Nonalcoholic fatty liver disease (NAFLD)

Name	AC	CK
Vitamin E	3	40
Silymarin	4	24
Coffee	2	21
Tea: Black	1	20
Tea: Green	1	20
Curcumin	6	16
Anthocyanins	3	13
Bilberry	2	12
Black Currant	2	12
Licorice	2	12
Spirulina	2	12
Resveratrol	2	11
Artichoke	1	10
Barberry	1	10
Carotenoids	1	10
Chlorella (Algae)	1	10
Coenzyme Q10	1	10
Garlic	1	10
Hibiscus sabdariffa	1	10
Orange	1	10
Polyunsaturated Fatty Acids (PUFAs)	1	10
Pomegranate	1	10
Vitamin C	1	10
Vitamin D	1	10
Berberine	4	8
Avocado	2	3
Chokeberry	2	3
Astaxanthin	1	2
Banaba	1	2
Bisdemethoxycurcumin	1	2
Broccoli	1	2
Camel Milk	1	2
Cannabidiol	1	2
Cannabinoids	1	2
Carnosic Acid	1	2
Eucalyptus	1	2
Fermented Foods and Beverages	1	2
Fructose	1	2
Ginkgo biloba	1	2
Hawthorn	1	2
Krill	1	2
Lactobacillus casei: Shirota	1	2
Lycopene	1	2
Pomegranate Peel	1	2
Pycnogenol (Pine Bark)	1	2
Raspberry ketone	1	2
Seaweed: Brown	1	2
Thymoquinone	1	2
Turmeric	1	2
Ursolic Acid	1	2
Xanthohumol	1	2
Black Tea	1	1
Blackberry	1	1
Blueberry	1	1
Fish	1	1
Fish Oil	1	1
Flavonoids	1	1
Green Tea	1	1
Nuts	1	1
Olive Oil	1	1
Omega-3 Fatty Acids	1	1
Polyphenols	1	1
Probiotics	1	1
Punicalagin	1	1
Red Wine Extract	1	1
Strawberry	1	1
Thistle	1	1
Walnut	1	1

Name	AC	CK
Fructose	15	31
High Fructose Corn Syrup	4	5
Trans Fatty Acids	2	3
Monosodium Glutamate (MSG)	1	2
Retinyl palmitate	1	1
Sugary soda	1	1

Name	AC	CK
Exercise	3	40
Dietary Modification: Low Glycemic Diet	1	1
Dietary Modification: Mediterranean Diet	1	1
Dietary Modification: Wheat/Gluten Free	1	1

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Pubmed Data : J Am Coll Nutr. 2015 Jul 9:1-8. Epub 2015 Jul 9. PMID: 26156412

Article Published Date : Jul 08, 2015

Study Type : Human Study

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Substances : Coenzyme Q10

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents

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Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

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Pubmed Data : Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396

Article Published Date : May 31, 2016

Study Type : Human Study

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Substances : Flaxseed

Diseases : Insulin Resistance, Liver Fibrosis, Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Integrative Medicine, Lifestyle Changes: Positive

Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Hepatoprotective

Additional Keywords : Significant Treatment Outcome

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Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

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Pubmed Data : J Clin Res Pediatr Endocrinol. 2015 Jun 5 ;7(2):121-7. PMID: 26316434

Article Published Date : Jun 04, 2015

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Pubmed Data : Ann Gastroenterol. 2014 ;27(4):387-394. PMID: 25331487

Article Published Date : Dec 31, 2013

Study Type : Human Study

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Substances : Spirulina

Diseases : Nonalcoholic fatty liver disease (NAFLD) , Quality of Life: Poor

Pharmacological Actions : Hepatoprotective, Hypolipidemic

Additional Keywords : Significant Treatment Outcome

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Supplementation of 500 mg resveratrol, along with lifestyle modification, is superior to lifestyle modification alone.Sep 30, 2014

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Pubmed Data : Nutr Res. 2014 Oct ;34(10):837-43. Epub 2014 Sep 23. PMID: 25311610

Pubmed Data : Nutr Res. 2016 Jan ;36(1):57-64. Epub 2015 Oct 31. PMID: 26773781

Article Published Date : Dec 31, 2015

Study Type : Animal Study

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Substances : Chokeberry

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, MicroRNA modulator

Additional Keywords : Risk Reduction

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Allium fistulosum attenuates the development of NAFLD.Mar 31, 2018

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Pubmed Data : Arch Physiol Biochem. 2016 Jul 16:1-8. Epub 2016 Jul 16. PMID: 27424611

Article Published Date : Jul 15, 2016

Study Type : Animal Study

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Substances : Hawthorn

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic

Additional Keywords : Risk Reduction

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Camel milk could provide a natural way to protect against NAFLD induced by a high-fat diet.Dec 31, 2012

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Pubmed Data : BMC Complement Altern Med. 2013 ;13:264. Epub 2013 Oct 13. PMID: 24119413

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Pubmed Data : Food Funct. 2016 Aug 4. Epub 2016 Aug 4. PMID: 27487733

Article Published Date : Aug 03, 2016

Study Type : Animal Study

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Substances : Licorice

Diseases : Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective

Additional Keywords : Gene Expression Regulation

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Pubmed Data : Front Physiol. 2015 ;6:140. Epub 2015 May 6. PMID: 25999863

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

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Substances : Xanthohumol

Diseases : Hepatic Steatosis, Liver Diseases, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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Kefir peptides can improve the symptoms of NAFLD.Dec 11, 2016

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Pubmed Data : Nutr Diabetes. 2016 Dec 12 ;6(12):e237. Epub 2016 Dec 12. PMID: 27941940

Article Published Date : Dec 11, 2016

Study Type : Animal Study

Additional Links

Substances : Kefir

Diseases : High Fructose Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Problem Substances : High Fructose Corn Syrup

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Pubmed Data : World J Gastroenterol. 2016 Dec 14 ;22(46):10180-10188. PMID: 28028366

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Pubmed Data : Int J Mol Sci. 2017 Jun 22 ;18(7). Epub 2017 Jun 22. PMID: 28640194

Article Published Date : Jun 21, 2017

Study Type : Animal Study

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Substances : Moringa oleifera

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic

Additional Keywords : Gene Expression Regulation

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Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines, inflammation and oxidative stress.Mar 31, 2018

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Pubmed Data : J Food Drug Anal. 2018 Apr ;26(2):778-787. Epub 2017 Dec 2. PMID: 29567249

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Pubmed Data : J Med Food. 2012 May ;15(5):495-503. PMID: 22551412

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Pubmed Data : Int Immunopharmacol. 2017 May 31 ;49:132-141. Epub 2017 May 31. PMID: 28577437

Article Published Date : May 30, 2017

Study Type : Animal Study

Additional Links

Substances : Rutin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Saffron extract and crocin supplements have hepatoprotective effect against non-alcoholic fatty liver disease and HFD-induced liver damage.Oct 21, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Oct 22 ;16(1):401. Epub 2016 Oct 22. PMID: 27770798

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Pubmed Data : Toxicol Appl Pharmacol. 2017 Apr 25. Epub 2017 Apr 25. PMID: 28454924

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Pubmed Data : J Toxicol Pathol. 2017 Oct ;30(4):263-273. Epub 2017 Jun 19. PMID: 29097836

Article Published Date : Sep 30, 2017

Study Type : Animal Study

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Substances : Beta-Caryophyllene

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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The present study revealed for the first time that carnosic acid has a protective effect against hepatocyte apoptosis in NAFLD.Dec 31, 2014

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Pubmed Data : Cell Death Dis. 2015 ;6:e1833. Epub 2015 Jul 23. PMID: 26203862

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Pubmed Data : Sci Rep. 2017 Jan 9 ;7:39328. Epub 2017 Jan 9. PMID: 28067231

Article Published Date : Jan 08, 2017

Study Type : Animal Study

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Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : glyphosate, glyphosate-based herbicides (GBH), Nonalcoholic fatty liver disease (NAFLD), Roundup (herbicide)

Problem Substances : Glyphosate, Roundup (herbicide)

Adverse Pharmacological Actions : Hepatotoxic

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Ursolic acid effectively ameliorated high fat diet induced hepatic steatosis.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(1):e86724. Epub 2014 Jan 29. PMID: 24489777

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Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:4390636. Epub 2017 Oct 17. PMID: 29234397

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Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):79-84. Epub 2014 Apr 25. PMID: 24944601

Article Published Date : Jun 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Thistle

Diseases : Liver Disease, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

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Curcumin eliminates the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC in vitro.Apr 30, 2014

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Pubmed Data : Lab Invest. 2014 May ;94(5):503-16. Epub 2014 Mar 10. PMID: 24614199

Article Published Date : Apr 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Advanced Glycation End products (AGE), Liver Cirrhosis, Nonalcoholic fatty liver disease (NAFLD) , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator

Additional Keywords : Gene Expression Regulation, Plant Extracts

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Dark chocolate may improve NAFLD and metabolic syndrome by reducing oxidative stress.Aug 31, 2016

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Pubmed Data : Hepatobiliary Surg Nutr. 2015 Apr ;4(2):109-16. PMID: 26005677

Article Published Date : Mar 31, 2015

Study Type : Review

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Increased Risk

Problem Substances : High Fructose Corn Syrup

Adverse Pharmacological Actions : Inflammatory

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Nobiletin might be useful for the prevention and treatment of nonalcoholic fatty liver diseases.Dec 31, 2017

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Pubmed Data : Evid Based Complement Alternat Med. 2018 ;2018:7420265. Epub 2018 Feb 7. PMID: 29552085

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Nobiletin, Nonalcoholic fatty liver disease (NAFLD)

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Patients with NASH was observed have a distinct gut microbiota when compared to control groups.Sep 04, 2017

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Pubmed Data : Eur J Nutr. 2017 Sep 5. Epub 2017 Sep 5. PMID: 28875318

Article Published Date : Sep 04, 2017

Study Type : Review

Additional Links

Diseases : Liver Disease, Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Microbiota

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Punicalagin could effectively attenuate FFA-induced lipotoxicity by activating Keap1-Nrf2 cytoprotective signaling pathway.Apr 30, 2016

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Pubmed Data : Mol Nutr Food Res. 2016 May ;60(5):1139-49. Epub 2016 Apr 14. PMID: 26989875

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Punicalagin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Nrf2 activation

Problem Substances : Retinyl palmitate

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Raw and processed Notoginseng Radix could be used in the treatment of NAFLD.Dec 31, 2015

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This reviews the molecular and clinical evidence for the benefits of different omega-3 fatty acid preparations in NAFLD.Oct 13, 2015

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Pubmed Data : Crit Rev Clin Lab Sci. 2015 Oct 14:1-15. Epub 2015 Oct 14. PMID: 26463349

Article Published Date : Oct 13, 2015

Study Type : Review

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Nonalcoholic fatty liver disease (NAFLD)

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View the Evidence: 183 Abstracts with Nonalcoholic fatty liver disease (NAFLD) Research

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Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Silymarin has positive efficacy to reduce transaminases levels in NAFLD patients.Nov 30, 2017

Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis.Mar 29, 2016

These results found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis.Nov 06, 2016

Vitamin E significantly improved liver function and histologic changes in patients with NAFLD/NASH.Jun 30, 2015

A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients. Apr 30, 2015

A higher dietary vitamin C intake might help reduce the risk of non-alcoholic fatty liver disease.Dec 31, 2015

An improved diet is particularly important for individuals with a high genetic risk for NAFLD.Mar 27, 2018

Artichoke leaf extracts have benefits in the management of NASH.Dec 31, 2015

Berberis extract can be used as a supplementary medication in treating NAFLD.Jan 31, 2015

Calcium plus calcitriol supplementation for 12 weeks may be potentially effective for biochemical parameters in NAFLD patients. Sep 27, 2016

Chlorella vulgaris supplementation have therapeutic value in patients with non-alcoholic fatty liver disease.Oct 31, 2012

Cocoa polyphenols improve endothelial function via Nox2 down-regulation in NASH patients.Nov 12, 2017

Consumption of fruits that are high in antioxidants could represent a useful means to improve the antioxidant status of NAFLD.Jul 13, 2016

Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis.Mar 31, 2014

CoQ10 supplement at a dosage of 100 mg could be effective for improving the systemic inflammation and biochemical variables in NAFLD.Jul 08, 2015

Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity.Mar 14, 2017

Exercise overcomes skeletal muscle insulin resistance. Aug 01, 2011

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Green tea extract therapy resulted in significant improvement in metabolic, chemical, inflammatory and radiological parameters of NAFLD patients.Jun 30, 2017

High intake of magnesium may be associated with reduced risks of fatty liver disease and prediabetes.Apr 01, 2018

Korean red ginseng might be effective in reducing pro-inflammatory cytokines and fatigue in overweight patients with NAFLD.Jun 30, 2016

Lifetime alcohol consumption with up to 13 units per week is associated with lower fibrosis stage in NAFLD. Sep 20, 2016

Maintenance of high cardiorespiratory fitness and stability of body weight are critical public health considerations for the treatment of NAFLD.Jul 20, 2016

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

National Health and Nutrition Examination Surveys data collected from 1988 to 2008 show that the prevalence of major causes of CLD remained stable, except for NAFLD, which increased steadily, along with the prevalence of metabolic conditions. Jun 01, 2011

Obese children with small intestinal bacterial overgrowth have an increased risk for developing NAFLD.Oct 08, 2017

Observations from this study suggest that cannabis use is associated with lower prevalence of NAFLD.Dec 31, 2016

Probiotic compounds can be effective in improving pediatric NAFLD.Oct 12, 2016

Serum 25(OH)D level was inversely associated with liver fat content in middle-aged and elderly Chinese men.Dec 31, 2015

Serum carotenoids are inversely associated with prevalence of NAFLD in middle aged and elderly Chinese.Dec 31, 2014

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.Mar 31, 2017

Short-term supplementation with Curcumin led to an improvement in different features of NAFLD.Jun 07, 2016

Short-term vitamin E treatment significantly improves abnormal liver enzyme levels in NAFLD patients with metabolic syndrome.Nov 30, 2015

Silymarin is effective in reduced ALT and AST in NAFLD.Jul 31, 2012

Silymarin may reduce liver fibrosis.Apr 14, 2017

Silymarin plus vitamin E could be beneficial in patients with non-alcoholic fatty liver disease.Jul 31, 2015

Supplementation at a high dosage of 6 g daily in NAFLD patients has strong and multiple beneficial metabolic effects and improves their health-related quality of life.Dec 31, 2013

Supplementation of 500 mg resveratrol, along with lifestyle modification, is superior to lifestyle modification alone.Sep 30, 2014

Tamoxifen and toremifene treatment is significantly associated with reversible NAFLD in Asian women.Jul 31, 2016

The risk of suspected NAFLD is increased in participants in higher quartiles of BPA exposure.Jan 31, 2018

There was a significant drop in liver enzymes in patients with non-alcoholic fatty liver disease following administration of licorice root extract.Aug 31, 2012

This study demonstrated a statistically significant correlation between low levels of folate and vitamin B12 with the histological severity of NASH.Apr 01, 2018

This study reveals a possible role of bisphenol A as an environmental factor involved in the promotion of NAFLD, particularly in T2DM patients.Jan 10, 2018

Uric acid levels are elevated in children with NAFLD, indicating that fructose consumption may contribute to its pathogenesis. Jun 21, 2011

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes.Jun 30, 2017

"Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome."Mar 21, 2012

A combination of flaxseed oil and astaxanthin may reduce NAFLD by reversing hepatic steatosis and reducing lipid accumulation and oxidative stress.Mar 12, 2017

A diet rich in saturated fat to a diet rich in unsaturated fat can attenuate NAFLD and atherosclerosis development.Dec 31, 2014

A polysaccharide rich ginkgo biloba extract has a protective effect against HFD-induced NAFLD.Jun 02, 2015

Administration of chokeberry powder may help attenuate high-fat diet-induced NAFLD.Dec 31, 2015

Allium fistulosum attenuates the development of NAFLD.Mar 31, 2018

Alpha mangostin attenuated hepatic steatosis in high fat-diet fed rats potentially through enhanced cellular antioxidant capacity.Dec 31, 2015

Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats.Jan 19, 2017

Aronia melanocarpa could be beneficial for non-alcoholic fatty liver disease.Dec 31, 2016

Astaxanthin and vitamin E effectively improved hepatic gene expression.Mar 07, 2017

Astaxanthin inhibited and reversed lipotoxicity-induced insulin resistance and steatohepatitis in mice.Dec 31, 2014

Avocado oil improves mitochondrial ETC function by attenuating the deleterious effects of oxidative stress in the liver of diabetic rats. Jun 09, 2015

Berberine alleviates hepatic lipid accumulation.Mar 01, 2018

Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.Dec 31, 2014

Berberine could be used in the treatment or prevention of obesity-associated NAFLD.Dec 31, 2015

Berberine may be a candidate therapeutic agent for the treatment of NASH.Oct 31, 2017

Berberine may be a new therapeutic strategy against hepatic steatosis and non-alcoholic steatohepatitis.Dec 31, 2015

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Bisphenol A could risk factor for non-alcoholic fatty liver disease.May 04, 2017

Blueberry and probiotics prevents NASH progression.Feb 26, 2017

C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model.Jul 15, 2016

Nonalcoholic fatty liver disease (NAFLD)

View the Evidence:
183 Abstracts with Nonalcoholic fatty liver disease (NAFLD) Research