Drug-Induced Nutrient Depletion: Statin Drugs

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View the Evidence: Ailments

"Lipid-lowering drugs and essential omega-6 and omega-3 fatty acids in patients with coronary heart disease."

Pubmed Data : Nutr Metab Cardiovasc Dis. 2005 Feb ;15(1):36-41. PMID: 15871849
Article Published Date : Jan 31, 2005
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Dietary Fatty Acid Imbalance: Omega3/Omega6 Ratio : CK(33) : AC(5), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Omega-3 Fatty Acid Deficiency : CK(20) : AC(1), Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords : Drug Synergy : CK(327) : AC(147)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

After a six-month administration of coenzyme Q10, muscle pain and sensitivity statistically significantly decreased.

Pubmed Data : Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519
Article Published Date : Nov 27, 2012
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(667) : AC(104)
Diseases : Death: Statin-Induced : CK(14) : AC(3), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Coq10 supplementation corrects statin-induced coq10 depletion without affecting the cholesterol lowering effect of simvastatin.

Pubmed Data : Mol Aspects Med. 1994;15 Suppl:s187-93. PMID: 7752830
Article Published Date : Jan 01, 1994
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(667) : AC(104)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords : Drug: Simvastatin : CK(22) : AC(3), Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)

Fluvastatin has been linked to adverse hepatic reactions.

Pubmed Data : Drug Saf. 2006 ;29(12):1163-72. PMID: 17147462
Article Published Date : Jan 01, 2006
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
Problem Substances : Fluvastatin : CK(75) : AC(15), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Lovastatin decreases coenzyme Q levels associated with compromised cardiac function in humans.

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8931-4. PMID: 2247468
Article Published Date : Nov 01, 1990
Study Type : Human Study
Additional Links
Diseases : Coronary Artery Disease : CK(1305) : AC(136), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), High Cholesterol : CK(1718) : AC(198), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Low serum vitamin D levels are associated with reversible myositis-myalgia in statin-treated patients.

Pubmed Data : Transl Res. 2009 Jan;153(1):11-6. Epub 2008 Dec 6. PMID: 19100953
Article Published Date : Jan 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin D : CK(1682) : AC(238)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Myalgias : CK(105) : AC(14), Myositis : CK(40) : AC(7), Statin-Induced Pathologies : CK(1570) : AC(315), Vitamin D Deficiency : CK(495) : AC(45)

Statin therapy is associated with decreased serum levels of zinc and copper.

Pubmed Data : J Trace Elem Med Biol. 2005;19(1):61-7. PMID: 16240674
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Copper Deficiency : CK(24) : AC(5), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Hyperlipidemia : CK(1211) : AC(109), Statin-Induced Pathologies : CK(1570) : AC(315), Zinc Deficiency : CK(44) : AC(7)
Problem Substances : Atorvastatin : CK(491) : AC(90), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Statins may adversely alter the response of muscle to exercise stress.

Pubmed Data : Arterioscler Thromb Vasc Biol. 2005 Dec ;25(12):2560-6. Epub 2005 Oct 13. PMID: 16224050
Article Published Date : Dec 01, 2005
Study Type : Human Study
Additional Links
Diseases : Athletic Performance : CK(479) : AC(61), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Exercise-Induced Tissue Damage : CK(40) : AC(8), Muscle Damage: Exercise-Induced : CK(71) : AC(12)
Pharmacological Actions : Proteasome Inhibitors : CK(41) : AC(27)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs.

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)

Type 2 diabetic patients patients treated with statin drugs have decreased coq10 levels and may be associated with subclinical diabetic cardiomyopathy reversible by CoQ10 supplementation.

Pubmed Data : Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID: 10337451
Article Published Date : Apr 01, 1999
Study Type : Human Study
Additional Links
Diseases : Cardiomyopathy : CK(77) : AC(15), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

A case of atorvastatin-induced pancreatitis has been reported.

Pubmed Data : Indian J Pharmacol. 2010 Oct ;42(5):324-5. PMID: 21206629
Article Published Date : Oct 01, 2010
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Pancreatitis : CK(164) : AC(40)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Atrial fibrillation induced by simvastatin treatment in a 61-year-old man has been reported.

Pubmed Data : Heart Vessels. 2003 Jul ;18(3):157-9. PMID: 12955433
Article Published Date : Jul 01, 2003
Study Type : Human: Case Report
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Statin precipitated lactic acidosis has been reported.

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664
Article Published Date : Sep 01, 2004
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Lactic Acidosis : CK(6) : AC(2), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90)

Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals.

Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Article Published Date : Jul 06, 1994
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Heart Failure : CK(711) : AC(97), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Myotoxicity : CK(317) : AC(79)

Lovastatin lowers tissue concentrations of CoQ10 which can be rectified by supplementation with CoQ10.

Pubmed Data : Proc Natl Acad Sci U S A. 1990 Nov;87(22):8928-30. PMID: 2247467
Article Published Date : Nov 01, 1990
Study Type : Animal Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
Additional Keywords : Statin-Coq10 Depletion : CK(36) : AC(5)

Pravastatin accelerates aging effect on diaphragm mitochondrial respiratory function in rats.

Pubmed Data : Biochem Mol Biol Int. 1998 Dec ;46(5):923-31. PMID: 9861446
Article Published Date : Dec 01, 1998
Study Type : Animal Study
Additional Links
Diseases : Aging : CK(1351) : AC(369), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Mitochondrial Dysfunction : CK(149) : AC(51), Respiratory Diseases : CK(174) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)

Simvastatin decreases coenzyme q10 levels in the left ventricle of the heart and skeletal muscle.

Pubmed Data : Physiol Res. 2007;56 Suppl 2:S49-54. Epub 2007 Sep 5. PMID: 17824807
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Hypertension : CK(2783) : AC(271), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Myotoxicity : CK(317) : AC(79)

Simvastatin worsens the myocardial mitochondrial respiration during ischemia probably due to depletion of coenzyme Q10.

Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576
Article Published Date : Sep 01, 1995
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Mitochondrial Dysfunction : CK(149) : AC(51), Myocardial Ischemia : CK(87) : AC(37), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Myotoxicity : CK(317) : AC(79)

Statin drugs adversely effect memory likely through depletion of coenzyme q10 and interference with mitochondrial function in the brain.

Pubmed Data : Neurosci Lett. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21763754
Article Published Date : Jul 08, 2011
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs interfere with neurological healing by inhibiting myelin formation.

Pubmed Data : J Neurosci. 2008 Dec 10 ;28(50):13609-14. PMID: 19074034
Article Published Date : Dec 10, 2008
Study Type : Animal Study
Additional Links
Diseases : Demyelinating Diseases : CK(1278) : AC(250), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Multiple Sclerosis : CK(716) : AC(133)
Additional Keywords : Remyelination : CK(15) : AC(10)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Atorvastin reduces coenzyme Q content and heart mitochondrial function in an animal model.

Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983
Article Published Date : Jan 01, 2011
Study Type : Review
Additional Links
Diseases : Congestive Heart Failure : CK(256) : AC(33), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Lipid Peroxidation : CK(403) : AC(127), Mitochondrial Dysfunction : CK(149) : AC(51)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Myotoxicity : CK(317) : AC(79)

Coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies.

Pubmed Data : Ochsner J. 2010 ;10(1):16-21. PMID: 21603349
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Coenzyme Q10 may be an effective adjunctive treatment of chronic heart failure.

Pubmed Data : Med Hypotheses. 2009 Sep;73(3):306-8. Epub 2009 May 5. PMID: 19409711
Article Published Date : Sep 01, 2009
Study Type : Review
Additional Links
Substances : Coenzyme Q10 : CK(667) : AC(104)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Heart Failure : CK(711) : AC(97), Statin-Induced Pathologies : CK(1570) : AC(315)

Muscle cells may be particularly susceptible to a statin-induced suppression of essential antioxidant selenoproteins

Pubmed Data : Toxicol Lett. 2012 Oct 20. Epub 2012 Oct 20. PMID: 23092657
Article Published Date : Oct 19, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Mineral Deficiencies: Selenium : CK(15) : AC(6), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Cerivastatin : CK(10) : AC(4)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Simvastatin-induced inhibition of mitochondrial respiration is likely associated myotoxicity.

Pubmed Data : Biochim Biophys Acta. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21839782
Article Published Date : Aug 04, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Mitochondrial Dysfunction : CK(149) : AC(51), Mitochondrial Myopathies : CK(46) : AC(9)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

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