Clogged Arteries

Clogged Arteries

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View the Evidence: Ailments

There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.

Pubmed Data : Diabetes Care. 2010 Jun;33(6):1224-9. Epub 2010 Mar 9. PMID: 20215447
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Mortality: All-Cause : CK(644) : AC(55)
Problem Substances : Glipizide : CK(64) : AC(6), Glyburide : CK(50) : AC(4)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

An omega-6 fatty acid rich diet may be associated with higher rates of coronary heart disease and cardiac mortality.

Pubmed Data : Br J Nutr. 2010 Dec;104(11):1586-600. PMID: 21118617
Article Published Date : Dec 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Omega-6 Fatty Acids: Excess/Disproportionate to Omega-3's : CK(36) : AC(3)

Calcium supplements with or without vitamin D increase the risk of cardiovascular events.

Pubmed Data : BMJ. 2011;342:d2040. Epub 2011 Apr 19. PMID: 21505219
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117), Stroke : CK(540) : AC(47)
Problem Substances : Calcium Carbonate : CK(176) : AC(19)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Cardiac mortality is associated with low levels of omega-3 and omega-6 fatty acids in the heart of cadavers with a history of coronary heart disease.

Pubmed Data : Nutr Res. 2009 Oct;29(10):696-704. PMID: 19917448
Article Published Date : Oct 01, 2009
Study Type : Meta Analysis
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319), Omega-6 Fatty Acids : CK(30) : AC(2)
Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Chocolate consumption is associated with a substantial reduction in the risk of cardiometabolic disorders.

Pubmed Data : BMJ. 2011 ;343:d4488. Epub 2011 Aug 26. PMID: 21875885
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Chocolate : CK(243) : AC(32)
Diseases : Blood Sugar Problems : CK(4050) : AC(693), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122), Stroke : CK(540) : AC(47)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Consuming small quantities of fish is associated with a reduction in coronary heart disease.

Pubmed Data : Am J Prev Med. 2005 Nov;29(4):335-46. PMID: 16242600
Article Published Date : Nov 01, 2005
Study Type : Meta Analysis
Additional Links
Substances : Fish : CK(241) : AC(21), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)

Consumption of trans-fatty acids from partially hydrogenated oils adversely affects multiple cardiovascular risk factors and contributes significantly to increased risk of oronary heart disease events.

Pubmed Data : Eur J Clin Nutr. 2009 May;63 Suppl 2:S5-21. PMID: 19424218
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173), Inflammation : CK(1077) : AC(363), Insulin Resistance : CK(1034) : AC(221), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Hydrogenated Oil : CK(148) : AC(23), Trans Fatty Acids : CK(281) : AC(39)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with myocardial infarction.

Pubmed Data : Ann Med. 2009;41(4):301-10. PMID: 19148838
Article Published Date : Jan 01, 2009
Study Type : Meta Analysis
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Cardiac Arrest : CK(40) : AC(2), Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Exposure to isoflavone-containing soy products may improve endothelial function.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Aug 14. Epub 2010 Aug 14. PMID: 20709515
Article Published Date : Aug 14, 2010
Study Type : Meta Analysis
Additional Links
Substances : Isoflavones : CK(627) : AC(124), phytoestrogens : CK(699) : AC(210), Soy : CK(1672) : AC(347), Soy Protein : CK(2307) : AC(56)
Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Endothelial Dysfunction : CK(897) : AC(173)

Fish and long-chain omega-3 fatty acid intake reduce the risk of coronary heart disease and total mortality in diabetic women.

Pubmed Data : Circulation. 2003 Apr 15;107(14):1852-7. Epub 2003 Mar 31. PMID: 12668520
Article Published Date : Apr 15, 2003
Study Type : Meta Analysis
Additional Links
Substances : Fish : CK(241) : AC(21), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Mortality: All-Cause : CK(644) : AC(55)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.

Pubmed Data : Diabetes Res Clin Pract. 2008 Dec;82(3):391-5. Epub 2008 Oct 21. PMID: 18945509
Article Published Date : Dec 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Drug: Metformin : CK(195) : AC(23)
Problem Substances : Glibenclamide : CK(122) : AC(3), Glipizide : CK(64) : AC(6)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Lowering serum cholesterol concentrations does not reduce mortality and is unlikely to prevent coronary heart disease.

Pubmed Data : BMJ. 1992 Jul 4;305(6844):15-9. PMID: 1638188
Article Published Date : Jul 04, 1992
Study Type : Meta Analysis
Additional Links
Diseases : Cholesterol: High : CK(922) : AC(156), Coronary Artery Disease : CK(1305) : AC(136)
Additional Keywords : Cholesterol Myth : CK(136) : AC(18)

Nonsteroidal antinflammatory drugs increase cardiovascular events in patients after hospitalization for serious coronary heart disease.

Pubmed Data : Circ Cardiovasc Qual Outcomes. 2009 May;2(3):155-63. Epub 2009 May 5. PMID: 20031832
Article Published Date : May 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Rofecoxib : CK(60) : AC(5)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.

Pubmed Data : J Am Coll Cardiol. 2010 Oct 19;56(17):1376-85. PMID: 20946994
Article Published Date : Oct 19, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Aspirin : CK(471) : AC(64)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.

Pubmed Data : Acta Diabetol. 2009 Jun;46(2):145-54. Epub 2009 Feb 5. PMID: 19194648
Article Published Date : Jun 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Congestive Heart Failure : CK(256) : AC(30), Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Drug: Metformin : CK(195) : AC(23)
Problem Substances : Sulfonylureas : CK(204) : AC(13)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Local vascular complications following angioplasty are seen in 5% to 10% of patients.

Pubmed Data : Korean Circ J. 2010 Dec;40(12):677-679. Epub 2010 Dec 31. PMID: 21267392
Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Diseases : Arteriovenous Fistula : CK(20) : AC(1), Coronary Artery Disease : CK(1305) : AC(136)
Anti Therapeutic Actions : Angioplasty : CK(40) : AC(4)

"Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly."

Pubmed Data : Atherosclerosis. 2011 Sep ;218(1):207-13. Epub 2011 May 10. PMID: 21621210
Article Published Date : Sep 01, 2011
Study Type : Human Study
Additional Links
Diseases : Atherosclerosis : CK(523) : AC(77), Carotid Artery Narrowing : CK(158) : AC(9)
Problem Substances : Bisphenol A : CK(217) : AC(54), Phthalates : CK(151) : AC(24)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

"Circulating levels of metals are related to carotid atherosclerosis in elderly."

Pubmed Data : Sci Total Environ. 2011 Dec 15. Epub 2011 Dec 15. PMID: 22178028
Article Published Date : Dec 15, 2011
Study Type : Human Study
Additional Links
Diseases : Atherosclerosis : CK(523) : AC(77), Intima Media Thickening : CK(1878) : AC(41)
Problem Substances : Aluminum : CK(154) : AC(41)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

"Lipid-lowering drugs and essential omega-6 and omega-3 fatty acids in patients with coronary heart disease."

Pubmed Data : Nutr Metab Cardiovasc Dis. 2005 Feb ;15(1):36-41. PMID: 15871849
Article Published Date : Jan 31, 2005
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Dietary Fatty Acid Imbalance: Omega3/Omega6 Ratio : CK(33) : AC(5), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Omega-3 Fatty Acid Deficiency : CK(20) : AC(1), Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords : Drug Synergy : CK(327) : AC(147)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

A B vitamin formula decreases the carotid artery thickness in patients at risk for cerebral ischemia.

Pubmed Data : Atherosclerosis. 2005 Jul;181(1):131-5. Epub 2005 Feb 16. PMID: 15939064
Article Published Date : Jul 01, 2005
Study Type : Human Study
Additional Links
Substances : B-complex : CK(278) : AC(32)
Diseases : Carotid Artery Narrowing : CK(158) : AC(9), Hyperhomocysteinemia : CK(377) : AC(57), Intima Media Thickening : CK(1878) : AC(41)

A high vitamin K2 (menaquinone) intake reduces the incidence of coronary heart disease.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10. Epub 2009 Jan 28. PMID: 19179058
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin K2 : CK(277) : AC(32), Vitamin K2: (MK-8) : CK(10) : AC(1), Vitamin K2: (MK-9) : CK(10) : AC(1), Vitamin K2: Menaquinone-7 : CK(88) : AC(14)
Diseases : Coronary Artery Disease : CK(1305) : AC(136)

A high-fat meal enriched with eicosapentaenoic acid reduces postprandial arterial stiffness in healthy men.

Pubmed Data : J Nutr. 2008 Feb;138(2):287-91. PMID: 18203893
Article Published Date : Feb 01, 2008
Study Type : Human Study
Additional Links
Substances : EPA (Eicosapentaenoic Acid) : CK(595) : AC(84)
Diseases : Arterial Hardening: Elasticity : CK(128) : AC(17)

A Mediterranean diet is associcated with a reduced risk of acute coronary events.

Pubmed Data : East Mediterr Health J. 2002 Jul-Sep;8(4-5):593-602. PMID: 15603042
Article Published Date : Jul 01, 2002
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136)
Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(500) : AC(58)

A Mediterranean diet moderates the development and clinical progression of coronary heart disease.

Pubmed Data : Vitam Horm. 2009;81:487-504. PMID: 15278010
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136)
Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(500) : AC(58)

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