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Article Count - 15
Cumulative Knowledge - 41

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Quick Summary: Current access displays 2 out of 3 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Soy	2	1	Log in \| Sign up
Soy Sauce	2	1	Log in \| Sign up

Quick Summary: Current access displays 2 out of 7 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Statin Drugs	13	4	Log in \| Sign up
Lovastatin	10	6	Log in \| Sign up

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View the Evidence: Ailments

Statin drugs have been linked to neurotoxicity.

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Pubmed Data : Neth J Med. 2006 Oct ;64(9):334-8. PMID: 17057271

Article Published Date : Oct 01, 2006

Study Type : Human Study

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Neurotoxicity : CK(37) : AC(15), Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin exhibits toxicity in human fetal brain cells.

Click here to read the entire abstract

Pubmed Data : Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9. PMID: 7708017

Article Published Date : Jan 01, 1995

Study Type : Human In Vitro

Additional Links

Diseases : Abortion: Spontaneous : CK(204) : AC(29), Birth Defects : CK(196) : AC(37), Neurotoxicity : CK(37) : AC(15), Prenatal Chemical Exposures : CK(322) : AC(86)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179), Teratogenic : CK(304) : AC(59)

Glyphosate-induced parkinsonism has been reported.

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Pubmed Data : Mov Disord. 2001 May ;16(3):565-8. PMID: 11391760

Article Published Date : May 01, 2001

Study Type : Human: Case Report

Additional Links

Diseases : Dopamine Levels: Low : CK(4) : AC(1), Glyphosate Toxicity : CK(22) : AC(12), Neurotoxicity : CK(37) : AC(15), Parkinsonian Disorders : CK(15) : AC(4), Substantia Nigra: Damage : CK(3) : AC(1)

Problem Substances : Glyphosate : CK(368) : AC(118)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

"Neurotoxicity of engineered nanoparticles from metals."

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Pubmed Data : CNS Neurol Disord Drug Targets. 2012 Feb ;11(1):65-80. PMID: 22229317

Article Published Date : Jan 31, 2012

Study Type : Animal Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15)

Anti Therapeutic Actions : Nanotechnology : CK(67) : AC(28)

Problem Substances : Nanoparticles : CK(24) : AC(13)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Dark soy sauce has a protective effect against acrylamide-induced neurotoxicity in rats by antioxidative activity.

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Pubmed Data : Toxicol Mech Methods. 2009 Jun;19(5):369-74. PMID: 19778214

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Soy : CK(1688) : AC(350), Soy Sauce : CK(18) : AC(6)

Diseases : Neurotoxicity : CK(37) : AC(15)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Neuroprotective Agents : CK(962) : AC(480)

Glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans.

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Pubmed Data : Neurotoxicology. 2011 Jun ;32(3):331-41. Epub 2011 Mar 3. PMID: 21376751

Article Published Date : Jun 01, 2011

Study Type : Animal Study

Additional Links

Diseases : Neurodegenerative Diseases : CK(1743) : AC(420), Neurotoxicity : CK(37) : AC(15)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Toluene exposure may result in acute neurobehavioral effects.

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Pubmed Data : Toxicology. 2009 Nov 9;265(1-2):34-40. Epub 2009 Sep 16. PMID: 19765629

Article Published Date : Nov 09, 2009

Study Type : Animal Study

Additional Links

Diseases : Aromatic Hydrocarbon Toxicity : CK(8) : AC(4), Neurotoxicity : CK(37) : AC(15), Petroleum Exposure And Toxicity : CK(49) : AC(18)

Problem Substances : Toluene : CK(20) : AC(6)

Treatment with sodium benzoate leads to neurotoxicity and malformation of zebrafish larvae.

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Pubmed Data : Neurotoxicol Teratol. 2007 Sep-Oct;29(5):562-9. Epub 2007 Jun 5. PMID: 17644306

Article Published Date : Sep 01, 2007

Study Type : Animal Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15)

Problem Substances : Sodium Benzoate : CK(202) : AC(16)

"Effect of pesticides on cell survival in liver and brain rat tissues."

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Pubmed Data : Ecotoxicol Environ Saf. 2009 Oct ;72(7):2025-32. Epub 2009 Jun 2. PMID: 19493570

Article Published Date : Oct 01, 2009

Study Type : In Vitro Study

Additional Links

Diseases : Chemically-Induced Liver Damage : CK(475) : AC(175), Glyphosate Toxicity : CK(22) : AC(12), Lipid Peroxidation : CK(403) : AC(127), Neurotoxicity : CK(37) : AC(15), Parkinson Disease : CK(543) : AC(79), Pesticide Toxicity : CK(147) : AC(45)

Problem Substances : Dimethoate : CK(3) : AC(1), Glyphosate : CK(365) : AC(116), Pesticides : CK(699) : AC(70), Zineb : CK(1) : AC(1)

Adverse Pharmacological Actions : Apoptotic : CK(8) : AC(7), Hepatotoxic : CK(283) : AC(80), Neurotoxic : CK(1076) : AC(179), Oxidant : CK(104) : AC(37)

Astaxanthin inhibits oxidative stress and cell death in mouse neural progenitor cells.

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Pubmed Data : J Microbiol Biotechnol. 2009 Nov;19(11):1355-63. PMID: 19996687

Article Published Date : Nov 01, 2009

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Neurotoxicity : CK(37) : AC(15)

Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Enzyme Inhibitors : CK(372) : AC(208), Neuroprotective Agents : CK(962) : AC(480), P38 Mitogen-Activated Protein Kinase Modulator : CK(6) : AC(5)

Common use of lupin proteins in processed foods despite potential toxicity to mammals

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Pubmed Data : Mol Nutr Food Res. 2008 Apr ;52(4):490-5. PMID: 18324702

Article Published Date : Mar 31, 2008

Study Type : Review

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Seizures : CK(122) : AC(28)

Additional Keywords : Food safety, Food toxins, Lupine, Protein replacer, Quinolizidine alkaloids

Problem Substances : Lupine : CK(7) : AC(3)

Exposure to glyphosate- and/or Mn/Zn-ethylene-bis-dithiocarbamate-containing pesticides leads to degeneration ofγ-aminobutyric acid and dopamine neurons in Caenorhabditis elegans.

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Pubmed Data : Neurotox Res. 2012 Apr ;21(3):281-90. Epub 2011 Sep 16. PMID: 21922334

Article Published Date : Apr 01, 2012

Study Type : In Vitro Study

Additional Links

Diseases : Dopamine Levels: Low : CK(4) : AC(1), Glyphosate Toxicity : CK(22) : AC(12), Neurodegenerative Diseases : CK(1743) : AC(420), Neurotoxicity : CK(37) : AC(15), Parkinson Disease : CK(543) : AC(79), Parkinsonian Disorders : CK(15) : AC(4), Substantia Nigra: Damage : CK(3) : AC(1)

Problem Substances : Glyphosate : CK(365) : AC(116)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin exhibits neurotoxic properties.

Click here to read the entire abstract

Pubmed Data : J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443

Article Published Date : Oct 01, 1995

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin induces neuronal cell death through interacting with signal transduction pathways that cell control growth and survival.

Click here to read the entire abstract

Pubmed Data : Mol Cell Neurosci. 2001 Feb ;17(2):329-41. PMID: 11178870

Article Published Date : Feb 01, 2001

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin induces neuronal cell death.

Click here to read the entire abstract

Pubmed Data : J Neurochem. 1999 Jun ;72(6):2278-85. PMID: 10349836

Article Published Date : Jun 01, 1999

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in neurons.

Click here to read the entire abstract

Pubmed Data : Neurobiol Aging. 2010 Sep ;31(9):1543-53. Epub 2008 Oct 31. PMID: 18951667

Article Published Date : Sep 01, 2010

Study Type : In Vitro Study

Additional Links

Diseases : Aging : CK(1351) : AC(369), Cognitive Decline/Dysfunction : CK(522) : AC(87), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Apoptotic : CK(1535) : AC(1155)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Mevastatin exhibits potential neurotoxicity.

Click here to read the entire abstract

Pubmed Data : J Neurosci Res. 2002 Jun 1 ;68(5):627-35. PMID: 12111853

Article Published Date : Jun 01, 2002

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Proteasome Inhibitors : CK(41) : AC(27)

Problem Substances : Mevastatin : CK(1) : AC(1)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxic properties.

Click here to read the entire abstract

Pubmed Data : Brain Res. 2000 Mar 17 ;859(1):169-72. PMID: 10720627

Article Published Date : Mar 17, 2000

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxicity in a neuronal cell model.

Click here to read the entire abstract

Pubmed Data : Neurosci Lett. 1996 Dec 6 ;220(1):21-4. PMID: 8977139

Article Published Date : Dec 06, 1996

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Antiproliferative : CK(1058) : AC(775), Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statins have been associated with arrest of DNA synthesis and proliferation in glial cells.

Click here to read the entire abstract

Pubmed Data : J Neurochem. 1986 Apr ;46(4):1283-91. PMID: 3633306

Article Published Date : Apr 01, 1986

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statins have been associated with cell death in primary neuronal culture.

Click here to read the entire abstract

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865

Article Published Date : Jan 01, 2007

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

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