Crohn's Disease

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Quick Summary: Current access displays 2 out of 17 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Boswellia	21	3	Log in \| Sign up
Lactobacillus rhamnosus GG	20	2	Log in \| Sign up

Quick Summary: Current access displays 2 out of 3 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Ferrous Fumarate	22	3	Log in \| Sign up
Oral Contraceptives	10	1	Log in \| Sign up

Quick Summary: 1 associated Therapeutic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Dietary Modification: Allergen Free Diet	10	1	Log in \| Sign up

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View the Evidence: Ailments

A combination of lactobacillus reuteri and lactobacillus rhamnosus reduces inflammation in patients with Crohn's disease or ulcerative colitis.

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Pubmed Data : Clin Exp Immunol. 2007 Sep;149(3):470-9. Epub 2007 Jun 22. PMID: 17590176

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Substances : Lactobacillus reuteri : CK(181) : AC(25), Lactobacillus rhamnosus GG : CK(211) : AC(28)

Diseases : Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109)

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343)

An exclusion diet and nutraceutical therapy has significant therapeutic effects in juvenile Crohn's disease.

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Pubmed Data : J Am Coll Nutr. 2009 Jun;28(3):277-85. PMID: 20150601

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Boswellia : CK(122) : AC(31), Colostrum : CK(59) : AC(11), Curcumin : CK(2890) : AC(1511), Fish extract : CK(32) : AC(4), Lactobacillus rhamnosus GG : CK(211) : AC(28), Multivitamin : CK(243) : AC(22)

Diseases : Crohn's Disease : CK(361) : AC(22)

Therapeutic Actions : Dietary Modification: Allergen Free Diet : CK(73) : AC(7)

Boswellia appears superior to mesalazine in safety and efficacy in the treatment of Crohn's disease.

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Pubmed Data : Z Gastroenterol. 2001 Jan;39(1):11-7. PMID: 11215357

Article Published Date : Jan 01, 2001

Study Type : Human Study

Additional Links

Substances : Boswellia : CK(122) : AC(31)

Diseases : Crohn's Disease : CK(361) : AC(22)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(897) : AC(158)

Glycoaminoglycans like glucosamine may contribute to improving conditions like ulcerative colitis, Crohn's disease and interstitial cystitis.

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Pubmed Data : Med Hypotheses. 1999 Apr;52(4):297-301. PMID: 10465666

Article Published Date : Apr 01, 1999

Study Type : Human Study

Additional Links

Substances : Glucosamine : CK(116) : AC(21)

Diseases : Crohn's Disease : CK(361) : AC(22), Interstitial Cystitis : CK(136) : AC(17), Ulcerative Colitis : CK(461) : AC(40)

Mastic gum has significant therapeutic value in patients with mildly to moderately active Crohns disease.

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Pubmed Data : World J Gastroenterol. 2007 Feb 7;13(5):748-53. PMID: 17278198

Article Published Date : Feb 07, 2007

Study Type : Human Study

Additional Links

Substances : Mastic gum : CK(47) : AC(9)

Diseases : Crohn's Disease : CK(361) : AC(22)

Pharmacological Actions : Interleukin-6 Downregulation : CK(500) : AC(137), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343)

Oral contraceptive agents are associated with an increased risk for the development of irritable bowel disease.

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Pubmed Data : Am J Gastroenterol. 2008 Sep;103(9):2394-400. Epub 2008 Aug 5. PMID: 18684177

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Diseases : Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109), Ulcerative Colitis : CK(461) : AC(40)

Problem Substances : Oral Contraceptives : CK(287) : AC(24)

Oral ferrous fumarate increases clinical disease activity in inflammatory bowel disease patients.

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Pubmed Data : Scand J Gastroenterol. 2005 Sep;40(9):1058-65. PMID: 16165718

Article Published Date : Sep 01, 2005

Study Type : Human Study

Additional Links

Diseases : Anemia: Iron Deficiency : CK(85) : AC(10), Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109)

Problem Substances : Ferrous Fumarate : CK(39) : AC(8)

Supplementation with omega-3 fatty acids may have a therapeutic effect in supporting Crohn's disease remission.

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Pubmed Data : Inflamm Bowel Dis. 2000 May;6(2):77-84. PMID: 10833065

Article Published Date : May 01, 2000

Study Type : Human Study

Additional Links

Substances : Antioxidant formulas : CK(477) : AC(72), Omega-3 Fatty Acids : CK(3255) : AC(319)

Diseases : Crohn's Disease : CK(361) : AC(22)

Treatment of iron deficiency with ferrous fumarate deteriorated plasma antioxidant status and increased specific clinical symptoms in patients with active Crohn disease.

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Pubmed Data : Scand J Gastroenterol. 2003 May;38(5):543-8. PMID: 12795468

Article Published Date : May 01, 2003

Study Type : Human Study

Additional Links

Diseases : Crohn's Disease : CK(361) : AC(22)

Problem Substances : Ferrous Fumarate : CK(39) : AC(8)

Wormwood contributes to significant improvement in treatment outcome for Crohn's disease.

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Pubmed Data : Phytomedicine. 2007 Feb;14(2-3):87-95. Epub 2007 Jan 19. PMID: 17240130

Article Published Date : Feb 01, 2007

Study Type : Human Study

Additional Links

Substances : Wormwood : CK(43) : AC(12)

Diseases : Crohn's Disease : CK(361) : AC(22)

Additional Keywords : Drug Sparing : CK(451) : AC(49)

An elemental diet ameliorates chronic inflammation in a rat model of granulomatous enteritis (Crohn's disease).

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Pubmed Data : Dig Dis Sci. 1997 Feb;42(2):408-19. PMID: 9052527

Article Published Date : Feb 01, 1997

Study Type : Animal Study

Additional Links

Diseases : Crohn's Disease : CK(361) : AC(22), Enteritis: Granulomatous : CK(2) : AC(1)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1144) : AC(420)

Oral ferrous fumarate, but not intravenous iron sucrose, increased clinical disease activity in inflammatory bowel disease patients.

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Pubmed Data : J Nutr. 2002 Oct;132(10):3146-50. PMID: 12368409

Article Published Date : Oct 01, 2002

Study Type : Animal Study

Additional Links

Diseases : Anemia: Iron Deficiency : CK(85) : AC(10), Colitis : CK(384) : AC(58), Crohn's Disease : CK(361) : AC(22), Inflammation : CK(994) : AC(348), Inflammatory Bowel Diseases : CK(1210) : AC(109), Ulcerative Colitis : CK(461) : AC(40)

Problem Substances : Ferrous Fumarate : CK(39) : AC(8)

Addison and Crohn disease increased in asthma patients present with celiac disease and immune thrombocytopenic purpura.

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Pubmed Data : Ann Epidemiol. 2010 Mar ;20(3):217-22. Epub 2009 Dec 29. PMID: 20036578

Article Published Date : Feb 28, 2010

Study Type : Review

Additional Links

Diseases : Addison's Disease : CK(156) : AC(4), Asthma : CK(847) : AC(129), Autoimmune Diseases : CK(5092) : AC(779), Celiac Disease : CK(1330) : AC(163), Crohn's Disease : CK(361) : AC(22)

Additional Keywords : Gene environment

Autoimmune diseases: defining approaches to the unique genetic landscapes

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Pubmed Data : Curr Opin Immunol. 2009 Dec ;21(6):596-605. Epub 2009 Nov 5. PMID: 19896815

Article Published Date : Nov 30, 2009

Study Type : Review

Additional Links

Diseases : Autoimmune Diseases : CK(5092) : AC(779), Crohn's Disease : CK(361) : AC(22)

Additional Keywords : Genome-wide assiciation studies (GWAS), non-MHC-related genes

Boswellia's immunomodulatory properties may make it ideal for the treatment of autoimmune and inflammatory diseases.

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Pubmed Data : Phytomedicine. 2010 Sep;17(11):862-7. Epub 2010 Aug 8. PMID: 20696559

Article Published Date : Sep 01, 2010

Study Type : Review

Additional Links

Substances : Boswellia : CK(122) : AC(31)

Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Asthma: Bronchial : CK(259) : AC(33), Autoimmune Diseases : CK(5092) : AC(779), Colitis: Ulcerative : CK(139) : AC(18), Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109), Osteoarthritis : CK(615) : AC(89)

Pharmacological Actions : Interleukin-1 alpha downregulation : CK(34) : AC(12), Interleukin-2 Downregulation : CK(4) : AC(3), Interleukin-4 downregulation : CK(37) : AC(12), Interleukin-6 Downregulation : CK(500) : AC(137), Leukotriene Antagonists : CK(38) : AC(9), NF-kappaB Inhibitor : CK(599) : AC(397), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343)

Curcumin may be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.

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Pubmed Data : Int Immunopharmacol. 2012 Jan ;12(1):302-11. Epub 2011 Oct 29. PMID: 22036766

Article Published Date : Jan 01, 2012

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Colitis : CK(384) : AC(58), Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1144) : AC(420), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1015) : AC(343)

Increased sucralose consumption may explain why Canada has the highest incidence of inflammatory bowel disease in the world.

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Pubmed Data : Can J Gastroenterol. 2011 Sep ;25(9):511. PMID: 21912763

Article Published Date : Sep 01, 2011

Study Type : Review

Additional Links

Diseases : Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109), Ulcerative Colitis : CK(461) : AC(40)

Problem Substances : Sucralose : CK(15) : AC(10)

Adverse Pharmacological Actions : Inflammatory : CK(135) : AC(37)

Sucralose consumption may contribute to inflammatory bowel disease.

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Pubmed Data : World J Gastroenterol. 2012 Apr 21 ;18(15):1708-22. PMID: 22553395

Article Published Date : Apr 21, 2012

Study Type : Review

Additional Links

Diseases : Clostridium Enterocolitis : CK(1) : AC(1), Crohn's Disease : CK(361) : AC(22), Inflammatory Bowel Diseases : CK(1210) : AC(109)

Problem Substances : Sucralose : CK(15) : AC(10)

Adverse Pharmacological Actions : Inflammatory : CK(135) : AC(37)

Tocotrienols have potenti antifibrogenic effects which may help prevent and/or treat bowel stenosis in Crohn's disease patients.

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Pubmed Data : Inflamm Bowel Dis. 2010 Aug 3. Epub 2010 Aug 3. PMID: 20684017

Article Published Date : Aug 03, 2010

Study Type : In Vitro Study

Additional Links

Substances : Tocotrienols : CK(22) : AC(16)

Diseases : Bowel Stenosis : CK(1) : AC(1), Crohn's Disease : CK(361) : AC(22)

Vitamin D deficiency may contribute to the development and geographical distribution of Crohn's disease.

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Pubmed Data : Med Hypotheses. 2009 Jul;73(1):94-6. Epub 2009 Mar 6. PMID: 19269107

Article Published Date : Jul 01, 2009

Study Type : Commentary

Additional Links

Substances : Vitamin D : CK(1502) : AC(218)

Diseases : Crohn's Disease : CK(361) : AC(22)

Dehydroepiandrosterone (DHEA) was demonstrated to be safe and effective in patients with refractory Crohn's disease or ulcerative colitis.

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Pubmed Data : Aliment Pharmacol Ther. 2003 Feb;17(3):409-14. PMID: 12562454

Article Published Date : Feb 01, 2003

Additional Links

Substances : DHEA (Dehydroepiandrosterone) : CK(230) : AC(37)

Diseases : Crohn's Disease : CK(361) : AC(22), Ulcerative Colitis : CK(461) : AC(40)

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