Diabetes Mellitus: Type 2

Diabetes Mellitus: Type 2

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View the Evidence: Ailments

There is a trend toward an increased overall mortality risk with glyburide versus glimepiride and glipizide versus glimepiride (1.39 [0.99-1.96]) in those with documented coronary artery disease.

Pubmed Data : Diabetes Care. 2010 Jun;33(6):1224-9. Epub 2010 Mar 9. PMID: 20215447
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Mortality: All-Cause : CK(644) : AC(55)
Problem Substances : Glipizide : CK(64) : AC(6), Glyburide : CK(50) : AC(4)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Among patients with impaired glucose tolerance or type 2 diabetes, rosiglitazone use for at least 12 months is associated with a significantly increased risk of myocardial infarction and heart failure.

Pubmed Data : JAMA. 2007 Sep 12;298(10):1189-95. PMID: 17848653
Article Published Date : Sep 12, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Heart Failure : CK(711) : AC(97), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Rosiglitazone (trade name Avandia) : CK(106) : AC(15)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Antidepressant users have a moderately elevated risk of type 2 diabetes mellitus compared with non-users, even after adjustment for BMI.

Pubmed Data : Diabetologia. 2011 Aug 3. Epub 2011 Aug 3. PMID: 21811871
Article Published Date : Aug 03, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8)
Problem Substances : Antidepressants : CK(245) : AC(33)

Aspirin does not prevent cardiovascular events in diabetes mellitus.

Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66. PMID: 20429671
Article Published Date : Jun 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Problem Substances : Aspirin : CK(471) : AC(64)

Chocolate consumption is associated with a substantial reduction in the risk of cardiometabolic disorders.

Pubmed Data : BMJ. 2011 ;343:d4488. Epub 2011 Aug 26. PMID: 21875885
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Chocolate : CK(243) : AC(32)
Diseases : Blood Sugar Problems : CK(4050) : AC(693), Cardiovascular Diseases : CK(5138) : AC(641), Coronary Artery Disease : CK(1305) : AC(136), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Metabolic Syndrome X : CK(645) : AC(122), Stroke : CK(540) : AC(47)
Pharmacological Actions : Cardioprotective : CK(702) : AC(196)

Chronic exposure to organochlorine compounds may contribute to type 2 diabetes and thyroid diseases.

Pubmed Data : Ann Ig. 2010 May-Jun;22(3):185-98. PMID: 20677670
Article Published Date : May 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Hyperthyroidism : CK(189) : AC(33), Hypothyroidism : CK(537) : AC(78), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Organochlorine pesticides : CK(260) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Cinnamon extract and/or cinnamon improves fasting blood sugar in people with type 2 diabetes or prediabetes.

Pubmed Data : J Med Food. 2011 Sep ;14(9):884-9. Epub 2011 Apr 11. PMID: 21480806
Article Published Date : Sep 01, 2011
Study Type : Meta Analysis
Additional Links
Substances : Cinnamon : CK(135) : AC(61)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59)
Pharmacological Actions : Hypoglycemic Agents : CK(563) : AC(156)

Countries with higher availability of HFCS have a higher prevalence of type 2 diabetes independent of obesity.

Pubmed Data : Glob Public Health. 2012 Nov 27. Epub 2012 Nov 27. PMID: 23181629
Article Published Date : Nov 26, 2012
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8)
Problem Substances : High Fructose Corn Syrup : CK(67) : AC(10)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744
Article Published Date : Jun 22, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

Initiating treatment of type 2 diabetes with glibenclamide or glipizide is associated with increased risk of coronary artery disease in comparison to gliclazide or glimepiride.

Pubmed Data : Diabetes Res Clin Pract. 2008 Dec;82(3):391-5. Epub 2008 Oct 21. PMID: 18945509
Article Published Date : Dec 01, 2008
Study Type : Meta Analysis
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Drug: Metformin : CK(195) : AC(23)
Problem Substances : Glibenclamide : CK(122) : AC(3), Glipizide : CK(64) : AC(6)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Intensive glucose lowering treatment increases all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes.

Pubmed Data : BMJ. 2011 ;343:d4169. Epub 2011 Jul 26. PMID: 21791495
Article Published Date : Jan 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Anti-diabetic drugs : CK(22) : AC(2)

Prolonged TV viewing is associated with increased risk of type 2 diabetes, cardiovascular disease, and all-cause mortality.

Pubmed Data : JAMA. 2011 Jun 15;305(23):2448-55. PMID: 21673296
Article Published Date : Jun 15, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Mortality: All-Cause : CK(644) : AC(55)
Anti Therapeutic Actions : Television Viewing : CK(60) : AC(4)

Rosiglitazone was associated with a significant increase in the risk of myocardial infarction and with an increase in the risk of death from cardiovascular causes.

Pubmed Data : N Engl J Med. 2007 Jun 14;356(24):2457-71. Epub 2007 May 21. PMID: 17517853
Article Published Date : Jun 14, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67), Cardiovascular Diseases : CK(5138) : AC(641), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Rosiglitazone (trade name Avandia) : CK(106) : AC(15)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Simvastatin contributes to insulin resistance in non-diabetic patients.

Pubmed Data : Diabetes Res Clin Pract. 2010 Jan ;87(1):98-107. Epub 2009 Nov 12. PMID: 19913318
Article Published Date : Jan 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59), Insulin Resistance : CK(1034) : AC(221)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14), Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Statin drugs increase the risk of diabetes and cause abnormal liver enzyme elevations.

Pubmed Data : QJM. 2011 Sep 14. Epub 2011 Sep 14. PMID: 21920996
Article Published Date : Sep 14, 2011
Study Type : Meta Analysis
Additional Links
Diseases : AST: Elevated : CK(26) : AC(4), Diabetes Insipidus : CK(35) : AC(5), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Elevated: ALT : CK(23) : AC(2), Elevated: Creatinine Kinase : CK(33) : AC(3), GGT : CK(73) : AC(10)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Sulfonylureas are associated with an increased risk of adverse cardiovascular events in type 2 diabetic patients.

Pubmed Data : Acta Diabetol. 2009 Jun;46(2):145-54. Epub 2009 Feb 5. PMID: 19194648
Article Published Date : Jun 01, 2009
Study Type : Meta Analysis
Additional Links
Diseases : Congestive Heart Failure : CK(256) : AC(33), Coronary Artery Disease : CK(1305) : AC(136), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Additional Keywords : Drug: Metformin : CK(195) : AC(23)
Problem Substances : Sulfonylureas : CK(204) : AC(13)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

There are 17 randomized trials on statin treatment showing an increased incidence of diabetes.

Pubmed Data : QJM. 2010 Oct 7. Epub 2010 Oct 7. PMID: 20934984
Article Published Date : Oct 07, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Blood Sugar Problems : CK(4050) : AC(693), Diabetes Mellitus: Type 1 : CK(1107) : AC(218), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Diabetogenic : CK(166) : AC(14)

There is significant evidence demonstrating that Qigong may be beneficial in type 2 diabetes.

Pubmed Data : Kidney Int. 2005 Sep;68(3):1244-9. PMID: 19632552
Article Published Date : Sep 01, 2005
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hyperglycemia : CK(2892) : AC(59), Insulin Resistance : CK(1034) : AC(221)

The consumption of omega-3 fatty acid supplements decreases homocysteine levels in diabetic patients.

Pubmed Data : Nutr Metab Cardiovasc Dis. 2010 Jun;20(5):326-31. Epub 2009 Jun 21. PMID: 19540739
Article Published Date : Jun 01, 2010
Study Type : Human Study
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Homocysteine: Elevated : CK(368) : AC(57)

"A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease."

Pubmed Data : Diabetologia. 2007 Sep ;50(9):1795-807. Epub 2007 Jun 22. PMID: 17583796
Article Published Date : Sep 01, 2007
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Heart Disease: Ischemic : CK(201) : AC(16), Myocardial Ischemia : CK(87) : AC(37)
Therapeutic Actions : Dietary Modification: Paleolithic/Stone Age Diet : CK(63) : AC(7)
Problem Substances : Insulin : CK(92) : AC(15)

"Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus."

Pubmed Data : Clin Nutr. 2011 Jun ;30(3):351-8. Epub 2010 Dec 16. PMID: 21163558
Article Published Date : Jun 01, 2011
Study Type : Human Study
Additional Links
Substances : Sesame Seed Oil : CK(85) : AC(14)
Diseases : A1C : CK(253) : AC(35), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Dyslipidemias : CK(176) : AC(33)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hypoglycemic Agents : CK(563) : AC(156)
Additional Keywords : Drug: Glibenclamide : CK(12) : AC(2), Drug Synergy : CK(327) : AC(147)

2,4-D exposure is associated with perturbations of lipid and glucose metabolism which may be associated with higher risk for acute myocardial infarction and type-2 diabets.

Pubmed Data : Environ Health. 2010;9:11. Epub 2010 Feb 26. PMID: 20187939
Article Published Date : Jan 01, 2010
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Myocardial Infarction : CK(2632) : AC(117)
Problem Substances : Chlorophenoxy herbicide : CK(20) : AC(2)

A combination of quercetin, ascorbyl palmitate and vitamin D appears to safely offer relief of symptomatic diabetic neuropathy.

Pubmed Data : J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. PMID: 16112498
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Substances : Ascorbyl Palmitate : CK(10) : AC(1), Quercetin : CK(318) : AC(136), Vitamin C : CK(1274) : AC(238), Vitamin D : CK(1682) : AC(238)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetic Neuropathies : CK(203) : AC(32), Peripheral Neuropathies : CK(394) : AC(31)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

A flaxseed-derived lignan supplement has therapeutic value in type 2 diabetics.

Pubmed Data : PLoS One. 2007 Nov 7;2(11):e1148. PMID: 17987126
Article Published Date : Nov 07, 2007
Study Type : Human Study
Additional Links
Substances : Flaxseed : CK(275) : AC(57), Lignans : CK(110) : AC(31)
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

A high fiber, low sodium, low fat diet is superior to metoprolol in hyptensive type 2 diabetic subjects.

Pubmed Data : Diabetes Res. 1984 Nov;1(4):201-7. PMID: 6099231
Article Published Date : Nov 01, 1984
Study Type : Human Study
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hypertension : CK(2783) : AC(271)
Additional Keywords : Drug: Metoprolol : CK(12) : AC(2), Therapeutic Action Superior to Drug Therapy : CK(240) : AC(25)
Problem Substances : Metoprolol : CK(84) : AC(9)

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