Excitotoxicity

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Quick Summary: Current access displays 2 out of 25 associated Substances
NameCumulative KnowledgeArticle CountFocus Articles
Curcumin55Log in | Sign up
Resveratrol53Log in | Sign up
View the Evidence: Ailments

The elimination of MSG, Aspartame and other excitotoxins from the diets of patients with fibromyalgia is a successful treatment option.

Pubmed Data : Ann Pharmacother. 2001 Jun;35(6):702-6. PMID: 11408989
Article Published Date : Jun 01, 2001
Study Type : Human Study
Additional Links
Diseases : Excitotoxicity : CK(52) : AC(30), Fibromyalgia : CK(507) : AC(55)
Problem Substances : Aspartame : CK(77) : AC(27), Monosodium Glutamate (MSG) : CK(39) : AC(12)

Acupuncture attenuates glutamate level in global ischemia model of rat.

Pubmed Data : Neurol Res. 2010 Feb;32 Suppl 1:79-83. PMID: 20034451
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Cerebral Ischemia : CK(274) : AC(50), Excitotoxicity : CK(52) : AC(30)
Therapeutic Actions : Acupuncture : CK(1313) : AC(144)

Ginger root extract has a neuroprotective effect against monosodium glutamate-induced toxicity in male rats.

Pubmed Data : Pak J Biol Sci. 2009 Feb 1;12(3):201-12. PMID: 19579948
Article Published Date : Feb 01, 2009
Study Type : Animal Study
Additional Links
Substances : Ginger : CK(295) : AC(90)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Grapeseed exhibits neuroprotective properties against excitotoxicity associated neuronal injury.

Pubmed Data : PLoS One. 2011;6(1):e14575. Epub 2011 Jan 24. PMID: 21283677
Article Published Date : Jan 01, 2011
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract : CK(168) : AC(57)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

L-theanine protects against glutamate-induced excitotoxicity in a mouse model.

Pubmed Data : Neuroscience. 2010 Jul 14;168(3):778-86. Epub 2010 Apr 21. PMID: 20416364
Article Published Date : Jul 14, 2010
Study Type : Animal Study
Additional Links
Substances : Theanine : CK(951) : AC(283)
Diseases : Alzheimer's Disease : CK(837) : AC(165), Excitotoxicity : CK(52) : AC(30)

Low-intensity swimming maintains normoglycemia, insulin tissue sensitivity, and normal lipid profile in mice programmed to develop metabolic syndrome.

Pubmed Data : Biomed Sci Instrum. 2007;43:272-7. PMID: 21539446
Article Published Date : Jan 01, 2007
Study Type : Animal Study
Additional Links
Diseases : Excitotoxicity : CK(52) : AC(30), Hyperlipidemia : CK(1212) : AC(109), Insulin Resistance : CK(995) : AC(212), Metabolic Syndrome X : CK(581) : AC(110), MSG Toxicity : CK(4) : AC(2)
Therapeutic Actions : Exercise: Swimming : CK(2) : AC(1)

Neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEA may protect against mercury-induced neurotoxicity.

Pubmed Data : Neurochem Res. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22015977
Article Published Date : Oct 21, 2011
Study Type : Animal Study
Additional Links
Substances : DHEA (Dehydroepiandrosterone) : CK(230) : AC(37)
Diseases : Excitotoxicity : CK(52) : AC(30), Mercury Poisoning : CK(201) : AC(46), Vaccine-induced Toxicity : CK(1086) : AC(163)
Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)
Problem Substances : Mercury : CK(96) : AC(11), Thimerosal : CK(351) : AC(22)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Nettle supplementation attenuates excitotoxin-induced brain lesions and memory loss in rats.

Pubmed Data : J Nutr Biochem. 2008 Dec 12. PMID: 19071007
Article Published Date : Dec 12, 2008
Study Type : Animal Study
Additional Links
Substances : Nettle : CK(44) : AC(13)
Diseases : Excitotoxicity : CK(52) : AC(30), Memory Loss : CK(113) : AC(32)

Quercetin, kaempferol and biapigenin from St. John's wort are neuroprotective against excitotoxicity.

Pubmed Data : Neurotox Res. 2008 May-Jun;13(3-4):265-79. PMID: 18522906
Article Published Date : May 01, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(74) : AC(51), Kaempferol : CK(27) : AC(22), Quercetin : CK(315) : AC(136), St. Johns Wort : CK(186) : AC(46)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Excitatory Amino Acid Agonists : CK(7) : AC(4), Neuroprotective Agents : CK(921) : AC(464)

Resveratrol has neuroprotective effect on ischemic injury.

Pubmed Data : Neurochem Int. 2010 Feb;56(3):495-500. Epub 2009 Dec 21. PMID: 20026214
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(938) : AC(590)
Diseases : Brain Ischemia : CK(94) : AC(38), Excitotoxicity : CK(52) : AC(30), Middle Cerebral Artery Occlusion (MCAO) : CK(587) : AC(24)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Neuroprotective Agents : CK(921) : AC(464)

Resveratrol may protect against gluatmate associated neurotoxicity.

Pubmed Data : J Neurochem. 2010 Mar;112(6):1477-87. Epub 2009 Dec 28. PMID: 20050970
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(938) : AC(590), Stilbenes : CK(126) : AC(92)
Diseases : Alzheimer's Disease : CK(837) : AC(165), Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Enzyme Inhibitors : CK(386) : AC(208), Interleukin-1 beta downregulation : CK(177) : AC(70), Neuroprotective Agents : CK(921) : AC(464)

Safranal, a constituent of Saffron, reduces kainic Acid treatment-induced glutamate and aspartate concentrations in the rat hippocampus.

Pubmed Data : Planta Med. 2008 Oct;74(12):1441-5. Epub 2008 Sep 24. PMID: 18816431
Article Published Date : Oct 01, 2008
Study Type : Animal Study
Additional Links
Substances : Saffron : CK(123) : AC(32), Safranal : CK(2) : AC(1)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Excitatory Amino Acid Agonists : CK(7) : AC(4)

Schisandra may protect against glutamate-induced toxicity.

Pubmed Data : J Neurosci Res. 2004 May 1;76(3):397-405. PMID: 15079869
Article Published Date : May 01, 2004
Study Type : Animal Study
Additional Links
Substances : Schisandra : CK(129) : AC(43)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity.

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity : CK(278) : AC(32), Excitotoxicity : CK(52) : AC(30), Neurodevelopmental Disorders : CK(163) : AC(13)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Problem Substances : Aspartame : CK(77) : AC(27), Brilliant Blue FCF : CK(4) : AC(3), L-glutamic Acid : CK(11) : AC(2), Quinoline Yellow : CK(1) : AC(1)
Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Autism spectrum disorders are associated with immunoexcitotoxicity.

Pubmed Data : Altern Ther Health Med. 2009 Jan-Feb;15(1):60-7. PMID: 19161050
Article Published Date : Jan 01, 2009
Study Type : Commentary
Additional Links
Substances : DHEA (Dehydroepiandrosterone) : CK(230) : AC(37)
Diseases : Autism Spectrum Disorders : CK(1118) : AC(108), Excitotoxicity : CK(52) : AC(30), Inflammation : CK(994) : AC(348), Mercury Poisoning : CK(201) : AC(46)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Autism spectrum disorders are associated with vaccination, heavy metal toxicity and excitotoxicity.

Pubmed Data : Altern Ther Health Med. 2008 Nov-Dec;14(6):46-53. PMID: 19043938
Article Published Date : Nov 01, 2008
Study Type : Commentary
Additional Links
Diseases : Autism Spectrum Disorders : CK(1118) : AC(108), Excitotoxicity : CK(52) : AC(30), Vaccine-induced Toxicity : CK(1086) : AC(163)
Anti Therapeutic Actions : Vaccination: All : CK(3588) : AC(266)

Curcumin and tannic acid protect against glutamate-induced excitotoxicity.

Pubmed Data : J Pharmacol Exp Ther. 2006 Aug;318(2):476-83. Epub 2006 Apr 27. PMID: 17118359
Article Published Date : Aug 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Catechin : CK(408) : AC(130), Curcumin : CK(2890) : AC(1511), Flavonoids : CK(868) : AC(290), Polyphenols : CK(412) : AC(169), Tannic Acid : CK(20) : AC(16)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Neuroprotective Agents : CK(921) : AC(464)

Curcumin inhibits glutamate-induced excitoxicity in vitro.

Pubmed Data : Mol Cell Biochem. 2007 Apr;298(1-2):187-94. Epub 2006 Nov 25. PMID: 17131042
Article Published Date : Apr 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2890) : AC(1511)
Diseases : Excitotoxicity : CK(52) : AC(30), Oxidative Stress : CK(1867) : AC(710)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Neuroprotective Agents : CK(921) : AC(464)

Curcumin protects against glutamate excitotoxicity.

Pubmed Data : Brain Res. 2008 May 19;1210:84-91. Epub 2008 Apr 16. PMID: 18420184
Article Published Date : May 19, 2008
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2890) : AC(1511)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Antidepressive Agents : CK(122) : AC(28), Apoptotic : CK(1416) : AC(1089), Enzyme Inhibitors : CK(386) : AC(208), Neuroprotective Agents : CK(921) : AC(464)

Curcumin treatment protects rat retinal neurons against excitotoxicity.

Pubmed Data : Exp Brain Res. 2005 Dec;167(4):641-8. Epub 2005 Aug 3. PMID: 16078027
Article Published Date : Dec 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2890) : AC(1511)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Apoptotic : CK(1416) : AC(1089)

Excitotoxicity is an important factor in autism.

Pubmed Data : Altern Ther Health Med. 2009 Mar-Apr;15(2):56-60. PMID: 19284184
Article Published Date : Mar 01, 2009
Study Type : Commentary
Additional Links
Diseases : Autism : CK(1340) : AC(65), Excitotoxicity : CK(52) : AC(30)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

IGF-I prevents glutamate-induced motor neuron programmed cell death.

Pubmed Data : Food Chem Toxicol. 2009 Jan 15. PMID: 15193297
Article Published Date : Jan 15, 2009
Study Type : In Vitro Study
Additional Links
Substances : Insulin-like Growth Factor (IGF-1) : CK(9) : AC(5)
Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Neuroprotective Agents : CK(921) : AC(464)

Methylcobalamin protects against glutamate-induced neurotoxicity in retinal cell culture.

Pubmed Data : Invest Ophthalmol Vis Sci. 1997 Apr;38(5):848-54. PMID: 9112980
Article Published Date : Apr 01, 1997
Study Type : In Vitro Study
Additional Links
Substances : Vitamin B12: methylcobalamin : CK(55) : AC(9), Vitamin B-12 : CK(752) : AC(94)
Diseases : Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Apoptotic : CK(1416) : AC(1089), Neuroprotective Agents : CK(921) : AC(464)

Polysaccharides from wolfberry (goji) antagonizes glutamate excitotoxicity in rat cortical neurons.

Pubmed Data : CNS Spectr. 1999 Dec;4(12):34-47. PMID: 19499323
Article Published Date : Dec 01, 1999
Study Type : In Vitro Study
Additional Links
Substances : Goji : CK(54) : AC(19)
Diseases : Alzheimer's Disease : CK(837) : AC(165), Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Neuroprotective Agents : CK(921) : AC(464)

Resveratrol protects against glutamate-induced neurotoxicity in primary cultured rat cortical cells.

Pubmed Data : Hum Exp Toxicol. 2010 Nov 17. Epub 2010 Nov 17. PMID: 21084527
Article Published Date : Nov 17, 2010
Study Type : In Vitro Study
Additional Links
Substances : Resveratrol : CK(938) : AC(590)
Diseases : Brain Damage : CK(89) : AC(41), Excitotoxicity : CK(52) : AC(30)
Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

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