Nonalcoholic fatty liver disease (NAFLD)

Name	AC	CK
Vitamin E	3	40
Silymarin	4	24
Coffee	2	21
Tea: Black	1	20
Tea: Green	1	20
Curcumin	6	16
Anthocyanins	3	13
Bilberry	2	12
Black Currant	2	12
Licorice	2	12
Spirulina	2	12
Resveratrol	2	11
Artichoke	1	10
Barberry	1	10
Carotenoids	1	10
Chlorella (Algae)	1	10
Coenzyme Q10	1	10
Garlic	1	10
Hibiscus sabdariffa	1	10
Orange	1	10
Polyunsaturated Fatty Acids (PUFAs)	1	10
Pomegranate	1	10
Vitamin C	1	10
Vitamin D	1	10
Berberine	4	8
Avocado	2	3
Chokeberry	2	3
Astaxanthin	1	2
Banaba	1	2
Bisdemethoxycurcumin	1	2
Broccoli	1	2
Camel Milk	1	2
Cannabidiol	1	2
Cannabinoids	1	2
Carnosic Acid	1	2
Eucalyptus	1	2
Fermented Foods and Beverages	1	2
Fructose	1	2
Ginkgo biloba	1	2
Hawthorn	1	2
Krill	1	2
Lactobacillus casei: Shirota	1	2
Lycopene	1	2
Pomegranate Peel	1	2
Pycnogenol (Pine Bark)	1	2
Raspberry ketone	1	2
Seaweed: Brown	1	2
Thymoquinone	1	2
Turmeric	1	2
Ursolic Acid	1	2
Xanthohumol	1	2
Black Tea	1	1
Blackberry	1	1
Blueberry	1	1
Fish	1	1
Fish Oil	1	1
Flavonoids	1	1
Green Tea	1	1
Nuts	1	1
Olive Oil	1	1
Omega-3 Fatty Acids	1	1
Polyphenols	1	1
Probiotics	1	1
Punicalagin	1	1
Red Wine Extract	1	1
Strawberry	1	1
Thistle	1	1
Walnut	1	1

Name	AC	CK
Fructose	15	31
High Fructose Corn Syrup	4	5
Trans Fatty Acids	2	3
Monosodium Glutamate (MSG)	1	2
Retinyl palmitate	1	1
Sugary soda	1	1

Name	AC	CK
Exercise	3	40
Dietary Modification: Low Glycemic Diet	1	1
Dietary Modification: Mediterranean Diet	1	1
Dietary Modification: Wheat/Gluten Free	1	1

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Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

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Pubmed Data : Clin Gastroenterol Hepatol. 2016 May 4. Epub 2016 May 4. PMID: 27155553

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Pubmed Data : J Am Coll Nutr. 2015 Jul 9:1-8. Epub 2015 Jul 9. PMID: 26156412

Article Published Date : Jul 08, 2015

Study Type : Human Study

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Substances : Coenzyme Q10

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents

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Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

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Pubmed Data : Int J Food Sci Nutr. 2016 Jun ;67(4):461-9. Epub 2016 Mar 17. PMID: 26983396

Article Published Date : May 31, 2016

Study Type : Human Study

Additional Links

Substances : Flaxseed

Diseases : Insulin Resistance, Liver Fibrosis, Liver Steatosis, Nonalcoholic fatty liver disease (NAFLD)

Therapeutic Actions : Integrative Medicine, Lifestyle Changes: Positive

Pharmacological Actions : Anti-Fibrotic, Enzyme Inhibitors, Hepatoprotective

Additional Keywords : Significant Treatment Outcome

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Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

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Pubmed Data : J Clin Res Pediatr Endocrinol. 2015 Jun 5 ;7(2):121-7. PMID: 26316434

Article Published Date : Jun 04, 2015

Study Type : Human Study

Additional Links

Substances : Polyunsaturated Fatty Acids (PUFAs)

Diseases : Nonalcoholic fatty liver disease (NAFLD) , Obesity

Pharmacological Actions : Hepatoprotective

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National Health and Nutrition Examination Surveys data collected from 1988 to 2008 show that the prevalence of major causes of CLD remained stable, except for NAFLD, which increased steadily, along with the prevalence of metabolic conditions. Jun 01, 2011

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Pubmed Data : Ann Gastroenterol. 2014 ;27(4):387-394. PMID: 25331487

Article Published Date : Dec 31, 2013

Study Type : Human Study

Additional Links

Substances : Spirulina

Diseases : Nonalcoholic fatty liver disease (NAFLD) , Quality of Life: Poor

Pharmacological Actions : Hepatoprotective, Hypolipidemic

Additional Keywords : Significant Treatment Outcome

[+]

Supplementation of 500 mg resveratrol, along with lifestyle modification, is superior to lifestyle modification alone.Sep 30, 2014

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Pubmed Data : Nutr Res. 2014 Oct ;34(10):837-43. Epub 2014 Sep 23. PMID: 25311610

Alpha mangostin attenuated hepatic steatosis in high fat-diet fed rats potentially through enhanced cellular antioxidant capacity.Dec 31, 2015

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Pubmed Data : Nutr Metab (Lond). 2016 ;13:88. Epub 2016 Dec 1. PMID: 27980597

Article Published Date : Dec 31, 2015

Study Type : Animal Study

Additional Links

Substances : Mangosteen

Diseases : High Fat Diet, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Catalase Up-Regulation, Glutathione Upregulation , Hepatoprotective, Superoxide Dismutase Up-regulation

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Aronia melanocarpa could be beneficial for non-alcoholic fatty liver disease.Dec 31, 2016

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Pubmed Data : Arch Physiol Biochem. 2016 Jul 16:1-8. Epub 2016 Jul 16. PMID: 27424611

Article Published Date : Jul 15, 2016

Study Type : Animal Study

Additional Links

Substances : Hawthorn

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Hypolipidemic

Additional Keywords : Risk Reduction

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Camel milk could provide a natural way to protect against NAFLD induced by a high-fat diet.Dec 31, 2012

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Pubmed Data : BMC Complement Altern Med. 2013 ;13:264. Epub 2013 Oct 13. PMID: 24119413

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Pubmed Data : Food Funct. 2016 Aug 4. Epub 2016 Aug 4. PMID: 27487733

Article Published Date : Aug 03, 2016

Kefir peptides can improve the symptoms of NAFLD.Dec 11, 2016

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Pubmed Data : J Nutr. 2016 Mar ;146(3):542-50. Epub 2016 Feb 10. PMID: 26865652

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Pubmed Data : World J Gastroenterol. 2016 Dec 14 ;22(46):10180-10188. PMID: 28028366

Article Published Date : Dec 13, 2016

Study Type : Animal Study

Additional Links

Substances : Lycopene

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Antioxidants, Hepatoprotective, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Antioxidants, Dose Response, Hepatoprotective, lycopene, Nonalcoholic fatty liver disease (NAFLD), Tumor Necrosis Factor (TNF) Alpha Inhibitor

[+]

Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation.Oct 08, 2017

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Pubmed Data : Biomed Pharmacother. 2017 Oct 9 ;96:328-335. Epub 2017 Oct 9. PMID: 29024899

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Pubmed Data : J Med Food. 2012 May ;15(5):495-503. PMID: 22551412

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Pubmed Data : Int Immunopharmacol. 2017 May 31 ;49:132-141. Epub 2017 May 31. PMID: 28577437

Article Published Date : May 30, 2017

Study Type : Animal Study

Additional Links

Substances : Rutin

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypolipidemic, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

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Saffron extract and crocin supplements have hepatoprotective effect against non-alcoholic fatty liver disease and HFD-induced liver damage.Oct 21, 2016

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Pubmed Data : BMC Complement Altern Med. 2016 Oct 22 ;16(1):401. Epub 2016 Oct 22. PMID: 27770798

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Pubmed Data : Toxicol Appl Pharmacol. 2017 Apr 25. Epub 2017 Apr 25. PMID: 28454924

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Pubmed Data : Sci Rep. 2017 Jan 9 ;7:39328. Epub 2017 Jan 9. PMID: 28067231

Article Published Date : Jan 08, 2017

Study Type : Animal Study

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : glyphosate, glyphosate-based herbicides (GBH), Nonalcoholic fatty liver disease (NAFLD), Roundup (herbicide)

Problem Substances : Glyphosate, Roundup (herbicide)

Adverse Pharmacological Actions : Hepatotoxic

[+]

Ursolic acid effectively ameliorated high fat diet induced hepatic steatosis.Dec 31, 2013

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Pubmed Data : PLoS One. 2014 ;9(1):e86724. Epub 2014 Jan 29. PMID: 24489777

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Pubmed Data : Exp Ther Med. 2014 Jul ;8(1):79-84. Epub 2014 Apr 25. PMID: 24944601

Article Published Date : Jun 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Thistle

Diseases : Liver Disease, Nonalcoholic fatty liver disease (NAFLD)

Pharmacological Actions : Hepatoprotective

Additional Keywords : Plant Extracts

[+]

Curcumin eliminates the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC in vitro.Apr 30, 2014

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Pubmed Data : Lab Invest. 2014 May ;94(5):503-16. Epub 2014 Mar 10. PMID: 24614199

Article Published Date : Apr 30, 2014

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Advanced Glycation End products (AGE), Liver Cirrhosis, Nonalcoholic fatty liver disease (NAFLD) , Oxidative Stress

Pharmacological Actions : Antioxidants, Hepatoprotective, NF-E2-Related Factor-2 (Nrf2) Modulator

Additional Keywords : Gene Expression Regulation, Plant Extracts

[+]

Dark chocolate may improve NAFLD and metabolic syndrome by reducing oxidative stress.Aug 31, 2016

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Pubmed Data : Hepatobiliary Surg Nutr. 2015 Apr ;4(2):109-16. PMID: 26005677

Article Published Date : Mar 31, 2015

Study Type : Review

Additional Links

Diseases : Nonalcoholic fatty liver disease (NAFLD)

Additional Keywords : Increased Risk

Problem Substances : High Fructose Corn Syrup

Adverse Pharmacological Actions : Inflammatory

[+]

Diseases : Diabetes Mellitus: Type 2, Insulin Resistance, Nonalcoholic fatty liver disease (NAFLD) , Obesity

Additional Keywords : Risk Reduction

[+]

This reviews the molecular and clinical evidence for the benefits of different omega-3 fatty acid preparations in NAFLD.Oct 13, 2015

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Pubmed Data : Crit Rev Clin Lab Sci. 2015 Oct 14:1-15. Epub 2015 Oct 14. PMID: 26463349

Article Published Date : Oct 13, 2015

Study Type : Review

Additional Links

Substances : Omega-3 Fatty Acids

Diseases : Nonalcoholic fatty liver disease (NAFLD)

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View the Evidence: 144 Abstracts with Nonalcoholic fatty liver disease (NAFLD) Research

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Physical activity reduces intrahepatic lipid content and markers of hepatocellular injury in patients with NAFLD.May 03, 2016

Polyunsaturated fatty acids supplementation can improve liver steatosis and liver functions.Dec 22, 2016

Studies on coffee and NAFLD suggest that coffee consumption could have a protective role on fibrosis.Mar 29, 2016

These results found a significantly decreased risk of NAFLD among coffee drinkers and significantly decreased risk of liver fibrosis.Nov 06, 2016

Vitamin E significantly improved liver function and histologic changes in patients with NAFLD/NASH.Jun 30, 2015

A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients. Apr 30, 2015

A higher dietary vitamin C intake might help reduce the risk of non-alcoholic fatty liver disease.Dec 31, 2015

Artichoke leaf extracts have benefits in the management of NASH.Dec 31, 2015

Berberis extract can be used as a supplementary medication in treating NAFLD.Jan 31, 2015

Calcium plus calcitriol supplementation for 12 weeks may be potentially effective for biochemical parameters in NAFLD patients. Sep 27, 2016

Chlorella vulgaris supplementation have therapeutic value in patients with non-alcoholic fatty liver disease.Oct 31, 2012

Consumption of fruits that are high in antioxidants could represent a useful means to improve the antioxidant status of NAFLD.Jul 13, 2016

Consumption of hibiscus sabdariffa extracts reduced obesity, abdominal fat, serum FFA and improved liver steatosis.Mar 31, 2014

CoQ10 supplement at a dosage of 100 mg could be effective for improving the systemic inflammation and biochemical variables in NAFLD.Jul 08, 2015

Curcumin prevented the development of immunological alterations in NAFLD.Dec 31, 2016

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity.Mar 14, 2017

Exercise overcomes skeletal muscle insulin resistance. Aug 01, 2011

Flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.May 31, 2016

Garlic may reduce the amount of fat in the liver and prevent or delay the progression of NAFLD.Dec 31, 2015

Genistein can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD.May 31, 2017

Korean red ginseng might be effective in reducing pro-inflammatory cytokines and fatigue in overweight patients with NAFLD.Jun 30, 2016

Lifetime alcohol consumption with up to 13 units per week is associated with lower fibrosis stage in NAFLD. Sep 20, 2016

Maintenance of high cardiorespiratory fitness and stability of body weight are critical public health considerations for the treatment of NAFLD.Jul 20, 2016

n-3 PUFA treatment is safe and efficacious in obese children with NAFLD and can improve ultrasonographic findings and the elevated transaminase levels.Jun 04, 2015

National Health and Nutrition Examination Surveys data collected from 1988 to 2008 show that the prevalence of major causes of CLD remained stable, except for NAFLD, which increased steadily, along with the prevalence of metabolic conditions. Jun 01, 2011

Observations from this study suggest that cannabis use is associated with lower prevalence of NAFLD.Dec 31, 2016

Serum 25(OH)D level was inversely associated with liver fat content in middle-aged and elderly Chinese men.Dec 31, 2015

Serum carotenoids are inversely associated with prevalence of NAFLD in middle aged and elderly Chinese.Dec 31, 2014

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD.Mar 31, 2017

Short-term supplementation with Curcumin led to an improvement in different features of NAFLD.Jun 07, 2016

Short-term vitamin E treatment significantly improves abnormal liver enzyme levels in NAFLD patients with metabolic syndrome.Nov 30, 2015

Silymarin is effective in reduced ALT and AST in NAFLD.Jul 31, 2012

Silymarin may reduce liver fibrosis.Apr 14, 2017

Silymarin plus vitamin E could be beneficial in patients with non-alcoholic fatty liver disease.Jul 31, 2015

Supplementation at a high dosage of 6 g daily in NAFLD patients has strong and multiple beneficial metabolic effects and improves their health-related quality of life.Dec 31, 2013

Supplementation of 500 mg resveratrol, along with lifestyle modification, is superior to lifestyle modification alone.Sep 30, 2014

Tamoxifen and toremifene treatment is significantly associated with reversible NAFLD in Asian women.Jul 31, 2016

There was a significant drop in liver enzymes in patients with non-alcoholic fatty liver disease following administration of licorice root extract.Aug 31, 2012

Uric acid levels are elevated in children with NAFLD, indicating that fructose consumption may contribute to its pathogenesis. Jun 21, 2011

"Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome."Mar 21, 2012

A combination of flaxseed oil and astaxanthin may reduce NAFLD by reversing hepatic steatosis and reducing lipid accumulation and oxidative stress.Mar 12, 2017

A diet rich in saturated fat to a diet rich in unsaturated fat can attenuate NAFLD and atherosclerosis development.Dec 31, 2014

A polysaccharide rich ginkgo biloba extract has a protective effect against HFD-induced NAFLD.Jun 02, 2015

Administration of chokeberry powder may help attenuate high-fat diet-induced NAFLD.Dec 31, 2015

Alpha mangostin attenuated hepatic steatosis in high fat-diet fed rats potentially through enhanced cellular antioxidant capacity.Dec 31, 2015

Aronia melanocarpa could be beneficial for non-alcoholic fatty liver disease.Dec 31, 2016

Astaxanthin and vitamin E effectively improved hepatic gene expression.Mar 07, 2017

Astaxanthin inhibited and reversed lipotoxicity-induced insulin resistance and steatohepatitis in mice.Dec 31, 2014

Avocado oil improves mitochondrial ETC function by attenuating the deleterious effects of oxidative stress in the liver of diabetic rats. Jun 09, 2015

Berberine alleviates NASH and its predisposing factors.Feb 29, 2016

Berberine ameliorates non alcoholic fatty liver disease and related metabolic disorders.Dec 31, 2014

Berberine could be used in the treatment or prevention of obesity-associated NAFLD.Dec 31, 2015

Berberine may be a new therapeutic strategy against hepatic steatosis and non-alcoholic steatohepatitis.Dec 31, 2015

Bisdemethoxycurcumin may act as a novel and potent therapeutic agent against NAFLD.Dec 31, 2015

Bisphenol A could risk factor for non-alcoholic fatty liver disease.May 04, 2017

Blueberry and probiotics prevents NASH progression.Feb 26, 2017

C. aronia exhibits therapeutic and protective effects on NAFLD in an animal model.Jul 15, 2016

Camel milk could provide a natural way to protect against NAFLD induced by a high-fat diet.Dec 31, 2012

Carnosic acid may be an effective agent in protecting rats from NAFLD-induced dopaminergic neuron injury.Dec 12, 2016

Chronic consumption of fructose in combination with trans fatty acids induces nonalcoholic steatohepatitis with fibrosis in rats.Jul 03, 2017

Chronic intake of fructose and fat may lead to the development of NAFLD over time and that this is associated with an increased translocation of bacterial endotoxin.Jun 15, 2015

Crocus sativus has a protective action against non-alcoholic fatty liver disease in diabetic rats.Apr 30, 2017

Curcumin prevents the NASH by mitochondria protection and apoptosis reduction and provided a possible novel treatment for NASH.Dec 31, 2014

Docosahexaenoic acid blocks progression of western diet-induced nonalcoholic steatohepatitis.Dec 31, 2016

Ecklonia cava treatment ameliorated hepatic steatosis by inhibiting inflammation and improving lipid metabolism.Dec 31, 2014

Eucalyptus and banaba inhibit NASH induced by high-fructose and high-glucose diet in rats.Dec 31, 2014

Fructose is used to induce fatty liver disease in a rat model of insulin resistance. Dec 01, 2009

Fructose is used to induce fatty liver disease in a rat model. Jan 01, 2010

Fuzhuan tea prevented diet-induced inflammation in the liver, and also altered intestinal function.Feb 17, 2016

Ginkgolide A may be feasible as a therapeutic agent for NAFLD patients.Mar 31, 2017

Glucoraphanin supplementation attenuated weight gain, decreased hepatic steatosis, and improved glucose tolerance and insulin sensitivity.Feb 15, 2017

Glycyrrhizic acid produces a markedly protective effect against non-alcoholic steatohepatitis.Aug 03, 2016

Nonalcoholic fatty liver disease (NAFLD)

View the Evidence:
144 Abstracts with Nonalcoholic fatty liver disease (NAFLD) Research