Rheumatoid Arthritis

Name	AC	CK
Vitamin D	3	30
Vitamin E	3	30
Curcumin	7	27
Fish Oil	5	24
Omega-3 Fatty Acids	5	24
Nigella sativa (aka Black Seed)	3	22
Cod Liver Oil	2	20
Tripterygium wilfordii	2	20
EPA (Eicosapentaenoic Acid)	3	13
Evening Primrose Oil	2	12
Krill	2	12
Pomegranate	2	11
Andrographis	1	10
Arginine	1	10
Ayurvedic Formulations	1	10
Bacillus coagulans	1	10
Bee Venom	1	10
Beta-hydroxy-beta-methylbutyrate	1	10
CLA (Conjugated Linoleic Acid)	1	10
EGCG (Epigallocatechin gallate)	7	10
Essential Fatty Acids	1	10
Eucalyptus	1	10
Folic Acid	1	10
Ginger	1	10
Glutamine	1	10
Lemon Verbena	1	10
Marjoram	1	10
Potassium	1	10
Rosemary	1	10
Silibinin	1	10
Tryptophan	1	10
Vitamin C	1	10
Vitamin K2	1	10
Vitamin K2: Menaquinone-7	1	10
Honokiol	1	5
Thymoquinone	3	5
Green Tea	2	4
Triphala	2	4
Turmeric	2	4
DHA (Docosahexaenoic Acid)	2	3
Flavonoids	2	3
Mussel: Green-lipped (Perna canaliculus)	2	3
Silver (nanoparticles)	1	3
Sulforaphane	2	3
Black Tea	1	2
Cannabinoids: Synthetic	1	2
Frankincense	1	2
Ginseng (Korean)	1	2
Guduchi	1	2
Isoliquiritigenin	1	2
Licorice	1	2
Myrrh	1	2
Naringenin	1	2
Olive Oil	1	2
Panax Ginseng	1	2
Resveratrol	2	2
Rose	1	2
Shikonin	1	2
Sumac	1	2
Tocotrienol: Delta	1	2
Apigenin	1	1
Avocado	1	1
Barley Grass	1	1
Berberine	1	1
Cucurbitacin E	1	1
Houttuynia cordata	1	1
Melatonin	1	1
Nettle	1	1
Soy	1	1
Unsaponifiables	1	1
Wheat Grass	1	1

Name	AC	CK
Tumor Necrosis Factor (TNF) Inhibitor Drugs	4	26
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)	4	24
Prednisone	3	23
Diclofenac	1	10
Gliadin	1	10
Glyphosate	1	10
High Fructose Corn Syrup	1	10
Hydroxychloroquine sulfate	1	10
Mineral Oil	1	10
Penicillamine	1	10
Pesticides	1	10
Statin Drugs	1	10
Sugar Sweetened Beverages	1	10
Aspirin	1	3
Corticosteroid	1	3
Etanercept	1	3
Infliximab	1	3
Methotrexate	1	2
Wheat Germ Agglutinin (WGA)	2	2
Lectins	1	1

Name	AC	CK
Dietary Modification: Vegetarian	2	20
Fasting/Caloric Restriction	2	20
Electroacupuncture	2	13
Aromatherapy	1	10
Aromatherapy Massage	1	10
Dietary Modification: Elemental Diet	1	10
Light Therapy	1	10
Reflexology	1	10
Tai Chi	1	10
Yoga	1	10
Mud therapy	1	3
Sauna Therapy	1	3

Name	AC	CK
Vaccination: All	3	13
Vaccination: Hepatitis B	3	13
Intrapartum Antibiotics: Group B Streptococcus	1	3
Vaccination: Adult Rubella	1	2
Vaccination: Diphtheria-Pertussis-Tetanus	1	1
Vaccination: HPV (Gardisil)	1	1
Vaccination: Haemophilus Influenzae	1	1
Vaccination: Influenza	1	1
Vaccination: Lyme disease	1	1
Vaccination: Mumps-Measles-Rubella (MMR)	1	1
Vaccination: Rabies	1	1
Vaccination: Rotavirus	1	1
Vaccination: Tetanus	1	1
Vaccination: Varicella (Chicken pox)	1	1

[+]

Some nonsteroidal antiinflammatory drugs can significantly increase C-reactive protein levels. Oct 31, 2012

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Arthritis Rheum. 2012 Nov ;64(11):3511-21. PMID: 22833186

Article Published Date : Oct 31, 2012

Study Type : Meta Analysis

Additional Links

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Additional Keywords : Risk Factors

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

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This meta-analysis found a statistically significant increase in the risk of dementia among patients with rheumatoid arthritis.Dec 31, 2015

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Exp Ther Med. 2015 Nov ;10(5):1812-1816. Epub 2015 Sep 15. PMID: 26640554

[+]

Excess free fructose beverage intake is significantly associated with arthritis in US adults aged 20-30 years.Dec 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Click here to read the entire abstract

Pubmed Data : Avicenna J Phytomed. 2016 Jan-Feb;6(1):34-43. PMID: 27247920

Click here to read the entire abstract

Pubmed Data : Eur J Clin Nutr. 2016 Aug 31. Epub 2016 Aug 31. PMID: 27577177

Article Published Date : Aug 30, 2016

Study Type : Human Study

Additional Links

Substances : Pomegranate

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants

[+]

Positive serum antigliadin antibodies without celiac disease have been associated with rhematoid arthritis and depression in the elderly.Oct 01, 2010

Click here to read the entire abstract

Pubmed Data : Scand J Gastroenterol. 2010 Oct;45(10):1197-202. PMID: 20545470

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oman Med J. 2016 Jul ;31(4):263-9. PMID: 27403238

Article Published Date : Jun 30, 2016

Study Type : Human Study

Additional Links

Substances : Silibinin

Diseases : C-Reactive Protein, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Natural Substance/Drug Synergy

[+]

Specific agricultural pesticides, solvents and chemical fertilizers may increase risk of rheumatoid arthritis in women.Jun 09, 2016

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Environ Health Perspect. 2016 Jun 10. Epub 2016 Jun 10. PMID: 27285288

Article Published Date : Jun 09, 2016

Study Type : Human Study

Additional Links

Diseases : Rheumatoid Arthritis

Additional Keywords : Increased Risk

Problem Substances : Glyphosate, Pesticides

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Tai Chi has statistically significant benefits on lower extremity range of motion, in particular ankle range of motion, for people with RA.Jan 01, 2004

Click here to read the entire abstract

Pubmed Data : Cochrane Database Syst Rev. 2004;(3):CD004849. PMID: 15266544

Article Published Date : Jan 01, 2004

Study Type : Human Study

Additional Links

Diseases : Rheumatoid Arthritis

Therapeutic Actions : Tai Chi

[+]

The addition of ascorbic acid significantly reduced the levels of all reactive oxygen species and reactive nitrogen species in RA patients.Jun 20, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Free Radic Biol Med. 2016 Jun 21 ;97:285-291. Epub 2016 Jun 21. PMID: 27344969

Article Published Date : Jun 20, 2016

Study Type : Human Study

Additional Links

Substances : Vitamin C

Diseases : Oxidative Stress, Rheumatoid Arthritis

Pharmacological Actions : Antioxidants

[+]

The data from this study suggests a possible link between exposure to T. gondii infection and rheumatoid arthritis.Jun 30, 2013

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Pubmed Data : Immunol Res. 2013 Jul ;56(2-3):287-92. PMID: 23553228

Article Published Date : Jun 30, 2013

Study Type : Human Study

Additional Links

Diseases : Autoimmune Diseases, Rheumatoid Arthritis, Toxoplasma gondii Infection, Toxoplasmosis

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The use of prednisone and TNF inhibitor drugs in the treatment of rheumatoid arthritis is associated with an increased rate of non-melanoma skin cancer. Nov 01, 2005

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Pubmed Data : J Rheumatol. 2005 Nov;32(11):2130-5. PMID: 16265690

Article Published Date : Nov 01, 2005

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Pubmed Data : Eur J Pharmacol. 2015 Aug 15 ;761:273-8. Epub 2015 Jun 11. PMID: 26073022

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Pubmed Data : Ann Rheum Dis. 1997 Nov;56(11):649-55. PMID: 9462166

Article Published Date : Nov 01, 1997

Study Type : Human Study

Additional Links

Substances : Vitamin E

Diseases : Arthritis: Rheumatoid, Rheumatoid Arthritis

Pharmacological Actions : Analgesics, Anti-Inflammatory Agents

Additional Keywords : Double Blind Trial

[+]

Vitamin K2 improves disease activity in rheumatoid arthritis. Nov 05, 2012

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Pubmed Data : Mod Rheumatol. 2012 Nov 6. Epub 2012 Nov 6. PMID: 23124653

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Clin Exp Pathol. 2015 ;8(7):7929-36. Epub 2015 Jul 1. PMID: 26339358

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Pubmed Data : JAMA. 1980 Mar 28;243(12):1260-1. PMID: 7359683

Article Published Date : Mar 28, 1980

Study Type : Human: Case Report

Additional Links

Diseases : Aging Skin, Rheumatoid Arthritis, Skin: Thinning

Problem Substances : Corticosteroid, Prednisone

[+]

This case report illustrates the increased risk of toxoplasmosis in rheumatoid arthritis patients treated with anti-TNF-α therapy.Jan 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Rheumatology (Oxford). 2014 Feb ;53(2):284. Epub 2013 Nov 4. PMID: 24191065

Article Published Date : Jan 31, 2014

Study Type : Human: Case Report

Additional Links

Diseases : Rheumatoid Arthritis, Toxoplasma gondii Infection, Toxoplasmosis

Additional Keywords : Increased Risk, Reactivation

Problem Substances : Tumor Necrosis Factor (TNF) Inhibitor Drugs

[+]

[Long-term remission induced by measles infection and followed by immunosuppressive therapy in a case of refractory juvenile rheumatoid arthritis].Feb 29, 1988

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Pubmed Data : Pediatr Med Chir. 1988 Mar-Apr;10(2):191-3. PMID: 3174483

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Article Publish Status : This is a free article. Click here to read the complete article.

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Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : J Pak Med Assoc. 2015 May ;65(5):519-25. PMID: 26028387

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Acta Cir Bras. 2014 Nov ;29(11):727-34. PMID: 25424293

Article Published Date : Oct 31, 2014

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Inflammation: Neutrophil-Mediated, Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

Additional Keywords : Natural Substances Versus Drugs

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

[+]

oral administration of shikonin in a mouse collagen antibody-induced model of RA led to a dose-dependent inhibition of arthritic disease.Dec 31, 2014

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Article Publish Status : This is a free article. Click here to read the complete article.

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Pubmed Data : Pharm Biol. 2015 Jan ;53(1):51-60. Epub 2014 Oct 7. PMID: 25289531

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Pubmed Data : Chem Biol Interact. 2009 Nov 10;182(1):29-36. Epub 2009 Aug 6. PMID: 19647729

Article Published Date : Nov 10, 2009

Study Type : In Vitro Study

Additional Links

Substances : Apigenin, Flavonoids

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Apoptotic

[+]

Barley contains compounds which may be of value in rheumatoid arthritis. Jul 01, 1998

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Pubmed Data : Roum Arch Microbiol Immunol. 1998 Jul-Dec;57(3-4):231-42. PMID: 11845435

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Pubmed Data : Mini Rev Med Chem. 2015 ;15(12):1002-10. PMID: 26156538

Article Published Date : Dec 31, 2014

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Pubmed Data : J Rheumatol. 1999 Dec;26(12):2517-22. PMID: 10606356

Article Published Date : Dec 01, 1999

Study Type : In Vitro Study

Additional Links

Substances : Nettle

Diseases : Arthritis: Rheumatoid, Rheumatoid Arthritis

[+]

Resveratrol may have therapeutic value in rhematoid arthritis.Jul 01, 2010

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2010 Jul;35(14):1878-82. PMID: 20939290

Article Published Date : Jul 01, 2010

Study Type : In Vitro Study

Additional Links

Substances : Resveratrol

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor Necrosis Factor (TNF) Alpha Inhibitor

Additional Keywords : Stilbenes

[+]

Review: green mussel extract has anti-inflammatory activity. Sep 01, 2000

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Pubmed Data : Allerg Immunol (Paris). 2000 Sep;32(7):272-8. PMID: 11094640

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2015 Sep 15 ;287(3):299-305. Epub 2015 Jun 29. PMID: 26134265

Article Published Date : Sep 14, 2015

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Rheumatoid Arthritis

Pharmacological Actions : Anti-Inflammatory Agents

[+]

Unsaponifiable extracts of avocado and soybean may inhibit the deleterious effects of interleukin-1 in osteoarticular diseases. Apr 01, 1991

Click here to read the entire abstract

Pubmed Data : Rev Rhum Mal Osteoartic. 1991 Apr;58(4):241-5. PMID: 1647544

Article Published Date : Apr 01, 1991

Study Type : In Vitro Study

Additional Links

Substances : Avocado, Soy, Unsaponifiables

Diseases : Osteoarthritis, Rheumatoid Arthritis

Pharmacological Actions : Interleukin-1 alpha downregulation, Interleukin-1 beta downregulation

Additional Keywords : Plant Extracts

[+]

Vaccination may contribute to causing a wide variety of autoimmune disorders. Feb 01, 2010

Click here to read the entire abstract

Pubmed Data : Discov Med. 2010 Feb;9(45):90-7. PMID: 20193633

Article Published Date : Feb 01, 2010

Study Type : Commentary

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View the Evidence: 118 Abstracts with Rheumatoid Arthritis Research

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Some nonsteroidal antiinflammatory drugs can significantly increase C-reactive protein levels. Oct 31, 2012

This meta-analysis found a statistically significant increase in the risk of dementia among patients with rheumatoid arthritis.Dec 31, 2015

These results establish specific alterations in the gut and oral microbiomes in individuals with RA and suggest potential ways of using microbiome composition for prognosis and diagnosis.Jul 26, 2015

40 arthritic patients divided into 2 groups, one was treated with an essential oil blend which decreased pain and depression levels.Jan 31, 2005

A decreased level of Vitamin D is a risk factor for the recurrence of rheumatoid arthritis.Oct 31, 2015

A vegetarian diet has a beneficial effect in patients with rheumatoid arthritis. Sep 01, 1999

An elemental diet for 2 weeks is as effective as prednisone in improving symptoms of active rheumatoid arthritis. Sep 01, 2007

Andrographis reduces subjective and objective symptoms of rheumatoid arthritis. Aug 01, 2009

Aromatherapy massage and reflexology can be used to help manage pain and fatigue in patients with rheumatoid arthritis.Mar 31, 2016

Atherothrombotic events in rheumatoid arthritis are predicted by homocysteine and folic acid reduces homocysteine levels.Sep 01, 2009

Bacillus coagulans is a viable adjunct therapy for relieving symptoms of rheumatoid arthritis. Jan 12, 2010

Bee venom has both a synergist and drug sparing effect when combined with drugs in the treatment of rheumatoid arthritis. Jun 01, 2008

Cashew may have anti-inflammatory activity in rheumatoid arthritis patients.Dec 06, 2006

Cod liver oil (omega-3 Fatty Acids) reduces the need for NSAIDs in patients with rheumatoid arthritis. May 01, 2008

Cod liver oil is safe and efficacious in the treatment of rheumatoid arthritis. Mar 01, 2002

Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA).Jan 31, 2012

Conjugated linoleic acid and vitamin E supplementation reduces inflammation in patients with active rheumatoid arthritis.Apr 01, 2009

Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis.Aug 01, 2011

Curcumin induces programmed cell death and inhibits proinflammatory prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis. Sep 01, 2007

Curcumin treatment is safe and superior to drug therapy in patients with active RA.Oct 31, 2012

Electroacupuncture can effectively decrease the proinflammatory cytokine of IL-1 and IL-6 and increase the inhibition cytokine of IL-4 and IL-10 and improve the internal environment of occurrence and progression of rheumatoid arthritis.Oct 01, 2010

EPO and EPO/fish oil produce a subjective improvement in rheumatoic arthritis patients and allow some patients to reduce or stop treatment with NSAIDsJan 31, 1988

Excess free fructose beverage intake is significantly associated with arthritis in US adults aged 20-30 years.Dec 31, 2015

Exposure to mineral oil is associated with rheumatoid arthritis. Jan 01, 2005

Fasting and a one-year vegetarian diet can reduce disease activity in some patients with rheumatoid arthritis.Jan 01, 1995

Fish oil supplementation decreases serum soluble receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio in female patients with rheumatoid arthritis.Dec 21, 2009

Fish oil supplementation reduces the need for NSAID requirement in patients with mild rheumatoid arthritis. Nov 01, 1993

Folate supplementation is protective against methotrexate induced side effects to the oral and gastrointestinal systems. Jan 01, 2000

Hepatitis B vaccination significantly increases the risk of a wide range of autoimmune diseases.Jun 01, 2005

Krill oil reduces symptoms of chronic inflammation and arthritis.Dec 01, 2005

Nigella sativa could improve inflammation and reduce oxidative stress in patients with rheumatoid arthritis.Dec 31, 2015

Oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine has therapeutic value in the treatment of rheumatoid cachexia. Jun 01, 2005

Persons with fibromyalgia and rheumatoid arthritis may have a hypothalamic-pituitary-adrenal axis disturbance (e.g. high cortisol). Feb 01, 2000

Phototherapy appears to be a plausible complementary option to reduce the inflammatory component in rheumatoid arthritis.Oct 31, 2015

POMx alleviates disease activity and improves some blood biomarkers of inflammation and oxidative stress in rheumatoid arthritis patients.Aug 30, 2016

Positive serum antigliadin antibodies without celiac disease have been associated with rhematoid arthritis and depression in the elderly.Oct 01, 2010

Potassium-rich diets may benefit patients with rheumatoid arthritis.Oct 01, 2009

Prednisone increases pneumonia risk in rheumatoid arthritis patients. Feb 01, 2006

Silibinin may improve the effects of methotrexate on certain biochemical and clinical markers of patients with active rheumatoid arthritis.Jun 30, 2016

Specific agricultural pesticides, solvents and chemical fertilizers may increase risk of rheumatoid arthritis in women.Jun 09, 2016

Statin drug use is associated with a significantly increased risk of rheumatoid arthritis. Oct 06, 2011

Supplementation of vit D in rheumatoid arthritis patients and vit D deficiency contributed to significant improvement in disease activity within a short duration.Oct 19, 2015

Supplementation with lemon verbena combined with omega-3 fatty acids may be considered for further investigation as a complementary and alternative treatment for improving joint status.Oct 31, 2011

Tai Chi has statistically significant benefits on lower extremity range of motion, in particular ankle range of motion, for people with RA.Jan 01, 2004

The addition of ascorbic acid significantly reduced the levels of all reactive oxygen species and reactive nitrogen species in RA patients.Jun 20, 2016

The data from this study suggests a possible link between exposure to T. gondii infection and rheumatoid arthritis.Jun 30, 2013

The use of prednisone and TNF inhibitor drugs in the treatment of rheumatoid arthritis is associated with an increased rate of non-melanoma skin cancer. Nov 01, 2005

Therapeutic mud applications may benefit cardiovascular patients with rheumatoid arthritis, osteoarthrosis and systemic scleroderma.Dec 01, 2003

There may be increased degradation of tryptophan in blood of patients with rheumatoid arthritis.Sep 01, 2003

These results suggest that menaquinone-7 improves disease activity in patients with rheumatoid arthritis.Aug 14, 2015

This study gives strength to the potential relevance of Nigella sativa in clinical management of rheumatoid arthritis.Apr 30, 2016

Treatment with monoclonal anti-TNF-alpha antibodies may be associated with increased risk of herpes zoster. Feb 18, 2009

Tripterygium wilfordii contains a compound which improves the safety and efficacy of methotrexate treatment in rheumatoid arthritis. Dec 01, 2001

Tripterygium wilfordii is superior to sulfasalazine in treating rheumatoid arthritis. Aug 18, 2009

Vitamin D deficiency is highly prevalent in RA patients and is associated with higher disease activity and worse QoL indices. Mar 31, 2015

Vitamin E exerts analgesic and anti-inflammatory activity in rheumatoid arthritis. Nov 01, 1997

Vitamin K2 improves disease activity in rheumatoid arthritis. Nov 05, 2012

Yoga decreases symptoms of rheumatoid arthritis in women. Jul 01, 2009

[D-penicillamine--side effects, pathogenesis and decreasing the risks].Dec 31, 1987

This study demonstrates that honokiol could possess potential anti-inflammatory effects.Dec 31, 2014

A 39-year-old woman with rheumatoid arthritis developed intrapartum anaphylaxis that led to fetal demise.Sep 01, 2007

Chronic inflammatory demyelinating polyneuropathy associated with tumor necrosis factor-alpha antagonists has been reported.May 01, 2010

EMMS therapy might be considered as effective treatments in reducing pain, depression, anxiety, and stress with improvement in physical functions.Sep 30, 2015

Nano-particulate silver showed long-lasting anti-Proteus activity in a normal human volunteer.Mar 31, 2014

Spontaneous skin tearing during systemic corticosteroid treatment has been reported.Mar 28, 1980

This case report illustrates the increased risk of toxoplasmosis in rheumatoid arthritis patients treated with anti-TNF-α therapy.Jan 31, 2014

[Long-term remission induced by measles infection and followed by immunosuppressive therapy in a case of refractory juvenile rheumatoid arthritis].Feb 29, 1988

Adult rubella and adult hepatitis B vaccines were statistically associated with chronic arthritis which persisted for at least one year.Nov 01, 2002

Curcumin suppresses type II collagen-induced arthritis in mice.Sep 01, 2009

EGCG could be useful for the prevention and treatment of rheumatoid arthritis and other inflammatory disorders.Dec 31, 2014

EGCG decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice.Mar 07, 2016

EGCG may regenerate the HOCl-production of MPO which is known to be impaired at chronic inflammatory diseases like RA.Dec 31, 2015

Rheumatoid Arthritis

View the Evidence:
118 Abstracts with Rheumatoid Arthritis Research