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Muscular Diseases
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Article Count
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View the Evidence: Ailments
Muscle complaints occur in 10% or more of patients started on high-dose statins.
Click here to read the entire abstract
Pubmed Data
: Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID:
17620856
Article Published Date
: Aug 01, 2007
Study Type
: Meta Analysis
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Creatine supplements combined with home exercises improve functional performance without significant adverse effects in patients with polymyositis or dermatomyositis.
Click here to read the entire abstract
Pubmed Data
: Arthritis Rheum. 2007 May 15;57(4):694-702. PMID:
17471547
Article Published Date
: May 15, 2007
Study Type
: Human Study
Additional Links
Substances
:
Creatine : CK(134) : AC(24)
Diseases
:
Dermatomyositis : CK(44) : AC(10)
,
Myopathies : CK(252) : AC(51)
,
Polymyositis : CK(63) : AC(8)
Therapeutic Actions
:
Exercise : CK(482) : AC(69)
Exposure to atorvastatin is associated with lactone and acid metabolites that are increased several-fold in patients with atorvastatin-induced myopathy.
Click here to read the entire abstract
Pubmed Data
: Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID:
16765141
Article Published Date
: Jun 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Myopathy associated with gluten sensitivity has been demonstrated.
Click here to read the entire abstract
Pubmed Data
: Muscle Nerve. 2007 Apr;35(4):443-50. PMID:
17143894
Article Published Date
: Apr 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Celiac Disease : CK(1527) : AC(215)
,
Gluten Sensitivity : CK(2477) : AC(270)
,
Myopathies : CK(252) : AC(51)
,
Wheat Intolerance : CK(2480) : AC(231)
Problem Substances
:
Gluten : CK(1755) : AC(144)
Myopathy prevalence is underestimated; in an outpatient cardiology clinic prevalence was found to be 33%.
Click here to read the entire abstract
Pubmed Data
: Curr Med Res Opin. 2012 Jun 11. Epub 2012 Jun 11. PMID:
22686958
Article Published Date
: Jun 11, 2012
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Osteomalacic myopathy may be the only presenting feature of celiac disease.
Click here to read the entire abstract
Pubmed Data
: Eur J Gastroenterol Hepatol. 2002 Nov;14(11):1271-4. PMID:
12439125
Article Published Date
: Nov 01, 2002
Study Type
: Human Study
Additional Links
Diseases
:
Celiac Disease : CK(1527) : AC(215)
,
Myopathies : CK(252) : AC(51)
,
Osteomalacia : CK(37) : AC(5)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
Simvastatin side effects are far higher than reported in clinical trials.
Click here to read the entire abstract
Pubmed Data
: N Z Med J. 1991 Nov 27 ;104(924):493-5. PMID:
1745460
Article Published Date
: Nov 27, 1991
Study Type
: Human Study
Additional Links
Diseases
:
Gastrointestinal Complaints : CK(21) : AC(3)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Statin drugs have been linked to myopathy, including rhabdomyolysis.
Click here to read the entire abstract
Pubmed Data
: Arch Intern Med. 2005 Dec 12-26;165(22):2671-6. PMID:
16344427
Article Published Date
: Dec 12, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Rhabdomyolysis : CK(165) : AC(38)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin drugs induce ultrastructural damage in skeletal muscle in patients without myalgia.
Click here to read the entire abstract
Pubmed Data
: J Pathol. 2006 Sep ;210(1):94-102. PMID:
16799920
Article Published Date
: Sep 01, 2006
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Pravastatin : CK(239) : AC(40)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin drugs lead to changes in statin sterol metabolism and aggressive statin treatment may adversely effect mitochondrial volume.
Click here to read the entire abstract
Pubmed Data
: Clin Pharmacol Ther. 2005 Jul;78(1):60-8. PMID:
16003294
Article Published Date
: Jul 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Mitochondrial Dysfunction : CK(149) : AC(51)
,
Mitochondrial Myopathies : CK(46) : AC(9)
,
Myopathies : CK(252) : AC(51)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage.
Click here to read the entire abstract
Pubmed Data
: J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID:
8463436
Article Published Date
: Mar 01, 1993
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
High Cholesterol : CK(1718) : AC(198)
,
Myopathies : CK(252) : AC(51)
Additional Keywords
:
Drug-Nutrient Depletion : CK(64) : AC(7)
,
Statin-Coq10 Depletion : CK(36) : AC(5)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
,
Pravastatin : CK(239) : AC(40)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Cytotoxic : CK(73) : AC(35)
Statin drugs, particularly simivastatin, increase the risk for significant creatine kinase elevation.
Click here to read the entire abstract
Pubmed Data
: Am J Cardiovasc Drugs. 2010 ;10(3):187-92. PMID:
20524720
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Creatine Phosphokinase (CK): Elevated : CK(75) : AC(9)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-associated myopathy is underestimated and occurs in 5-10% of patients who receive them.
Click here to read the entire abstract
Pubmed Data
: Int J Cardiol. 2011 Aug 1. Epub 2011 Aug 1. PMID:
21813193
Article Published Date
: Aug 01, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-induced muscle toxicity may be associated with altered oxidation of fatty acids.
Click here to read the entire abstract
Pubmed Data
: Endocrine. 2009 Feb;35(1):38-46. Epub 2008 Dec 3. PMID:
19051066
Article Published Date
: Feb 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-induced myopathic weakness causing disability is an underappreciated side effect.
Click here to read the entire abstract
Pubmed Data
: Neurorehabil Neural Repair. 2005 Sep ;19(3):259-63. PMID:
16093417
Article Published Date
: Sep 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statins appear to cause muscle damage and impair oxidative metabolism.
Click here to read the entire abstract
Pubmed Data
: J Submicrosc Cytol Pathol. 2004 Jan ;36(1):85-9. PMID:
15311678
Article Published Date
: Jan 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Mitochondrial Dysfunction : CK(149) : AC(51)
,
Mitochondrial Myopathies : CK(46) : AC(9)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statins increase exercise-related muscle injury, which worsens with the age of the individual.
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2011 Oct 27. Epub 2011 Oct 27. PMID:
22036108
Article Published Date
: Oct 27, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Muscle Damage: Exercise-Induced : CK(71) : AC(12)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statins up-regulate the expression of HMGCR, the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy .
Click here to read the entire abstract
Pubmed Data
: Arthritis Rheum. 2011 Mar ;63(3):713-21. PMID:
21360500
Article Published Date
: Mar 01, 2011
Study Type
: Human Study
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Unintended consequences of statin drug use are increased risk of esophageal cancer, kidney failure, cataract, liver dysfunction and myopathies.
Click here to read the entire abstract
Pubmed Data
: BMJ. 2010;340:c2197. Epub 2010 May 20. PMID:
20488911
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Cardiovascular Diseases : CK(5138) : AC(641)
,
Cataract : CK(182) : AC(55)
,
Chemically-Induced Liver Damage : CK(475) : AC(175)
,
Esophageal Cancer : CK(328) : AC(55)
,
Kidney Failure : CK(668) : AC(41)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Fluvastatin : CK(75) : AC(15)
,
Pravastatin : CK(239) : AC(40)
,
Rosuvastatin : CK(68) : AC(16)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Neuroleptic malignant syndrome as a possible statin drug reaction has been reported.
Click here to read the entire abstract
Pubmed Data
: Clin Neuropharmacol. 2009 Nov-Dec;32(6):348-9. PMID:
19952877
Article Published Date
: Nov 01, 2009
Study Type
: Human: Case Report
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Neuroleptic Malignant Syndrome : CK(3) : AC(1)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anti-Bacterial Agents : CK(970) : AC(316)
,
Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Pravastatin-associated myopathy has been reported.
Click here to read the entire abstract
Pubmed Data
: Recenti Prog Med. 1995 May ;86(5):198-200. PMID:
7604176
Article Published Date
: May 01, 1995
Study Type
: Human: Case Report
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Pravastatin : CK(239) : AC(40)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin therapy may result in progressive myopathy with up-regulation of MHC-I associated with an endoplasmic reticulum stress response.
Click here to read the entire abstract
Pubmed Data
: Neuromuscul Disord. 2007 Feb ;17(2):194-200. Epub 2007 Jan 22. PMID:
17241784
Article Published Date
: Feb 01, 2007
Study Type
: Human: Case Report
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Skeletal Muscle: Changes to MHC I expression : CK(4) : AC(2)
,
Skeletal Muscle Changes: Endoplasmic Reticulum Stress : CK(3) : AC(1)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions
:
Anti-Inflammatory Agents : CK(1230) : AC(433)
Problem Substances
:
Atorvastatin : CK(491) : AC(90)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin treatment may contribute to presymptomatic neuromuscular disorders.
Click here to read the entire abstract
Pubmed Data
: Arch Intern Med. 2006 Jul 24 ;166(14):1519-24. PMID:
16864763
Article Published Date
: Jul 24, 2006
Study Type
: Human: Case Report
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Neuromuscular Diseases : CK(16) : AC(4)
,
Presymptomatic Metabolic Myopathy : CK(3) : AC(1)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin use may be contraindicated in hypothyroidism.
Click here to read the entire abstract
Article Publish Status
: This is a free article.
Click here to read the complete article.
Pubmed Data
: Can Fam Physician. 2007 Mar ;53(3):428-31. PMID:
17872677
Article Published Date
: Mar 01, 2007
Study Type
: Human: Case Report
Additional Links
Diseases
:
Hyperlipidemia : CK(1211) : AC(109)
,
Hypothyroidism : CK(537) : AC(78)
,
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Myotoxicity : CK(317) : AC(79)
Statin-associated myopathy with normal creatine kinase levels has been reported.
Click here to read the entire abstract
Pubmed Data
: APMIS. 2005 Sep ;113(9):635-7. PMID:
16218940
Article Published Date
: Sep 01, 2005
Study Type
: Human: Case Report
Additional Links
Diseases
:
Myopathies : CK(252) : AC(51)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
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