Parkinson Disease

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Quick Summary: Current access displays 2 out of 43 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Mucuna pruriens (aka Velvet Beans)	37	7	Log in \| Sign up
Coenzyme Q10	36	6	Log in \| Sign up

Quick Summary: Current access displays 2 out of 4 associated Problem Substances

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Cholinesterase Inhibitor Drugs	1	1	Log in \| Sign up
Donepezil (trade name Aricept)	1	1	Log in \| Sign up

Quick Summary: Current access displays 2 out of 6 associated Therapeutic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Tai Chi	30	3	Log in \| Sign up
Dancing	20	2	Log in \| Sign up

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View the Evidence: Ailments

"Tai chi training appears to reduce balance impairments in patients with mild-to-moderate Parkinson's disease, with additional benefits of improved functional capacity and reduced falls."

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Pubmed Data : N Engl J Med. 2012 Feb 9 ;366(6):511-9. PMID: 22316445

Article Published Date : Feb 09, 2012

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79), Posture Disorders : CK(30) : AC(3)

Therapeutic Actions : Tai Chi : CK(382) : AC(38)

A ketogenic diet has anticonvulsant and neuroprotective effects.

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Pubmed Data : Przegl Lek. 2010;67(3):205-12. PMID: 20687386

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79)

Therapeutic Actions : Dietary Modification: Low Carbohydrate/Ketogenic : CK(141) : AC(20)

Pharmacological Actions : Anticonvulsants : CK(113) : AC(29), Neuroprotective Agents : CK(921) : AC(464)

A naturally occuring L-Dopa rich plant extract of Mucuna pruriens was found to be an effective treatment for patients with Parkinson's disease.

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Pubmed Data : J Altern Complement Med. 1995 Fall;1(3):249-55. PMID: 9395621

Article Published Date : Sep 01, 1995

Study Type : Human Study

Additional Links

Substances : Mucuna pruriens (aka Velvet Beans) : CK(39) : AC(8)

Diseases : Parkinson Disease : CK(541) : AC(79)

Acupuncture in combination with Madopa may improve cerebral glucose metabolism in Parkinson's disease.

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Pubmed Data : Cardiovasc Hematol Agents Med Chem. 2007 Oct;5(4):295-9. PMID: 19922349

Article Published Date : Oct 01, 2007

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79)

Therapeutic Actions : Acupuncture : CK(1313) : AC(144)

Although hip bone mineral density is strongly related to hip fracture risk in elderly white women, other clinical risk factors also are independent predictors of long-term risk.

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Pubmed Data : J Am Geriatr Soc. 2004 Sep;52(9):1479-86. PMID: 15341549

Article Published Date : Sep 01, 2004

Study Type : Human Study

Additional Links

Diseases : Bone Fractures : CK(1598) : AC(69), Diabetes Mellitus: Type 2 : CK(3142) : AC(328), Hip Fracture : CK(1783) : AC(21), Osteoporosis : CK(1090) : AC(205), Parkinson Disease : CK(541) : AC(79), Vision Loss : CK(40) : AC(4)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Coenzyme Q10 appears to slow the progressive deterioration of function in Parkinson disease.

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Pubmed Data : Arch Neurol. 2002 Oct;59(10):1541-50. PMID: 12374491

Article Published Date : Oct 01, 2002

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10 : CK(669) : AC(104)

Diseases : Parkinson Disease : CK(541) : AC(79)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Coenzyme Q10 may contribute to the pathophysiology of Parkinson's disease.

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Pubmed Data : Neurosci Lett. 2008 Dec 5;447(1):17-9. Epub 2008 Sep 30. PMID: 18840506

Article Published Date : Dec 05, 2008

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10 : CK(669) : AC(104)

Diseases : Parkinson Disease : CK(541) : AC(79)

Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease.

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Pubmed Data : Neurosci Lett. 2003 May 8;341(3):201-4. PMID: 12697283

Article Published Date : May 08, 2003

Study Type : Human Study

Additional Links

Substances : Coenzyme Q10 : CK(669) : AC(104)

Diseases : Parkinson Disease : CK(541) : AC(79)

Dietary vitamin B6 consumption is inversely correlated to risk for Parkinsons disease.

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Pubmed Data : Neurology. 2006 Jul 25;67(2):315-8. PMID: 16864826

Article Published Date : Jul 25, 2006

Study Type : Human Study

Additional Links

Substances : Vitamin B-6 : CK(412) : AC(48)

Diseases : Parkinson Disease : CK(541) : AC(79)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

Ginkgo biloba extract may attentuate the neurotoxic effects of levodopa in parkinson disease.

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Pubmed Data : J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):151-3. PMID: 12973934

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba : CK(511) : AC(97)

Diseases : Parkinson Disease : CK(541) : AC(79)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

High homocysteine levels are associated with neurodegenerative conditions such as Parkinson's disease, ALS and progressive supranuclear palsy.

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Pubmed Data : Dement Geriatr Cogn Disord. 2010 Jul;29(6):553-9. Epub 2010 Jul 3. PMID: 20606437

Article Published Date : Jul 01, 2010

Study Type : Human Study

Additional Links

Diseases : Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Hyperhomocysteinemia : CK(368) : AC(57), Parkinson Disease : CK(541) : AC(79), Supranuclear Palsy: Progressive : CK(10) : AC(1)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

High homocysteine levels may be associated with the pathogenesis of neurological disorders.

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Pubmed Data : Front Biosci (Schol Ed). 2010;2:359-72. Epub 2010 Jan 1. PMID: 20036953

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : B-complex : CK(278) : AC(32)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Epilepsy : CK(128) : AC(27), High Homocysteine : CK(368) : AC(57), Hyperhomocysteinemia : CK(368) : AC(57), Multiple Sclerosis : CK(706) : AC(133), Parkinson Disease : CK(541) : AC(79), Stroke : CK(539) : AC(46)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Higher total serum cholesterol concentrations are associated with a modest slower clinical progression of Parkinson's disease.

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Pubmed Data : PLoS One. 2011 ;6(8):e22854. Epub 2011 Aug 11. PMID: 21853051

Article Published Date : Jan 01, 2011

Study Type : Human Study

Additional Links

Substances : Cholesterol : CK(392) : AC(43)

Diseases : Parkinson Disease : CK(541) : AC(79)

Homocysteine-lowering therapy may prevent bone loss in Parkinson's disease patients taking levodopa.

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Pubmed Data : Mov Disord. 2010 Feb 15;25(3):332-40. PMID: 19938151

Article Published Date : Feb 15, 2010

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(408) : AC(80), Vitamin B-12 : CK(752) : AC(94)

Diseases : Homocystinuria : CK(10) : AC(1), Parkinson Disease : CK(541) : AC(79)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

L-dopa causes high homocysteine levels which may be prevented with B-vitamin supplementation.

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Pubmed Data : Biometals. 2008 Sep 4. [Epub ahead of print] PMID: 14994447

Article Published Date : Sep 04, 2008

Study Type : Human Study

Additional Links

Substances : B-complex : CK(278) : AC(32)

Diseases : High Homocysteine : CK(368) : AC(57), Parkinson Disease : CK(541) : AC(79)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Mucuna pruriens is effective in treating the symptoms of Parkinson's disease, without the concomitant increase in dyskinesias that occurs with conventional L-dopa preparations.

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Pubmed Data : J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1672-7. PMID: 15548480

Article Published Date : Dec 01, 2004

Study Type : Human Study

Additional Links

Substances : Mucuna pruriens (aka Velvet Beans) : CK(39) : AC(8)

Diseases : Parkinson Disease : CK(541) : AC(79)

Neurotoxicity from pertussis infection may be casually related to the pathogenesis of Parkinson's disease.

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Pubmed Data : Int J Epidemiol. 1996 Dec;25(6):1301-11. PMID: 9027539

Article Published Date : Dec 01, 1996

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79), Pertussis : CK(122) : AC(14), Whooping Cough : CK(56) : AC(7)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

Reflexology may limit further deteroration or maintain improvement of wellbeing in Parkinson's disease patients.

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Pubmed Data : Complement Ther Clin Pract. 2010 May;16(2):96-100. Epub 2009 Nov 4. PMID: 20347841

Article Published Date : May 01, 2010

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79)

Therapeutic Actions : Massage/Therapeutic Touch : CK(720) : AC(73)

Relaxation guided imagery can dramatically reduce Parkinson's disease tremor.

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Pubmed Data : Mov Disord. 2009 Oct 30;24(14):2059-62. PMID: 19768725

Article Published Date : Oct 30, 2009

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79), Tremor : CK(39) : AC(8)

Therapeutic Actions : Relaxation Therapy : CK(70) : AC(7)

Sam-e appears to be well tolerated and effect in the treatment of depression in Parkinson's disease.

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Pubmed Data : Mov Disord. 2000 Nov;15(6):1225-9. PMID: 11104210

Article Published Date : Nov 01, 2000

Study Type : Human Study

Additional Links

Substances : SAMe (S-adenosylmethionine) : CK(89) : AC(17)

Diseases : Parkinson Disease : CK(541) : AC(79)

Short duration, intensive tango dancing is an appropriate and effective treatment for patients with mild to moderately severe Parkinson disease.

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Pubmed Data : Planta Med. 1996 Oct;62(5):405-9. PMID: 19632547

Article Published Date : Oct 01, 1996

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79)

Therapeutic Actions : Dancing : CK(220) : AC(22)

Tai Chi appears to be an appropriate, safe and effective form of exercise for some individuals with mild-moderately severe Parkinson disease.

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Pubmed Data : Gait Posture. 2008 Oct;28(3):456-60. Epub 2008 Apr 18. PMID: 18378456

Article Published Date : Oct 01, 2008

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79)

Therapeutic Actions : Tai Chi : CK(382) : AC(38)

Tango lessons improve balance, endurance, balance confidence, and quality of life in a participant with severe Parkinson disease.

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Pubmed Data : Disabil Rehabil. 2010;32(8):679-84. PMID: 20205582

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Diseases : Parkinson Disease : CK(541) : AC(79), Quality of Life: Poor : CK(170) : AC(16)

Therapeutic Actions : Dancing : CK(220) : AC(22)

A compound extracted from Chinese skullcap known as baicalein has neuroprotective effects in experimental parkinsonianism in vivo and in vitro.

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Pubmed Data : Pharmacol Biochem Behav. 2009 Jun;92(4):642-8. Epub 2009 Mar 25. PMID: 19327378

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Chinese Skullcap : CK(103) : AC(62)

Diseases : Parkinson Disease : CK(541) : AC(79), Parkinsonism : CK(12) : AC(8)

A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.

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Pubmed Data : Parkinsonism Relat Disord. 2010 Aug;16(7):458-65. Epub 2010 May 31. PMID: 20570206

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Substances : Dopa bean : CK(41) : AC(9)

Diseases : Dyskinesia Syndromes : CK(8) : AC(3), Parkinson Disease : CK(541) : AC(79), Parkinsonian Disorders : CK(15) : AC(4)

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