Nonalcoholic fatty liver disease (NAFLD)

Name	AC	CK
Silymarin	7	56
Vitamin E	4	42
Coffee	3	41
Curcumin	9	38
Polyunsaturated Fatty Acids (PUFAs)	2	30
Vitamin D	4	24
Omega-3 Fatty Acids	2	21
Tea: Black	1	20
Tea: Green	1	20
Berberine	7	14
Anthocyanins	3	13
Polyphenols	3	13
Probiotics	3	13
Resveratrol	3	13
Bilberry	2	12
Black Currant	2	12
Cannabinoids	2	12
DHA (Docosahexaenoic Acid)	2	12
Genistein	2	12
Licorice	2	12
Pomegranate	2	12
Spirulina	2	12
Chocolate	2	11
Green Tea	2	11
Artichoke	1	10
Barberry	1	10
Calcium	1	10
Cannabis	1	10
Carotenoids	1	10
Chlorella (Algae)	1	10
Cocoa	1	10
Coenzyme Q10	1	10
Flaxseed	1	10
Garlic	1	10
Ginseng (Korean)	1	10
Hibiscus sabdariffa	1	10
Magnesium	1	10
Orange	1	10
Vitamin C	1	10
Astaxanthin	3	6
Carnosic Acid	3	6
Astragaloside	1	5
Chokeberry	3	5
Ginkgo biloba	2	4
Ginsenosides	2	4
Lycopene	2	4
Mangiferin	2	4
Saffron	2	4
Ursolic Acid	2	4
Avocado	2	3
Beta-Caryophyllene	2	3
Blueberry	2	3
Moringa oleifera	2	3
Nobiletin	2	3
Panax Notoginseng	2	3
Turmeric	2	3
Banaba	1	2
Bisdemethoxycurcumin	1	2
Blue Honeysuckle	1	2
Broccoli	1	2
Camel Milk	1	2
Cannabidiol	1	2
Citrulline	1	2
Crocin	1	2
Dragon Fruit	1	2
Eucalyptus	1	2
Fermented Foods and Beverages	1	2
Flaxseed Oil	1	2
Fructose	1	2
Fucoidan	1	2
Ginger	1	2
Hawthorn	1	2
Honokiol	1	2
Hydroxytyrosol	1	2
Kefir	1	2
Krill	1	2
Lactobacillus casei: Shirota	1	2
Lactobacillus paracasei	1	2
Lactobacillus rhamnosus GG	1	2
Loquat	1	2
Luteolin	1	2
Mangosteen	1	2
Mulberry	1	2
Onion	1	2
Parthenolide	1	2
Pomegranate Peel	1	2
Pomegranate flower	1	2
Prebiotics	1	2
Pumpkin Seeds	1	2
Pycnogenol (Pine Bark)	1	2
Quercetin	1	2
Raspberry ketone	1	2
Red Sage	1	2
Rutin	1	2
Seaweed: Brown	1	2
Sesamin	1	2
Star Fruit	1	2
Sulforaphane	1	2
Thymoquinone	1	2
Virgin Coconut Oil	1	2
Wogonin	1	2
Xanthohumol	1	2
Xanthones	1	2
Arctigenin	1	1
Black Tea	1	1
Blackberry	1	1
Fish	1	1
Fish Oil	1	1
Flavonoids	1	1
Mugwort	1	1
Naringenin	1	1
Nuts	1	1
Olive Oil	1	1
Punicalagin	1	1
Red Wine Extract	1	1
Strawberry	1	1
Thistle	1	1
Walnut	1	1

Name	AC	CK
Fructose	16	33
Bisphenol A	3	22
High Fructose Corn Syrup	8	12
Tamoxifen	1	10
Trans Fatty Acids	3	5
Monosodium Glutamate (MSG)	2	4
Glyphosate	1	2
Irinotecan	1	2
Roundup (herbicide)	1	2
Retinyl palmitate	1	1
Sugary soda	1	1

Name	AC	CK
Exercise	4	42
Dietary Modification: Mediterranean Diet	2	11
Integrative Medicine	1	10
Lifestyle Changes: Positive	1	10
Dietary Modification: Low Glycemic Diet	1	1
Dietary Modification: Wheat/Gluten Free	1	1

Name	AC	CK	Focus
Western Diet	1	2

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Minerva Med. 2018 Dec ;109(6):418-428. Epub 2018 Sep 13. PMID: 30221912

Article Published Date : Nov 30, 2018

Study Type : Human Study

Additional Links

Substances : Omega-3 Fatty Acids, Probiotics

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interferon Gamma Reducer, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Berberis extract can be used as a supplementary medication in treating NAFLD.Jan 31, 2015

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Pubmed Data : Hepat Mon. 2015 Feb ;15(2):e25067. Epub 2015 Feb 5. PMID: 25788958

Pubmed Data : Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396

Article Published Date : May 31, 2016

Study Type : Human Study

Additional Links

Substances : Flaxseed

Diseases : Insulin Resistance, Liver Fibrosis, Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Integrative Medicine, Lifestyle Changes: Positive

Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Hepatoprotective

Additional Keywords : Significant Treatment Outcome

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Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

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Pubmed Data : Med Hypotheses. 2019 Mar ;124:40-41. Epub 2019 Feb 4. PMID: 30798914

Article Published Date : Feb 28, 2019

Study Type : Human Study

Additional Links

Diseases : Chemically-Induced Liver Damage, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : High Fructose Corn Syrup

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Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

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Pubmed Data : Nutrients. 2018 Nov 18 ;10(11). Epub 2018 Nov 18. PMID: 30453660

Article Published Date : Nov 17, 2018

Study Type : Human Study

Additional Links

Substances : Fiber

Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Gastroprotective

Problem Substances : Insulin

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Korean red ginseng might be effective in reducing pro-inflammatory cytokines and fatigue in overweight patients with NAFLD.Jun 30, 2016

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Pubmed Data : J Ginseng Res. 2016 Jul ;40(3):203-10. Epub 2015 Aug 4. PMID: 27616896

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Pubmed Data : J Clin Res Pediatr Endocrinol. 2015 Jun 5 ;7(2):121-7. PMID: 26316434

Article Published Date : Jun 04, 2015

Study Type : Human Study

Additional Links

Substances : Polyunsaturated Fatty Acids (PUFAs)

Diseases : Nonalcoholic fatty liver disease (NAFLD), Obesity

Pharmacological Actions : Hepatoprotective

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N. sativa seed oil seems to be safe and improve liver steatosis and injury and blood levels of triglycerides, LDL-C and HDL-C in the NAFLD patients.Apr 23, 2019

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Pubmed Data : J Ethnopharmacol. 2019 Apr 24 ;234:106-111. Epub 2019 Jan 11. PMID: 30639231

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Pubmed Data : PLoS One. 2017 ;12(4):e0176416. Epub 2017 Apr 25. PMID: 28441459

Article Published Date : Dec 31, 2016

Study Type : Human Study

Additional Links

Substances : Cannabinoids , Cannabis

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Risk Reduction, Significant Treatment Outcome

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Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease.Dec 31, 2017

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Pubmed Data : Ann Gastroenterol. 2014 ;27(4):387-394. PMID: 25331487

Article Published Date : Mar 24, 2019

Study Type : Animal Study

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD), Obesity

Therapeutic Actions : Acupuncture

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic, Malondialdehyde Down-regulation

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Administration of chokeberry powder may help attenuate high-fat diet-induced NAFLD.Dec 31, 2015

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Pubmed Data : Nutr Res. 2016 Jan ;36(1):57-64. Epub 2015 Oct 31. PMID: 26773781

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Chokeberry

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, MicroRNA modulator

Additional Keywords : Risk Reduction

[+]

Allium fistulosum attenuates the development of NAFLD.Mar 31, 2018

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Pubmed Data : Biochem Biophys Res Commun. 2018 Mar 2. Epub 2018 Mar 2. PMID: 29505790

Article Published Date : Mar 01, 2018

Study Type : Animal Study

Additional Links

Substances : Berberine

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Hypolipidemic

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Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

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Pubmed Data : Arch Iran Med. 2016 Mar ;19(3):197-203. PMID: 26923892

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Pubmed Data : PLoS One. 2016 ;11(2):e0147745. Epub 2016 Feb 16. PMID: 26881746

Pubmed Data : Drug Res (Stuttg). 2018 May 2. Epub 2018 May 2. PMID: 29719880

Article Published Date : May 01, 2018

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective

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Camel milk could provide a natural way to protect against NAFLD induced by a high-fat diet.Dec 31, 2012

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Pubmed Data : BMC Complement Altern Med. 2013 ;13:264. Epub 2013 Oct 13. PMID: 24119413

Combined hydroxytyrosol and eicosapentaenoic acid drastically decreases NAFLD development.Dec 31, 2017

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:5109503. Epub 2018 Jul 2. PMID: 30057681

Article Published Date : Dec 31, 2017

Study Type : Animal Study

Additional Links

Substances : EPA (Eicosapentaenoic Acid), Hydroxytyrosol

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective

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Consumption of red cabbage should be a natural therapy to treat NASH in diabetic patients.Dec 31, 2017

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Pubmed Data : Oxid Med Cell Longev. 2018 ;2018:7019573. Epub 2018 Sep 30. PMID: 30363947

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Pubmed Data : Eur J Nutr. 2012 Feb ;51(1):57-68. Epub 2011 Mar 29. PMID: 21445622

Article Published Date : Jan 31, 2012

Study Type : Animal Study

Additional Links

Substances : D-Limonene

Diseases : High Fat Diet, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, Pancreato Protective Agents

[+]

Dietary flaxseed oil prevents western-type diet-induced non-alcoholic fatty liver disease.Dec 31, 2016

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Pubmed Data : Oxid Med Cell Longev. 2017 ;2017:3256241. Epub 2017 Sep 7. PMID: 29081885

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Flaxseed Oil

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Risk Reduction

Anti Therapeutic Actions : Western Diet

[+]

Diosgenin is a potential agent for preventing the development of NAFLD.Jan 31, 2018

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Pubmed Data : Cell Physiol Biochem. 2018 ;49(3):1163-1179. Epub 2018 Sep 7. PMID: 30196282

Article Published Date : Dec 31, 2017

Study Type : Transgenic Animal Study

Additional Links

Substances : Reishi Mushroom

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Polysaccharides

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Genipin Reverses high fat diet-induced liver damage.Dec 31, 2017

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[+]

Hydroxytyrosol may reduce the liver alterations induced in high fat diet-fed mice.Apr 18, 2017

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Pubmed Data : Food Funct. 2017 Apr 19 ;8(4):1526-1537. PMID: 28386616

Article Published Date : Apr 18, 2017

Study Type : Animal Study

Additional Links

Substances : Hydroxytyrosol

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, NF-kappaB Inhibitor

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In vitro and in vivo data indicate that the hop constituent xanthohumol affects several critical pathophysiological steps during the development and course of chronic liver disease.Dec 31, 2014

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Pubmed Data : Front Physiol. 2015 ;6:140. Epub 2015 May 6. PMID: 25999863

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Xanthohumol

Diseases : Hepatic Steatosis, Liver Diseases, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

[+]

Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced fatty liver in mice.Aug 31, 2018

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Pubmed Data : Anim Nutr. 2018 Sep ;4(3):288-293. Epub 2018 Jun 27. PMID: 30175257

Article Published Date : Aug 31, 2018

Study Type : Animal Study

Additional Links

Substances : Blue Honeysuckle

Diseases : Fatty Liver, High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation

Additional Keywords : Anti-Obesity Agents

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Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet.Sep 30, 2018

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Pubmed Data : Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct ;1863(10):1274-1284. Epub 2018 Aug 7. PMID: 30305244

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Pubmed Data : Nutr Diabetes. 2016 Dec 12 ;6(12):e237. Epub 2016 Dec 12. PMID: 27941940

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Pubmed Data : Molecules. 2018 Dec 5 ;23(12). Epub 2018 Dec 5. PMID: 30563142

Article Published Date : Dec 04, 2018

Study Type : Animal Study

Additional Links

Substances : Blue Honeysuckle

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Hepatoprotective, Interleukin-2 Downregulation, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Microbiota

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L. paracasei Jlus66 has great potential as a probiotic in protecting from NAFLD.Nov 05, 2017

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Pubmed Data : Food Funct. 2017 Nov 6. Epub 2017 Nov 6. PMID: 29106426

Article Published Date : Nov 05, 2017

Study Type : Animal Study

Additional Links

Substances : Lactobacillus paracasei

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective, Prophylactic Agents

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Lactobaccilus casei Shirota protects from fructose-induced fatty liver in an animal model. Jun 26, 2012

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Pubmed Data : J Nutr Biochem. 2012 Jun 27. Epub 2012 Jun 27. PMID: 22749137

Article Published Date : Jun 26, 2012

Study Type : Animal Study

Additional Links

Substances : Lactobacillus casei: Shirota

Diseases : Fructose-Induced Toxicity , Liver Stress: Fructose-Induced, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Problem Substances : Fructose

Adverse Pharmacological Actions : Hepatotoxic, Lipogenesis Up-Regulation

[+]

Lactobacillus mali ameliorated hepatic steatosis by modulating lipid metabolism and antioxidant activity.Dec 31, 2017

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Pubmed Data : Mol Nutr Food Res. 2018 04 ;62(8):e1700903. Epub 2018 Apr 3. PMID: 29508520

Lycopene could provide potential benefits against smoke carcinogen-induced pulmonary and hepatic injury.Apr 25, 2016

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Pubmed Data : Int J Cancer. 2016 Apr 26. Epub 2016 Apr 26. PMID: 27116542

Article Published Date : Apr 25, 2016

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Liver Cancer, Nonalcoholic fatty liver disease (NAFLD), Tobacco Toxicity

Pharmacological Actions : Anticarcinogenic Agents, Hepatoprotective

[+]

Lycopene has a protective effect on non-alcoholic fatty liver disease.Dec 13, 2016

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Pubmed Data : World J Gastroenterol. 2016 Dec 14 ;22(46):10180-10188. PMID: 28028366

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Pubmed Data : Int J Mol Sci. 2017 Jun 22 ;18(7). Epub 2017 Jun 22. PMID: 28640194

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Pubmed Data : J Sci Food Agric. 2016 Sep 22. Epub 2016 Aug 22. PMID: 27717115

Article Published Date : Sep 21, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Prophylactic Agents

Additional Keywords : Risk Reduction

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Pomegranate peel extract might be considered as a potential lead material in the treatment of NAFLD and obesity.Feb 29, 2016

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Pubmed Data : Prev Nutr Food Sci. 2016 Mar ;21(1):14-23. Epub 2016 Mar 31. PMID: 27069901

Article Published Date : Feb 29, 2016

Study Type : Animal Study

Additional Links

Substances : Pomegranate Peel

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective

Additional Keywords : Plant Extracts

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Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.Apr 30, 2012

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Pubmed Data : J Med Food. 2012 May ;15(5):495-503. PMID: 22551412

Article Published Date : Apr 30, 2012

Study Type : Animal Study

Additional Links

Substances : Raspberry ketone

Diseases : C-Reactive Protein, Fatty Liver, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Phytotherapy, Plant Extracts

[+]

Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis.Nov 01, 2009

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Pubmed Data : J Nutr. 2009 Nov;139(11):2067-71. Epub 2009 Sep 23. PMID: 19776184

Article Published Date : Nov 01, 2009

Study Type : Animal Study

Additional Links

Diseases : Fatty Liver, Fructose-Induced Toxicity , Liver Stress: Fructose-Induced, Metabolic Syndrome X, Nonalcoholic fatty liver disease (NAFLD)

Problem Substances : Fructose

Adverse Pharmacological Actions : Hepatotoxic, Lipogenesis Up-Regulation

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Pubmed Data : Nutrients. 2019 Jan 18 ;11(1). Epub 2019 Jan 18. PMID: 30669332

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Pubmed Data : J Toxicol Pathol. 2017 Oct ;30(4):263-273. Epub 2017 Jun 19. PMID: 29097836

Article Published Date : Sep 30, 2017

Study Type : Animal Study

Additional Links

Substances : Beta-Caryophyllene

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

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The present study revealed for the first time that carnosic acid has a protective effect against hepatocyte apoptosis in NAFLD.Dec 31, 2014

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Pubmed Data : Cell Death Dis. 2015 ;6:e1833. Epub 2015 Jul 23. PMID: 26203862

Ultra-low dose of Roundup herbicide non-alcoholic contributes to fatty liver disease in rats following chronic exposure.Jan 08, 2017

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Pubmed Data : Sci Rep. 2017 Jan 9 ;7:39328. Epub 2017 Jan 9. PMID: 28067231

Article Published Date : Jan 08, 2017

Study Type : Animal Study

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : glyphosate, glyphosate-based herbicides (GBH), Nonalcoholic fatty liver disease (NAFLD), Roundup (herbicide)

Problem Substances : Glyphosate, Roundup (herbicide)

Adverse Pharmacological Actions : Hepatotoxic

[+]

Ursolic acid effectively ameliorated high fat diet induced hepatic steatosis.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(1):e86724. Epub 2014 Jan 29. PMID: 24489777

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Pubmed Data : Nutrients. 2017 Apr 14 ;9(4). Epub 2017 Apr 14. PMID: 28420094

Article Published Date : Apr 13, 2017

Study Type : Review

Additional Links

Substances : Astaxanthin, Cryptoxanthin

Diseases : Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD), Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective

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Changes to the microbiome can cause dysmotility, gut inflammation and other immunological changes in the gut that might contribute to liver injury.Jun 30, 2016

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Pubmed Data : Nat Rev Gastroenterol Hepatol. 2016 Jul ;13(7):412-25. Epub 2016 Jun 8. PMID: 27273168

Article Published Date : Jun 30, 2016

Study Type : Review

Additional Links

Diseases : Dysbiosis, Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Microbiota, Risk Factors

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Cirsium japonicum might be a preventative treatment of NAFLD.Jun 30, 2014

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Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):79-84. Epub 2014 Apr 25. PMID: 24944601

Article Published Date : Jun 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Thistle

Diseases : Liver Disease, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

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Curcumin eliminates the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC in vitro.Apr 30, 2014

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Pubmed Data : Hepatobiliary Surg Nutr. 2015 Apr ;4(2):109-16. PMID: 26005677

Pubmed Data : Dig Liver Dis. 2004 May ;36(5):333-6. PMID: 15191202

Article Published Date : Apr 30, 2004

Study Type : Review

Additional Links

Diseases : Celiac Disease, Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Dietary Modification: Wheat/Gluten Free

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Micellar solubilization enhanced the bioavailability and beneficial effects of xanthohumol on different components of the metabolic syndrome.Apr 16, 2019

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Pubmed Data : Mol Nutr Food Res. 2016 May ;60(5):1139-49. Epub 2016 Apr 14. PMID: 26989875

Article Published Date : Apr 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Punicalagin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Cytoprotective, Hepatoprotective, Nrf2 activation

Problem Substances : Retinyl palmitate

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Raw and processed Notoginseng Radix could be used in the treatment of NAFLD.Dec 31, 2015

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Pubmed Data : Sci Rep. 2019 Mar 1 ;9(1):3228. Epub 2019 Mar 1. PMID: 30824780

Article Published Date : Feb 28, 2019

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Pubmed Data : Cell Mol Life Sci. 2019 Jan 25. Epub 2019 Jan 25. PMID: 30683985

Article Published Date : Jan 24, 2019

Study Type : Review

Additional Links

Substances : Probiotics

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Gut-liver axis

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The molecular mechanisms of protection of a Mediterranean diet against nonalcoholic fatty liver disease.Aug 01, 2016

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Pubmed Data : Int J Food Sci Nutr. 2016 Aug 2:1-10. Epub 2016 Aug 2. PMID: 27484357

Nonalcoholic fatty liver disease (NAFLD) is a Sub of the following Topic

View the Evidence: 278 Abstracts with Nonalcoholic fatty liver disease (NAFLD) Research

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Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Silymarin has positive efficacy to reduce transaminases levels in NAFLD patients.Nov 30, 2017

Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis.Mar 29, 2016

These results found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis.Nov 06, 2016

This meta-analysis supports a positive significant association between higher consumption of sugar sweetened beverages and NAFLD.May 13, 2018

Vitamin E significantly improved liver function and histologic changes in patients with NAFLD/NASH.Jun 30, 2015

8 weeks of provision of a diet low in free sugar content compared with usual diet resulted in significant improvement in hepatic steatosis.Jan 21, 2019

A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients. Apr 30, 2015

A higher dietary vitamin C intake might help reduce the risk of non-alcoholic fatty liver disease.Dec 31, 2015

An improved diet is particularly important for individuals with a high genetic risk for NAFLD.Mar 27, 2018

Artichoke leaf extracts have benefits in the management of NASH.Dec 31, 2015

Beneficial effects of probiotic combination with omega-3 fatty acids in NAFLD.Nov 30, 2018

Berberis extract can be used as a supplementary medication in treating NAFLD.Jan 31, 2015

Calcium plus calcitriol supplementation for 12 weeks may be potentially effective for biochemical parameters in NAFLD patients. Sep 27, 2016

Chlorella vulgaris supplementation have therapeutic value in patients with non-alcoholic fatty liver disease.Oct 31, 2012

Cocoa polyphenols improve endothelial function via Nox2 down-regulation in NASH patients.Nov 12, 2017

Consumption of fruits that are high in antioxidants could represent a useful means to improve the antioxidant status of NAFLD.Jul 13, 2016

Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis.Mar 31, 2014

CoQ10 supplement at a dosage of 100 mg could be effective for improving the systemic inflammation and biochemical variables in NAFLD.Jul 08, 2015

Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

Delta-tocotrienol was safe, and it effectively improved aminotransferase levels and inflammatory and oxidative stress markers in patients with NAFLD.Dec 31, 2017

DHA supplementation improves liver steatosis in children with NAFLD. Oct 31, 2013

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity.Mar 14, 2017

Exercise overcomes skeletal muscle insulin resistance. Aug 01, 2011

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5.Feb 28, 2019

Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Green tea extract therapy resulted in significant improvement in metabolic, chemical, inflammatory and radiological parameters of NAFLD patients.Jun 30, 2017

High intake of magnesium may be associated with reduced risks of fatty liver disease and prediabetes.Apr 01, 2018

High levels of urinary BPA were associated with NAFLD in a nationally representative sample of adults in the US.Mar 28, 2019

Inclusion of dried grapes in diet was beneficial in NAFLD patients with non-significant fibrosis.Nov 08, 2016

Increasing nutritional fiber results in reduced serum ZO levels, reduced liver enzymes and improved hepatic steatosis in patients with NAFLDNov 17, 2018

Korean red ginseng might be effective in reducing pro-inflammatory cytokines and fatigue in overweight patients with NAFLD.Jun 30, 2016

Lifetime alcohol consumption with up to 13 units per week is associated with lower fibrosis stage in NAFLD. Sep 20, 2016

Maintenance of high cardiorespiratory fitness and stability of body weight are critical public health considerations for the treatment of NAFLD.Jul 20, 2016

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

N. sativa seed oil seems to be safe and improve liver steatosis and injury and blood levels of triglycerides, LDL-C and HDL-C in the NAFLD patients.Apr 23, 2019

National Health and Nutrition Examination Surveys data collected from 1988 to 2008 show that the prevalence of major causes of CLD remained stable, except for NAFLD, which increased steadily, along with the prevalence of metabolic conditions. Jun 01, 2011

Obese children with small intestinal bacterial overgrowth have an increased risk for developing NAFLD.Oct 08, 2017

Observations from this study suggest that cannabis use is associated with lower prevalence of NAFLD.Dec 31, 2016

Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease.Dec 31, 2017

Probiotic compounds can be effective in improving pediatric NAFLD.Oct 12, 2016

Serum 25(OH)D level was inversely associated with liver fat content in middle-aged and elderly Chinese men.Dec 31, 2015

Serum carotenoids are inversely associated with prevalence of NAFLD in middle aged and elderly Chinese.Dec 31, 2014

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.Mar 31, 2017

Short-term supplementation with Curcumin led to an improvement in different features of NAFLD.Jun 07, 2016

Short-term vitamin E treatment significantly improves abnormal liver enzyme levels in NAFLD patients with metabolic syndrome.Nov 30, 2015

Silymarin is effective in reduced ALT and AST in NAFLD.Jul 31, 2012

Silymarin may reduce liver fibrosis.Apr 14, 2017

Silymarin plus vitamin E could be beneficial in patients with non-alcoholic fatty liver disease.Jul 31, 2015

Supplementation at a high dosage of 6 g daily in NAFLD patients has strong and multiple beneficial metabolic effects and improves their health-related quality of life.Dec 31, 2013

Supplementation of 500 mg resveratrol, along with lifestyle modification, is superior to lifestyle modification alone.Sep 30, 2014

Synbiotic yogurt consumption improved hepatic steatosis and liver enzyme concentrations in patients with NAFLD.Jul 31, 2018

Tamoxifen and toremifene treatment is significantly associated with reversible NAFLD in Asian women.Jul 31, 2016

The risk of suspected NAFLD is increased in participants in higher quartiles of BPA exposure.Jan 31, 2018

There was a significant drop in liver enzymes in patients with non-alcoholic fatty liver disease following administration of licorice root extract.Aug 31, 2012

These results suggest that a sugar-rich diet might contribute to the development of early stages of NAFLD in overweight children.Sep 18, 2018

This study demonstrated a statistically significant correlation between low levels of folate and vitamin B12 with the histological severity of NASH.Apr 01, 2018

This study reveals a possible role of bisphenol A as an environmental factor involved in the promotion of NAFLD, particularly in T2DM patients.Jan 10, 2018

Treatment of non-alcoholic steatohepatitis patients with vitamin D.Sep 28, 2018

Uric acid levels are elevated in children with NAFLD, indicating that fructose consumption may contribute to its pathogenesis. Jun 21, 2011

Vitamin E and hydroxytyrosol may be a promising strategy that could be easily diet integrated to improve NAFLD-related liver damage in children.Feb 10, 2019

Zataria multiflora supplementation for 12 weeks improved insulin resistance in patients with NAFLD.Nov 30, 2018

Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes.Jun 30, 2017

"Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome."Mar 21, 2012

6-gingerol ameliorates age-related hepatic steatosisDec 31, 2018

6-gingerol ameliorates age-related hepatic steatosis.Dec 31, 2018

A combination of flaxseed oil and astaxanthin may reduce NAFLD by reversing hepatic steatosis and reducing lipid accumulation and oxidative stress.Mar 12, 2017

A diet rich in saturated fat to a diet rich in unsaturated fat can attenuate NAFLD and atherosclerosis development.Dec 31, 2014

A polysaccharide rich ginkgo biloba extract has a protective effect against HFD-induced NAFLD.Jun 02, 2015

Nonalcoholic fatty liver disease (NAFLD)

View the Evidence:
278 Abstracts with Nonalcoholic fatty liver disease (NAFLD) Research