Liver Fibrosis

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156 Substances Researched for Liver Fibrosis
NameACCKFocus
Curcumin3456Locked
Coffee553Locked
Vitamin D434Locked
Tanshinone IIA221Locked
Astaxanthin711Locked
Ginsenosides611Locked
Blueberry510Locked
Flaxseed110Locked
Puerarin510Locked
Sea buckthorn110Locked
Resveratrol48Locked
Curcumol67Locked
Flavonoids47Locked
Ursolic Acid47Locked
Crocin36Locked
Myricetin36Locked
Olive36Locked
Pomegranate36Locked
Astragaloside45Locked
Indole-3-Carbinol35Locked
Paeoniflorin35Locked
Schisandra15Locked
Alpha-Lipoic Acid24Locked
Asiatic Acid24Locked
Astragalus24Locked
Chrysin24Locked
Cucurbitacin B 24Locked
Fermented Foods and Beverages24Locked
Gallic Acid24Locked
Ginkgo biloba24Locked
Lotus 24Locked
Melatonin24Locked
Naringenin 24Locked
Paeonol24Locked
Phosphatidylcholine24Locked
Pomegranate Seed24Locked
Probiotics24Locked
Rosemary24Locked
Safflower24Locked
Selenium24Locked
Shikonin24Locked
Berberine23Locked
Emodin23Locked
Fucoidan23Locked
Liquiritigenin23Locked
Peony23Locked
Rosemaric Acid23Locked
Silibinin23Locked
2-Methoxyestradiol12Locked
Anthocyanins12Locked
Apricot Kernel12Locked
Arginine12Locked
Bee Propolis12Locked
Beta-Elemene12Locked
Bupleurum12Locked
Caffeic acid phenethyl ester12Locked
Cannabinoids 12Locked
Cannabis12Locked
Carvacrol12Locked
Celastrol12Locked
Chinese Skullcap 12Locked
Chlorella (Algae)12Locked
Chlorogenic Acid12Locked
Coenzyme Q1012Locked
Cucurbitacin E 12Locked
Dandelion 12Locked
EGCG (Epigallocatechin gallate)22Locked
Ellagic Acid12Locked
Evodiamine12Locked
Fenugreek12Locked
Ferulic acid22Locked
Fish Oil12Locked
Garlic12Locked
Garlic: Aged12Locked
Genistein12Locked
Ginger12Locked
Gingerol 12Locked
Ginseng12Locked
Grape Seed Extract12Locked
Green Tea12Locked
Gynostemma22Locked
Hesperidin12Locked
Hydrogen Water12Locked
Isothiocyanates12Locked
Juniper12Locked
Kaempferol12Locked
Krill12Locked
L-Carnitine12Locked
Lactobacillus fermentum12Locked
Lactobacillus plantarum12Locked
Lactobacillus reuteri12Locked
Lactobacillus rhamnosus GG12Locked
Lecithin12Locked
Licorice12Locked
Loquat Seeds12Locked
Luteolin12Locked
Medium Chain Triglycerides12Locked
Milk Thistle12Locked
Modified Citrus Pectin 12Locked
Noni12Locked
Oleic acid12Locked
Oligonol12Locked
Omega-3 Fatty Acids12Locked
Oridonin12Locked
Palm Oil12Locked
Palmitoylethanolamide 12Locked
Panax Notoginseng12Locked
Phospholipids12Locked
Piperine12Locked
Piperlongumine 12Locked
Polyphenols12Locked
Polyunsaturated Fatty Acids (PUFAs)12Locked
Pomegranate Peel12Locked
Prunella vulgaris12Locked
Pterostilbene12Locked
Quercetin12Locked
Radish12Locked
Red Sage12Locked
Red Wine Extract12Locked
Reishi Mushroom12Locked
Rhubarb12Locked
Saikosaponin12Locked
Salvia miltiorrhiza12Locked
Saturated fatty acids12Locked
Silymarin12Locked
Skullcap: Chinese12Locked
Solanum nigrum (black nightshade)12Locked
Spirulina12Locked
Taurine12Locked
Thymoquinone12Locked
Turmeric12Locked
Vitamin C12Locked
Vitamin E12Locked
Vitamin E: Gamma-tocotrienol12Locked
Wogonin12Locked
Xanthohumol12Locked
Zataria multiflora12Locked
Amla Fruit11Locked
Bee Venom11Locked
Betulinic acid11Locked
Bitter Melon11Locked
Cannabidiol11Locked
Carnosol11Locked
Celery seed11Locked
Diosgenin11Locked
Dong Quai11Locked
Fucoxanthin 11Locked
Honokiol11Locked
Hops11Locked
Lycopene11Locked
Phellinus Linteus11Locked
Procyanidin B2 11Locked
Rose 11Locked
Sulforaphane11Locked
Vitamin A11Locked
Zinc11Locked
8 Problem Substances Researched for Liver Fibrosis
NameACCKFocus
Gluten110Locked
High Fructose Corn Syrup36Locked
Fructose24Locked
Cholesterol Lowering Drugs13Locked
Concanavalin A23Locked
Bisphenol A 12Locked
Trans Fatty Acids12Locked
Antibiotics11Locked
3 Therapeutic Actions Researched for Liver Fibrosis
NameACCKFocus
Dietary Modification: Wheat/Gluten Free110Locked
Integrative Medicine110Locked
Lifestyle Changes: Positive110Locked
1 Problematic Actions Researched for Liver Fibrosis
NameACCKFocus
Western Diet24Locked

View the Evidence:
365 Abstracts with Liver Fibrosis Research

[+]

Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells.Nov 30, 2022

Pubmed Data : FASEB J. 2022 Dec ;36(12):e22665. PMID: 36398583
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1α in liver fibrosis.Feb 29, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Prolif. 2020 Mar ;53(3):e12762. Epub 2020 Mar 2. PMID: 32119185
Article Published Date : Feb 29, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Angiogenic, Anti-Fibrotic
[+]

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells.Jan 09, 2018

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Redox Biol. 2018 10 ;19:375-387. Epub 2018 Sep 7. PMID: 30237126
Article Published Date : Jan 09, 2018
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
[+]

Curcumol may be one of the mechanisms of antihepatic fibrosis by inhibiting the activity of the NF-κB signaling.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8590638. Epub 2020 May 28. PMID: 32595742
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, NF-kappaB Inhibitor
[+]

Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl-2 in hepatic stellate cells.May 08, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Biochem Mol Toxicol. 2022 May 9:e23097. Epub 2022 May 9. PMID: 35532220
Article Published Date : May 08, 2022
Study Type : In Vitro Study
Additional Links
Substances : Organosulfur Compounds
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Hepatoprotective
[+]

EGCG has antifibrogenic activity relevant to the prevention and treatment of liver fibrosis. Jul 01, 2006

Pubmed Data : Lab Invest. 2006 Jul;86(7):697-709. Epub 2006 May 8. PMID: 16682975
Article Published Date : Jul 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Fibrosis: Liver, Liver Fibrosis
Pharmacological Actions : Glutathione Upregulation
[+]

EGCG may have benefit as a protective agent in settings of liver injury.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2016 ;11(12):e0167435. Epub 2016 Dec 9. PMID: 27935974
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate)
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator
[+]

Emblica officinalis (amla) fruit reverses profibrinogenic events due to its antioxidant activity. Jun 01, 1998

Pubmed Data : Atherosclerosis. 1998 Jun;138(2):329-34. PMID: 15997120
Article Published Date : Jun 01, 1998
Study Type : In Vitro Study
Additional Links
Substances : Amla Fruit
Diseases : Fibrosis: Liver, Liver Fibrosis
[+]

Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Des Devel Ther. 2018 ;12:4107-4115. Epub 2018 Dec 3. PMID: 30584275
Article Published Date : Dec 31, 2017
Study Type : In Vitro Study
Additional Links
Substances : Ferulic acid
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Fruiting bodies of P. linteus could have potential for the inhibition of activated hepatic stellate cells.Dec 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2016 ;17(5). Epub 2016 May 6. PMID: 27164091
Article Published Date : Dec 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Phellinus Linteus
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Fucoidan: Biological Activity in Liver Diseases Nov 04, 2020

Pubmed Data : Am J Chin Med. 2020 Nov 5:1-16. Epub 2020 Nov 5. PMID: 33148007
Article Published Date : Nov 04, 2020
Study Type : Review
Additional Links
Substances : Fucoidan
Diseases : Ischemia, Liver Cancer, Liver Damage: Drug-Induced, Liver Disease, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Hepatoprotective
Additional Keywords : Polysaccharides
[+]

Fucoxanthin exerts anti-fibrogenic effects in hepatic stellate cells.Apr 10, 2019

Pubmed Data : Biochem Biophys Res Commun. 2019 Apr 11. Epub 2019 Apr 11. PMID: 30982574
Article Published Date : Apr 10, 2019
Study Type : In Vitro Study
Additional Links
Substances : Fucoxanthin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic
Additional Keywords : Gene Expression Regulation
[+]

Galangin has an anti-fibrogenic effect and may represent a promising agent in the treatment of hepatic fibrosis.Oct 31, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biol Pharm Bull. 2020 Nov 1 ;43(11):1634-1642. Epub 2020 Sep 4. PMID: 32893252
Article Published Date : Oct 31, 2020
Study Type : In Vitro Study
Additional Links
Substances : Flavonoids
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Apoptotic
[+]

Ginsenoside Rd, a natural production for attenuating fibrogenesis and inflammation in hepatic fibrosis.Jun 18, 2023

Pubmed Data : Food Funct. 2023 Jun 19 ;14(12):5606-5619. Epub 2023 Jun 19. PMID: 37249244
Article Published Date : Jun 18, 2023
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Inflammation, Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-18 down-regulation, Interleukin-1 beta downregulation, Interleukin-23 Downregulation
[+]

Gut microbiome alterations caused by early-life exposures to antibiotics may contribute to scleroderma pathogenesis.Oct 31, 2017

Pubmed Data : J Invest Dermatol. 2017 Nov ;137(11):2253-2255. PMID: 29055411
Article Published Date : Oct 31, 2017
Study Type : Review
Additional Links
Diseases : Antibiotic Toxicity , Dysbiosis, Liver Fibrosis, Scleroderma
Additional Keywords : Risk Factors
Problem Substances : Antibiotics
[+]

Gynostemma pentaphyllum saponins have anti-hepatic fibrosis and protective activity against H2O2-induced injury.Oct 02, 2017

Pubmed Data : Phytochemistry. 2017 Oct 3 ;144:226-232. Epub 2017 Oct 3. PMID: 28985570
Article Published Date : Oct 02, 2017
Study Type : In Vitro Study
Additional Links
Substances : Gynostemma
Diseases : Hydrogen Peroxide Induced Toxicity, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Gypenosides ameliorate carbon tetrachloride-induced liver fibrosis.Dec 31, 2016

Pubmed Data : Am J Chin Med. 2017 ;45(5):1061-1074. Epub 2017 Jun 28. PMID: 28659031
Article Published Date : Dec 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Gynostemma
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
[+]

Harmine suppresses collagen production in hepatic stellate cells by inhibiting DYRK1B.Jan 15, 2022

Pubmed Data : Biochem Biophys Res Commun. 2022 04 16 ;600:136-141. Epub 2022 Feb 16. PMID: 35219102
Article Published Date : Jan 15, 2022
Study Type : In Vitro Study
Additional Links
Substances : Harmine
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Apr ;112:108600. Epub 2019 Feb 16. PMID: 30780110
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Rosemaric Acid
Diseases : Liver Cancer, Liver Cirrhosis, Liver Diseases, Liver Fibrosis
Pharmacological Actions : Hepatoprotective
[+]

Honokiol acts as a potent anti-fibrotic agent in the liver.Dec 11, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Mol Sci. 2021 Dec 12 ;22(24). Epub 2021 Dec 12. PMID: 34948151
Article Published Date : Dec 11, 2021
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Liver Cirrhosis, Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

Indole-3-carbinol and its major derivatives: Their pharmacokinetics and important roles in hepatic protection.Dec 31, 2015

Pubmed Data : Curr Drug Metab. 2016 ;17(4):401-9. PMID: 26651978
Article Published Date : Dec 31, 2015
Study Type : Review
Additional Links
Substances : Indole-3-Carbinol
Diseases : Liver Damage, Liver Disease, Liver Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Apoptotic, Anti-Fibrotic, Hepatoprotective
[+]

Inhibition of liver fibrosis using vitamin A‑coupled liposomes to deliver matrix metalloproteinase‑2 siRNA in vitro.Aug 31, 2015

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mol Med Rep. 2015 Sep ;12(3):3453-61. Epub 2015 May 25. PMID: 26017616
Article Published Date : Aug 31, 2015
Study Type : In Vitro Study
Additional Links
Substances : Vitamin A
Diseases : Liver Fibrosis
Pharmacological Actions : Hepatoprotective, Matrix metalloproteinase-2 (MMP-2) inhibitor
Additional Keywords : MicroRNA
[+]

Inonotsuoxide B suppresses hepatic stellate cell activation and proliferation.May 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2022 Jun ;23(6):417. Epub 2022 Apr 28. PMID: 35601068
Article Published Date : May 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Chaga Mushroom (Inonotus obliquus)
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antiproliferative , Hepatoprotective, MicroRNA modulator
[+]

Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Phytomedicine. 2020 Jan ;66:153108. Epub 2019 Oct 4. PMID: 31790896
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Liquiritigenin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator
[+]

Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis.Nov 30, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Drug Deliv. 2021 Dec ;28(1):2534-2547. PMID: 34854788
Article Published Date : Nov 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Asiatic Acid
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Lycopene inhibits hepatic stellate cell activation and modulates cellular lipid storage and signaling.Apr 16, 2019

Pubmed Data : Food Funct. 2019 Apr 17 ;10(4):1974-1984. PMID: 30889234
Article Published Date : Apr 16, 2019
Study Type : In Vitro Study
Additional Links
Substances : Lycopene
Diseases : Liver Fibrosis
Pharmacological Actions : Antiproliferative , Cell cycle arrest, Hypolipidemic
[+]

Mechanism and progress of natural products in the treatment of NAFLD-related fibrosis.Dec 03, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2023 Dec 4 ;28(23). Epub 2023 Dec 4. PMID: 38067665
Article Published Date : Dec 03, 2023
Study Type : Review
Additional Links
Substances : Flavonoids
Diseases : Liver Cirrhosis, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Hepatoprotective
[+]

Paeoniae radix reduces PDGF-stimulated hepatic stellate cell migration.Feb 29, 2012

Pubmed Data : Planta Med. 2012 Mar ;78(4):341-8. Epub 2012 Jan 13. PMID: 22399273
Article Published Date : Feb 29, 2012
Study Type : In Vitro Study
Additional Links
Substances : Peony
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

Paeoniflorin is a natural product with multiple targets in liver diseases.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2020 ;11:531. Epub 2020 Apr 28. PMID: 32410996
Article Published Date : Dec 31, 2019
Study Type : Review
Additional Links
Substances : Paeoniflorin
Diseases : Liver Cancer, Liver Disease, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Anti-metastatic, Antioxidants, Apoptotic, Hepatoprotective, Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor, Immunomodulatory, NF-kappaB Inhibitor, Nrf2 activation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Paeoniflorin-free subfraction of Paeonia lactiflora Pall. shows the potential of anti-hepatic fibrosis.Dec 04, 2022

Pubmed Data : J Ethnopharmacol. 2022 Dec 5 ;299:115678. Epub 2022 Sep 1. PMID: 36058476
Article Published Date : Dec 04, 2022
Study Type : In Vitro Study
Additional Links
Substances : Paeoniflorin
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Parthenolide ameliorates fibrogenesis and inflammation in hepatic fibrosis.Sep 30, 2021

Pubmed Data : Phytother Res. 2021 Oct ;35(10):5680-5693. Epub 2021 Jul 12. PMID: 34250656
Article Published Date : Sep 30, 2021
Study Type : In Vitro Study
Additional Links
Substances : Parthenolide
Diseases : Inflammation, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-18 down-regulation, Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation, Interleukin-6 Downregulation
[+]

Phloretin ameliorates succinate-induced liver fibrosis by regulating hepatic stellate cells.Jul 31, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Endocrinol Metab (Seoul). 2023 Aug ;38(4):395-405. Epub 2023 Aug 3. PMID: 37533177
Article Published Date : Jul 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Phloretin
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Plantamajoside exerts antifibrosis effects in the liver by inhibiting hepatic stellate cell activation.Sep 30, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Exp Ther Med. 2019 Oct ;18(4):2421-2428. Epub 2019 Aug 2. PMID: 31555353
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Plantago
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Potential therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis.May 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Ann Transl Med. 2021 Jun ;9(11):932. PMID: 34350247
Article Published Date : May 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Gotu Kola
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Preventive and therapeutic role of Tanshinone ⅡA in hepatology.Mar 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomed Pharmacother. 2019 Apr ;112:108676. Epub 2019 Feb 21. PMID: 30797157
Article Published Date : Mar 31, 2019
Study Type : Review
Additional Links
Substances : Tanshinone IIA
Diseases : Fatty Liver, Liver Cancer, Liver Damage, Liver Disease, Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Chemotherapeutic, Hepatoprotective
[+]

Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis.Jul 20, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Cell Mol Med. 2019 Jul 21. Epub 2019 Jul 21. PMID: 31328391
Article Published Date : Jul 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Procyanidin B2
Diseases : Liver Fibrosis
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic
[+]

Promising hepatoprotective effects of lycopene in different liver diseases.Nov 30, 2022

Pubmed Data : Life Sci. 2022 Dec 1 ;310:121131. Epub 2022 Oct 25. PMID: 36306869
Article Published Date : Nov 30, 2022
Study Type : Review
Additional Links
Substances : Carotenoids, Lycopene
Diseases : Alcoholic Liver Disease, Liver Cancer, Liver Fibrosis, Liver Injury: Ischemia/reperfusion , Nonalcoholic fatty liver disease (NAFLD), Phthalate Toxicity
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Aflatoxin, Bisphenol A , Heavy Metals, Phthalates
[+]

Pterostilbene exerts cytotoxicity on activated hepatic stellate cells.Oct 31, 2023

Pubmed Data : Food Chem Toxicol. 2023 Nov ;181:114042. Epub 2023 Sep 16. PMID: 37722617
Article Published Date : Oct 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Pterostilbene
Diseases : Inflammation, Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antiproliferative , Hepatoprotective
[+]

Research review on the pharmacological effects of astragaloside IV.Jan 31, 2017

Pubmed Data : Fundam Clin Pharmacol. 2017 Feb ;31(1):17-36. Epub 2016 Sep 23. PMID: 27567103
Article Published Date : Jan 31, 2017
Study Type : Review
Additional Links
Substances : Astragaloside
Diseases : Asthma, Cardiovascular Diseases, Diabetic Nephropathy, Inflammation, Liver Fibrosis, Oxidative Stress
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Cardioprotective, Immunomodulatory
[+]

Saikosaponin-d protects against liver fibrosis.May 10, 2021

Pubmed Data : Biochem Cell Biol. 2021 May 11. Epub 2021 May 11. PMID: 33974808
Article Published Date : May 10, 2021
Study Type : In Vitro Study
Additional Links
Substances : Saikosaponin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-1 beta downregulation, Transforming growth factor beta (TGF-β) inhibitor
[+]

Salvianolic acid A suppresses CCl 4-induced liver fibrosis.Jan 19, 2022

Pubmed Data : Drug Chem Toxicol. 2022 Jan 20:1-10. Epub 2022 Jan 20. PMID: 35057680
Article Published Date : Jan 19, 2022
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Antioxidants, Heme oxygenase-1 up-regulation, Hepatoprotective, Nrf2 activation
[+]

Salvianolic acid B inhibits autophagy and activation of hepatic stellate cells.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Pharmacol. 2022 ;13:938856. Epub 2022 Aug 4. PMID: 35991894
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Autophagy Inhibitors
[+]

Salvianolic acid B suppresses hepatic fibrosis.May 31, 2023

Pubmed Data : Acta Pharmacol Sin. 2023 Jun ;44(6):1191-1205. Epub 2023 Jan 10. PMID: 36627345
Article Published Date : May 31, 2023
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis.Nov 30, 2022

Pubmed Data : Phytomedicine. 2022 Dec ;107:154435. Epub 2022 Sep 5. PMID: 36155216
Article Published Date : Nov 30, 2022
Study Type : In Vitro Study
Additional Links
Substances : Salvia miltiorrhiza
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, MicroRNA modulator, NF-kappaB Inhibitor
[+]

Silibinin inhibits the proliferation, activation and migration of LX-2 cells without inducing cytotoxicity and oxidative stress.Aug 31, 2016

Pubmed Data : J Clin Exp Hepatol. 2016 Sep ;6(3):167-174. Epub 2016 Aug 13. PMID: 27746612
Article Published Date : Aug 31, 2016
Study Type : In Vitro Study
Additional Links
Substances : Silibinin
Diseases : Liver Fibrosis
Pharmacological Actions : Antiproliferative , Hepatoprotective
[+]

Study on mechanism of curcumol against liver fibrosis based on autophagy and apoptosis of hepatic stellate cells.Jan 31, 2022

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2022 Feb ;47(3):730-736. PMID: 35178956
Article Published Date : Jan 31, 2022
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Apoptotic, Autophagy Up-regulation
[+]

Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused.Sep 30, 2019

Pubmed Data : Hum Cell. 2019 Oct ;32(4):403-410. Epub 2019 Jul 5. PMID: 31278688
Article Published Date : Sep 30, 2019
Study Type : In Vitro Study
Additional Links
Substances : Sulforaphane
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, MicroRNA modulator
[+]

Tanshinone IIA and hepatocellular carcinoma.Dec 31, 2022

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Front Oncol. 2023 ;13:1071415. Epub 2023 Jan 31. PMID: 36798821
Article Published Date : Dec 31, 2022
Study Type : Review
Additional Links
Substances : Tanshinone IIA
Diseases : Liver Cancer, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Chemopreventive, Hepatoprotective
[+]

The anti-toxic effect of the date palm fruit extract loaded on chitosan nanoparticles against CCl4-induced liver fibrosis in a mouse model.Apr 29, 2023

Pubmed Data : Int J Biol Macromol. 2023 Apr 30 ;235:123804. Epub 2023 Feb 24. PMID: 36842736
Article Published Date : Apr 29, 2023
Study Type : In Vitro Study
Additional Links
Substances : Dates
Diseases : Inflammation, Liver Cirrhosis, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
[+]

The combination of astragaloside IV and ferulic acid is a promising candidate for the treatment of hepatic fibrosis.Jan 02, 2020

Pubmed Data : Dig Dis Sci. 2020 Jan 3. Epub 2020 Jan 3. PMID: 31900718
Article Published Date : Jan 02, 2020
Study Type : In Vitro Study
Additional Links
Substances : Astragaloside, Ferulic acid
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Transforming growth factor beta (TGF-β) inhibitor
Additional Keywords : Natural Substance Synergy
[+]

The molecular bases underlying the hepatoprotective effects of coffee.Jan 22, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2017 Jan 23 ;9(1). Epub 2017 Jan 23. PMID: 28124992
Article Published Date : Jan 22, 2017
Study Type : Review
Additional Links
Substances : Coffee
Diseases : Liver Cancer, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anticarcinogenic Agents, Hepatoprotective
[+]

The present study reviews current understanding of the mechanisms of the anti-inflammatory properties of bee venom.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxins (Basel). 2015 ;7(11):4758-72. Epub 2015 Nov 16. PMID: 26580653
Article Published Date : Dec 31, 2014
Study Type : Review
Additional Links
Substances : Bee Venom
Diseases : Atherosclerosis, Fibrosis, Inflammation, Liver Fibrosis, Skin Diseases
Pharmacological Actions : Anti-Inflammatory Agents
[+]

The present study suggests that betulinic acid has anti-hepatic fibrosis activity.Dec 31, 2018

Pubmed Data : J Nat Med. 2019 Jan ;73(1):179-189. Epub 2018 Oct 30. PMID: 30377904
Article Published Date : Dec 31, 2018
Study Type : In Vitro Study
Additional Links
Substances : Betulinic acid
Diseases : Liver Fibrosis
Pharmacological Actions : Autophagy Up-regulation, Hepatoprotective
[+]

The results provide an evidence for the promising antifibrotic effect of honokiol.Nov 20, 2019

Pubmed Data : Life Sci. 2019 Nov 21 ;240:117096. Epub 2019 Nov 21. PMID: 31760097
Article Published Date : Nov 20, 2019
Study Type : In Vitro Study
Additional Links
Substances : Honokiol
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, Hepatoprotective
Problem Substances : Concanavalin A
[+]

Therapeutic effects of berberine on liver fibrosis.Dec 31, 2021

Pubmed Data : Front Pharmacol. 2022 ;13:814871. Epub 2022 Mar 2. PMID: 35308208
Article Published Date : Dec 31, 2021
Study Type : Review
Additional Links
Substances : Berberine
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

These data collectively unravel that ginsenoside Rg3 may serve a promising anti-hepatic fibrosis treatment.Jun 11, 2020

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Cell Death Dis. 2020 Jun 12 ;11(6):454. Epub 2020 Jun 12. PMID: 32532964
Article Published Date : Jun 11, 2020
Study Type : In Vitro Study
Additional Links
Substances : Ginsenosides
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective, Transforming growth factor beta (TGF-β) inhibitor
[+]

These results provide that diosgenin may have potential to treat liver fibrosis.Dec 31, 2014

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Clin Exp Med. 2015 ;8(11):20323-9. Epub 2015 Nov 15. PMID: 26884947
Article Published Date : Dec 31, 2014
Study Type : In Vitro Study
Additional Links
Substances : Diosgenin
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

This article focuses on advances in the effects of curcumin and its derivatives for treatment of liver injury, non-alcoholic fatty liver disease, liver fibrosis and hepatocarcinoma.Oct 31, 2014

Pubmed Data : Yao Xue Xue Bao. 2014 Nov ;49(11):1483-90. PMID: 25757271
Article Published Date : Oct 31, 2014
Study Type : Review
Additional Links
Substances : Curcumin
Diseases : Liver Cancer, Liver Damage, Liver Diseases, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Chemopreventive, Hepatoprotective
[+]

This provided a new theoretical basis for curcumol to ameliorate liver fibrosis.Nov 03, 2020

Pubmed Data : Life Sci. 2020 Nov 4:118696. Epub 2020 Nov 4. PMID: 33157090
Article Published Date : Nov 03, 2020
Study Type : In Vitro Study
Additional Links
Substances : Curcumol
Diseases : Liver Fibrosis
Pharmacological Actions : Angiogenesis Inhibitors, Anti-Fibrotic
[+]

This review summarizes the hepatoprotective properties of G. lucidum.Apr 12, 2023

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2023 Apr 13 ;15(8). Epub 2023 Apr 13. PMID: 37111092
Article Published Date : Apr 12, 2023
Study Type : Review
Additional Links
Substances : Reishi Mushroom
Diseases : Liver Damage, Liver Fibrosis, Nonalcoholic fatty liver disease (NAFLD)
Pharmacological Actions : Anti-Fibrotic, Antiviral Agents, Hepatoprotective
[+]

This study confirmed the promising anti-inflammatory and anti-liver fibrosis actions of Rosanortriterpenes A-B.Dec 31, 2019

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2020 ;2020:8872945. Epub 2020 Nov 10. PMID: 33224259
Article Published Date : Dec 31, 2019
Study Type : In Vitro Study
Additional Links
Substances : Rose
Diseases : Inflammation, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Nitric Oxide Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor
[+]

Total glucosides of paeony inhibits liver fibrosis and inflammatory response.Dec 31, 2021

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2022 ;14(6):4321-4336. Epub 2022 Jun 15. PMID: 35836848
Article Published Date : Dec 31, 2021
Study Type : In Vitro Study
Additional Links
Substances : Peony
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Hepatoprotective
[+]

Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway.Apr 18, 2018

Pubmed Data : J Cell Physiol. 2018 Apr 19. Epub 2018 Apr 19. PMID: 29672850
Article Published Date : Apr 18, 2018
Study Type : In Vitro Study
Additional Links
Substances : Ursolic Acid
Diseases : Chemically-Induced Liver Damage, Liver Fibrosis
Pharmacological Actions : Anti-Fibrotic, Hepatoprotective
[+]

Xanthohumol, a compound derived from hops, inhibits hepatic inflammation and fibrosis.Jan 19, 2010

Pubmed Data : Mol Nutr Food Res. 2010 Jan 19. Epub 2010 Jan 19. PMID: 20087858
Article Published Date : Jan 19, 2010
Study Type : In Vitro Study
Additional Links
Substances : Hops
Diseases : Liver Fibrosis
Pharmacological Actions : Anti-Inflammatory Agents
[+]

Zinc supplementation attenuates alcohol and acetaldehyde-induced toxicity. Aug 01, 2009

Pubmed Data : Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17. PMID: 19376089
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Zinc
Diseases : Alcohol Toxicity , Alcoholic Liver Disease, Liver Cirrhosis: Alcoholic , Liver Fibrosis

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