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Article Count - 78
Cumulative Knowledge - 560

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View the Evidence: Ailments

Pill-induced esophageal injury is a common occurence.

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Pubmed Data : Endoscopy. 2005 Aug;37(8):740-4. PMID: 16032493

Article Published Date : Aug 01, 2005

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78)

Problem Substances : Alendronate (trade name Fosamax) : CK(166) : AC(27), Aspirin : CK(471) : AC(64), Bisphosphonates : CK(496) : AC(61), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Potassium Chloride : CK(70) : AC(7)

Prophylactic oseltamivir treatment in children resulted in 51% experiencing adverse reactions.

Click here to read the entire abstract

Pubmed Data : Euro Surveill. 2009 Jul 30;14(30):19285. Epub 2009 Jul 30. PMID: 19643061

Article Published Date : Jul 30, 2009

Study Type : Human Study

Additional Links

Diseases : Childhood Infections : CK(275) : AC(29), Drug-Induced Toxicity : CK(560) : AC(78), Influenza : CK(654) : AC(102)

Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Receiving hypnotic prescriptions was associated with greater than threefold increased hazards of death even when prescribed<18 pills/year.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : BMJ Open. 2012 ;2(1):e000850. Epub 2012 Feb 27. PMID: 22371848

Article Published Date : Jan 01, 2012

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Mortality: All-Cause : CK(644) : AC(55)

Problem Substances : Barbiturates : CK(10) : AC(1), Benzodiazepines : CK(10) : AC(1), Eszopiclone : CK(60) : AC(3), Hypnotic Drugs : CK(134) : AC(14), Sedative antihistamines : CK(10) : AC(1), Temazepam : CK(10) : AC(1), Zaleplon : CK(60) : AC(3), Zolpidem (trade name Ambien) : CK(199) : AC(25)

Regular intake of non-opioid analgesics is associated with an increased risk of restless legs syndrome in patients maintained on antidepressants.

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Pubmed Data : Eur J Med Res. 2002 Aug 30;7(8):368-78. PMID: 12204845

Article Published Date : Aug 30, 2002

Study Type : Human Study

Additional Links

Diseases : Anxiety Disorders : CK(659) : AC(82), Depression : CK(674) : AC(88), Drug-Induced Toxicity : CK(560) : AC(78), Restless Legs Syndrome : CK(91) : AC(8)

Problem Substances : Analgesic: Non-opioid : CK(20) : AC(2)

Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study.

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Pubmed Data : Cancer Prev Res (Phila). 2010 Sep;3(9):1168-75. Epub 2010 Aug 17. PMID: 20716633

Article Published Date : Sep 01, 2010

Study Type : Human Study

Additional Links

Substances : Resveratrol : CK(977) : AC(590)

Diseases : Cancers: All : CK(9062) : AC(2869), Drug-Induced Toxicity : CK(560) : AC(78)

Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Detoxifier : CK(306) : AC(101)

Additional Keywords : Stilbenes : CK(402) : AC(242)

Risk documentation occured in only 20% of women age 15-45 prescribed a medication known to contribute to birth defects.

Click here to read the entire abstract

Pubmed Data : J Am Board Fam Med. 2011 May-Jun;24(3):262-71. PMID: 21551398

Article Published Date : May 01, 2011

Study Type : Human Study

Additional Links

Diseases : Birth Defects : CK(196) : AC(37), Drug-Induced Toxicity : CK(560) : AC(78), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Angiotensin-Converting Enzyme (ACE) Inhibitor : CK(70) : AC(7), Angiotensin Receptor Blockers (ARBs) : CK(20) : AC(2), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Teratogenic : CK(304) : AC(59)

Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage.

Click here to read the entire abstract

Pubmed Data : J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID: 8463436

Article Published Date : Mar 01, 1993

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), High Cholesterol : CK(1718) : AC(198), Myopathies : CK(252) : AC(51)

Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)

Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35)

Statin-induced lupus has been identified within a nationwide pharmacovigilance database.

Click here to read the entire abstract

Pubmed Data : Lupus. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22333565

Article Published Date : Feb 14, 2012

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Lupus Erythematosus: Systemic : CK(949) : AC(53), Lupus-Like Syndrome : CK(29) : AC(5)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Statin-induced muscle toxicity may be associated with altered oxidation of fatty acids.

Click here to read the entire abstract

Pubmed Data : Endocrine. 2009 Feb;35(1):38-46. Epub 2008 Dec 3. PMID: 19051066

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Taking non-aspirin NSAIDs in early pregnancy doubles the risk of miscarriage.

Click here to read the entire abstract

Pubmed Data : BMJ. 2011 ;343:d5769. Epub 2011 Sep 9. PMID: 21908536

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Diseases : Abortion: Spontaneous : CK(204) : AC(29), Drug-Induced Toxicity : CK(560) : AC(78), Miscarriage : CK(507) : AC(35)

Pharmacological Actions : Teratogens : CK(10) : AC(1)

Problem Substances : Celecoxib : CK(50) : AC(4), Diclofenac : CK(72) : AC(7), Ibuprofen : CK(162) : AC(19), Naproxen : CK(54) : AC(7), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Rofecoxib : CK(60) : AC(5)

Adverse Pharmacological Actions : Teratogenic : CK(304) : AC(59)

Tamoxifen treatment results in adverse structural and functional changes in the brain in women.

Click here to read the entire abstract

Pubmed Data : Neuroimage. 2004 Jan;21(1):364-71. PMID: 14741674

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Memory Disorders: Drug-Induced : CK(77) : AC(12)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

The prophylactic use of oseltamivir in children results in side effects including high rates of gastrointestinal and neuropsychiatric reactions.

Click here to read the entire abstract

Pubmed Data : Euro Surveill. 2009 Jul 30;14(30):19287. Epub 2009 Jul 30. PMID: 19643062

Article Published Date : Jul 30, 2009

Study Type : Human Study

Additional Links

Diseases : Childhood Infections : CK(275) : AC(29), Drug-Induced Toxicity : CK(560) : AC(78)

Problem Substances : Oseltamivir (trade name Tamiflu) : CK(142) : AC(14)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Women treated with tamoxifen in the adjuvant setting experienced symptoms of sexual dysfunction.

Click here to read the entire abstract

Pubmed Data : J Clin Oncol. 1999 May;17(5):1488-92. PMID: 10334535

Article Published Date : May 01, 1999

Study Type : Human Study

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Sexual Dysfunction : CK(74) : AC(13)

Additional Keywords : Drug: Tamoxifen : CK(380) : AC(57)

Problem Substances : Tamoxifen : CK(319) : AC(39)

A case of mesalazine-induced lung injury improved by only discontinuation of mesalazine has been reported.

Click here to read the entire abstract

Pubmed Data : Nihon Kokyuki Gakkai Zasshi. 2009 Jun;47(6):543-7. PMID: 19601534

Article Published Date : Jun 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Respiratory Diseases : CK(174) : AC(29), Ulcerative Colitis : CK(429) : AC(39)

Problem Substances : Mesalamine : CK(41) : AC(8), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

A case of acute disseminated encephalomyelitis associated with Epstein-Barr virus reactivation during infliximab therapy has been reported.

Click here to read the entire abstract

Pubmed Data : Rinsho Shinkeigaku. 2010 Jul;50(7):461-6. PMID: 20681262

Article Published Date : Jul 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Encephalomyelitis : CK(12) : AC(7), Epstein-Barr Virus Infections : CK(100) : AC(43)

Problem Substances : Infliximab : CK(68) : AC(8)

Adverse Pharmacological Actions : Immunosuppressive : CK(155) : AC(23)

Acute cholestatic hepatitis induced by fenofibrate has been reported.

Click here to read the entire abstract

Pubmed Data : J Clin Pharm Ther. 2009 Oct;34(5):599-602. PMID: 19744016

Article Published Date : Oct 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Drug-Induced Toxicity : CK(560) : AC(78), Hepatitis : CK(64) : AC(23)

Problem Substances : Fenofibrates : CK(133) : AC(19)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Concomitant administration of simvastatin and danazol has been associated with fatal rhabdomyolysis.

Click here to read the entire abstract

Pubmed Data : Clin Ther. 2010 May;32(5):909-14. PMID: 20685498

Article Published Date : May 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Rhabdomyolysis : CK(165) : AC(38), Rhabdomyolysis: Fatal : CK(6) : AC(2)

Problem Substances : Danazol : CK(4) : AC(2), Simvastatin : CK(713) : AC(143)

Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe has been reported.

Click here to read the entire abstract

Pubmed Data : Ann Clin Biochem. 2005 Sep ;42(Pt 5):402-4. PMID: 16168199

Article Published Date : Sep 01, 2005

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Hepatitis : CK(64) : AC(23), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Additional Keywords : Drug Interaction : CK(64) : AC(8)

Problem Substances : Atorvastatin : CK(491) : AC(90)

Hearing loss due to aspirin has been reported.

Click here to read the entire abstract

Pubmed Data : Ther Drug Monit. 2009 Feb;31(1):1-2. PMID: 19155962

Article Published Date : Feb 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Hearing Loss : CK(97) : AC(24)

Problem Substances : Aspirin : CK(471) : AC(64), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Hemolysis induced by cefazolin and cephalothin in a patient with penicillin sensitivity has been reported.

Click here to read the entire abstract

Pubmed Data : Transfusion. 1978 May-Jun;18(3):369-73. PMID: 96555

Article Published Date : May 01, 1978

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78)

Problem Substances : Cefazolin : CK(6) : AC(2), Cephalothin : CK(3) : AC(1)

Adverse Pharmacological Actions : Hemolytic : CK(17) : AC(4)

Infliximab-induced demyelination may cause visual disturbance mistaken for recurrence of uveitis.

Click here to read the entire abstract

Pubmed Data : Ocul Immunol Inflamm. 2010 Dec;18(6):482-4. Epub 2010 Aug 25. PMID: 20735341

Article Published Date : Dec 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Drug-Induced Toxicity : CK(560) : AC(78), Uveitis : CK(63) : AC(10)

Problem Substances : Infliximab : CK(68) : AC(8)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Mesalamine may cause pericarditis.

Click here to read the entire abstract

Pubmed Data : Pharmacotherapy. 2002 Mar;22(3):391-4. PMID: 11898896

Article Published Date : Mar 01, 2002

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Pericarditis : CK(35) : AC(5)

Problem Substances : Mesalamine : CK(41) : AC(8), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Mesalazine-induced eosinophilic variant of Wegener's granulomatosis in an ulcerative colitis patient has been reported.

Click here to read the entire abstract

Pubmed Data : J Ayub Med Coll Abbottabad. 2009 Oct-Dec;21(4):171-3. PMID: 21067054

Article Published Date : Oct 01, 2009

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Ulcerative Colitis : CK(429) : AC(39), Wegener Granulomatosis : CK(3) : AC(1)

Problem Substances : Mesalamine : CK(41) : AC(8), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Post-surgery severe hypocalcemia in primary hyperparathyroidism preoperatively treated with zoledronic acid has been reported.

Click here to read the entire abstract

Pubmed Data : Hormones (Athens). 2010 Oct;9(4):338-42. PMID: 21112866

Article Published Date : Oct 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Hypocalcemia : CK(7) : AC(3)

Problem Substances : Zoledronic Acid : CK(69) : AC(13)

Rhabdomyolysis with atorvastatin and fusidic acid has been reported.

Click here to read the entire abstract

Pubmed Data : Postgrad Med J. 2008 Jun ;84(992):325-7. PMID: 18644925

Article Published Date : Jun 01, 2008

Study Type : Human: Case Report

Additional Links

Diseases : Drug-Induced Toxicity : CK(560) : AC(78), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Problem Substances : Atorvastatin : CK(491) : AC(90), Fusidic acid : CK(6) : AC(2), Statin Drugs : CK(3969) : AC(465)

Health Guide: Chemical Exposures

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