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Multiple Myeloma

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Article Count - 53
Cumulative Knowledge - 167

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Quick Summary: Current access displays 2 out of 30 associated Substances

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View the Evidence: Ailments

An oral enzyme preparation used as an additive therapy in patients with multiple myeloma significantly prolongs survival time.

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Pubmed Data : Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S38-44. PMID: 11561871

Article Published Date : Jul 01, 2001

Study Type : Human Study

Additional Links

Substances : Enzyme Therapy : CK(298) : AC(64)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Antibodies contained in"M"component of some patients with multiple myeloma may be directed to food antigens such as gliadin.

Click here to read the entire abstract

Pubmed Data : Leuk Res. 2006 Dec ;30(12):1585-6. Epub 2006 Mar 6. PMID: 16516966

Article Published Date : Dec 01, 2006

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53)

Problem Substances : Gliadin : CK(2509) : AC(110)

Crude oil exposure has been linked to acute myelogenous leukemia and multiple myeloma, in part due to benzene.

Click here to read the entire abstract

Pubmed Data : Cancer Causes Control. 2008 Feb;19(1):13-23. Epub 2007 Sep 29. PMID: 17906934

Article Published Date : Feb 01, 2008

Study Type : Human Study

Additional Links

Diseases : Leukemia: Acute myelogenous leukemia (AML) : CK(96) : AC(28), Multiple Myeloma : CK(156) : AC(53)

Problem Substances : Benzene : CK(130) : AC(22), Crude Oil/Petroleum : CK(273) : AC(34)

Curcumin has therapeutic value in patients with monoclonal gammopathy, a possible precursor to multiple myeloma.

Click here to read the entire abstract

Pubmed Data : Clin Cancer Res. 2009 Sep 15;15(18):5917-22. Epub 2009 Sep 8. PMID: 19737963

Article Published Date : Sep 15, 2009

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Monoclonal Gammopathies : CK(10) : AC(1), Multiple Myeloma : CK(156) : AC(53)

Curcumin might have the potential to slow the disease process in patients with Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM)

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Pubmed Data : Am J Hematol. 2012 May ;87(5):455-60. Epub 2012 Apr 4. PMID: 22473809

Article Published Date : Apr 30, 2012

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Gammopathy: Monoclonal : CK(10) : AC(1), Multiple Myeloma : CK(156) : AC(53), Smoldering multiple myeloma (SMM) : CK(10) : AC(1)

High dose simvastatin may be harmful for patients with multiple myeloma.

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Pubmed Data : Hematol Oncol. 2009 Mar;27(1):17-22. PMID: 18668701

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53)

Problem Substances : Simvastatin : CK(713) : AC(143)

In men,≥1 daily serving of diet soda increased risks of NHL and multiple myleoma.

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Pubmed Data : Am J Clin Nutr. 2012 Oct 24. Epub 2012 Oct 24. PMID: 23097267

Article Published Date : Oct 23, 2012

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53), Non-Hodgkin Lymphoma : CK(525) : AC(67)

Problem Substances : Aspartame : CK(103) : AC(30)

Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Multiple myeloma incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study appears to be higher.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2005 Jan ;113(1):49-54. PMID: 15626647

Article Published Date : Jan 01, 2005

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53)

Problem Substances : Glyphosate : CK(365) : AC(116)

Multiple myeloma patients exhibit humoral immunoreactivity to gliadin and to tissue transglutaminase, not unlike those with celiac disease.

Click here to read the entire abstract

Pubmed Data : BMC Immunol. 2008;9:22. Epub 2008 May 28. PMID: 18507842

Article Published Date : Jan 01, 2008

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53), Wheat Intolerance : CK(2480) : AC(231)

Problem Substances : Gliadin : CK(2509) : AC(110), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Ozone therapy may have a therapeutic role to play in bisphosphonate-associated osteonecrosis of the jaw in multiple myeloma patients.

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Pubmed Data : Haematologica. 2007 Sep;92(9):1289-90. PMID: 17768133

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Diseases : Multiple Myeloma : CK(156) : AC(53), Osteonecrosis : CK(112) : AC(16)

Therapeutic Actions : Ozone Therapy : CK(42) : AC(6)

Patients with multiple myeloma have immunoreactivity to gliadin similar to those with celiac disease.

Click here to read the entire abstract

Pubmed Data : BMC Immunol. 2009;10:32. Epub 2009 May 31. PMID: 19480718

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Celiac Disease : CK(1527) : AC(215), Multiple Myeloma : CK(156) : AC(53), Wheat Intolerance : CK(2480) : AC(231)

Additional Keywords : Differences in Immunoreactivity Within Different Wheat Cultivars : CK(11) : AC(2), Diseases that are Linked : CK(2122) : AC(270)

Problem Substances : Gliadin : CK(2509) : AC(110), Wheat : CK(2542) : AC(309)

Adverse Pharmacological Actions : Immunoreactive : CK(127) : AC(17)

Zoledronic acid may cause renal toxicity in 37.7% of patients with multiple myeloma.

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Pubmed Data : J Cancer Res Ther. 2010 Jan-Mar;6(1):31-5. PMID: 20479544

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Kidney Damage : CK(120) : AC(42), Multiple Myeloma : CK(156) : AC(53)

Problem Substances : Zoledronic Acid : CK(69) : AC(13)

Agaricus blazei inhibits myeloma in vivo.

Click here to read the entire abstract

Pubmed Data : J Oleo Sci. 2007;56(4):179-88. PMID: 17898480

Article Published Date : Jan 01, 2007

Study Type : Animal Study

Additional Links

Substances : Agaricus Blazei : CK(52) : AC(12)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Curcumin (from turmeric) circumvents chemoresistance and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in mice.

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Pubmed Data : Mol Cancer Ther. 2009 Apr;8(4):959-70. PMID: 19372569

Article Published Date : Apr 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268), Multi-Drug Resistant Cancers : CK(6) : AC(5)

Isothiocyanates exhibit anti-myeloma activity.

Click here to read the entire abstract

Pubmed Data : Haematologica. 2011 Aug ;96(8):1170-9. Epub 2011 Jun 28. PMID: 21712538

Article Published Date : Aug 01, 2011

Study Type : Transgenic Animal Study

Additional Links

Substances : Isothiocyanate : CK(2) : AC(1), Sulforaphane : CK(520) : AC(171)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

"Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways."

Click here to read the entire abstract

Pubmed Data : Oncol Rep. 2012 Nov ;28(5):1851-8. Epub 2012 Aug 22. PMID: 22922937

Article Published Date : Oct 31, 2012

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane : CK(520) : AC(171)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Chemosensitizer : CK(197) : AC(159)

"The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma."

Click here to read the entire abstract

Pubmed Data : Leuk Lymphoma. 2011 Jun ;52(6):1085-97. Epub 2011 Mar 21. PMID: 21417826

Article Published Date : Jun 01, 2011

Study Type : In Vitro Study

Additional Links

Substances : Andrographis : CK(81) : AC(35), Feverfew : CK(41) : AC(21)

Diseases : Cancer Stem Cells : CK(988) : AC(42), Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)

Additional Keywords : Cancer Stem Cells : CK(30) : AC(24), Plant Extracts : CK(3572) : AC(1216)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

A compound found within the Toxicodendron vernicifluum called butein significantly potentiates the therapeutic effects of chemotherapy in multiple melanoma cells.

Click here to read the entire abstract

Pubmed Data : Mol Pharmacol. 2009 Mar;75(3):525-33. Epub 2008 Dec 22. PMID: 19103760

Article Published Date : Mar 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Lacquer Tree : CK(12) : AC(3)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Baicalein, a compound found within Skullcap, suppresses proliferation and induces programmed cell death in human myeloma cells.

Click here to read the entire abstract

Pubmed Data : Blood. 2005 Apr 15;105(8):3312-8. Epub 2004 Dec 30. PMID: 15626742

Article Published Date : Apr 15, 2005

Study Type : In Vitro Study

Additional Links

Substances : Chinese Skullcap : CK(97) : AC(57)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Beta-lapachone, a compound found within the Tabebuia tree, may have a therapeutic role in the treatment of multiple myeloma. - Article 1.

Click here to read the entire abstract

Pubmed Data : Exp Hematol. 2002 Jul;30(7):711-20. PMID: 12135668

Article Published Date : Jul 01, 2002

Study Type : In Vitro Study

Additional Links

Substances : Tabebuia : CK(10) : AC(9)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Beta-lapachone, a compound found within the Tabebuia tree, may have a therapeutic role in the treatment of multiple myeloma. - Article 2.

Click here to read the entire abstract

Pubmed Data : Mol Med. 2000 Dec;6(12):1008-15. PMID: 11474117

Article Published Date : Dec 01, 2000

Study Type : In Vitro Study

Additional Links

Substances : Tabebuia : CK(10) : AC(9)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Boswellic acid inhibits gene products in multiple myeloma cells involved in proliferation, survival and angiogenesis.

Click here to read the entire abstract

Pubmed Data : Mol Cancer Res. 2009 Jan;7(1):118-28. PMID: 19147543

Article Published Date : Jan 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Boswellia : CK(122) : AC(31)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Chinese skullcap induces cell death in Acute Lymphocytic Leukemia, Lymphoma and Myeloma cell lines.

Click here to read the entire abstract

Pubmed Data : Leuk Res. 2007 Apr;31(4):523-30. Epub 2006 Sep 26. PMID: 17007926

Article Published Date : Apr 01, 2007

Study Type : In Vitro Study

Additional Links

Substances : Chinese Skullcap : CK(97) : AC(57)

Diseases : Acute lymphoblastic leukemia (ALL) : CK(96) : AC(29), Lymphoma : CK(209) : AC(69), Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Apoptotic : CK(1489) : AC(1114)

Curcumin acts synergistically with the chemotherapeutic agent bortexomib in treating multiple myeloma cells.

Click here to read the entire abstract

Pubmed Data : Mol Oncol. 2008 Dec;2(4):317-26. Epub 2008 Oct 7. PMID: 19383353

Article Published Date : Dec 01, 2008

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Curcumin has an inhibitory effect on angiogenesis induced by brain derived neurotrophic factor from multiple myeloma cells.

Click here to read the entire abstract

Pubmed Data : Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Feb;14(1):70-4. PMID: 16584595

Article Published Date : Feb 01, 2006

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : Multiple Myeloma : CK(156) : AC(53)

Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Antineoplastic Agents : CK(877) : AC(496)

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