Middle Cerebral Artery Occlusion (MCAO)

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View the Evidence: Ailments

Acorus calamus has a neuroprotective effect against middle cerebral artery occlusion-induced ischaemia in rat.

Pubmed Data : Hum Exp Toxicol. 2006 Apr;25(4):187-94. PMID: 16696294
Article Published Date : Apr 01, 2006
Study Type : Animal Study
Additional Links
Substances : Acorus calamus : CK(11) : AC(6)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Acupuncture attenuates neuronal cell death in middle cerebral artery occlusion model of focal ischemia.

Pubmed Data : Neurol Res. 2010 Feb;32 Suppl 1:84-7. PMID: 20034452
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Therapeutic Actions : Acupuncture : CK(1294) : AC(147)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Apigenin may play an important neuroprotective role in acute transient focal cerebral ischemia-reperfusion injury in rats.

Pubmed Data : Zhong Yao Cai. 2008 Jun;31(6):870-3. PMID: 18998572
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(76) : AC(51)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Astaxanthin has neuroprotective properties in an animal model of focal cerebral artery occlusion.

Pubmed Data : Brain Res. 2010 Nov 11;1360:40-8. Epub 2010 Sep 21. PMID: 20846510
Article Published Date : Nov 11, 2010
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke models

Pubmed Data : Neurosci Lett. 2008 Dec 5 ;447(1):31-6. Epub 2008 Sep 30. PMID: 18838103
Article Published Date : Dec 05, 2008
Study Type : Animal Study
Additional Links
Substances : Berberine : CK(156) : AC(75)
Diseases : Brain Ischemia : CK(94) : AC(38), Hypoxia : CK(100) : AC(41), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Ischemia Reperfusion Injury

Crocin, a constituent of Saffron, can significantly reduce infarcted areas caused by occlusion of the middle cerebral artery (MCA) in mice.

Pubmed Data : Biochim Biophys Acta. 2007 Apr;1770(4):578-84. Epub 2006 Dec 5. PMID: 17215084
Article Published Date : Apr 01, 2007
Study Type : Animal Study
Additional Links
Substances : Carotenoids : CK(1055) : AC(213), Crocin : CK(4) : AC(2), Saffron : CK(135) : AC(34)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Curcumin (from Turmeric) has a protective effect against Middle Cerebral Artery Occlusion (MCAO)

Pubmed Data : Neurochem Res. 2008 Jun;33(6):1036-43. Epub 2008 Jan 18. PMID: 18204970
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Brain Ischemia : CK(94) : AC(38), Cerebral Ischemia : CK(263) : AC(50), Cerebral Stroke : CK(46) : AC(7), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Stroke: Attenuation/Recovery : CK(105) : AC(21), Stroke: Prevention : CK(143) : AC(20)

Curcumin exhibits neuroprotective properties when given 4h post-ischemia in the rat thromboembolic stroke models.

Pubmed Data : Behav Brain Res. 2008 Nov 21;193(2):289-97. Epub 2008 Jun 19. PMID: 18611416
Article Published Date : Nov 21, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Brain Ischemia : CK(94) : AC(38), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Stroke : CK(540) : AC(47), Stroke: Attenuation/Recovery : CK(105) : AC(21), Thromboembolism : CK(205) : AC(19)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Curcumin has a neuroprotective effect in in middle cerebral artery occlusion induced focal cerebral ischemia in rats.

Pubmed Data : Life Sci. 2004 Jan 9;74(8):969-85. PMID: 14672754
Article Published Date : Jan 09, 2004
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Brain Ischemia : CK(94) : AC(38), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Curcumin has neuroprotective effect on transient focal cerebral ischemia in rats.

Pubmed Data : Brain Res. 2008 Sep 10;1229:224-32. Epub 2008 Jul 8. PMID: 18640105
Article Published Date : Sep 10, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Brain Ischemia : CK(94) : AC(38), Cerebral Ischemia: Transient : CK(12) : AC(6), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Curcumin improves outcomes and attenuates focal cerebral ischemic injury.

Pubmed Data : Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID: 19774461
Article Published Date : Mar 01, 2010
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Oxidative Stress : CK(1945) : AC(710), Stroke: Recovery : CK(68) : AC(9)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Curcumin protects rat brains against focal ischemia.

Pubmed Data : Brain Res. 2009 Jul 28;1282:133-41. Epub 2009 May 13. PMID: 19445907
Article Published Date : Jul 28, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Brain Ischemia : CK(94) : AC(38), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Neuroprotective Agents : CK(962) : AC(480)

Embelia ribes extract enhances the antioxidant defense against middle cerebral artery occlusion- induced focal cerebral ischemia in rats and exhibits neuroprotective activity.

Pubmed Data : Fundam Clin Pharmacol. 2008 Jun;22(3):305-14. PMID: 18485149
Article Published Date : Jun 01, 2008
Study Type : Animal Study
Additional Links
Substances : Embelia ribes : CK(16) : AC(8)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Glucosamine exerts a neuroprotective effect via suppression of inflammation in rat brain ischemia/reperfusion injury.

Pubmed Data : Glia. 2010 Nov 15 ;58(15):1881-92. PMID: 20737476
Article Published Date : Nov 15, 2010
Study Type : Animal Study
Additional Links
Substances : Glucosamine : CK(116) : AC(21)
Diseases : Brain: Microglial Activation : CK(67) : AC(38), Brain Inflammation : CK(79) : AC(35), Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208), Neuroprotective Agents : CK(962) : AC(480), NF-kappaB Inhibitor : CK(595) : AC(401)

Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.

Pubmed Data : Mol Cell Biochem. 2007 Feb;296(1-2):85-95. Epub 2006 Sep 8. PMID: 18438924
Article Published Date : Feb 01, 2007
Study Type : Animal Study
Additional Links
Substances : Huperzine : CK(44) : AC(24)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Mitochondrial Diseases : CK(149) : AC(50)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)

Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits.

Pubmed Data : Stroke. 2006 Oct;37(10):2620-4. Epub 2006 Aug 31. PMID: 16946145
Article Published Date : Oct 01, 2006
Study Type : Animal Study
Additional Links
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Stroke: Attenuation/Recovery : CK(105) : AC(21)
Therapeutic Actions : Laser Treatment : CK(48) : AC(9), Laser Treatment: Low-Level : CK(39) : AC(9)
Pharmacological Actions : Neurorestorative : CK(50) : AC(14)

Onion exhibits a neuroprotective effect on cerebral ischemia and injury.

Pubmed Data : Fitoterapia. 2008 Feb;79(2):86-96. Epub 2007 Aug 11. PMID: 17900821
Article Published Date : Feb 01, 2008
Study Type : Animal Study
Additional Links
Substances : Onion : CK(452) : AC(42)
Diseases : Brain Injury: Traumatic : CK(68) : AC(21), Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Resveratrol has a neuroprotective effect on ischemic injury mediated by improving brain energy metabolism and alleviating oxidative stress in rats.

Pubmed Data : Neuropharmacology. 2011 Feb-Mar;60(2-3):252-8. Epub 2010 Sep 22. PMID: 20868700
Article Published Date : Feb 01, 2011
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Brain Ischemia : CK(94) : AC(38), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480), Xanthine oxidase inhibitor : CK(25) : AC(11)

Resveratrol has neuroprotective effect on ischemic injury.

Pubmed Data : Neurochem Int. 2010 Feb;56(3):495-500. Epub 2009 Dec 21. PMID: 20026214
Article Published Date : Feb 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Brain Ischemia : CK(94) : AC(38), Excitotoxicity : CK(56) : AC(33), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Resveratrol may attenuate ischemia.

Pubmed Data : Neuroscience. 2010 Mar 17;166(2):445-54. Epub 2009 Dec 28. PMID: 20040366
Article Published Date : Mar 17, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590), Stilbenes : CK(128) : AC(92)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Heat Shock Protein Inducer : CK(51) : AC(17), Neuroprotective Agents : CK(962) : AC(480)

Resveratrol protects against experimental stroke.

Pubmed Data : Exp Neurol. 2010 Jul;224(1):325-9. Epub 2010 Apr 8. PMID: 20381489
Article Published Date : Jul 01, 2010
Study Type : Animal Study
Additional Links
Substances : Resveratrol : CK(977) : AC(590)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Stroke: Prevention : CK(143) : AC(20)
Pharmacological Actions : Neuroprotective Agents : CK(962) : AC(480)
Additional Keywords : Stilbenes : CK(402) : AC(242)

Rutin protects the neural damage induced by transient focal ischemia in rats.

Pubmed Data : Brain Res. 2009 Oct 6;1292:123-35. Epub 2009 Jul 22. PMID: 19631195
Article Published Date : Oct 06, 2009
Study Type : Animal Study
Additional Links
Substances : Rutin : CK(93) : AC(30)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Neuroprotective Agents : CK(962) : AC(480), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)

Saffron has a neuroprotective effect in the middle cerebral artery (MCA) occlusion (MCAO) model of acute cerebral ischemia in rats.

Pubmed Data : J Med Food. 2006;9(2):246-53. PMID: 16822211
Article Published Date : Jan 01, 2006
Study Type : Animal Study
Additional Links
Substances : Saffron : CK(135) : AC(34)
Diseases : Cerebral Ischemia : CK(263) : AC(50), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.

Pubmed Data : Chem Biol Interact. 2010 Jan 5;183(1):255-63. PMID: 19835851
Article Published Date : Jan 05, 2010
Study Type : Animal Study
Additional Links
Substances : Lignans : CK(110) : AC(31)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Turmeric oil has a neuroprotective property in transient focal ischemia in rat brain.

Pubmed Data : Neurochem Res. 2008 Sep;33(9):1672-82. Epub 2007 Oct 23. PMID: 17955367
Article Published Date : Sep 01, 2008
Study Type : Animal Study
Additional Links
Substances : Turmeric : CK(2995) : AC(1585)
Diseases : Cerebral Ischemia: Transient : CK(12) : AC(6), Middle Cerebral Artery Occlusion (MCAO) : CK(592) : AC(24), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Apoptotic : CK(1489) : AC(1114), Neuroprotective Agents : CK(962) : AC(480)

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