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Leukemia: Chronic myelogenous leukemia (CML)
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Additional Topics Details for this Page
Article Count
- 18
Cumulative Knowledge
- 28
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Leukemia: Chronic myelogenous leukemia (CML) is a Sub of the following Topic
Leukemia
What is Cumulative Knowledge?
Cumulative Knowledge
is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.
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Quick Summary: Current access displays 2 out of 15 associated Substances
Name
Cumulative Knowledge
Article Count
Focus Articles
Curcumin
14
5
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Turmeric
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View the Evidence: Ailments
Curcumin acts as an adjuvant to imatinib in decreasing the NO levels and may help in the treatment of CML patients.
Click here to read the entire abstract
Pubmed Data
: J Oncol Pharm Pract. 2011 Aug 15. Epub 2011 Aug 15. PMID:
21844132
Article Published Date
: Aug 15, 2011
Study Type
: Human Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
,
Turmeric : CK(2995) : AC(1585)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Nitric Oxide Inhibitor : CK(108) : AC(57)
Additional Keywords
:
Drug: Imatinib : CK(10) : AC(1)
,
Drug Synergy : CK(327) : AC(147)
Galangin, a compound found within Alpinia galanga, acts as a chemosensitizer in drug-resistant leukemia cells.
Click here to read the entire abstract
Pubmed Data
: Cancer Lett. 2008 Jul 8;265(2):289-97. Epub 2008 Apr 18. PMID:
18374481
Article Published Date
: Jul 08, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Alpinia galanga : CK(5) : AC(4)
,
Flavonoids : CK(909) : AC(289)
Diseases
:
Cancers: Drug Resistant : CK(225) : AC(147)
,
Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
,
Cell cycle arrest : CK(390) : AC(319)
,
Chemosensitizer : CK(197) : AC(159)
Triptolide, a constituent of Tripterygium wilfordii, induces programmed cell death in drug-resistant chronic myelogenous leukemia cells.
Click here to read the entire abstract
Pubmed Data
: Clin Cancer Res. 2009 Mar 1;15(5):1686-97. Epub 2009 Feb 24. PMID:
19240172
Article Published Date
: Mar 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Tripterygium wilfordii : CK(95) : AC(24)
Diseases
:
Cancers: Drug Resistant : CK(225) : AC(147)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
A fermentation extract derived from rice bran and seaweed extract inhibits breast cancer and chronic myelogenous leukemia (CML) cell line growth.
Click here to read the entire abstract
Pubmed Data
: Int J Mol Med. 2004 Nov;14(5):925-9. PMID:
15492867
Article Published Date
: Nov 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Fermented Foods and Beverages : CK(670) : AC(133)
,
Rice Bran : CK(29) : AC(14)
,
Seaweed : CK(83) : AC(16)
Diseases
:
Breast Cancer : CK(2354) : AC(621)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Antiproliferative : CK(1052) : AC(775)
Betulinic acid induces programmed cell death in human chronic myelogenous leukemia (CML) cells.
Click here to read the entire abstract
Pubmed Data
: Toxicol Lett. 2005 Mar 15;155(3):343-51. PMID:
15649617
Article Published Date
: Mar 15, 2005
Study Type
: In Vitro Study
Additional Links
Substances
:
Betulinic acid : CK(6) : AC(6)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
Curcumin inhibits chronic myelogenous leukemia cells (K562).
Click here to read the entire abstract
Pubmed Data
: J Altern Complement Med. 2007 Nov;13(9):985-7. PMID:
15182583
Article Published Date
: Nov 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Leukemia : CK(670) : AC(258)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
Curcumin may have therapeutic value in chronic myelocytic leukemia (CML).
Click here to read the entire abstract
Pubmed Data
: Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):572-6. PMID:
15498113
Article Published Date
: Oct 01, 2004
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Antiproliferative : CK(1052) : AC(775)
Curcumin may have therapeutic value in treating human chronic myelogenous leukemia due to its ability to regulate NF-kappB genes and pathways.
Click here to read the entire abstract
Pubmed Data
: Ann N Y Acad Sci. 2009 Aug;1171:436-47. PMID:
19723087
Article Published Date
: Aug 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Interleukin-10 downregulation : CK(73) : AC(21)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells.
Click here to read the entire abstract
Pubmed Data
: Acta Pharmacol Sin. 2007 Jan;28(1):105-10. PMID:
17184589
Article Published Date
: Jan 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Curcumin : CK(2910) : AC(1482)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Antiproliferative : CK(1052) : AC(775)
,
Apoptotic : CK(1489) : AC(1114)
,
Chemosensitizer : CK(197) : AC(159)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
EGCG has anti-leukemia activity and enhances imatinib-induced cell death.
Click here to read the entire abstract
Pubmed Data
: Cancer Sci. 2009 Feb;100(2):349-56. PMID:
19200260
Article Published Date
: Feb 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Chemosensitizer : CK(197) : AC(159)
Additional Keywords
:
Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Gleditsia sinensis might be potentially used as a chemotherapeutic drug to treat patients with acute and chronic myelogenous leukemia.
Click here to read the entire abstract
Pubmed Data
: Oncol Rep. 2003 Sep-Oct;10(5):1601-7. PMID:
12883747
Article Published Date
: Sep 01, 2003
Study Type
: In Vitro Study
Additional Links
Substances
:
Gleditsia sinensis : CK(4) : AC(3)
Diseases
:
Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
Resveratrol has chemotherapeutic potential in treating chronic myelogenous leukemia.
Click here to read the entire abstract
Pubmed Data
: PLoS One. 2010;5(1):e8719. Epub 2010 Jan 14. PMID:
20090934
Article Published Date
: Jan 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
,
Stilbenes : CK(128) : AC(92)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Heat Shock Protein Down-Regulation : CK(1) : AC(1)
Additional Keywords
:
Drug Synergy : CK(327) : AC(147)
Resveratrol induces apoptosis in chronic myelogenous leukemia cells.
Click here to read the entire abstract
Pubmed Data
: Cancer Sci. 2008 Jun;99(6):1109-16. Epub 2008 Apr 21. PMID:
18429957
Article Published Date
: Jun 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
Resveratrol induces apoptosis in Imatinib-resistant chronic myelogenous leukemia cells.
Click here to read the entire abstract
Pubmed Data
: FASEB J. 2008 Jun;22(6):1894-904. Epub 2008 Feb 1. PMID:
18245170
Article Published Date
: Jun 01, 2008
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Cancers: Drug Resistant : CK(225) : AC(147)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Apoptotic : CK(1489) : AC(1114)
Resveratrol may have anti-chronic myelogenous leukemia activity.
Click here to read the entire abstract
Pubmed Data
: Autophagy. 2010 Jul 21;6(5). Epub 2010 Jul 21. PMID:
20458181
Article Published Date
: Jul 21, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
Diseases
:
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells.
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2010 Feb 1;70(3):1042-52. Epub 2010 Jan 26. PMID:
20103647
Article Published Date
: Feb 01, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
,
Stilbenes : CK(128) : AC(92)
Diseases
:
Cancers: Drug Resistant : CK(225) : AC(147)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
Pharmacological Actions
:
Antineoplastic Agents : CK(877) : AC(496)
,
Autophagy Up-regulation : CK(18) : AC(13)
,
C-Jun N-Terminal Kinases (JNK) Modulator : CK(2) : AC(2)
Triptolide inhibits transcription factor NF-kappa B, which translates into a therapeutic effect against various leukemias, multiple myeloma and myelodysplastic syndrome.
Click here to read the entire abstract
Pubmed Data
: Curr Mol Pharmacol. 2010 Jul 2. Epub 2010 Jul 2. PMID:
20594187
Article Published Date
: Jul 02, 2010
Study Type
: In Vitro Study
Additional Links
Substances
:
Tripterygium wilfordii : CK(95) : AC(24)
,
Triptolide : CK(11) : AC(9)
Diseases
:
Leukemia : CK(670) : AC(258)
,
Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28)
,
Leukemia: Chronic Lymphocytic Leukemia (CLL) : CK(51) : AC(23)
,
Leukemia: Chronic myelogenous leukemia (CML) : CK(28) : AC(18)
,
Multiple Myeloma : CK(156) : AC(53)
,
Myelodysplastic Syndrome : CK(198) : AC(18)
Pharmacological Actions
:
Chemosensitizer : CK(197) : AC(159)
,
NF-kappaB Inhibitor : CK(595) : AC(401)
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