Statin-Induced Pathologies

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Quick Summary: Current access displays 2 out of 6 associated Substances
NameCumulative KnowledgeArticle CountFocus Articles
Coenzyme Q10527Log in | Sign up
Cholesterol 302Log in | Sign up
View the Evidence: Ailments

In a pooled analysis of data from 5 statin trials, intensive-dose statin therapy was associated with an increased risk of new-onset diabetes compared with moderate-dose statin therapy.

Pubmed Data : JAMA. 2011 Jun 22;305(24):2556-64. PMID: 21693744
Article Published Date : Jun 22, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 2 : CK(3142) : AC(328), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Diabetogenic : CK(124) : AC(14)

Lipid-lowering drugs contribute to erectile dysfunction.

Pubmed Data : Fam Pract. 2002 Feb ;19(1):95-8. PMID: 11818357
Article Published Date : Feb 01, 2002
Study Type : Meta Analysis
Additional Links
Diseases : Erectile Dysfunction : CK(510) : AC(41), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3769) : AC(442)

Lowering cholesterol concentrations may increase mortality.

Pubmed Data : BMJ. 1990 Aug 11 ;301(6747):309-14. PMID: 2144195
Article Published Date : Aug 11, 1990
Study Type : Meta Analysis
Additional Links
Substances : Cholesterol : CK(392) : AC(43)
Diseases : Mortality: All-Cause : CK(644) : AC(55), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(699) : AC(142)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349)

Pancreatitis, while rare, is a possible side effect of taking statin drugs.

Pubmed Data : Drug Saf. 2006 ;29(12):1123-32. PMID: 17147459
Article Published Date : Jan 01, 2006
Study Type : Meta Analysis
Additional Links
Diseases : Pancreatitis : CK(170) : AC(40), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)

Pravastatin therapy was associated with an increasing risk of cancer as age increases.

Pubmed Data : CMAJ. 2007 Feb 27 ;176(5):649-54. PMID: 17325332
Article Published Date : Feb 27, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(8467) : AC(2708), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(699) : AC(142)
Problem Substances : Pravastatin : CK(239) : AC(40)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Statin drugs increase the risk of diabetes.

Pubmed Data : Curr Opin Cardiol. 2011 Jul;26(4):342-7. PMID: 21499090
Article Published Date : Jul 01, 2011
Study Type : Meta Analysis
Additional Links
Diseases : Diabetes Mellitus: Type 1 : CK(1041) : AC(221), Drug-Induced Toxicity : CK(538) : AC(78), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Diabetogenic : CK(124) : AC(14)

The use of statins for LDL suppression is associated with increased risk for cancer.

Pubmed Data : J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
Article Published Date : Jul 31, 2007
Study Type : Meta Analysis
Additional Links
Diseases : Cancers: All : CK(8467) : AC(2708), Chemically-Induced Liver Damage : CK(453) : AC(175), High Cholesterol : CK(1755) : AC(198), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Carcinogenic : CK(871) : AC(110)

Concomitant use of erythromycin and simvastatin may increase the cataract risk.

Pubmed Data : Arch Intern Med. 2001 Sep 10 ;161(16):2021-6. PMID: 11525705
Article Published Date : Sep 10, 2001
Study Type : Human Study
Additional Links
Diseases : Cataract : CK(175) : AC(55), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Anti-Bacterial Agents : CK(895) : AC(291)
Problem Substances : Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)

Forty-five of 358 statin-treated patients demonstrated a 15% increase in LDL cholesterol levels, leading to suspicion of statin escape phenomenon.

Pubmed Data : Eur J Intern Med. 2005 Jun ;16(3):192-194. PMID: 15967335
Article Published Date : Jun 01, 2005
Study Type : Human Study
Additional Links
Diseases : Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Statin Drugs : CK(3769) : AC(442)

Among top sports performers only about 20% tolerate statin treatment without side-effects.

Pubmed Data : Br J Clin Pharmacol. 2004 Apr ;57(4):525-8. PMID: 15025753
Article Published Date : Apr 01, 2004
Study Type : Human Study
Additional Links
Diseases : Athletic Performance : CK(489) : AC(63), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Myotoxicity : CK(298) : AC(76)

An adverse grapefruit juice-simvastatin interaction has been identified.

Pubmed Data : Clin Pharmacol Ther. 1998 Nov ;64(5):477-83. PMID: 9834039
Article Published Date : Nov 01, 1998
Study Type : Human Study
Additional Links
Substances : Grapefruit : CK(109) : AC(30)
Diseases : Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins.

Pubmed Data : Mol Cell Biochem. 2003 Jul;249(1-2):129-40. PMID: 12956408
Article Published Date : Jul 01, 2003
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104), Vitamin E : CK(1290) : AC(218)
Diseases : Atherosclerosis : CK(282) : AC(77), Cholesterol: Oxidation : CK(447) : AC(98), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Enzyme Inhibitors : CK(386) : AC(208)

Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients

Pubmed Data : J Am Coll Cardiol. 2010 Mar 23 ;55(12):1209-16. PMID: 20298928
Article Published Date : Mar 23, 2010
Study Type : Human Study
Additional Links
Diseases : High Cholesterol : CK(1755) : AC(198), Hyperglycemia : CK(2867) : AC(59), Insulin Resistance : CK(995) : AC(212), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90), Insulin : CK(67) : AC(9), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31)

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.

Pubmed Data : Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526
Article Published Date : Jun 01, 2004
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5007) : AC(648), Coenzyme Q10 Deficiency : CK(83) : AC(13), Statin-Induced Pathologies : CK(1543) : AC(315), Stroke : CK(539) : AC(46)
Problem Substances : Atorvastatin : CK(486) : AC(90)

Atorvastatin may cause nightmares.

Article Publish Status : This is a free article. Click here to read the entire article.
Pubmed Data : BMJ. 2006 Apr 22 ;332(7547):950. PMID: 16627511
Article Published Date : Apr 22, 2006
Study Type : Human Study
Additional Links
Diseases : Nightmare : CK(13) : AC(2), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(699) : AC(142)
Problem Substances : Atorvastatin : CK(486) : AC(90)

Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol.

Pubmed Data : J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122
Article Published Date : Jan 01, 2005
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), High Cholesterol : CK(1755) : AC(198), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation.

Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254
Article Published Date : Nov 15, 2004
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104)
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Heart Failure : CK(669) : AC(97), Hypertension : CK(2615) : AC(260), Statin-Induced Pathologies : CK(1543) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(699) : AC(142), Antioxidants : CK(3503) : AC(1292)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Cardiotoxic : CK(604) : AC(74)

Atorvastatin-induced acute pancreatitis has been reported.

Pubmed Data : J Pharmacol Pharmacother. 2011 Jan ;2(1):40-2. PMID: 21701646
Article Published Date : Jan 01, 2011
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(453) : AC(175), Pancreatitis : CK(170) : AC(40), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90)
Adverse Pharmacological Actions : Hepatotoxic : CK(266) : AC(73)

Autoimmune hepatitis associated with atorvastatin use has been reported.

Pubmed Data : Eur J Gastroenterol Hepatol. 2003 Aug ;15(8):921-4. PMID: 12867804
Article Published Date : Aug 01, 2003
Study Type : Human Study
Additional Links
Diseases : Chemically-Induced Liver Damage : CK(453) : AC(175), Hepatitis: Autoimmune : CK(41) : AC(8), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Hepatotoxic : CK(266) : AC(73)

Cholesterol lowering medications also alter measurable hormonal concentrations.

Pubmed Data : J Clin Pharm Ther. 2004 Feb ;29(1):71-3. PMID: 14748901
Article Published Date : Feb 01, 2004
Study Type : Human Study
Additional Links
Diseases : Hormonal Perturbations: Dopamine Elevation : CK(10) : AC(1), Hormonal Perturbations: Homovanillic acid (HVA) Elevations : CK(10) : AC(1), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90), Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3769) : AC(442)

Cholesterol-lowering drugs may contribute to skin disorders.

Pubmed Data : Hautarzt. 1995 Feb ;46(2):76-80. PMID: 7706076
Article Published Date : Feb 01, 1995
Study Type : Human Study
Additional Links
Diseases : Eczema : CK(1006) : AC(87), Hyperlipidemia : CK(1212) : AC(109), Psoriasis : CK(270) : AC(42), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Pravastatin : CK(239) : AC(40), Simvastatin : CK(760) : AC(143), Statin Drugs : CK(3769) : AC(442)

Cholesterol-lowering medications reduce DHEA-secretory responses and sperm motility.

Pubmed Data : Metabolism. 1993 Sep ;42(9):1146-52. PMID: 8412767
Article Published Date : Sep 01, 1993
Study Type : Human Study
Additional Links
Diseases : DHEA: Low : CK(38) : AC(8), Sperm Quality: Low : CK(150) : AC(28), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3769) : AC(442)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(461) : AC(76)

Coenzyme Q10 has a corrective effect on statin-induced lowering of plasma coenzyme Q10 levels.

Pubmed Data : Atherosclerosis. 2007 Dec;195(2):e182-9. Epub 2007 Aug 6. PMID: 17681347
Article Published Date : Dec 01, 2007
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104)
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Statin-Induced Pathologies : CK(1543) : AC(315)

Coq10 supplementation corrects statin-induced coq10 depletion without affecting the cholesterol lowering effect of simvastatin.

Pubmed Data : Mol Aspects Med. 1994;15 Suppl:s187-93. PMID: 7752830
Article Published Date : Jan 01, 1994
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(669) : AC(104)
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs : CK(106) : AC(29), Statin-Induced Pathologies : CK(1543) : AC(315)
Additional Keywords : Drug: Simvastatin : CK(22) : AC(3), Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)

Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin has been observed.

Pubmed Data : Clin Pharmacol Ther. 2007 May ;81(5):650-3. Epub 2007 Feb 28. PMID: 17329991
Article Published Date : May 01, 2007
Study Type : Human Study
Additional Links
Diseases : Mitochondrial Dysfunction : CK(145) : AC(50), Statin-Induced Pathologies : CK(1543) : AC(315)
Problem Substances : Atorvastatin : CK(486) : AC(90), Statin Drugs : CK(3769) : AC(442)

Related Blogs

Statin Drugs Linked To Arthritis, Heart Trouble And More
Written by Sayer Ji
Research revealing the broad spectrum toxicity of statin drugs continues to accumulate unabated. Adding to a growing body of clinical evidence that they may cause over 300 adverse health effects, a new study reveals that these cholesterol-lowering drugs may be contributing to an epidemic of arthritis and autoimmunity in exposed populations, as well.
Statins Raise Diabetes Risk by 48% for Postmenopausal Women
Written by Margie King, Health Coach
More and more women are being prescribed cholesterol-lowering statins and some doctors are even recommending the drugs be added to the water supply or dispensed at the McDonald’s drive-thru windows. However, postmenopausal women using statins may be increasing their risk of diabetes according to a study published by the Archives of Internal Medicine.

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