Hypothyroidism

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Quick Summary: 30 associated Substances
NameCumulative KnowledgeArticle CountFocus Articles
Soy302Log in | Sign up
Ginseng, unspecified species202Log in | Sign up
Isoflavones201Log in | Sign up
Soy Protein 201Log in | Sign up
Zinc202Log in | Sign up
Genistein143Log in | Sign up
Iodine123Log in | Sign up
B-complex101Log in | Sign up
Carnitine101Log in | Sign up
Magnesium101Log in | Sign up
Vitamin B-12101Log in | Sign up
Ashwagandha42Log in | Sign up
Guggul42Log in | Sign up
Taurine42Log in | Sign up
Vitamin C42Log in | Sign up
Ayurvedic formulation: Liv5221Log in | Sign up
Bauhinia purpurea21Log in | Sign up
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View the Evidence: Ailments

Chronic exposure to organochlorine compounds may contribute to type 2 diabetes and thyroid diseases.

Pubmed Data : Ann Ig. 2010 May-Jun;22(3):185-98. PMID: 20677670
Article Published Date : May 01, 2010
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3142) : AC(328), Diabetes Mellitus: Type 2: Prevention : CK(92) : AC(8), Hyperthyroidism : CK(213) : AC(38), Hypothyroidism : CK(516) : AC(78), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Organochlorine pesticides : CK(260) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(461) : AC(76)

Safety Study: There is little evidence that in those with normal thyroid function soy has any adverse effects. In those with hypothyroidism adequate iodine should be consumed to counterbalance the soy consumption.

Pubmed Data : Thyroid. 2006 Mar;16(3):249-58. PMID: 16571087
Article Published Date : Mar 01, 2006
Study Type : Meta Analysis
Additional Links
Substances : Isoflavones : CK(627) : AC(124), Soy : CK(1698) : AC(332), Soy Protein : CK(2307) : AC(56)
Diseases : Hypothyroidism : CK(516) : AC(78)

A number of commonly used drugs interfere with the absorption of lovothyroxine.

Pubmed Data : Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):781-92. PMID: 19942153
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78)
Problem Substances : Antacids: Aluminium-Containing : CK(22) : AC(3), Bile Acid Sequestrants : CK(10) : AC(1), Calcium Carbonate : CK(176) : AC(19), Ferrous Sulphate : CK(22) : AC(3), Phosphate Binders : CK(10) : AC(1), Proton-Pump Inhibitors : CK(228) : AC(28), Raloxifene : CK(103) : AC(11), Sucralfate : CK(10) : AC(1)

Bisphenol A and pthalate exposure may adversely affect thyroid function.

Pubmed Data : Environ Health Perspect. 2011 Jul 11. Epub 2011 Jul 11. PMID: 21749963
Article Published Date : Jul 11, 2011
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Bisphenol A : CK(147) : AC(39), Phthalates : CK(151) : AC(24)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid : CK(44) : AC(14)

Carnitine supplementation may correct carnitine deficiences associated with both hypo- and hyperthyroidism.

Pubmed Data : Phytother Res. 2011 Mar 31. Epub 2011 Mar 31. PMID: 15803480
Article Published Date : Mar 31, 2011
Study Type : Human Study
Additional Links
Substances : Carnitine : CK(672) : AC(69)
Diseases : Hyperthyroidism : CK(213) : AC(38), Hypothyroidism : CK(516) : AC(78)

Congenital hypothyroidism and mental retardation may be linked to iodine and trace mineral deficiencies.

Pubmed Data : Sante. 2007 Jan-Mar;17(1):41-50. PMID: 17897901
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Iodine Deficiency : CK(75) : AC(11), Mental Retardation : CK(71) : AC(7)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1144) : AC(420)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Dessicated thyroid (Armour) has been associated with superior clinical outcomes compared to levothyroxine in the treatment of hypothyroidism.

Pubmed Data : Altern Med Rev. 2004 Jun;9(2):157-79. PMID: 15253676
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78)
Additional Keywords : Superiority of Natural Substances versus Drugs : CK(897) : AC(158)
Problem Substances : Levothyroxine : CK(74) : AC(9)

Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men.

Pubmed Data : Environ Health Perspect. 2007 Jul;115(7):1029-34. PMID: 17637918
Article Published Date : Jul 01, 2007
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78)
Problem Substances : Phthalates : CK(151) : AC(24)

Effects of exposure to polychlorinated biphenyls and organochlorine pesticides have an adverse effect on thyroid function during pregnancy.

Pubmed Data : Am J Epidemiol. 2008 Aug 1;168(3):298-310. Epub 2008 Jun 10. PMID: 18550560
Article Published Date : Aug 01, 2008
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Pregnancy: Environmental Exposures : CK(29) : AC(6)
Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Polychlorinated biphenyls (PCBs) : CK(177) : AC(23)

Exposure to organochloride compounds alter thyroid hormone levels during pregnancy.

Pubmed Data : Environ Sci Technol. 2009 Oct 15;43(20):7909-15. PMID: 19921913
Article Published Date : Oct 15, 2009
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Pregnancy: Environmental Exposures : CK(29) : AC(6)
Problem Substances : Dichloro-diphenyl-trichloroethane (DDT) : CK(70) : AC(7), Hexachlorobenzene (HCB) : CK(20) : AC(2), Organochlorine compounds : CK(105) : AC(13), Organochlorine pesticides : CK(260) : AC(30), Pesticides : CK(667) : AC(69), Polychlorinated biphenyls (PCBs) : CK(177) : AC(23)

Ginseng improves the condition of patients with congestive heart failure and raises levels of T3 and T4.

Pubmed Data : Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Apr;19(4):209-11. PMID: 11783267
Article Published Date : Apr 01, 1999
Study Type : Human Study
Additional Links
Substances : Ginseng, unspecified species : CK(53) : AC(15)
Diseases : Congestive Heart Failure : CK(244) : AC(30), Heart Failure : CK(669) : AC(97), Hypothyroidism : CK(516) : AC(78)

Hypothyroidism is a protective factor in acute stroke patients.

Pubmed Data : Clin Endocrinol (Oxf). 2006 Sep;65(3):369-72. PMID: 16918958
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Stroke : CK(539) : AC(46)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

In thyroid replacement resistant hypothyroidism autoimmunity and gastroenterologic pathologies are common.

Pubmed Data : Minerva Chir. 1993 Nov;48(21-22):1319-23. PMID: 8152564
Article Published Date : Nov 01, 1993
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(5092) : AC(779), Hypothyroidism : CK(516) : AC(78)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Infants with congenital hypothyroidism may do well to avoid soy-based formula.

Pubmed Data : J Am Coll Nutr. 1997 Jun;16(3):280-2. PMID: 9176836
Article Published Date : Jun 01, 1997
Study Type : Human Study
Additional Links
Diseases : Food Intolerances: Soy : CK(30) : AC(3), Hypothyroidism : CK(516) : AC(78), Infant Nutrition: Infant Formula : CK(278) : AC(33)
Problem Substances : Infant Formula : CK(464) : AC(59)

Intolerance to wheat (CD autoantibodies) is higher than background rates in those with Turner syndrome.

Pubmed Data : Clin Exp Immunol. 2009 May;156(2):205-10. Epub 2009 Feb 26. PMID: 19298606
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(5092) : AC(779), Celiac Disease : CK(1330) : AC(163), Diabetes Mellitus: Type 1 : CK(1041) : AC(221), Hypothyroidism : CK(516) : AC(78), Turner Syndrome : CK(10) : AC(1)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)
Problem Substances : Wheat : CK(2254) : AC(263)
Adverse Pharmacological Actions : Immunotoxic : CK(206) : AC(38)

Iodine deficiency is a major determinant in the occurence of thyroid underfunction in pregnant women.

Pubmed Data : Eur J Endocrinol. 2009 Apr;160(4):611-7. Epub 2009 Jan 29. PMID: 19179457
Article Published Date : Apr 01, 2009
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Iodine Deficiency : CK(75) : AC(11), Pregnancy Complications : CK(166) : AC(19), Prenatal Nutrition : CK(168) : AC(23), Prenatal Nutrition: Prevention of Problems : CK(355) : AC(38)

Iodine deficiency may be a common problem in premature newborns.

Pubmed Data : Semin Perinatol. 2008 Dec;32(6):407-12. PMID: 19007678
Article Published Date : Dec 01, 2008
Study Type : Human Study
Additional Links
Substances : Iodine : CK(116) : AC(20)
Diseases : Hypothyroidism : CK(516) : AC(78), Premature Birth : CK(412) : AC(43)

Levothyroxine may be a risk factor for hypoglycaemia in patients with liver disease.

Pubmed Data : J Clin Pharm Ther. 2003 Oct;28(5):355-61. PMID: 14632959
Article Published Date : Oct 01, 2003
Study Type : Human Study
Additional Links
Diseases : Hypoglycemia : CK(274) : AC(21), Hypothyroidism : CK(516) : AC(78), Liver Disease : CK(114) : AC(30)
Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)
Problem Substances : Levothyroxine : CK(74) : AC(9)

Levothyroxine replacement therapy increases coagulation (fibrinogen) following initiation of treatment.

Pubmed Data : J Endocrinol Invest. 2005 May;28(5):398-404. PMID: 16075920
Article Published Date : May 01, 2005
Study Type : Human Study
Additional Links
Diseases : Blood Coagulation Disorders : CK(42) : AC(8), Drug-Induced Toxicity : CK(538) : AC(78), Fibrinogen: Elevated : CK(114) : AC(13), Hypothyroidism : CK(516) : AC(78)
Problem Substances : Levothyroxine : CK(74) : AC(9)

Levothyroxine use is associated with increased risk of hypoglycemia in patients with liver impairment.

Pubmed Data : Int J Clin Pharmacol Ther. 2008 Jan;46(1):1-13. PMID: 18218292
Article Published Date : Jan 01, 2008
Study Type : Human Study
Additional Links
Diseases : Hypoglycemia : CK(274) : AC(21), Hypothyroidism : CK(516) : AC(78), Liver Disease : CK(114) : AC(30)
Problem Substances : Levothyroxine : CK(74) : AC(9)

Magnesium prevents exercise-induced reduction in thyroid hormone activity in both sedentary and athletic individuals.

Pubmed Data : Neuro Endocrinol Lett. 2007 Oct;28(5):708-12. PMID: 17984925
Article Published Date : Oct 01, 2007
Study Type : Human Study
Additional Links
Substances : Magnesium : CK(827) : AC(116)
Diseases : Athletic Performance: Recovery : CK(160) : AC(16), Exercise-Induced Hormone Fluctuations : CK(40) : AC(4), Hypothyroidism : CK(516) : AC(78)

Non-malignant thyroid disease may occur after a wide range of radiation exposures

Pubmed Data : Radiat Res. 2010 Dec;174(6):877-88. Epub 2010 Sep 7. PMID: 21128812
Article Published Date : Dec 01, 2010
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Radiation Induced Illness : CK(1024) : AC(249), Thyroid Nodule : CK(92) : AC(11)
Anti Therapeutic Actions : Radation Exposure: Low-Dose : CK(55) : AC(9)

Organochlorine compound exposures may disrupt thyroid function, resulting in neurotoxicity in preschool children.

Pubmed Data : Environ Health Perspect. 2011 Jun 30. Epub 2011 Jun 30. PMID: 21719373
Article Published Date : Jun 30, 2011
Study Type : Human Study
Additional Links
Diseases : Childhood Chemical Exposures : CK(155) : AC(17), Childhood Cognitive Disorders : CK(180) : AC(14), Hypothyroidism : CK(516) : AC(78), Pesticide-Induced Toxicity: Organochlorines : CK(32) : AC(4), Pesticide Toxicity : CK(147) : AC(44), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Organochlorine compounds : CK(105) : AC(13)
Adverse Pharmacological Actions : Endocrine Disruptor: Thyroid : CK(44) : AC(14)

Organophosphate pesticide exposure has been associated with thyroid hormone changes in human subjects.

Pubmed Data : Toxicol Appl Pharmacol. 2010 Feb 15;243(1):19-26. Epub 2009 Nov 13. PMID: 19914268
Article Published Date : Feb 15, 2010
Study Type : Human Study
Additional Links
Diseases : Hyperthyroidism : CK(213) : AC(38), Hypothyroidism : CK(516) : AC(78), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Organophosphates : CK(38) : AC(7)

Organophosphate pesticide exposure may adversely effect the thyroid.

Pubmed Data : Toxicol Appl Pharmacol. 2010 Aug 5. Epub 2010 Aug 5. PMID: 20691716
Article Published Date : Aug 05, 2010
Study Type : Human Study
Additional Links
Diseases : Hypothyroidism : CK(516) : AC(78), Inappropriate TSH Secretion Syndrome : CK(20) : AC(2), Thyroid Diseases : CK(182) : AC(23)
Problem Substances : Organophosphates : CK(38) : AC(7), Pesticides : CK(667) : AC(69)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(461) : AC(76)

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Perchlorate and The Post-Organic Era
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Perchlorate is an environmental pollutant primarily associated with releases by defense contractors, military operations and aerospace programs, as it is a key ingredient in rocket fuel. It is now found in virtually all humans tested, and it is continually making its way up the food chain through ground and drinking water, into feed and edible plants, animals products, milk and breast milk - contaminating conventional and organically grown food, alike. It is now distributed widely throughout...
Synthroid (Levothyroxine Sodium) IS NOT Thyroxine
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Synthroid (levothyroxine sodium), as the name implies, is NOT natural, is NOT bio-equivalent to the hormone thyroxine (T4) produced by the human thyroid, but rather is a SYNTHETIC hormone-like substance with radically different structural (see image below) and functional properties.

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