Statin-Induced Pathologies

Views 8368
Jump to
Abstracts Focused Research Topics
Download the GMI DOC on this Topic

Sign in to Purchase/Download Documents

Sign in / Register

Focus Your Research

Click any topic below to filter + focus research
17 Substances Researched for Statin-Induced Pathologies
NameACCKFocus
Coenzyme Q101372Locked
Cholesterol 230Locked
Grapefruit323Locked
Vitamin E212Locked
Olive leaf extract110Locked
Policosanol110Locked
Red Yeast Rice110Locked
Vitamin D110Locked
Vitamin C24Locked
Alpha-Lipoic Acid12Locked
Camel Milk 12Locked
Ginkgo biloba12Locked
L-Carnitine12Locked
Quercetin12Locked
Thymoquinone12Locked
Astragaloside11Locked
Sesamol11Locked
22 Problem Substances Researched for Statin-Induced Pathologies
NameACCKFocus
Statin Drugs2641421Locked
Simvastatin105475Locked
Atorvastatin69338Locked
Lovastatin46181Locked
Pravastatin 28180Locked
Cholesterol Lowering Drugs1088Locked
Rosuvastatin1670Locked
Fenofibrates858Locked
Fluvastatin630Locked
Angiotensin-Converting Enzyme (ACE) Inhibitor 220Locked
Angiotensin Receptor Blockers (ARBs)110Locked
Atenolol110Locked
Insulin 110Locked
Pitavastatin110Locked
Cerivastatin49Locked
Fusidic acid26Locked
Antibiotics13Locked
Gemfibrozil13Locked
Lisinopril 13Locked
Cyclosporins12Locked
Mevastatin11Locked
Statin11Locked
3 Problematic Actions Researched for Statin-Induced Pathologies
NameACCKFocus
Surgical Procedures13Locked
Vaccination: All13Locked
Vaccination: Influenza13Locked

View the Evidence:
369 Abstracts with Statin-Induced Pathologies Research

[+]

Interstitial lung disease has been reported as a side effect of statins.Jan 01, 2006

Pubmed Data : Therapie. 2006 Jan-Feb;61(1):57-67. PMID: 16792155
Article Published Date : Jan 01, 2006
Study Type : Review
Additional Links
Diseases : Lung Diseases: Interstitial, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
[+]

It is thought that as many as 25% of statin users who exercise may experience muscle fatigue, weakness, aches, and cramping due to statin therapy and potentially dismissed by the patient and physician.Dec 01, 2006

Pubmed Data : Am J Physiol Cell Physiol. 2006 Dec ;291(6):C1208-12. Epub 2006 Aug 2. PMID: 16885396
Article Published Date : Dec 01, 2006
Study Type : Review
Additional Links
Diseases : Muscle Damage: Exercise-Induced, Myalgias, Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Lipid-lowering drugs may contribute to erectile dysfunction.Oct 01, 2002

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Fam Pract. 2002 Oct ;19(5):567. PMID: 12356716
Article Published Date : Oct 01, 2002
Study Type : Review
Additional Links
Diseases : Erectile Dysfunction, Statin-Induced Pathologies
Problem Substances : Cholesterol Lowering Drugs, Fenofibrates, Statin Drugs
[+]

Lovastatin exhibits neurotoxic properties.Oct 01, 1995

Pubmed Data : J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443
Article Published Date : Oct 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Enzyme Inhibitors
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin induces neuronal cell death through interacting with signal transduction pathways that cell control growth and survival. Feb 01, 2001

Pubmed Data : Mol Cell Neurosci. 2001 Feb ;17(2):329-41. PMID: 11178870
Article Published Date : Feb 01, 2001
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin induces neuronal cell death. Jun 01, 1999

Pubmed Data : J Neurochem. 1999 Jun ;72(6):2278-85. PMID: 10349836
Article Published Date : Jun 01, 1999
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage, Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin inhibits testosterone production in testicular cells.Sep 01, 1990

Pubmed Data : Exp Clin Endocrinol. 1990 Sep ;96(1):15-24. PMID: 2279522
Article Published Date : Sep 01, 1990
Study Type : In Vitro Study
Additional Links
Diseases : Low Testosterone, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Lovastatin may adversely affect myelin formation and the remyelination process. Apr 01, 1994

Pubmed Data : J Neurochem. 1994 Apr ;62(4):1539-45. PMID: 8133281
Article Published Date : Apr 01, 1994
Study Type : In Vitro Study
Additional Links
Diseases : Demyelinating Diseases, Statin-Induced Pathologies
Additional Keywords : Remyelination
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death.Dec 15, 2003

Pubmed Data : Toxicol Appl Pharmacol. 2003 Dec 15 ;193(3):346-55. PMID: 14678744
Article Published Date : Dec 15, 2003
Study Type : In Vitro Study
Additional Links
Diseases : Heart Failure, Statin-Induced Pathologies
Pharmacological Actions : Apoptotic
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Cytotoxic
[+]

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in neurons.Sep 01, 2010

Pubmed Data : Neurobiol Aging. 2010 Sep ;31(9):1543-53. Epub 2008 Oct 31. PMID: 18951667
Article Published Date : Sep 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Aging, Cognitive Decline/Dysfunction, Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Mevastatin exhibits potential neurotoxicity. Jun 01, 2002

Pubmed Data : J Neurosci Res. 2002 Jun 1 ;68(5):627-35. PMID: 12111853
Article Published Date : Jun 01, 2002
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Proteasome Inhibitors
Problem Substances : Mevastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Muscle cells may be particularly susceptible to a statin-induced suppression of essential antioxidant selenoproteinsOct 19, 2012

Pubmed Data : Toxicol Lett. 2012 Oct 20. Epub 2012 Oct 20. PMID: 23092657
Article Published Date : Oct 19, 2012
Study Type : In Vitro Study
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Myopathies, Statin-Induced Pathologies
Problem Substances : Cerivastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Muscle problems due to statins have been underestimated and may be as prevalent as 10%.Jan 01, 2010

Pubmed Data : Ned Tijdschr Geneeskd. 2010 ;154:A1684. PMID: 21435278
Article Published Date : Jan 01, 2010
Study Type : Review
Additional Links
Diseases : Muscle Soreness, Myalgias, Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Myopathy is a therapeutic limitation of statin drug therapy. Sep 01, 2006

Pubmed Data : Expert Opin Drug Saf. 2006 Sep ;5(5):651-66. PMID: 16907655
Article Published Date : Sep 01, 2006
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Observational studies suggest that myalgia can occur in up to 10% of persons prescribed statins.Jun 16, 2009

Pubmed Data : Ann Intern Med. 2009 Jun 16 ;150(12):858-68. PMID: 19528564
Article Published Date : Jun 16, 2009
Study Type : Review
Additional Links
Diseases : Myalgias, Myopathies, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

Patients with statin-induced myopathy show high MHC class I expression due to the immunomodulatory activity of the drugs. Sep 01, 2009

Pubmed Data : Ann N Y Acad Sci. 2009 Sep;1173:746-51. PMID: 19758224
Article Published Date : Sep 01, 2009
Study Type : Commentary
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

Postmortem analysis of Alzheimer brains reveals a loss in membrane cholesterol content, indicating that statin drugs may be contribute to neurodegenerative conditions. Apr 01, 2011

Pubmed Data : Neurol Sci. 2011 Apr ;32(2):195-201. Epub 2010 Oct 19. PMID: 20957505
Article Published Date : Apr 01, 2011
Study Type : Review
Additional Links
Diseases : Neurodevelopmental Disorders, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Pravastatin may contribute to the pathology of eye diseases by inhibit cholesterol synthesis in the lens.Sep 01, 1989

Pubmed Data : J Lipid Res. 1989 Sep ;30(9):1411-20. PMID: 2513368
Article Published Date : Sep 01, 1989
Study Type : In Vitro Study
Additional Links
Diseases : Eye Diseases, Lens Damage, Lens Diseases, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
[+]

Proteinuria is a known adverse effect of statin use. May 01, 2006

Pubmed Data : Drug Discov Today. 2006 May ;11(9-10):458-64. PMID: 16635810
Article Published Date : May 01, 2006
Study Type : Review
Additional Links
Diseases : Proteinuria, Statin-Induced Pathologies
Problem Substances : Rosuvastatin, Statin Drugs
[+]

Review provides evidence that mitochondrial mechanisms for statin-induced muscle adverse effects (AEs) have implications to non-muscle AEs ranging from thyroid dysfunction to neuropathy to cognitive loss.Jan 01, 2008

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cardiovasc Drugs. 2008 ;8(6):373-418. PMID: 19159124
Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Diseases : Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Review: Clinical characterization and molecular mechanisms of statin myopathy.Aug 01, 2008

Pubmed Data : Expert Rev Cardiovasc Ther. 2008 Aug ;6(7):955-69. PMID: 18666846
Article Published Date : Aug 01, 2008
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Review: Drug-induced liver injury associated with statins.Nov 01, 2009

Pubmed Data : Semin Liver Dis. 2009 Nov ;29(4):412-22. Epub 2009 Oct 13. PMID: 19826975
Article Published Date : Nov 01, 2009
Study Type : Review
Additional Links
Diseases : Chemically-Induced Liver Damage, Hepatitis: Autoimmune , Hepatitis: Cholestatic, Liver Damage, Liver Disease, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic
[+]

Review: molecular pathogenesis of statin myopathy.May 01, 2005

Pubmed Data : Muscle Nerve. 2005 May ;31(5):572-80. PMID: 15712281
Article Published Date : May 01, 2005
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Rosuvastatin's hepatotoxic potential may due to its exceptionally high rate of uptake in the liver.Feb 28, 2007

Pubmed Data : World J Gastroenterol. 2007 Feb 28 ;13(8):1286-8. PMID: 17451217
Article Published Date : Feb 28, 2007
Study Type : Review
Additional Links
Diseases : Chemically-Induced Liver Damage, Statin-Induced Pathologies
Problem Substances : Rosuvastatin
Adverse Pharmacological Actions : Hepatotoxic
[+]

Simvastatin disrupts IGF-1 signaling by decreasing its activity. Feb 01, 2007

Pubmed Data : J Toxicol Sci. 2007 Feb ;32(1):57-67. PMID: 17327694
Article Published Date : Feb 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Insulin-like Growth Factor-1: Signaling Abnormalities, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Simvastatin exhibits neurotoxic properties. Mar 17, 2000

Pubmed Data : Brain Res. 2000 Mar 17 ;859(1):169-72. PMID: 10720627
Article Published Date : Mar 17, 2000
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage, Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Simvastatin exhibits neurotoxicity in a neuronal cell model. Dec 06, 1996

Pubmed Data : Neurosci Lett. 1996 Dec 6 ;220(1):21-4. PMID: 8977139
Article Published Date : Dec 06, 1996
Study Type : In Vitro Study
Additional Links
Diseases : Brain Damage, Neurotoxicity, Statin-Induced Pathologies
Pharmacological Actions : Antiproliferative , Enzyme Inhibitors
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Simvastatin interferes with oligodendrocyte function, particularly the prior step in remyelination, indicating it may be harmful in demyelination diseases like MS. Nov 15, 2010

Pubmed Data : J Neurosci Res. 2010 Nov 15 ;88(15):3361-75. PMID: 20857509
Article Published Date : Nov 15, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Demyelinating Diseases, Multiple Sclerosis, Neuropathies, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Neurotoxic
[+]

Simvastatin may inhibit adrenal function and/or responsiveness. Oct 01, 2008

Pubmed Data : J Pharmacol Exp Ther. 2008 Oct;327(1):130-6. Epub 2008 Jul 1. PMID: 18593956
Article Published Date : Oct 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Hypoadrenalism, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
[+]

Simvastatin reduces steroid hormone production in rat ovarian cells.Sep 21, 2011

Pubmed Data : Biol Reprod. 2011 Sep 21. Epub 2011 Sep 21. PMID: 21918126
Article Published Date : Sep 21, 2011
Study Type : In Vitro Study
Additional Links
Diseases : Ovarian Diseases, Ovarian Failure, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Endocrine Disruptor: Ovary
[+]

Simvastatin suppresses human testicular testosterone synthesis.Apr 01, 1991

Pubmed Data : J Steroid Biochem Mol Biol. 1991 Apr ;38(4):465-8. PMID: 2031860
Article Published Date : Apr 01, 1991
Study Type : In Vitro Study
Additional Links
Diseases : Low Testosterone, Pregnancy: Environmental Exposures, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor, Teratogenic
[+]

Simvastatin treatment induces morphology alterations and cell death in mouse cochlear neuronal cells.Feb 01, 2009

Pubmed Data : Acta Otolaryngol. 2009 Feb ;129(2):166-74. PMID: 18607908
Article Published Date : Feb 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Cochlear Neuronal Damage, DNA damage, Hearing Disorders, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Some patients on simvastatin could be vulnerable to depression, violence, or suicide during the initial treatment period. Feb 28, 2005

Pubmed Data : Psychiatry Res. 2005 Feb 28 ;133(2-3):197-203. PMID: 15740995
Article Published Date : Feb 28, 2005
Study Type : Review
Additional Links
Diseases : Depression, Statin-Induced Pathologies, Suicidal Behavior, Violence
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Simvastatin
[+]

Statin drugs (HMG-CoA reductase inhibitors) induce programmed cell death in human liver cells. Jun 15, 2004

Pubmed Data : Biochem Pharmacol. 2004 Jun 15;67(12):2175-86. PMID: 15163549
Article Published Date : Jun 15, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

Statin drugs are associated with iatrognic myopathy. Oct 01, 2010

Pubmed Data : Curr Opin Neurol. 2010 Oct ;23(5):445-9. PMID: 20581681
Article Published Date : Oct 01, 2010
Study Type : Review
Additional Links
Diseases : Myopathy: Iatrogenic, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs are known in some cases to induce autoimmune myopathies such as dermatomyositis, polymyositis, and immune-mediated necrotizing myopathies (IMNM).Jun 01, 2011

Pubmed Data : Nat Rev Neurol. 2011 Jun ;7(6):343-54. Epub 2011 Jun 8. PMID: 21654717
Article Published Date : Jun 01, 2011
Study Type : Review
Additional Links
Diseases : Dermatomyositis, Immune-Mediated Necrotizing Myopathies , Polymyositis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Immunotoxic
[+]

Statin drugs decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells.Mar 01, 2005

Pubmed Data : Biol Reprod. 2005 Mar ;72(3):538-45. Epub 2004 Sep 22. PMID: 15385411
Article Published Date : Mar 01, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Ovarian Diseases, Ovulation Disorders, Statin-Induced Pathologies
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Apoptotic, Endocrine Disruptor: Ovary
[+]

Statin drugs deplete dolichol, which may contribute to statin toxicity and neurodegenerative diseases. Apr 01, 2004

Pubmed Data : J Alzheimers Dis. 2004 Apr ;6(2):129-35. PMID: 15096696
Article Published Date : Apr 01, 2004
Study Type : Review
Additional Links
Diseases : Molecular Pathologies: Dolichol Depletion, Neurodegenerative Diseases, Statin-Induced Pathologies
Pharmacological Actions : Antioxidants
Problem Substances : Statin Drugs
[+]

Statin drugs disrupt IGF-I signaling.Sep 10, 2004

Pubmed Data : J Biol Chem. 2004 Sep 10 ;279(37):38353-9. Epub 2004 Jul 7. PMID: 15247258
Article Published Date : Sep 10, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Insulin-like Growth Factor-1: Signaling Abnormalities, Statin-Induced Pathologies
Pharmacological Actions : Antiproliferative , Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Endocrine Disruptor
[+]

Statin drugs exhibit myotoxicity. Mar 01, 1995

Pubmed Data : Toxicol Appl Pharmacol. 1995 Mar ;131(1):163-74. PMID: 7878672
Article Published Date : Mar 01, 1995
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs have been linked to rhabdomyolysis, myositis and kidney failure. Oct 21, 2011

Pubmed Data : Curr Vasc Pharmacol. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22022768
Article Published Date : Oct 21, 2011
Study Type : Review
Additional Links
Diseases : Kidney Damage: Drug-Induced, Kidney Failure, Myositis, Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Nephrotoxic
[+]

Statin drugs induce cell death in mouse kidney cells.Oct 01, 1997

Pubmed Data : Kidney Int. 1997 Oct ;52(4):962-72. PMID: 9328935
Article Published Date : Oct 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Kidney Damage, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Apoptotic, Cytotoxic, Nephrotoxic
[+]

Statin drugs induce cell death in rat myotubes. Nov 01, 2004

Pubmed Data : Toxicol Appl Pharmacol. 2004 Nov 1 ;200(3):237-50. PMID: 15504460
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs may cause myopathy by lowering vitamin E levels. Nov 05, 2009

Pubmed Data : Med Hypotheses. 2009 Nov 5. Epub 2009 Nov 5. PMID: 19896775
Article Published Date : Nov 05, 2009
Study Type : Review
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Statin-Induced Pathologies, Vitamin E Deficiency
Additional Keywords : Statin-Vitamin E Deficiency
Problem Substances : Statin Drugs
[+]

Statin drugs may induce selenium deficiency which may explain many of its enigmatic side effects.Mar 13, 2004

Pubmed Data : Lancet. 2004 Mar 13;363(9412):892-4. PMID: 15031036
Article Published Date : Mar 13, 2004
Study Type : Review
Additional Links
Diseases : Coronary Artery Disease, Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin drugs may intefere with neurological function in the brain by inhibiting cholesterol biosynthesis and synaptic transmission.Sep 07, 2011

Pubmed Data : J Neurochem. 2011 Sep 7. Epub 2011 Sep 7. PMID: 21899539
Article Published Date : Sep 07, 2011
Study Type : Review
Additional Links
Diseases : Drug-Induced Toxicity , Neurologic Disorders, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statin drugs may interfere with the immune cell function. Nov 01, 1991

Pubmed Data : Am J Physiol. 1991 Nov ;261(5 Pt 1):C780-6. PMID: 1659206
Article Published Date : Nov 01, 1991
Study Type : In Vitro Study
Additional Links
Diseases : Immune Disorders: Low Immune Function, Statin-Induced Pathologies
Problem Substances : Lovastatin, Simvastatin, Statin Drugs
[+]

Statin drugs may reduce T cell responses associated with inhibiting influenza A virus. Jan 01, 2010

Pubmed Data : Cell Immunol. 2010 ;264(1):71-7. Epub 2010 May 4. PMID: 20483407
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Influenza A, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Immunosuppressive
[+]

Statin drugs result in coq10 depletion associated with congestive heart failure and which may be rectified by supplementation. Jan 01, 2003

Pubmed Data : Biofactors. 2003;18(1-4):101-11. PMID: 14695925
Article Published Date : Jan 01, 2003
Study Type : Review
Additional Links
Substances : Coenzyme Q10
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, Heart Failure, Statin-Induced Pathologies
Additional Keywords : Drug-Nutrient Depletion, Statin-Coq10 Depletion
[+]

Statin therapy alters the expression of genes that regulate calcium homeostasis and membrane repair in skeletal muscle.Jul 01, 2010

Pubmed Data : Am J Pathol. 2010 Jul ;177(1):291-9. Epub 2010 May 20. PMID: 20489141
Article Published Date : Jul 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Skeletal Muscle: Drug-Induced Changes, Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

Statin therapy may increase the risk for posttransplantation squamous cell carcinoma.Aug 01, 2010

Pubmed Data : Transpl Immunol. 2010 Aug ;23(4):224-5. Epub 2010 Jun 17. PMID: 20591670
Article Published Date : Aug 01, 2010
Study Type : Commentary
Additional Links
Diseases : Skin Cancer, Squamous cell carcinoma, Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

Statin toxicity is pleiotropic in nature. Mar 01, 2010

Pubmed Data : FEMS Yeast Res. 2010 Mar ;10(2):188-98. Epub 2009 Nov 3. PMID: 20002195
Article Published Date : Mar 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Additional Keywords : Saccharomyces Cerevisiae
Problem Substances : Atorvastatin
[+]

Statin-associated myopathy is a significant problem with a prevalence rate between 1-5%. Apr 02, 2003

Pubmed Data : JAMA. 2003 Apr 2 ;289(13):1681-90. PMID: 12672737
Article Published Date : Apr 02, 2003
Study Type : Review
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

statin-induced inhibition of protein synthesis is an underlying mechanism for statin-induced cardiomyocyte cell death.Jan 01, 2007

Pubmed Data : Cardiovasc Toxicol. 2007 ;7(1):1-9. PMID: 17646677
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Heart Failure, Statin-Induced Pathologies
Pharmacological Actions : Apoptotic
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Cytotoxic
[+]

Statin-induced liver injury may result from the suppression of selenoprotein expression.Jun 01, 2009

Pubmed Data : Mol Pharmacol. 2009 Jun;75(6):1421-9. Epub 2009 Mar 30. PMID: 19332511
Article Published Date : Jun 01, 2009
Study Type : In Vitro Study
Additional Links
Diseases : Chemically-Induced Liver Damage, Drug-Induced Nutrient Depletion: Statin Drugs, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Statin-Selenium Deficiency
Problem Substances : Atorvastatin, Statin Drugs
[+]

Statin-induced myopathy is associated with skeletal muscle cell MHC I expression changes.Feb 01, 2010

Pubmed Data : Muscle Nerve. 2010 Feb ;41(2):179-84. PMID: 19813190
Article Published Date : Feb 01, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Skeletal Muscle: Changes to MHC I expression, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statin-mediated myopathy is likely mediated by reductions in protein prenylation and especially N-linked glycosylation.Apr 15, 2010

Pubmed Data : Biochem Pharmacol. 2010 Apr 15 ;79(8):1200-9. Epub 2009 Dec 14. PMID: 20018177
Article Published Date : Apr 15, 2010
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins alter mitochondrial function which may be associated with myotoxicity in skeletal muscle.Apr 15, 2005

Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):1067-75. PMID: 15752763
Article Published Date : Apr 15, 2005
Study Type : In Vitro Study
Additional Links
Diseases : Mitochondrial Dysfunction , Mitochondrial Myopathies, Statin-Induced Pathologies
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]

Statins and fenofibrates may exert their wide range of adverse side effects through interfering with selenoprotein expression.Oct 01, 2004

Pubmed Data : Trends Cardiovasc Med. 2004 Oct;14(7):273-81. PMID: 15542379
Article Published Date : Oct 01, 2004
Study Type : Review
Additional Links
Diseases : Drug-Induced Nutrient Depletion: Statin Drugs, High Cholesterol, Mineral Deficiencies: Selenium, Statin-Induced Pathologies
Additional Keywords : Drug-Nutrient Depletion, Statin-Selenium Deficiency
Problem Substances : Fenofibrates, Statin Drugs
[+]

Statins have been associated with arrest of DNA synthesis and proliferation in glial cells. Apr 01, 1986

Pubmed Data : J Neurochem. 1986 Apr ;46(4):1283-91. PMID: 3633306
Article Published Date : Apr 01, 1986
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

Statins have been associated with cell death in primary neuronal culture.Jan 01, 2007

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865
Article Published Date : Jan 01, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Neurotoxicity, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Neurotoxic
[+]

The adverse effects associated with statin drug use has been linked to mitochondrial dysfunction.Jan 01, 2008

Article Published Date : Jan 01, 2008
Study Type : Review
Additional Links
Diseases : Mitochondrial Dysfunction , Myopathies, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The adverse effects of statins may be amplified in the elderly, and include cancer, neurodegenerative conditions, heart failure and accelerated aging. May 01, 2005

Pubmed Data : Expert Opin Drug Saf. 2005 May ;4(3):389-97. PMID: 15934847
Article Published Date : May 01, 2005
Study Type : Commentary
Additional Links
Diseases : Cancers: All, Elderly: Age Specific Diseases, Heart Failure, Neurodegenerative Diseases, Statin-Induced Pathologies
Problem Substances : Statin Drugs
[+]

The incidence of statin-induced rhabdomyolysis is higher in practice than in controlled trials in which high-risk subjects are excluded. May 01, 2006

Pubmed Data : Am J Med. 2006 May ;119(5):400-9. PMID: 16651050
Article Published Date : May 01, 2006
Study Type : Review
Additional Links
Diseases : Rhabdomyolysis, Statin-Induced Pathologies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The myotoxicity of statin drugs may be due to the inhibition of the geranylgeranylation of low-molecular-weight proteins in the muscle cells.Jul 01, 1997

Pubmed Data : Toxicol Appl Pharmacol. 1997 Jul ;145(1):99-110. PMID: 9221829
Article Published Date : Jul 01, 1997
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies, Statin-Induced Pathologies
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy.Jan 01, 2004

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045
Article Published Date : Jan 01, 2004
Study Type : In Vitro Study
Additional Links
Diseases : Skeletal Muscle Changes: Ultrastructural Changes, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]

The statin drug lovastatin induces concentration-dependent cell death in cardiomyoctyes.Jan 01, 2008

Pubmed Data : Pharmacology. 2008 ;82(1):74-82. Epub 2008 May 27. PMID: 18504415
Article Published Date : Jan 01, 2008
Study Type : In Vitro Study
Additional Links
Diseases : Heart Failure, Statin-Induced Pathologies
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Cardiotoxic, Cytotoxic
[+]

This systematic review suggests that there is an association between atorvastatin treatment and new onset diabetes mellitus.Dec 31, 2017

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Int J Endocrinol. 2018 ;2018:8380192. Epub 2018 Oct 22. PMID: 30425742
Article Published Date : Dec 31, 2017
Study Type : Review
Additional Links
Diseases : Diabetes Mellitus: Type 1, Diabetes Mellitus: Type 2, Statin-Induced Pathologies
Additional Keywords : Increased Risk
Problem Substances : Atorvastatin
[+]

Treatment with atorvastatin is associated with mitochondrial oxidative stress, which activates apoptosis and contributes to myopathy. Sep 27, 2015

Pubmed Data : Antioxid Redox Signal. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26414931
Article Published Date : Sep 27, 2015
Study Type : In Vitro Study
Additional Links
Diseases : Oxidative Stress, Statin-Induced Pathologies
Problem Substances : Atorvastatin, Statin Drugs

Copyright: molekuul / 123RF Stock Photo

Statin-Induced Pathologies Related Articles

Cholesterol Drugs Linked To Eye Damage, JAMA Study Confirms Anew
Written by Sayer Ji, Founder
Statins are taken by millions of people worldwide, but most are unaware that their use has been linked to worsening eye health, along with over 300 adverse health effects.
Are Statin Drugs Killing the Health Benefits of Omega-3 Fat?
Written by Sayer Ji, Founder
There is a growing awareness that the unintended, adverse health effects of cholesterol-lowering statin drugs far outweigh their purported benefits. But new research now indicates that these chemicals may even be interfering with the heart-protective effects of beneficial fatty acids in those who are on them.
A New Greek Name for Statin Toxicity: Polymyalgia Rheumatica
Written by Sayer Ji, Founder
Over 30 billion dollars worth of this drug is sold annually and yet it may be benefiting no one. In fact, there are over 300 adverse effects associated with its use, not the least of which is the weakening of the heart muscle. In order to cover-up the symptoms of statin-induced muscle damage new "diseases" have been coined, including polymyalgia rheumatica.
Long Term Cholesterol Drug Use Doubles Risk of Breast Cancer
Written by Sayer Ji, Founder
A new study published in the journal Cancer Epidemiology, Biomarkers & Prevention indicates that women who are long-term users of statin drugs have between 83-143% increased risk of breast cancer.
Statin Drugs Found To Accelerate Arterial Calcification
Written by Sayer Ji, Founder
Statin drugs are already known to greatly increase the risk of developing type 2 diabetes, but newly published research now indicates they also accelerate cardiovascular complications associated with the disease, including coronary artery and aortic artery calcifications.
Confirmed Once Again: Statins Likely Harm The Heart
Written by Sayer Ji, Founder
New research published in the journal PLoS indicates that the use of the cholesterol-lowing class of drugs known as statins is associated with an increased prevalence of microalbuminuria, a well-known marker of vascular dysfunction, affecting both cardiovascular and kidney disease risk.
A Pox on Cholesterol Lowering Drugs: Statins Raise Herpes Zoster (Shingles) Risk
Written by Sayer Ji, Founder
Following in the wake of new U.S. guidelines that will require 70 million Americans take statin drugs, new research finds they increase the risk of herpest zoster (shingles), adding to the over 300 adverse health effects linked to this drug class.
Blind to the Truth: The Eye-Damaging Effects of Statins
Written by Sayer Ji, Founder
How long will it take medical doctors and their patients to see the truth? Will it take being physically blinded before they arrive at this awareness? Eye-associated adverse effects, including loss of vision, may be the tipping point when it comes to recognizing the profound range of damaging health effects associated with statin drug use
International Study Confirms LDL-Cholesterol Doesn't Predict Heart Disease Risk; Statin Drugs Probably Useless
Written by Sayer Ji, Founder
A recent international study published in the highest ranking cardiovascular journal in the world confirms what we’ve been saying at GreenMedInfo for over a decade: LDL cholesterol is not an accurate predictor of future cardiovascular events and statin drugs are useless at best, toxic to the heart at worst.
Cholesterol Lowing Statins Found To Damage Peripheral Nerves
Written by Sayer Ji, Founder
The neurotoxicity of statin drugs are back in the news. Following on the heels of the FDA decision earlier this year to require statin drugs manufacturers to add "memory loss" as a side effect of this chemical class, a new study in published in the Journal of Diabetes reveals a clear association between statin use and peripheral neuropathy in a US population 40 years of age and older.
International Study Confirms LDL-Cholesterol Doesn't Predict Heart Disease Risk; Statin Drugs Probably Useless
Written by Sayer Ji, Founder
A recent international study published in the highest ranking cardiovascular journal in the world confirms what we’ve been saying at GreenMedInfo for over a decade: LDL cholesterol is not an accurate predictor of future cardiovascular events and statin drugs are useless at best, toxic to the heart at worst.
Do the New Guidelines for Statins Make Sense?
Written by Dr. Michael Murray
Under the current guidelines, statins are recommended for about 15 percent of adults. With the new guidelines 44 percent of men and 22 percent of women would meet the criteria for taking a statin. Is this good, evidence-based medicine or misguided?
Lower Your Cholesterol, Increase Your Diabetes Risk By 48%
Written by Sayer Ji, Founder
A recent study, published in the Archives of Internal Medicine, found that the cholesterol-lowering drugs known as statins increase the risk of diabetes within postmenopausal women by 48%. This new finding adds to a growing body of clinical evidence that statin drugs are fundamentally diabetogenic, which is not surprising considering the National Library of Medicine contains peer-reviewed, published research on over 300 other known adverse effects associated with their use.
Are Statin Drugs Killing the Health Benefits of Omega-3 Fat?
Written by Sayer Ji, Founder
There is a growing awareness that the unintended, adverse health effects of cholesterol-lowering statin drugs far outweigh their purported benefits. But new research now indicates that these chemicals may even be interfering with the heart-protective effects of beneficial fatty acids in those who are on them.
Do Cholesterol Drugs Have Men By Their Gonads?
Written by Sayer Ji, Founder
Cholesterol-lowering drugs have been known to hit men 'below the belt' for years, contributing both to erectile dysfunction and low testosterone. Now, new research reveals they actually damage men's testicles and sperm.
Statin Drugs Found To Accelerate Arterial Calcification
Written by Sayer Ji, Founder
Statin drugs are already known to greatly increase the risk of developing type 2 diabetes, but newly published research now indicates they also accelerate cardiovascular complications associated with the disease, including coronary artery and aortic artery calcifications.
Do the New Guidelines for Statins Make Sense?
Written by Dr. Michael Murray
Under the current guidelines, statins are recommended for about 15 percent of adults. With the new guidelines 44 percent of men and 22 percent of women would meet the criteria for taking a statin. Is this good, evidence-based medicine or misguided?
Statins Provide No Benefit: Study of 4 Million People
Written by Heidi Stevenson
Aside from demonstrating that statins provide no benefit to most people, this study also demonstrates that the so-called gold standard, randomized double blinded placebo controlled, study is a farce. Add to that, though, the fact that statins have severe and deadly adverse effects, it's apparent that these drugs are doing great harm while providing no benefit.
Exercise Stops The Mitochondrial Aging Process In Its Tracks
Written by Sayer Ji, Founder
As we age, mitochondrial density (the number of mitochondria per cell), and mitochondrial quality (its genetic and structural integrity) decline. This is largely due to stress, environmental radiation and chemical exposures, prescribed drugs, nutritional deficiencies, imbalances and/or incompatibilities, and mitochondrial DNA defects inherited maternally, but is also a natural part of getting older.
Confirmed Once Again: Statins Likely Harm The Heart
Written by Sayer Ji, Founder
New research published in the journal PLoS indicates that the use of the cholesterol-lowing class of drugs known as statins is associated with an increased prevalence of microalbuminuria, a well-known marker of vascular dysfunction, affecting both cardiovascular and kidney disease risk.
Natural Niacin Beats Prescription Zetia for Cholesterol
Written by Margie King, Health Coach
What can Merck's prescription drug Zetia do for you that niacin can't? Apparently, nothing at all. In fact, it could worsen your atherosclerosis.
13 Alternatives to Viagra That Won't Fall Flat
Written by Sayer Ji, Founder
Viagra is a multi-billion dollar blockbuster drug, but it has serious side effects. Thankfully evidence-based natural alternatives abound...
13 Alternatives to Viagra That Won't Fall Flat
Written by Sayer Ji, Founder
Viagra is a multi-billion dollar blockbuster drug, but it has serious side effects. Thankfully evidence-based natural alternatives abound...
Statin Drugs Linked to Arthritis, Heart Trouble and More
Written by Sayer Ji, Founder
Research revealing the broad spectrum toxicity of statin drugs continues to accumulate unabated. Adding to a growing body of clinical evidence that they may cause over 300 adverse health effects, a new study reveals that these cholesterol-lowering drugs may be contributing to an epidemic of arthritis and autoimmunity in exposed populations, as well.

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.