]

The present study reveals the protective role of M. koenigii extract against cyclophosphamide induced nephrotoxicity.Jul 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Asian Pac J Trop Med. 2017 Aug ;10(8):808-812. Epub 2017 Aug 24. PMID: 28942830

Article Published Date : Jul 31, 2017

Study Type : Animal Study

Additional Links

Substances : Curry Leaves

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Chemoprotective Agents, Renoprotective

[+]

The results of our study confirmed the antioxidant effects of spirulina against cyclophosphamide induced adverse effects in testicular tissue.Dec 31, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Vet Res Forum. 2018 ;9(1):35-41. Epub 2018 Mar 15. PMID: 29719662

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : Spirulina

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Thymoquinone can reduce the level of bilirubin in systemic circulation in disease conditions that lead to hyperbilirubinemia and liver toxicity.Jun 01, 2016

Click here to read the entire abstract

Pubmed Data : Biochimie. 2016 Jun 2. Epub 2016 Jun 2. PMID: 27265787

Article Published Date : Jun 01, 2016

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Hyperbilirubinemia: Hereditary

Pharmacological Actions : Hepatoprotective

[+]

Thymoquinone supplementation attenuates cyclophosphamide induced cardiotoxicity.Apr 30, 2011

Click here to read the entire abstract

Pubmed Data : J Biochem Mol Toxicol. 2011 May-Jun;25(3):135-42. Epub 2010 Oct 18. PMID: 20957680

Article Published Date : Apr 30, 2011

Study Type : Animal Study

Additional Links

Substances : Thymoquinone

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cardioprotective, Chemoprotective Agents, Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.Mar 23, 2015

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Pubmed Data : Hum Exp Toxicol. 2015 Mar 24. Epub 2015 Mar 24. PMID: 25805601

Article Published Date : Mar 23, 2015

Study Type : Animal Study

Additional Links

Substances : Coconut Oil

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Antioxidants, Catalase Up-Regulation, Cytoprotective, Superoxide Dismutase Up-regulation

[+]

Vitamin C can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : J Adv Pharm Technol Res. 2017 Apr-Jun;8(2):73-79. PMID: 28516060

Article Published Date : Mar 31, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Cytoprotective

Problem Substances : Cyclophosphamide

[+]

Watercress has promising properties to be used as health promoter or protective agent against oxidative damage.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Medicina (B Aires). 2017 ;77(3):201-206. PMID: 28643677

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Watercress

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemoprotective Agents

[+]

Curcumin has antimutagenic activity. Jun 01, 2008

Click here to read the entire abstract

Pubmed Data : Int J Antimicrob Agents. 2008 Jun;31(6):572-6. Epub 2008 Apr 28. PMID: 10682600

Article Published Date : Jun 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage

Pharmacological Actions : Antimutagenic Agents, Genoprotective

[+]

Curcumin has antimutagenic potential. Mar 25, 2002

Click here to read the entire abstract

Pubmed Data : Mutat Res. 2002 Mar 25;515(1-2):197-202. PMID: 11909768

Article Published Date : Mar 25, 2002

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, DNA damage

Pharmacological Actions : Antimutagenic Agents, Genoprotective

[+]

Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.Nov 30, 1990

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Jpn J Pharmacol. 1990 Dec ;54(4):447-54. PMID: 2087006

Article Published Date : Nov 30, 1990

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Immunomodulatory

[+]

Immunostimulatory polysaccharide isolated from the leaves of Diospyros kaki Thumb modulate macrophage via TLR2.Jul 31, 2015

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2015 Aug ;79:971-82. Epub 2015 Jun 17. PMID: 26093315

Article Published Date : Jul 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Persimmon

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide

Pharmacological Actions : Immunostimulatory

[+]

This study clearly demonstrated the potentiality of sesamol against cyclophosphamide induced organ toxicity and oxidative stress.Dec 31, 2013

Click here to read the entire abstract

Pubmed Data : Anticancer Agents Med Chem. 2014 ;14(7):975-83. PMID: 24372526

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Sesamol

Diseases : Chemotherapy-Induced Toxicity: Cyclophosphamide, Inflammation, Lipid Peroxidation, Oxidative Stress

Pharmacological Actions : Antioxidants, Chemoprotective Agents

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Our results suggest that the Aronia extract supplementation in breast cancer patients has a beneficial effect on thiols concentration in plasma. Dec 31, 2012

Somatostatin combined with melatonin, retinoids, vitamin D3, and low doses of cyclophosphamide led to an overall clinical benefit been achieved in 75% of cases.Dec 31, 2012

Therapy-related acute myeloid leukemia and myelodysplastic syndrome has been reported. Sep 01, 2005

Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis.Mar 22, 2018

20(S)-ginsenoside Rg(3) showed the significant protective effects on cyclophosphamide-induced cell DNA damage and apoptosis.Jan 31, 2008

A combination of curcumin with piperine exhibited profound cardioprotection compared to curcumin alone-treated group.Dec 31, 2016

A diet supplemented with whole Chlorella vulgaris has beneficial effects on cyclophosphamide induced immunosuppression.Jul 05, 2017

A enriched extract of blueberry anthocyanins protected against cyclophosphamide induced lung damage.Oct 15, 2014

Administration of M. vulgare extract was found to be beneficial by attenuating cyclophosphamide-induced liver damage.Mar 31, 2016

Alleviation of cyclophosphamide-induced hemorrhagic cystitis by dietary pomegranate.May 03, 2018

An enriched blueberry anthocyanin extract attenuated the cyclophosphamide induced cardiac injury.Dec 31, 2014

An extract of Moringa oleifera leaves could protect the spermatogonial cells from cyclophosphamide induced damage.Apr 21, 2016

An extract of P. oleracea leaves ameliorated the immunosuppressive action of cyclophosphamide in mice.Apr 05, 2018

Annato seed extracts could prevent oxidative stress that is occasioned by cyclophosphamide administration.Feb 28, 2011

Apricot Kernel Oil Ameliorates Cyclophosphamide-Associated Immunosuppression in Rats.Jun 03, 2016

Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat.Feb 01, 2010

Astaxanthin protects against cyclophosphamide-induced oxidative stress and DNA damage.Aug 14, 2009

Bitter apple pretreatment attenuates cyclophosphamide-induced oxidative stress and the subsequent DNA damage in mice.Dec 31, 2012

Camel milk may have an immunopotentiating role in diseases or conditions associated with leukopenia or drug-induced toxicities.Aug 31, 2017

Carvacrol attenuates cyclophosphamide-induced oxidative stress in rat kidney.Feb 02, 2017

Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells.Mar 31, 2005

Clove postively modulates humoral and cell-mediated immune responses and prevents cyclophosphamide-induced immunosuppression in mice. Jul 01, 2009

Combined extracts of pumpkin seed and ginger might be used as a protective agent against cyclophosphamide induced reproductive toxicity.Aug 31, 2016

Corn silk polysaccharides have potent inhibitory effects on implanted H22 tumors.Sep 30, 2014

Curcumin inhibits lipid peroxidation and cholesterol levels in mice.Oct 01, 1992

Curcumin protects against cyclophosphamide-induced haemorrhagic cystitis.Apr 16, 2004

Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs.Oct 01, 2009

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity.Jul 31, 2013

Gallic acid has the capacity to protect against reproductive toxicity induced by cyclophosphamide.Jul 28, 2015

Gene expression signatures that predict radiation exposure in mice and humans.Mar 31, 2007

Ginsenoside Rg3 significantly inhibited growth and angiogenesis of ovarian cancer when used alone or combined with cyclophosphamide.Apr 04, 2007

H. sabdariffa L. presented a protective effect to cyclophosphamide induced damage to DNA.Dec 31, 2016

Immune-enhancing effect of nanometric Lactobacillus plantarum nF1 in a mouse model of cyclophosphamide-induced immunosuppression.Nov 14, 2017

In this study deuterium depleted water led to a statistically significant increased survival rate compared with control groups fed with normal distilled water after irradiation, 61% versus 25%.Jun 30, 1999

Morinda officinalis extract can repair cytoxan-induced damage to rat spermatogenesis.Apr 30, 2015

Moringa leaves play an important role in ameliorating and protecting the bladder from CP toxicity.Jan 31, 2015

Nigella sativa oil and thymoquinone have protective effects against toxicity induced by the anticancer drug cyclophosphamide.Dec 31, 2009

Nigella sativa oil can protect against Cyclophosphamide-induced DNA damage and hepatotoxicity.Mar 31, 2017

Pumpkin seed extract might be used as protective agent against cyclophosphamide induced reproductive toxicity.Sep 30, 2014

Punicalagin protected rat livers against cyclophosphamide toxicity.Jun 30, 2016

Resveratrol may confer multi-organ protection against cyclophosphamide toxicity via antioxidant and anti-inflammatory mechanisms.May 01, 2017

Royal jelly provided biochemical and histo-pathological improvement in cyclophosphamide induced prostatic tissue toxicity.Mar 20, 2017

Saffron, garlic and curcumin protect against yclophosphamide induced genotoxicity in mice.Jan 01, 2004

Supplementation of diet with lycopene and melatonin provided antioxidant defense with strong protective activity against cyclophosphamide induced cytotoxicity.Jun 30, 2014

Tatariside possess notable antitumor effects against HCC and might play a favorable role in drug combination therapy against tumors with protective effect on liver.Jul 14, 2015

Taurine is suggested to be a potential candidate to ameliorate cyclophosphamide induced cardiorenal toxicity.Jul 17, 2015

The immunomodulatory activity of litchi pulp polysaccharides was accompanied with its antioxidant activity.Oct 31, 2016

The present findings clearly suggest the protective role of mangiferin as a powerful antioxidant preventing cardiotoxicity caused by cyclophosphamide.May 31, 2017

The present study reveals the protective role of M. koenigii extract against cyclophosphamide induced nephrotoxicity.Jul 31, 2017

The results of our study confirmed the antioxidant effects of spirulina against cyclophosphamide induced adverse effects in testicular tissue.Dec 31, 2017

Thymoquinone can reduce the level of bilirubin in systemic circulation in disease conditions that lead to hyperbilirubinemia and liver toxicity.Jun 01, 2016

Thymoquinone supplementation attenuates cyclophosphamide induced cardiotoxicity.Apr 30, 2011

Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.Mar 23, 2015

Vitamin C can be effective on some of the sperm parameters and can reduce cyclophosphamide-induced complications in animal model.Mar 31, 2017

Watercress has promising properties to be used as health promoter or protective agent against oxidative damage.Dec 31, 2016

Curcumin has antimutagenic activity. Jun 01, 2008

Curcumin has antimutagenic potential. Mar 25, 2002

Immunomodulating activity of ginsenoside Rg1 from Panax ginseng.Nov 30, 1990

Immunostimulatory polysaccharide isolated from the leaves of Diospyros kaki Thumb modulate macrophage via TLR2.Jul 31, 2015

This study clearly demonstrated the potentiality of sesamol against cyclophosphamide induced organ toxicity and oxidative stress.Dec 31, 2013

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Chemotherapy-Induced Toxicity: Cyclophosphamide

View the Evidence:
60 Abstracts with Chemotherapy-Induced Toxicity: Cyclophosphamide Research