Pancreatic Cancer

 

 

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View the Evidence: Ailments

Oral curcumin is safe and feasible in patients with pancreatic cancer.

Pubmed Data : Cancer Chemother Pharmacol. 2010 Sep 22. Epub 2010 Sep 22. PMID: 20859741
Article Published Date : Sep 22, 2010
Study Type : Human Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cancers: Drug Resistant : CK(225) : AC(147), Pancreatic Cancer : CK(530) : AC(168)
Additional Keywords : Drug Synergy : CK(327) : AC(147)

Pancreatic cancer risk may be associated with higher pesticide and herbicide exposure.

Pubmed Data : Int J Epidemiol. 1998 Oct;27(5):781-7. PMID: 9839733
Article Published Date : Oct 01, 1998
Study Type : Human Study
Additional Links
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Pancreatic disease may be caused by hepatic detoxification caused by excessive consumption of drugs, cigarettes, alcohol and coffee.

Pubmed Data : Lancet. 1983 Oct 29;2(8357):1000-3. PMID: 6138545
Article Published Date : Oct 29, 1983
Study Type : Human Study
Additional Links
Diseases : Alcohol Toxicity : CK(212) : AC(85), Pancreatic Cancer : CK(530) : AC(168), Pancreatic Diseases : CK(16) : AC(4), Tobacco Toxicity : CK(166) : AC(15)

Reducing dietary sugar, glycemic load and insulin levels may reduce the risk of pancreatic cancer.

Pubmed Data : J Natl Cancer Inst. 2002 Sep 4;94(17):1293-300. PMID: 12208894
Article Published Date : Sep 04, 2002
Study Type : Human Study
Additional Links
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Therapeutic Actions : Dietary Modification: Low Glycemic Diet : CK(60) : AC(6)
Problem Substances : Foods: High Glycemic Load : CK(10) : AC(1)

Statin use may increase the risk of pancreatic cancer:

Pubmed Data : Pancreas. 2011 Jul ;40(5):669-72. PMID: 21654539
Article Published Date : Jul 01, 2011
Study Type : Human Study
Additional Links
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Problem Substances : Statin Drugs : CK(3969) : AC(465)

The consumption of folate rich foods (not from supplements) is associated with reduced pancreatic cancer risk.

Pubmed Data : J Natl Cancer Inst. 2006 Mar 15;98(6):407-13. PMID: 16537833
Article Published Date : Mar 15, 2006
Study Type : Human Study
Additional Links
Substances : Folic Acid : CK(542) : AC(77)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

The consumption of sugar-sweetened soft drinks may be associated with a modest but significant increase in risk of pancreatic cancer among women who have an underlying degree of insulin resistance.

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2098-105. PMID: 16172216
Article Published Date : Sep 01, 2005
Study Type : Human Study
Additional Links
Diseases : Insulin Resistance : CK(1034) : AC(221), Pancreatic Cancer : CK(530) : AC(168)
Additional Keywords : Diseases that are Linked : CK(2122) : AC(270)
Problem Substances : Sugary soda : CK(149) : AC(20)

Unsaturated fats, and not saturated ones like stearate, may promote pancreatic carcinogenesis.

Pubmed Data : Thromb Res. 2009 Jul;124(3):328-34. Epub 2009 Apr 5. PMID: 2572741
Article Published Date : Jul 01, 2009
Study Type : Human Study
Additional Links
Substances : Stearic Acid (stearate) : CK(23) : AC(8)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Vitamin D may have significant value in the prevention and treatment of pancreatic cancer. - Article 2.

Pubmed Data : Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1688-95. PMID: 16985031
Article Published Date : Sep 01, 2006
Study Type : Human Study
Additional Links
Substances : Vitamin D : CK(1682) : AC(238)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Vitamin E and C, selected carotenoids and folate intakes are correlated with a reduced risk for pancreatic cancer.

Pubmed Data : Ann Oncol. 2010 Jun 7. Epub 2010 Jun 7. PMID: 20530201
Article Published Date : Jun 07, 2010
Study Type : Human Study
Additional Links
Substances : Carotenoids : CK(1055) : AC(213), Folate: Dietary : CK(62) : AC(7), Vitamin C : CK(1274) : AC(238), Vitamin E : CK(1285) : AC(221)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Additional Keywords : Risk Reduction : CK(1909) : AC(196)

Dandelion root induces selective apoptosis and autophagy in human pancreatic cancer cells in a dose and time dependent manner.

Pubmed Data : Pancreas. 2012 Oct ;41(7):1039-47. PMID: 22647733
Article Published Date : Sep 30, 2012
Study Type : Human In Vitro
Additional Links
Substances : Dandelion : CK(91) : AC(30)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Autophagy Up-regulation : CK(18) : AC(13)
Additional Keywords : Selective Cytotoxicity : CK(58) : AC(41)

Zerumbone was able to induce apoptosis of pancreatic carcinoma cell lines

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2012 ;2012:936030. Epub 2012 Jan 29. PMID: 22454691
Article Published Date : Jan 01, 2012
Study Type : Human In Vitro
Additional Links
Substances : Ginger : CK(310) : AC(89), Zerumbone : CK(5) : AC(1)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Caspase-3 Activation : CK(23) : AC(15), P21 Activation : CK(8) : AC(1), Tumor Suppressor Protein p53 Upregulation : CK(146) : AC(105)
Additional Keywords : Zerumbone

A high omega-3 fatty acid diet mitigates pancreatic precancer development in a mouse experimental model.

Pubmed Data : J Surg Res. 2009 May 15. PMID: 19631339
Article Published Date : May 15, 2009
Study Type : Animal Study
Additional Links
Substances : Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

A Western-style diet induced pancreatic epithelial cell hyperproliferation in mice, further suggesting that increased fat content and decreased calcium and vitamin D contribute to the development of pancreatic neoplasms.

Pubmed Data : J Natl Cancer Inst. 1996 Nov 6;88(21):1586-90. PMID: 8901857
Article Published Date : Nov 06, 1996
Study Type : Animal Study
Additional Links
Substances : Calcium : CK(232) : AC(35), Vitamin D : CK(1682) : AC(238)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)
Anti Therapeutic Actions : Western Diet : CK(86) : AC(24)

Apigenin enhances the anti-tumor effect of gemcitabine.

Pubmed Data : Cancer Lett. 2008 Jan 18;259(1):39-49. Epub 2007 Oct 29. PMID: 17967505
Article Published Date : Jan 18, 2008
Study Type : Animal Study
Additional Links
Substances : Apigenin : CK(76) : AC(51)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114), NF-kappaB Inhibitor : CK(595) : AC(401)
Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Artesunate, a novel derivative of artemisin, has in vitro and in vivo anticancer activity against pancreatic cancer. It exhibits selective cytotoxicity and has in vivo antitumor activity similar to that of gemcitabine.

Pubmed Data : Cancer Chemother Pharmacol. 2010 Apr;65(5):895-902. Epub 2009 Aug 19. PMID: 19690861
Article Published Date : Apr 01, 2010
Study Type : Animal Study
Additional Links
Substances : Artemisinin : CK(59) : AC(13)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Antineoplastic Agents : CK(877) : AC(496), Apoptotic : CK(1489) : AC(1114)
Additional Keywords : Drug: Gemcitabine : CK(36) : AC(13), Selective Cytotoxicity : CK(58) : AC(41), Superiority of Natural Substances versus Drugs : CK(826) : AC(164)

Benzyl isothiocyanate and sulforaphane protect against initiation of pancreatic carcinogenesis in hamsters.

Pubmed Data : Cancer Lett. 2006 Sep 28;241(2):275-80. Epub 2006 Jan 4. PMID: 16386831
Article Published Date : Sep 28, 2006
Study Type : Animal Study
Additional Links
Substances : Benzyl isothiocyanate : CK(4) : AC(3), Sulforaphane : CK(520) : AC(171)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Chemopreventive : CK(1528) : AC(382), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)
Additional Keywords : Isothiocyanates : CK(70) : AC(23), Stilbenes : CK(402) : AC(242)

Boswellic acid suppresses growth and metastatis of human pancreatic tumors (nude mouse model).

Pubmed Data : PLoS One. 2011 ;6(10):e26943. Epub 2011 Oct 31. PMID: 22066019
Article Published Date : Jan 01, 2011
Study Type : Transgenic Animal Study
Additional Links
Substances : Boswellia : CK(122) : AC(31)
Diseases : Cancer Metastasis : CK(272) : AC(135), Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Anti-metastatic : CK(192) : AC(115), Apoptotic : CK(1489) : AC(1114), Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), Vascular Endothelial Growth Factor Inhibitors : CK(13) : AC(8)

Capsaicin is an effective inhibitor of in vitro and in vivo growth of pancreatic cancer cells.

Pubmed Data : Apoptosis. 2008 Dec;13(12):1465-78. PMID: 19002586
Article Published Date : Dec 01, 2008
Study Type : Animal Study
Additional Links
Substances : Cayenne : CK(139) : AC(20)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Cucurbitacin B, a compound found within plants such as Bitter Apple, potentials the effect of gemcitabine and has profound antiproliferative effects against pancreatic cancer cell lines, in vitro and in vivo.

Pubmed Data : Cancer Res. 2009 Jul 15;69(14):5876-84. PMID: 19605406
Article Published Date : Jul 15, 2009
Study Type : Animal Study
Additional Links
Substances : Bitter Apple : CK(2) : AC(1)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

Curcumin and omega-3 fatty acids provide synergistic pancreatic tumor inhibitory properties in a mouse experimental model.

Pubmed Data : Nutr Cancer. 2008;60 Suppl 1:81-9. PMID: 19003584
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Curcumin inhibits the growth of pancreatic cancer in a mouse experimental model.

Pubmed Data : Anticancer Res. 2009 Jun;29(6):1895-9. PMID: 19528445
Article Published Date : Jun 01, 2009
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Pancreatic Cancer : CK(530) : AC(168)

Curcumin potentiates the activity of the chemotherapy agent gemcitabine in vitro and in vivo animal models of pancreatic cancer.

Pubmed Data : Cancer Res. 2007 Apr 15;67(8):3853-61. PMID: 17440100
Article Published Date : Apr 15, 2007
Study Type : Animal Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Additional Keywords : Chemotherapeutic Synergy: Gemcitabine : CK(10) : AC(8), Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)

EGCG, a green tea polyphenol, inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer in vivo.

Pubmed Data : Front Biosci. 2008 Jan 1;13:440-52. PMID: 17981559
Article Published Date : Jan 01, 2008
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109), Green Tea : CK(930) : AC(294)
Diseases : Pancreatic Cancer : CK(530) : AC(168)
Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101)

Emodin exerts anti-metastatic activity in pancreatic cancer both in vitro and in vivo.

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2011 Nov ;36(22):3167-71. PMID: 22375400
Article Published Date : Nov 01, 2011
Study Type : Animal Study
Additional Links
Substances : Emodin : CK(32) : AC(19)
Diseases : Cancer Metastasis : CK(272) : AC(135), Pancreatic Cancer : CK(530) : AC(168), Pancreatic Cancer: Metastatic : CK(2) : AC(1)
Pharmacological Actions : Anti-Angiogenic : CK(143) : AC(101), Anti-metastatic : CK(192) : AC(115), Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30), NF-kappaB Inhibitor : CK(595) : AC(401)

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