NSAID-induced toxicity

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View the Evidence: Ailments

Acetaminophen and diphenhydramine premedication for for allergic and febrile nonhemolytic transfusion reactions may be ineffective and unsafe.

Pubmed Data : Transfus Med Rev. 2007 Jan;21(1):1-12. PMID: 17174216
Article Published Date : Jan 01, 2007
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Blood Transfusion : CK(60) : AC(4)
Problem Substances : Diphenhydramine : CK(72) : AC(9), Tylenol : CK(125) : AC(13)

Acetaminophen use after measles-mumps-rubella vaccination is associated with autistic disorder.

Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737
Article Published Date : May 01, 2008
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Autism Spectrum Disorders : CK(1140) : AC(108)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Tylenol : CK(125) : AC(13)

Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.

Pubmed Data : Am J Cardiol. 2004 Oct 1;94(7):975-7. PMID: 15464695
Article Published Date : Oct 01, 2004
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Drug-Induced Nutrient Depletion: Aspirin : CK(10) : AC(1), Drug-Induced Nutrient Depletion: Vitamin B-12 : CK(20) : AC(2), Vitamin B 12 Deficiency : CK(220) : AC(34)
Pharmacological Actions : Platelet Aggregation Inhibitors : CK(173) : AC(37)
Additional Keywords : Aspirin-Vitamin b12 Deficiency : CK(10) : AC(1), Drug-Nutrient Depletion : CK(64) : AC(7)

Autism may be associated with the use of acetaminophen in children.

Pubmed Data : Altern Med Rev. 2009 Dec;14(4):364-72. PMID: 20030462
Article Published Date : Dec 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Autism : CK(1262) : AC(65)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)

Chronic tylenol use is associated wtih an almost two-fold increased risk of blood cancer.

Pubmed Data : J Clin Oncol. 2011 May 9. Epub 2011 May 9. PMID: 21555699
Article Published Date : May 09, 2011
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Leukemia: Chronic Lymphocytic Leukemia (CLL) : CK(51) : AC(23), Lymphoma : CK(209) : AC(69)
Problem Substances : Tylenol : CK(125) : AC(13)
Adverse Pharmacological Actions : Carcinogenic : CK(912) : AC(117)

Drug-induced liver toxicity (particularly acetaminophen-induced liver toxicity) has replaced viral hepatitis as the most single frequent cause of acute liver failutre in ubran

Pubmed Data : Z Gastroenterol. 2009 Sep;47(9):807-13. Epub 2009 Sep 11. PMID: 19750427
Article Published Date : Sep 01, 2009
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Chemically-Induced Liver Damage : CK(475) : AC(175)
Problem Substances : Tylenol : CK(125) : AC(13)

Harmful effects of NSAIDs among patients with hypertension and coronary artery disease include increased cardiac mortality.

Pubmed Data : Am J Med. 2011 Jul;124(7):614-20. Epub 2011 May 18. PMID: 21596367
Article Published Date : Jul 01, 2011
Study Type : Human Study
Additional Links
Diseases : Cardiac Mortality : CK(703) : AC(67), Coronary Artery Disease : CK(1305) : AC(136), Hypertension : CK(2783) : AC(271), NSAID-induced toxicity : CK(230) : AC(50)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.

Pubmed Data : World J Gastroenterol. 2011 Jan 14 ;17(2):226-30. PMID: 21245996
Article Published Date : Jan 14, 2011
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Gastrointestinal Hemorrhage : CK(33) : AC(4), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)
Problem Substances : Aspirin : CK(471) : AC(64)

Tylenol use has been linked to unexplained dyspepsia.

Pubmed Data : Dig Dis Sci. 1988 Jun;33(6):641-8. PMID: 3371135
Article Published Date : Jun 01, 1988
Study Type : Human Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Dyspepsia : CK(422) : AC(21)
Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115), Tylenol : CK(125) : AC(13)

Under hypoxic conditions, the presence of aspirin would not help to inhibit further platelet activation.

Pubmed Data : Eur J Clin Invest. 1999 May;29(5):438-44. PMID: 10354201
Article Published Date : May 01, 1999
Study Type : Human Study
Additional Links
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Hypoxia : CK(100) : AC(41)
Problem Substances : Aspirin : CK(471) : AC(64)

Vitamin C attenuates aspirin-induced gastric damage.

Pubmed Data : Zhongguo Zhen Jiu. 2009 May;29(5):382-4. PMID: 17218764
Article Published Date : May 01, 2009
Study Type : Human Study
Additional Links
Substances : Vitamin C : CK(1274) : AC(238)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)

"Aspirin's ability to induce intestinal injury in rats is dependent on bile and can be reversed if pre-associated with phosphatidylcholine."

Pubmed Data : J Physiol Pharmacol. 2011 Aug ;62(4):491-6. PMID: 22100851
Article Published Date : Aug 01, 2011
Study Type : Animal Study
Additional Links
Substances : Phosphatidylcholine : CK(101) : AC(22)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24)
Pharmacological Actions : Gastroprotective : CK(62) : AC(31)
Problem Substances : Aspirin : CK(471) : AC(64)

"ulforaphane Protects Small Intestinal Mucosa From Aspirin/NSAID-Induced Injury by Enhancing Host Defense Systems Against Oxidative Stress and by Inhibiting Mucosal Invasion of Anaerobic Enterobacteria."

Pubmed Data : Curr Pharm Des. 2012 Aug 23. Epub 2012 Aug 23. PMID: 22950492
Article Published Date : Aug 22, 2012
Study Type : Animal Study
Additional Links
Substances : Sulforaphane : CK(520) : AC(171)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), NSAID-induced toxicity : CK(230) : AC(50)

6-gingerol, an active ingredient of ginger, protects acetaminophen-induced liver damage in mice.

Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2011 Nov ;9(11):1264-9. PMID: 22088594
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Gingerol : CK(4) : AC(2)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Liver Damage: Drug-Induced : CK(46) : AC(10)
Pharmacological Actions : Hepatoprotective : CK(557) : AC(272)

A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions.

Pubmed Data : J Ethnopharmacol. 1999 Jun;65(3):283-8. PMID: 10404428
Article Published Date : Jun 01, 1999
Study Type : Animal Study
Additional Links
Substances : Banana : CK(123) : AC(36), Flavonoids : CK(909) : AC(289)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

Acetaminophen (Tylenol) includes the toxicity associated with chronic exposure to depleted uranium.

Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469
Article Published Date : Jan 05, 2007
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Uranium Poisoning : CK(28) : AC(19)
Additional Keywords : Toxic Substance Synergy : CK(5) : AC(3)
Problem Substances : Tylenol : CK(125) : AC(13), Uranium : CK(46) : AC(21)
Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Nephrotoxic : CK(162) : AC(38)

Alpha lipoic acid protects against acetaminophen-induced liver and kidney damage.

Pubmed Data : Toxicology. 2008 Jan 20;243(3):261-70. Epub 2007 Oct 23. PMID: 18068886
Article Published Date : Jan 20, 2008
Study Type : Animal Study
Additional Links
Substances : Alpha-Lipoic Acid : CK(384) : AC(82)
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26)

Antipyretics increase influenza-associated mortality.

Pubmed Data : J R Soc Med. 2010 Oct;103(10):403-11. PMID: 20929891
Article Published Date : Oct 01, 2010
Study Type : Animal Study
Additional Links
Diseases : Acetaminophen (Tylenol) Toxicity : CK(100) : AC(26), Aspirin-Induced Toxicity : CK(83) : AC(24), Influenza : CK(654) : AC(102), Influenza: Mortality : CK(2) : AC(1)
Problem Substances : Aspirin : CK(471) : AC(64), Ibuprofen : CK(162) : AC(19), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1383) : AC(115)

Astaxanthin protects against gastric ulcer formation.

Pubmed Data : Phytother Res. 2011 Dec 14. Epub 2011 Dec 14. PMID: 22170791
Article Published Date : Dec 14, 2011
Study Type : Animal Study
Additional Links
Substances : Astaxanthin : CK(353) : AC(117)
Diseases : Alcohol Toxicity : CK(212) : AC(85), Aspirin-Induced Toxicity : CK(83) : AC(24), Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57), Gastroprotective : CK(62) : AC(31)

Banana powder has anti-ulcerogenic properties.

Pubmed Data : J Ethnopharmacol. 1986 Oct;18(1):33-44. PMID: 3821133
Article Published Date : Oct 01, 1986
Study Type : Animal Study
Additional Links
Substances : Banana : CK(123) : AC(36)
Diseases : Aspirin-Induced Toxicity : CK(83) : AC(24), Corticosteroid-Induced Toxicity : CK(78) : AC(17), Duodenal Ulcer : CK(89) : AC(26), Gastric Ulcer : CK(246) : AC(91), NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions : Anti-Ulcer Agents : CK(162) : AC(57)

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