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Fructose-Induced Toxicity

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Article Count - 49
Cumulative Knowledge - 140

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Fructose

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Quick Summary: Current access displays 2 out of 21 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Berberine	4	2	Log in \| Sign up
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View the Evidence: Ailments

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.

Click here to read the entire abstract

Pubmed Data : J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20. PMID: 19381015

Article Published Date : May 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Abdominal Obesity (Midsection Fat) : CK(348) : AC(53), Dyslipidemias : CK(176) : AC(33), Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1849) : AC(275)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Fructose has been strongly linked with hypertension, hyperuricemia and inflammation in experimental models and humans.

Click here to read the entire abstract

Pubmed Data : Nephrol Dial Transplant. 2011 May 25. Epub 2011 May 25. PMID: 21613382

Article Published Date : May 25, 2011

Study Type : Human Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension : CK(2783) : AC(271), Hyperuricemia : CK(253) : AC(32), Inflammation : CK(1077) : AC(363)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Hypertensive : CK(68) : AC(9), Inflammatory : CK(150) : AC(37)

Fructose-induced hyperuricemia may play a role in essential hypertension.

Click here to read the entire abstract

Pubmed Data : Metabolism. 1977 Nov;26(11):1219-23. PMID: 909398

Article Published Date : Nov 01, 1977

Study Type : Human Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension : CK(2783) : AC(271), Hyperuricemia : CK(253) : AC(32)

Problem Substances : Fructose : CK(356) : AC(103)

Mean fasting serum fructose level was significantly higher at 5.7+/-2.5 mM in patients with pancreatic cancer than those with no pancreatic cancer.

Click here to read the entire abstract

Pubmed Data : Pancreas. 2009 Aug;38(6):706-12. PMID: 19506535

Article Published Date : Aug 01, 2009

Study Type : Human Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Pancreatic Cancer : CK(530) : AC(168)

Problem Substances : Fructose : CK(356) : AC(103)

A high fructose diet may contribute to the development of fatty liver, gluconeogenesis up-regulation and inflammation.

Click here to read the entire abstract

Pubmed Data : Endocrinology. 2010 May;151(5):2040-9. Epub 2010 Mar 8. PMID: 20211973

Article Published Date : May 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122), Fructose-Induced Toxicity : CK(138) : AC(49), Hyperglycemia : CK(2892) : AC(59), Inflammation : CK(1077) : AC(363), Liver Stress: Fructose-Induced : CK(19) : AC(10), Triglycerides: Elevated : CK(340) : AC(65)

Problem Substances : Insulin : CK(92) : AC(15)

Adverse Pharmacological Actions : Dyslipidemic : CK(22) : AC(7), Gluconeogenesis Up-Regulation : CK(8) : AC(4), Inflammatory : CK(150) : AC(37), Lipogenesis Up-Regulation : CK(10) : AC(6)

Abelmoschus moschatus compares favorably to the drug rosiglitazone in improving insulin sensitivity in fructose-fed rats.

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Pubmed Data : Phytother Res. 2010 Feb;24(2):233-9. PMID: 19610024

Article Published Date : Feb 01, 2010

Study Type : Animal Study

Additional Links

Substances : Abelmoschus moschatus : CK(2) : AC(1)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221)

Allopurinol, quercetin and rutin ameliorate renal inflammasome activation and lipid accumulation in fructose-fed rats.

Click here to read the entire abstract

Pubmed Data : Biochem Pharmacol. 2012 Jul 1 ;84(1):113-25. Epub 2012 Mar 16. PMID: 22426011

Article Published Date : Jun 30, 2012

Study Type : Animal Study

Additional Links

Substances : Quercetin : CK(318) : AC(136), Rutin : CK(93) : AC(30)

Diseases : Dyslipidemias : CK(176) : AC(33), Fructose-Induced Toxicity : CK(138) : AC(49), Hyperuricemia : CK(253) : AC(32), Insulin Resistance : CK(1034) : AC(221)

Additional Keywords : Drug: Allopurinol : CK(6) : AC(3)

Problem Substances : Fructose : CK(356) : AC(103)

Astaxanthin prevents fructose-induced adverse changes in insulin signaling and inflammation in obese rats.

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Pubmed Data : Food Funct. 2011 Nov 17. Epub 2011 Nov 17. PMID: 22089895

Article Published Date : Nov 17, 2011

Study Type : Animal Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Inflammation : CK(1077) : AC(363), Insulin Resistance : CK(1034) : AC(221), Obesity : CK(1849) : AC(275), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Anti-Adipogenic : CK(87) : AC(44), Anti-Inflammatory Agents : CK(1230) : AC(433), Insulin Sensitizers : CK(167) : AC(36)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Obesogenic : CK(49) : AC(9)

Berberine can prevent fructose-induced insulin resistance in rats

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9. Epub 2006 May 17. PMID: 18563319

Article Published Date : Oct 01, 2006

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221), Liver Stress: Fructose-Induced : CK(19) : AC(10)

Berberine protects against fructose-and-salt induced hypertensive renal injury.

Click here to read the entire abstract

Pubmed Data : Zhong Yao Cai. 2011 Mar ;34(3):412-5. PMID: 21823461

Article Published Date : Mar 01, 2011

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension: Renal : CK(2) : AC(1), Kidney Diseases : CK(424) : AC(71)

Pharmacological Actions : Renoprotective : CK(191) : AC(90)

Problem Substances : Fructose : CK(356) : AC(103), Sodium Chloride : CK(14) : AC(3)

Adverse Pharmacological Actions : Nephrotoxic : CK(162) : AC(38)

Bitter melon attenuates fructose-induced insulin resistance in fructose-fed rats.

Click here to read the entire abstract

Pubmed Data : Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1612-20. PMID: 19429344

Article Published Date : Nov 01, 2005

Study Type : Animal Study

Additional Links

Substances : Bitter Melon : CK(65) : AC(18)

Diseases : Adiponectin: Low Levels : CK(88) : AC(25), Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats.

Click here to read the entire abstract

Pubmed Data : Am J Hypertens. 2005 Jun;18(6):864-70. PMID: 15925749

Article Published Date : Jun 01, 2005

Study Type : Animal Study

Additional Links

Substances : Resveratrol : CK(977) : AC(590)

Diseases : Arteriosclerosis : CK(2154) : AC(123), Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Stilbenes : CK(402) : AC(242)

Coconut water has therapeutic effects on oxidative stress in fructose fed insulin resistant hypertensive rats.

Click here to read the entire abstract

Pubmed Data : Asian Pac J Trop Med. 2012 Apr ;5(4):270-6. PMID: 22449517

Article Published Date : Apr 01, 2012

Study Type : Animal Study

Additional Links

Substances : Coconut Water : CK(46) : AC(14)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49)

Coenzyme Q10 and α-lipoic acid have therapeutic properties in fructose fed rats.

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Clin Biochem Nutr. 2012 Mar ;50(2):145-51. Epub 2011 Sep 3. PMID: 22448096

Article Published Date : Mar 01, 2012

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(384) : AC(82), Coenzyme Q10 : CK(667) : AC(104)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Metabolic Syndrome X : CK(645) : AC(122), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Problem Substances : Fructose : CK(356) : AC(103)

Cyperus rotundus suppresses AGE formation and protein oxidation in a model of fructose-mediated protein glycoxidation.

Click here to read the entire abstract

Pubmed Data : Int J Biol Macromol. 2007 Dec 1;41(5):572-8. Epub 2007 Jul 27. PMID: 17765965

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Cyperus rotundus : CK(7) : AC(4), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Fructose-Induced Toxicity : CK(138) : AC(49)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Even moderate consumption of fructose results in unfavorable changes in markers of liver health.

Click here to read the entire abstract

Pubmed Data : Physiol Behav. 2009 Dec 7;98(5):618-24. Epub 2009 Oct 6. PMID: 19815021

Article Published Date : Dec 07, 2009

Study Type : Animal Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Liver Stress: Fructose-Induced : CK(19) : AC(10)

Exercise improves fructose-induced insulin resistance, hyperinsulinemia and hypertension.

Click here to read the entire abstract

Pubmed Data : Hypertension. 1988 Aug;12(2):129-32. PMID: 3410522

Article Published Date : Aug 01, 1988

Study Type : Animal Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hyperinsulinism : CK(1182) : AC(41), Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221)

Therapeutic Actions : Exercise : CK(482) : AC(69)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Hypertensive : CK(68) : AC(9)

Fish and argan oil have a beneficial effect on diet-induced insulin resistance and glucose intolerance.

Click here to read the entire abstract

Pubmed Data : Metabolism. 2009 Jul;58(7):909-19. PMID: 19394055

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Argan Oil : CK(2) : AC(1), Fish Oil : CK(615) : AC(95)

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Insulin Resistance : CK(1034) : AC(221)

Additional Keywords : Fructose Toxicity : CK(18) : AC(2)

Fish oil ameliorates insulin resistance and hypertension in a fructose-fed rat model.

Click here to read the entire abstract

Pubmed Data : Metabolism. 1997 Nov;46(11):1252-8. PMID: 9361681

Article Published Date : Nov 01, 1997

Study Type : Animal Study

Additional Links

Substances : Fish Oil : CK(615) : AC(95)

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221)

Free fructose/glucose at a 50/50 ratio is more harmful than sucrose in an animal model.

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2011 Jul 29. Epub 2011 Jul 29. PMID: 21800086

Article Published Date : Jul 29, 2011

Study Type : Animal Study

Additional Links

Diseases : Diabetes Mellitus: Type 2: Prevention : CK(142) : AC(8), Fructose-Induced Toxicity : CK(138) : AC(49)

Problem Substances : Fructose : CK(356) : AC(103)

Fructose can be used to induce insulin resistance and hypertension in rats.

Click here to read the entire abstract

Pubmed Data : Hypertension. 1987 Nov;10(5):512-6. PMID: 3311990

Article Published Date : Nov 01, 1987

Study Type : Animal Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Hypertension : CK(2783) : AC(271), Insulin Resistance : CK(1034) : AC(221)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Hypertensive : CK(68) : AC(9)

Fructose causes renal damage in an animal model of metabolic syndrome.

Click here to read the entire abstract

Pubmed Data : Pediatr Nephrol. 2011 May 1. Epub 2011 May 1. PMID: 21533627

Article Published Date : May 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49), Kidney Damage : CK(120) : AC(42), Metabolic Syndrome X : CK(645) : AC(122)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Nephrotoxic : CK(162) : AC(38)

Fructose consumption interferes with hippocampus regeneration in the brain.

Click here to read the entire abstract

Pubmed Data : Regul Pept. 2011 Feb 25 ;167(1):26-30. Epub 2010 Nov 27. PMID: 21115071

Article Published Date : Feb 25, 2011

Study Type : Animal Study

Additional Links

Diseases : Brain Injury: Hippocampal Damage : CK(35) : AC(16), Fructose-Induced Toxicity : CK(138) : AC(49)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Fructose exhibits mild opioid activity as determined by a naltrxone blocking test in rats.

Click here to read the entire abstract

Pubmed Data : Pharmacol Biochem Behav. 2010 Mar ;95(1):56-62. Epub 2009 Dec 13. PMID: 20006967

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Diseases : Fructose-Induced Toxicity : CK(138) : AC(49)

Additional Keywords : Food Opioids : CK(20) : AC(14), Fructose-Opiate Connection : CK(7) : AC(4)

Problem Substances : Fructose : CK(356) : AC(103)

Fructose induces adverse changes associated with fatty liver disease in an animal model.

Click here to read the entire abstract

Pubmed Data : Lab Invest. 2011 Feb;91(2):283-93. Epub 2010 Oct 18. PMID: 20956972

Article Published Date : Feb 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Fatty Liver : CK(493) : AC(122), Fructose-Induced Toxicity : CK(138) : AC(49)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80)

Related Blogs

Is Fructose As Addictive As Alcohol?

Written by Sayer Ji, Founder

Fructose, which literally means "fruit sugar," sounds so sweet and innocent. And indeed, when incorporated into the diet in moderate amounts, say, in the form of fruit - always organic and raw, when possible – it's about as pure and wholesome as food gets. Not so for industrially processed fructose in isolate form, which may be as addictive as alcohol and morphine

Why You Should Ditch Sugar In Favor of Honey

Written by Sayer Ji, Founder

Increasingly, it is hard to find honey being used in foods or as a sweetener. Instead, sugar and corn-derived high fructose corn syrup has displaced it. But honey is vastly different than sugar.

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