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Article Count - 29
Cumulative Knowledge - 171

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Quick Summary: Current access displays 2 out of 26 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Saccharomyces Boulardii	12	3	Log in \| Sign up
Cranberry	10	1	Log in \| Sign up

Quick Summary: Current access displays 2 out of 5 associated Problem Substances

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Proton-Pump Inhibitors	40	4	Log in \| Sign up
Histamine Receptor Antagonists	30	3	Log in \| Sign up

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View the Evidence: Ailments

The continued spread of Clostridium difficile infections and resultant healthcare burden underscores the need for judicious use of antibiotics

Click here to read the entire abstract

Pubmed Data : J Hosp Infect. 2012 May ;81(1):1-14. Epub 2012 Apr 11. PMID: 22498638

Article Published Date : Apr 30, 2012

Study Type : Meta Analysis

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29)

Problem Substances : Antibiotics : CK(180) : AC(19)

Children exposed to proton pump inhibitor therapy are at higher risk for the development of Clostridium difficile-associated disease.

Click here to read the entire abstract

Pubmed Data : Aliment Pharmacol Ther. 2009 Dec 29. Epub 2009 Dec 29. PMID: 20047577

Article Published Date : Dec 29, 2009

Study Type : Human Study

Additional Links

Diseases : Acid Reflux: In Infants & Children : CK(20) : AC(2), Childhood Infections : CK(275) : AC(29), Clostridium Infections : CK(171) : AC(29), Infant Infections : CK(420) : AC(45)

Additional Keywords : Iatrogenic Disease : CK(226) : AC(26)

Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Cranberry compares favorably to the drug trimethoprim in the prevention of recurrent urinary tract infections in older women, without increasing the risk of antibiotic resistance/super-infection and/or fungal infection.

Click here to read the entire abstract

Pubmed Data : J Antimicrob Chemother. 2009 Feb;63(2):389-95. Epub 2008 Nov 28. PMID: 19042940

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : Cranberry : CK(226) : AC(41)

Diseases : Clostridium Infections : CK(171) : AC(29), Fungal Infection : CK(243) : AC(119), Urinary Tract Infections : CK(338) : AC(47)

Additional Keywords : Natural Substances Versus Drugs : CK(988) : AC(165)

Increasing levels of pharmacologic acid suppression are associated with increased risks of nosocomial C difficile infection.

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2010 May 10;170(9):784-90. PMID: 20458086

Article Published Date : May 10, 2010

Study Type : Human Study

Additional Links

Diseases : Bacterial Infections and Mycoses : CK(127) : AC(51), Clostridium Infections : CK(171) : AC(29)

Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12)

Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Infant formula feeding is associated with increased rates of Clostridium difficile infection and sudden infant death syndrome.

Click here to read the entire abstract

Pubmed Data : Pediatrics. 1982 Jul;70(1):91-5. PMID: 7088640

Article Published Date : Jul 01, 1982

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29), Infant Nutrition: Infant Formula : CK(278) : AC(33), Sudden Infant Death Syndrome (SIDS) : CK(138) : AC(18)

Problem Substances : Infant Formula : CK(485) : AC(63)

Lactobacillus plantarum reduces the negative effects of antibiotic treatment with Clostridium difficile.

Click here to read the entire abstract

Pubmed Data : Dig Dis Sci. 2007 Sep;52(9):2082-6. Epub 2007 Apr 10. PMID: 17420953

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Substances : Lactobacillus plantarum : CK(90) : AC(16)

Diseases : Clostridium Infections : CK(171) : AC(29)

Additional Keywords : Drug: Metronidazole : CK(62) : AC(7), Drug Side Effect Attenuation : CK(252) : AC(49)

Over-use of proton pump inhibitors may be fuelling the current epidemic of Clostridium difficile-associated diarrhoea.

Click here to read the entire abstract

Pubmed Data : J Hosp Infect. 2008 Sep;70(1):1-6. Epub 2008 Jul 3. PMID: 18602190

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72), Drug-Induced Toxicity : CK(560) : AC(78)

Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Patients in hospital who received proton pump inhibitors were at increased risk of Clostridium difficile diarrhea.

Click here to read the entire abstract

Pubmed Data : CMAJ. 2004 Jul 6;171(1):33-8. PMID: 15238493

Article Published Date : Jul 06, 2004

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72)

Problem Substances : Histamine Receptor Antagonists : CK(97) : AC(12), Proton-Pump Inhibitors : CK(218) : AC(27)

Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Patients taking oligofructose were less likely to develop further diarrhea caused by antibiotic treatment for Clostridium difficile than those taking the placebo.

Click here to read the entire abstract

Pubmed Data : Clin Gastroenterol Hepatol. 2005 May;3(5):442-8. PMID: 15880313

Article Published Date : May 01, 2005

Study Type : Human Study

Additional Links

Substances : Prebiotics : CK(114) : AC(15)

Diseases : Clostridium Infections : CK(171) : AC(29)

Additional Keywords : Drug: Metronidazole : CK(62) : AC(7), Drug: Vancomycin : CK(20) : AC(2)

Proton pump inhibitor therapy may increased the risk of clostridium difficile-associated diarrhea.

Click here to read the entire abstract

Pubmed Data : J Natl Med Assoc. 2007 May;99(5):500-4. PMID: 17534007

Article Published Date : May 01, 2007

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72)

Additional Keywords : Increased Risk : CK(50) : AC(5)

Problem Substances : Proton-Pump Inhibitors : CK(218) : AC(27)

Proton pump inhibitor use during incident Clostridium difficile infection treatment was associated with a 42% increased risk of recurrence.

Click here to read the entire abstract

Pubmed Data : Arch Intern Med. 2010 May 10;170(9):772-8. PMID: 20458084

Article Published Date : May 10, 2010

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29)

Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Proton pump inhibitors are associated with elevated risk of developing clostridium difficile-associated diarrhea in hospitalized patients.

Click here to read the entire abstract

Pubmed Data : Am J Gastroenterol. 2008 Sep;103(9):2308-13. Epub 2008 Aug 12. PMID: 18702653

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72)

Additional Keywords : Increased Risk : CK(50) : AC(5)

Saccharomyces boulardii has therapeutic value in treating Clostridium difficile infection.

Click here to read the entire abstract

Pubmed Data : Can J Gastroenterol. 2009 Dec;23(12):817-21. PMID: 20011734

Article Published Date : Dec 01, 2009

Study Type : Human Study

Additional Links

Substances : Saccharomyces Boulardii : CK(137) : AC(23)

Diseases : Clostridium Infections : CK(171) : AC(29), Constipation : CK(316) : AC(36), Diarrhea : CK(544) : AC(72)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

The use of acid-suppressive therapy, particularly proton pump inhibitors, and NSAIDs are associated with an increased risk of community-acquired C difficile.

Click here to read the entire abstract

Pubmed Data : JAMA. 2005 Dec 21;294(23):2989-95. PMID: 16414946

Article Published Date : Dec 21, 2005

Study Type : Human Study

Additional Links

Diseases : Clostridium Infections : CK(171) : AC(29), Diarrhea : CK(544) : AC(72), Low Immune Function: Natural Killer Cells : CK(108) : AC(21)

Problem Substances : Antacids: Aluminium-Containing : CK(22) : AC(3), Histamine Receptor Antagonists : CK(97) : AC(12), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Green tea leaf extract exhibits anti-Clostridium activity.

Click here to read the entire abstract

Pubmed Data : J Food Prot. 2007 Jun;70(6):1429-33. PMID: 17612073

Article Published Date : Jun 01, 2007

Study Type : Animal Study

Additional Links

Substances : Green Tea : CK(930) : AC(294)

Diseases : Clostridium Infections : CK(171) : AC(29)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Kefir may reduce diarrhea for those treated for Clostridium difficile with antibiotics.

Click here to read the entire abstract

Pubmed Data : Minn Med. 2009 Jul;92(7):38-40. PMID: 19708314

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Kefir : CK(7) : AC(4)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Probiotics may have a preventive and therapeutic role in antibiotic-associated diarrhea subsequent to treatment for Clostridium difficile.

Click here to read the entire abstract

Pubmed Data : Nutr Clin Pract. 2009 Feb-Mar;24(1):33-40. PMID: 19244146

Article Published Date : Feb 01, 2009

Study Type : Animal Study

Additional Links

Substances : Probiotics : CK(2468) : AC(245)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Whey may have a therapeutic role in treating Clostridium difficile-associated diarrhea.

Click here to read the entire abstract

Pubmed Data : Int J Cancer. 2003 Aug 20;106(2):178-86. PMID: 18808082

Article Published Date : Aug 20, 2003

Study Type : Animal Study

Additional Links

Substances : Whey : CK(323) : AC(72)

Diseases : Clostridium Infections : CK(171) : AC(29)

Yeast, beef and pork extracts counteract Clostridium difficile toxin A enterotoxicity.

Click here to read the entire abstract

Pubmed Data : FEMS Microbiol Lett. 2009 Jun;295(2):218-25. Epub 2009 Apr 14. PMID: 19416358

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Beef : CK(2) : AC(1), Pork : CK(2) : AC(1), Yeast : CK(48) : AC(8)

Diseases : Clostridium Infections : CK(171) : AC(29)

Biochanin A selectively inhibits the growth of Clostridium.

Click here to read the entire abstract

Pubmed Data : Molecules. 2010;15(3):1270-9. Epub 2010 Mar 3. PMID: 20335979

Article Published Date : Jan 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Biochanin A : CK(9) : AC(8)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Carvacrol, cinnamaldehyde, thymol, or oregano oil inhibit Clostridum prefringens in beef.

Click here to read the entire abstract

Pubmed Data : J Food Prot. 2006 Jul;69(7):1546-51. PMID: 16865884

Article Published Date : Jul 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Carvacrol : CK(67) : AC(9), Cinnamaldehyde : CK(170) : AC(17), Cinnamon : CK(135) : AC(61), Oregano : CK(48) : AC(26), Thyme : CK(39) : AC(22), Thymol : CK(41) : AC(2)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Garlic has an inhibitory effect on Clostridium growth.

Click here to read the entire abstract

Pubmed Data : Rev Argent Microbiol. 1988 Jan-Mar;20(1):17-24. PMID: 3051126

Article Published Date : Jan 01, 1988

Study Type : In Vitro Study

Additional Links

Substances : Garlic : CK(485) : AC(160)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Green tea polyphenols have an inhibitory effect on Clostridium growth.

Click here to read the entire abstract

Pubmed Data : J Biosci Bioeng. 2000;90(1):81-5. PMID: 16232822

Article Published Date : Jan 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Green Tea : CK(930) : AC(294), Polyphenols : CK(427) : AC(174)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Lactobacillus bulgaricus can inhibit the cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells.

Click here to read the entire abstract

Pubmed Data : Gut Pathog. 2009;1(1):8. Epub 2009 Apr 27. PMID: 19397787

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Lactobacilius bulgaricus : CK(35) : AC(8)

Diseases : Clostridium Infections : CK(171) : AC(29)

Pharmacological Actions : Antiviral Agents : CK(613) : AC(280)

Phyllanthus muellerianus exhibits antimicrobial properties.

Click here to read the entire abstract

Pubmed Data : J Ethnopharmacol. 2011 Apr 4. Epub 2011 Apr 4. PMID: 21470574

Article Published Date : Apr 04, 2011

Study Type : In Vitro Study

Additional Links

Substances : Phyllanthus Muellerianus : CK(1) : AC(1)

Diseases : Clostridium Infections : CK(171) : AC(29), Clostridium Sporogenes : CK(1) : AC(1), Dental Caries : CK(275) : AC(32), Steptococcal Infections : CK(1) : AC(1), Streptococcus pyogenes : CK(18) : AC(16), Tetanus : CK(32) : AC(5)

Pharmacological Actions : Antimicrobial : CK(22) : AC(20)

Additional Keywords : Science Confirms Tradition : CK(72) : AC(49)

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Fluoroquinolone Antibiotics Linked To Severe Liver Damage

Written by Case Adams, Naturopath

In a nine-year population study, Canadian researchers have determined that at least two fluoroquinolone-based antibiotics – commonly given to patients with respiratory infections, diarrhea, conjunctivitis and other infections — cause acute liver damage.

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