Drug-Induced Nutrient Depletion: Statin Drugs

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Quick Summary: Current access displays 2 out of 3 associated Substances
NameCumulative KnowledgeArticle CountFocus Articles
Coenzyme Q10123Log in | Sign up
Vitamin D101Log in | Sign up
View the Evidence: Ailments

Coq10 supplementation corrects statin-induced coq10 depletion without affecting the cholesterol lowering effect of simvastatin.

Pubmed Data : Mol Aspects Med. 1994;15 Suppl:s187-93. PMID: 7752830
Article Published Date : Jan 01, 1994
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315)
Additional Keywords : Drug: Simvastatin : CK(22) : AC(3), Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)

Fluvastatin has been linked to adverse hepatic reactions.

Pubmed Data : Drug Saf. 2006 ;29(12):1163-72. PMID: 17147462
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(453) : AC(175), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29)
Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Hepatotoxic : CK(266) : AC(73)

Lovastatin decreases coenzyme Q levels associated with compromised cardiac function in humans.

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8931-4. PMID: 2247468
Article Published Date : Nov 01, 1990
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1303) : AC(136), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), High Cholesterol : CK(1755) : AC(198), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74)

Low serum vitamin D levels are associated with reversible myositis-myalgia in statin-treated patients.

Pubmed Data : Transl Res. 2009 Jan;153(1):11-6. Epub 2008 Dec 6. PMID: 19100953
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin D : CK(1502) : AC(218)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Myalgias : CK(105) : AC(14), Myositis : CK(40) : AC(7), Statin-Induced Pathologies : CK(1543) : AC(315), Vitamin D Deficiency : CK(348) : AC(33)

Statins may adversely alter the response of muscle to exercise stress.

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance : CK(489) : AC(63), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Exercise-Induced Tissue Damage : CK(40) : AC(8), Muscle Damage: Exercise-Induced : CK(71) : AC(12)
Pharmacological Actions : Proteasome Inhibitors : CK(40) : AC(25)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs.

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3769) : AC(442)

Type 2 diabetic patients patients treated with statin drugs have decreased coq10 levels and may be associated with subclinical diabetic cardiomyopathy reversible by CoQ10 supplementation.

Pubmed Data : Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID: 10337451
Article Published Date : Apr 01, 1999
Study Type : Human Study
Additional Links
Diseases : Cardiomyopathy : CK(77) : AC(15), Diabetes: Cardiovascular Illness : CK(654) : AC(104), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315)
Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)
Problem Substances : Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74)

A case of atorvastatin-induced pancreatitis has been reported.

Pubmed Data : Indian J Pharmacol. 2010 Oct ;42(5):324-5. PMID: 21206629
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Pancreatitis : CK(170) : AC(40)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)

Atrial fibrillation induced by simvastatin treatment in a 61-year-old man has been reported.

Pubmed Data : Heart Vessels. 2003 Jul ;18(3):157-9. PMID: 12955433
Article Published Date : Jul 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29)
Problem Substances : Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74)

Statin precipitated lactic acidosis has been reported.

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664
Article Published Date : Sep 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Lactic Acidosis : CK(6) : AC(2), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(699) : AC(142)
Problem Substances : Atorvastatin : CK(486) : AC(90)

Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals.

Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Article Published Date : Jul 06, 1994
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Heart Failure : CK(669) : AC(97), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74), Myotoxicity : CK(298) : AC(76)

Lovastatin lowers tissue concentrations of CoQ10 which can be rectified by supplementation with CoQ10.

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8928-30. PMID: 2247467
Article Published Date : Nov 01, 1990
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29)
Additional Keywords : Statin-Coq10 Depletion : CK(36) : AC(5)

Pravastatin accelerates aging effect on diaphragm mitochondrial respiratory function in rats.

Pubmed Data : Biochem Mol Biol Int. 1998 Dec ;46(5):923-31. PMID: 9861446
Article Published Date : Dec 01, 1998
Study Type : Animal Study
Additional Links
Diseases : Aging : CK(1341) : AC(369), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Mitochondrial Dysfunction : CK(145) : AC(50), Respiratory Diseases : CK(174) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3769) : AC(442)

Simvastatin decreases coenzyme q10 levels in the left ventricle of the heart and skeletal muscle.

Pubmed Data : Physiol Res. 2007;56 Suppl 2:S49-54. Epub 2007 Sep 5. PMID: 17824807
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5007) : AC(648), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Hypertension : CK(2615) : AC(260), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74), Myotoxicity : CK(298) : AC(76)

Simvastatin worsens the myocardial mitochondrial respiration during ischemia probably due to depletion of coenzyme Q10.

Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576
Article Published Date : Sep 01, 1995
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Mitochondrial Dysfunction : CK(145) : AC(50), Myocardial Ischemia : CK(87) : AC(37), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Enzyme Inhibitors : CK(386) : AC(208)
Problem Substances : Simvastatin : CK(760) : AC(143)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74), Myotoxicity : CK(298) : AC(76)

Statin drugs adversely effect memory likely through depletion of coenzyme q10 and interference with mitochondrial function in the brain.

Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754
Article Published Date : Jul 08, 2011
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(514) : AC(87), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Statin drugs interfere with neurological healing by inhibiting myelin formation.

Pubmed Data : J Neurosci. 2008 Dec 10 ;28(50):13609-14. PMID: 19074034
Article Published Date : Dec 10, 2008
Study Type : Animal Study
Additional Links
Diseases : Demyelinating Diseases : CK(1396) : AC(250), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Multiple Sclerosis : CK(706) : AC(133)
Additional Keywords : Remyelination : CK(15) : AC(10)
Problem Substances : Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies.

Pubmed Data : Ochsner J. 2010 ;10(1):16-21. PMID: 21603349
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Myopathies : CK(241) : AC(51), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Myotoxicity : CK(298) : AC(76)

Coenzyme Q10 may be an effective adjunctive treatment of chronic heart failure.

Pubmed Data : Med Hypotheses. 2009 Sep;73(3):306-8. Epub 2009 May 5. PMID: 19409711
Article Published Date : Sep 01, 2009
Study Type : Review
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Heart Failure : CK(669) : AC(97), Statin-Induced Pathologies : CK(1543) : AC(315)

Simvastatin-induced inhibition of mitochondrial respiration is likely associated myotoxicity.

Pubmed Data : Biochim Biophys Acta. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21839782
Article Published Date : Aug 04, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Mitochondrial Dysfunction : CK(145) : AC(50), Mitochondrial Myopathies : CK(46) : AC(9)
Problem Substances : Simvastatin : CK(760) : AC(143)
Adverse Pharmacological Actions : Myotoxicity : CK(298) : AC(76)

Statin drugs may cause myopathy by lowering vitamin E levels.

Pubmed Data : Med Hypotheses. 2009 Nov 5. Epub 2009 Nov 5. PMID: 19896775
Article Published Date : Nov 05, 2009
Study Type : Review
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315), Vitamin E Deficiency : CK(15) : AC(4)
Additional Keywords : Statin-Vitamin E Deficiency : CK(1) : AC(1)
Problem Substances : Statin Drugs : CK(3769) : AC(442)

Statin drugs may deplete the body of selenoproteins.

Pubmed Data : World J Gastroenterol. 2005 Dec 21;11(47):7466-72. PMID: 19534648
Article Published Date : Dec 21, 2005
Study Type : Review
Additional Links
Substances : Selenium : CK(574) : AC(94)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Mineral Deficiencies: Selenium : CK(15) : AC(6)

Statin drugs may induce selenium deficiency which may explain many of its enigmatic side effects.

Pubmed Data : Lancet. 2004 Mar 13;363(9412):892-4. PMID: 15031036
Article Published Date : Mar 13, 2004
Study Type : Review
Additional Links
Diseases : Coronary Artery Disease : CK(1303) : AC(136), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), High Cholesterol : CK(1755) : AC(198), Mineral Deficiencies: Selenium : CK(15) : AC(6), Statin-Induced Pathologies : CK(1543) : AC(315)
Additional Keywords : Statin-Selenium Deficiency : CK(4) : AC(3)
Problem Substances : Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Myotoxicity : CK(298) : AC(76)

Statin drugs result in coq10 depletion associated with congestive heart failure and which may be rectified by supplementation.

Pubmed Data : Biofactors. 2003;18(1-4):101-11. PMID: 14695925
Article Published Date : Jan 01, 2003
Study Type : Review
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Heart Failure : CK(669) : AC(97), Statin-Induced Pathologies : CK(1543) : AC(315)
Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)

Statin-induced liver injury may result from the suppression of selenoprotein expression.

Pubmed Data : Mol Pharmacol. 2009 Jun;75(6):1421-9. Epub 2009 Mar 30. PMID: 19332511
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(453) : AC(175), Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Mineral Deficiencies: Selenium : CK(15) : AC(6), Statin-Induced Pathologies : CK(1543) : AC(315)
Additional Keywords : Statin-Selenium Deficiency : CK(4) : AC(3)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)

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