Cognitive Decline/Dysfunction

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Quick Summary: Current access displays 2 out of 67 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Ginkgo biloba	30	3	Log in \| Sign up
Green Tea	22	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 16 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Fluoride	44	4	Log in \| Sign up
Tamoxifen	40	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 8 associated Therapeutic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Dietary Modification: Mediterranean Diet	20	2	Log in \| Sign up
Aromatherapy	10	1	Log in \| Sign up

Quick Summary: 1 associated Problematic Actions

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View the Evidence: Ailments

Children who live in a fluorosis area have 5 times higher odds of developing low IQ than those who live in a nonfluorosis area or a slight fluorosis area.

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Pubmed Data : Biol Trace Elem Res. 2008;126(1-3):115-20. Epub 2008 Aug 10. PMID: 18695947

Article Published Date : Jan 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Cognitive Decline/Dysfunction : CK(514) : AC(87), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)

Problem Substances : Fluoride : CK(224) : AC(33)

Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Exposure to high levels of fluoride may adversely influence children's intelligence development.

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Pubmed Data : Zhongguo Dang Dai Er Ke Za Zhi. 2008 Dec;10(6):723-5. PMID: 19102839

Article Published Date : Dec 01, 2008

Study Type : Meta Analysis

Additional Links

Diseases : Childhood Cognitive Disorders : CK(180) : AC(14), Cognitive Decline/Dysfunction : CK(514) : AC(87), Fluoride Toxicity : CK(147) : AC(43), Fluorosis : CK(219) : AC(6), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Prenatal Nutrition: Learning/Intelligence of Offspring : CK(118) : AC(15)

Problem Substances : Fluoride : CK(224) : AC(33)

Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Rates of autism, speech disorders, mental retardation, infantile spasms, and thinking abnormalities were higher in children exposured to higher thimerosal levels.

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Pubmed Data : J Toxicol Environ Health A. 2006 Aug;69(15):1481-95. PMID: 16766480

Article Published Date : Aug 01, 2006

Study Type : Meta Analysis

Additional Links

Diseases : Autism : CK(1340) : AC(65), Cognitive Decline/Dysfunction : CK(514) : AC(87), Infantile Spasms : CK(50) : AC(4), Mental Retardation : CK(71) : AC(7), Neurodevelopmental Disorders : CK(163) : AC(13)

Problem Substances : Thimerosal : CK(351) : AC(22)

Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Tamoxifen interferes with cognitive function in breast cancer patients.

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Pubmed Data : Breast Cancer Res Treat. 2000 Nov;64(2):165-76. PMID: 11194452

Article Published Date : Nov 01, 2000

Study Type : Meta Analysis

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Drug-Induced Toxicity : CK(538) : AC(78), Memory Disorders: Drug-Induced : CK(74) : AC(12)

Additional Keywords : Drug: Tamoxifen : CK(357) : AC(53)

Problem Substances : Tamoxifen : CK(296) : AC(39)

Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

A high adherence to the Mediterranean diet has been associated with slower cognitive decline, with reduced risk of mild cognitive impairment conversion to Alzheimer's disease and with reduced risk of Alzheimer's disease.

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Pubmed Data : Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):241-9. PMID: 18635428

Article Published Date : Jul 01, 2006

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(492) : AC(57)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

A higher consumption of green tea is associated with a lower prevalence of cognitive impairment in humans.

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Pubmed Data : Am J Clin Nutr. 2006 Feb;83(2):355-61. PMID: 16469995

Article Published Date : Feb 01, 2006

Study Type : Human Study

Additional Links

Substances : Green Tea : CK(952) : AC(283)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

A moderate intake of EPA and DHA may postpone cognitive decline in elderly men.

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Pubmed Data : Am J Clin Nutr. 2007 Apr;85(4):1142-7. PMID: 17413117

Article Published Date : Apr 01, 2007

Study Type : Human Study

Additional Links

Substances : DHA (Docosahexaenoic Acid) : CK(562) : AC(100), EPA (Eicosapentaenoic Acid) : CK(575) : AC(84), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Elderly: Age Specific Diseases : CK(423) : AC(37)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

B vitamins appear to slow cognitive and clinical decline in people with mild cognitive impairment, in particular in those with elevated homocysteine.

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Pubmed Data : Int J Geriatr Psychiatry. 2011 Jul 21. Epub 2011 Jul 21. PMID: 21780182

Article Published Date : Jul 21, 2011

Study Type : Human Study

Additional Links

Substances : Folic Acid : CK(572) : AC(77), Vitamin B-12 : CK(752) : AC(94), Vitamin B-6 : CK(412) : AC(48)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87), High Homocysteine : CK(368) : AC(57), Neurodegenerative Diseases : CK(1701) : AC(420)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Bacopa enhances cognitive performance in the aging.

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Pubmed Data : J Altern Complement Med. 2008 Jul;14(6):707-13. PMID: 18611150

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Bacopa : CK(47) : AC(18)

Diseases : Aging : CK(1341) : AC(369), Aging: Brain : CK(702) : AC(68), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Dance therapy improves cognitive functioning, quality of life and psychological well-being in elderly persons.

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Pubmed Data : Bull Soc Sci Med Grand Duche Luxemb. 2010;Spec No 1(1):219-27. PMID: 20653191

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Elderly: Age Specific Diseases : CK(423) : AC(37)

Therapeutic Actions : Dancing : CK(220) : AC(22)

Dangshen (Codonopsis pilosula) and Bai guo (Gingko biloba) enhance learning and memory.

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Pubmed Data : Altern Ther Health Med. 2004 Jul-Aug;10(4):52-6. PMID: 15285274

Article Published Date : Jul 01, 2004

Study Type : Human Study

Additional Links

Substances : Codonopsis pilosula : CK(23) : AC(4), Ginkgo biloba : CK(511) : AC(97)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Memory Disorders : CK(211) : AC(65)

Decreased sunlight exposure is associated with an increased probability of cognitive impairment among depressed individuals.

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Pubmed Data : Cell Mol Life Sci. 2009 Aug;66(16):2759-71. Epub 2009 Jul 5. PMID: 19638195

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Depression: Unipolar : CK(631) : AC(79)

Therapeutic Actions : Sunlight exposure : CK(427) : AC(39)

Ginger is a potential cognitive enhancer for middle-aged women.

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Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:383062. Epub 2011 Dec 22. PMID: 22235230

Article Published Date : Jan 01, 2012

Study Type : Human Study

Additional Links

Substances : Ginger : CK(295) : AC(90)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Ginkgo biloba improves cognitive functioning and behavioral symptoms in patients with age-associated cognitive impairment or dementia.

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Pubmed Data : Arzneimittelforschung. 2007;57(1):4-11. PMID: 17341003

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba : CK(511) : AC(97)

Diseases : Aging: Brain : CK(702) : AC(68), Cognitive Decline/Dysfunction : CK(514) : AC(87), Dementia : CK(207) : AC(31)

Gum chewing gum increases mental alertness.

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Pubmed Data : Nutr Neurosci. 2009 Apr;12(2):81-8. PMID: 19356310

Article Published Date : Apr 01, 2009

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Therapeutic Actions : Gum Chewing : CK(70) : AC(7)

High monounsaturated fatty and polyunsaturated fatty acid intake associated with a typical Mediterranean diet protects against age-related cognitive decline.

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Pubmed Data : Neurobiol Aging. 2006 Nov;27(11):1694-704. Epub 2005 Oct 26. PMID: 16256248

Article Published Date : Nov 01, 2006

Study Type : Human Study

Additional Links

Substances : Monounsaturated fatty acids : CK(50) : AC(5), Polyunsaturated Fatty Acids (PUFAs) : CK(98) : AC(14)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(492) : AC(57)

Higher intake of polyunsaturated fatty acids (PUFA) and fish oil was associated with better semantic memory and global cognitive function.

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Pubmed Data : Int J Geriatr Psychiatry. 2008 Jul;23(7):741-7. PMID: 18188871

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Polyunsaturated Fatty Acids (PUFAs) : CK(98) : AC(14)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Higher sugar intake appears to be associated with lower cognitive function.

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Pubmed Data : Br J Nutr. 2011 Jun 1:1-10. Epub 2011 Jun 1. PMID: 21736803

Article Published Date : Jun 01, 2011

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Intelligence Quotient (IQ): Low/Impaired : CK(150) : AC(12), Learning disorders : CK(154) : AC(36)

Problem Substances : Fructose : CK(361) : AC(97), Sucrose : CK(16) : AC(4)

Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance.

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Pubmed Data : J Nutr. 2009 Jan;139(1):120-7. Epub 2008 Dec 3. PMID: 19056649

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Substances : Black Tea : CK(167) : AC(40), Cocoa : CK(502) : AC(43), Flavonoids : CK(868) : AC(290), Green Tea : CK(952) : AC(283), Wine : CK(72) : AC(15)

Diseases : Aging: Brain : CK(702) : AC(68), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Kava enhances cognitive performance and cheerful mood.

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Pubmed Data : Hum Psychopharmacol. 2004 Jun;19(4):243-50. PMID: 15181652

Article Published Date : Jun 01, 2004

Study Type : Human Study

Additional Links

Substances : Kava Kava : CK(239) : AC(39)

Diseases : Anxiety Disorders : CK(641) : AC(82), Cognitive Decline/Dysfunction : CK(514) : AC(87), Mood Disorders : CK(123) : AC(13)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158), Superio+ : CK(10) : AC(1)

Lion's mane improves mild cognitive impairment in human subjects.

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Pubmed Data : Phytother Res. 2009 Mar ;23(3):367-72. PMID: 18844328

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : Lion's Mane (Hericium Erinaceus) : CK(41) : AC(18)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife.

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Pubmed Data : Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1556-62. Epub 2008 Jun 30. PMID: 18591462

Article Published Date : Aug 01, 2008

Study Type : Human Study

Additional Links

Substances : Cholesterol : CK(392) : AC(43)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Memory Disorders : CK(211) : AC(65)

Additional Keywords : Cholesterol Ratio: ldl/hdl : CK(10) : AC(2)

Medium Chain Triglycerides (coconut fat) increase cognitive performance in Alzheimer's disease.

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Pubmed Data : J Agric Food Chem. 2006 Mar 22;54(6):2123-8. PMID: 15123336

Article Published Date : Mar 22, 2006

Study Type : Human Study

Additional Links

Substances : Coconut : CK(124) : AC(35), Coconut Oil : CK(75) : AC(18), Medium Chain Triglycerides : CK(46) : AC(12)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Phosphatidylserine improves symptoms of cognitive decline in the elderly both in terms of behavioral and cognitive parameters.

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Pubmed Data : Aging (Milano). 1993 Apr;5(2):123-33. PMID: 8323999

Article Published Date : Apr 01, 1993

Study Type : Human Study

Additional Links

Substances : Phosphatidylserine : CK(122) : AC(18)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Phosphatidylserine potentiates the memory-enhancing and calming effects of ginkgo biloba.

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Pubmed Data : Pneumonol Alergol Pol. 2008;76(3):131-41. PMID: 17457961

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba : CK(511) : AC(97), Phosphatidylserine : CK(122) : AC(18)

Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

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