Melasma

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16 Substances Researched for Melasma

Name	AC	CK
Pycnogenol (Pine Bark)	3	21
Silymarin	2	11
Ellagic Acid	1	10
Melatonin	1	10
Milk Thistle	1	10
Pine Bark Extract	1	10
Tomato	1	10
Vitamin C	1	10
Astragalus	1	1
Ginseng (Korean)	1	1
Grape Seed Extract	1	1
Niacinamide	1	1
Parsley	1	1
Resveratrol	1	1
Sesamol	1	1
Zinc	1	1

1 Therapeutic Actions Researched for Melasma

Name	AC	CK	Focus
Laser Treatment: Low-Level	1	10

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

View the Evidence:
12 Abstracts with Melasma Research

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A randomized, double-blind, split-face study of topical silymarin vs 2% hydroquinone cream in melasmas.Nov 30, 2022

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Pubmed Data : J Drugs Dermatol. 2022 Dec 1 ;21(12):1304-1310. PMID: 36468967

Article Published Date : Nov 30, 2022

Study Type : Human Study

Additional Links

Substances : Milk Thistle

Diseases : Melasma

Additional Keywords : Natural Substances Versus Drugs

[+]

Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma.Nov 30, 2021

Click here to read the entire abstract

Pubmed Data : Lasers Surg Med. 2021 Dec ;53(10):1341-1347. Epub 2021 Jun 8. PMID: 34101206

Article Published Date : Nov 30, 2021

Study Type : Human Study

Additional Links

Substances : Silymarin

Diseases : Melasma

Therapeutic Actions : Laser Treatment: Low-Level

[+]

Efficacy of microneedling with topical vitamin C in the treatment of melasma.Feb 14, 2019

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Pubmed Data : J Cosmet Dermatol. 2019 Feb 15. Epub 2019 Feb 15. PMID: 30770637

Article Published Date : Feb 14, 2019

Study Type : Human Study

Additional Links

Substances : Vitamin C

Diseases : Melasma

[+]

Ellagic acid significantly decreases the level of melanin in patients with melasma.Sep 01, 2008

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Pubmed Data : J Dermatol. 2008 Sep;35(9):570-4. PMID: 18837701

Article Published Date : Sep 01, 2008

Study Type : Human Study

Additional Links

Substances : Ellagic Acid

Diseases : Melasma

[+]

Melatonin and oxidative stress in melasma - an unexplored territory; a prospective study.Mar 04, 2020

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Pubmed Data : Int J Dermatol. 2020 Mar 5. Epub 2020 Mar 5. PMID: 32141063

Article Published Date : Mar 04, 2020

Study Type : Human Study

Additional Links

Substances : Melatonin

Diseases : Melasma, Oxidative Stress

Pharmacological Actions : Antioxidants

[+]

Pycnogenol is well-tolerated and increases the effectiveness of broad-spectrum sunscreen and the triple combination in the treatment of facial melasma in women.Aug 24, 2020

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Pubmed Data : J Eur Acad Dermatol Venereol. 2020 Aug 25. Epub 2020 Aug 25. PMID: 32841433

Article Published Date : Aug 24, 2020

Study Type : Human Study

Additional Links

Substances : Pycnogenol (Pine Bark)

Diseases : Melasma

[+]

Pycnogenol was judged safe and therapeutically effective in patients suffering from melasma. Sep 01, 2002

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Pubmed Data : Phytother Res. 2002 Sep;16(6):567-71. PMID: 12237816

Article Published Date : Sep 01, 2002

Study Type : Human Study

Additional Links

Substances : Pine Bark Extract, Pycnogenol (Pine Bark)

Diseases : Melasma

[+]

The effectiveness of tomato extract on superoxide dismutase (SOD) and severity degree of patients with melasma.May 31, 2022

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Pubmed Data : Ital J Dermatol Venerol. 2022 Jun ;157(3):262-269. PMID: 35707866

Article Published Date : May 31, 2022

Study Type : Human Study

Additional Links

Substances : Tomato

Diseases : Melasma

Pharmacological Actions : Antioxidants, Superoxide Dismutase Up-regulation

Additional Keywords : Plant Extracts

[+]

Astragalus contains a compound, calycosin, which inhibits melanin biosynthesis without apparent cytotoxicity. Sep 01, 2010

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Pubmed Data : Biotechnol J. 2010 Sep;5(9):961-9. PMID: 19182387

Article Published Date : Sep 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Astragalus

Diseases : Hyperpigmentation, Melasma

Additional Keywords : Skin-Lightening

[+]

Resveratrol as a multifunctional topical hypopigmenting agent.Feb 21, 2019

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2019 Feb 22 ;20(4). Epub 2019 Feb 22. PMID: 30813264

Article Published Date : Feb 21, 2019

Study Type : Review

Additional Links

Substances : Resveratrol

Diseases : Melasma

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Tyrosinase inhibitors

[+]

Sesamol represents a new skin-whitening agent for use in cosmetics.Sep 30, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Dermatol. 2015 Oct ;24(10):761-6. Epub 2015 Jul 14. PMID: 26010596

Article Published Date : Sep 30, 2015

Study Type : In Vitro Study

Additional Links

Substances : Sesamol

Diseases : Freckles, Melasma

Pharmacological Actions : Antioxidants

[+]

Treatment of melasma: a review of less commonly used antioxidants.Aug 19, 2020

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Pubmed Data : Int J Dermatol. 2020 Aug 20. Epub 2020 Aug 20. PMID: 32815582

Article Published Date : Aug 19, 2020

Study Type : Review

Additional Links

Substances : Ginseng (Korean), Grape Seed Extract, Niacinamide, Parsley, Pycnogenol (Pine Bark), Silymarin, Zinc

Diseases : Melasma

Pharmacological Actions : Antioxidants

Research Articles 12
Cumulative Knowledge Score 19
Overall Research Rating GOOD

Melasma Related Articles

Treating Dark Spots Naturally: Silymarin Cream Versus Hydroquinone

Written by GreenMedInfo Research Group

While topical hydroquinone cream is the standard treatment for melasma, silymarin, naturally derived from milk thistle, may offer a solution that is not only effective, but perfectly safe

Treating Dark Spots Naturally: Silymarin Cream Versus Hydroquinone

Written by GreenMedInfo Research Group

While topical hydroquinone cream is the standard treatment for melasma, silymarin, naturally derived from milk thistle, may offer a solution that is not only effective, but perfectly safe

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This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

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Focus Your Research

Click any topic below to filter + focus research

View the Evidence: 12 Abstracts with Melasma Research

Limited to Members Only

Currently Available Sorting Options

A randomized, double-blind, split-face study of topical silymarin vs 2% hydroquinone cream in melasmas.Nov 30, 2022

Efficacy and safety of topical silymarin versus low fluence 1064-nm Q switched Nd:YAG laser in the treatment of melasma.Nov 30, 2021

Efficacy of microneedling with topical vitamin C in the treatment of melasma.Feb 14, 2019

Ellagic acid significantly decreases the level of melanin in patients with melasma.Sep 01, 2008

Melatonin and oxidative stress in melasma - an unexplored territory; a prospective study.Mar 04, 2020

Pycnogenol is well-tolerated and increases the effectiveness of broad-spectrum sunscreen and the triple combination in the treatment of facial melasma in women.Aug 24, 2020

Pycnogenol was judged safe and therapeutically effective in patients suffering from melasma. Sep 01, 2002

The effectiveness of tomato extract on superoxide dismutase (SOD) and severity degree of patients with melasma.May 31, 2022

Astragalus contains a compound, calycosin, which inhibits melanin biosynthesis without apparent cytotoxicity. Sep 01, 2010

Resveratrol as a multifunctional topical hypopigmenting agent.Feb 21, 2019

Sesamol represents a new skin-whitening agent for use in cosmetics.Sep 30, 2015

Treatment of melasma: a review of less commonly used antioxidants.Aug 19, 2020

Melasma Related Articles

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Melasma

View the Evidence:
12 Abstracts with Melasma Research