Adverse Pharmacological Actions Display Page

Total Number of Adverse Pharmacological Actions Indexed - 120

What is Cumulative Knowledge?

Cumulative Knowledge is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.

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Adverse Pharmacological Actions Display Page

Adverse Pharmacological Action Name	CK	AC
Xenobiotic	2	1
Vascular Endothelial Growth Factor C Up-Regulation	1	1
Vascular Cell Adhesion Molecule-1 (VCAM-1) Up-Regulation	2	1
Uterotrophic	1	1
Ulcerogenic	66	9
Tumorigenic	12	8
Tumor Suppressor Protein p53 Down-regulation/Antibody Formation	10	1
Tumor necrosis factorα (TNFα) up-regulation	42	4
Tumor Marker Elevation: Chromogranin	10	1
Thyroid Suppressive	18	5
Teratogenic	304	59
Telomerase Inhibition	12	3
Sulfotransferase inhibitors	1	1
SIRT1 Modulator	2	1
Serotonin Down-Regulation	2	1
Radiotoxic	12	3
Racemization	1	1
Prothrombic	2	1
Prostaglandin E2 up-regulation	2	1
Proliferative	13	3
Progeriatric	2	2
Profibrotic	4	2
Phototoxicity	1	1
Photomutagenic	1	1
P-selectin upregulation	2	1
Oxidant	104	37
Ototoxic	2	1
Obesogenic	49	9
Nitric Oxide Synthase (eNOS) Down-Regulation	2	1
NF-kappaB up-regulation	3	2
Neurotoxic	1076	179
Nephrotoxic	162	38
Necrotic	5	3
Myotoxicity	317	79
Myopiagenic	2	1
Myelotoxicity	10	1
Mutagenic	22	11
Multidrug resistance 1 (p-glycoprotein 1) upregulation	1	1
Midkine up-regulation	1	1
Mevalonate Pathway Enzyme Inhibitors	1	1
MCP-1 (CCL2) up-regulation	2	1
Mast cell degranulation stimulator	2	1
Malondialdehyde (MDA) Up-Regulation	2	1
Lipogenesis Up-Regulation	10	6
Leukemogen	2	1
Irritant	49	9
Interleukin-8 up-regulation	2	1
Interleukin-6 up-regulation	14	3
Interleukin-4 Up-Regulation	1	1
Interleukin-15 downregulation	11	2
Interleukin-1 up-regulation	2	1
Insulinotropic	2	2
Insecticide	1	1
iNOS upregulation	1	1
Inflammatory	150	37
Infectious	2	1
Immunotoxic	230	38
Immunosuppressive	155	23
Immunoreactive	127	17
Hypoglycemic	12	2
Hypnotic	10	1
Hypertensive	68	9
Hepatotoxic	283	80
Hemorrhagic	14	3
Hemolytic	17	4
Hematoxic	22	2
Hallucinogenic	30	3
Glutathione S-transferase Inducer (xenobiotic)	2	1
Glutathione Down-Regulation	4	2
Gluconeogenesis Up-Regulation	8	4
Genotoxic	146	61
Gastrotoxic	20	2
Excitotoxic	10	1
Estrogenic	59	12
Estrogen Agonist	13	4
Endocrine Disruptor: Uterus	1	1
Endocrine Disruptor: Thyroid	67	14
Endocrine Disruptor: Testes	1	1
Endocrine Disruptor: Pituitary	10	1
Endocrine Disruptor: Pancreas	4	2
Endocrine Disruptor: Ovary	2	2
Endocrine Disruptor: Insulin Resistance	152	31
Endocrine Disruptor	478	81
Endocrine disruption: Leptin resistance	6	3
Embryotoxic	9	5
Dyslipidemic	22	7
Diabetogenic	166	14
Dehydrating	10	1
Cytotoxicity	1	1
Cytotoxic	73	35
Cycloogenase-2 enzyme upregulation	1	1
Corrosive	10	1
Clastogenic	6	2
Circulating Gastrin and Chromogranin A: Elevated	10	1
Chemoresistance upregulation	1	1
Cell Cycle Inhibitor	3	1
Cataractogenic	3	2
Cardiotoxic	638	79
Carcinogenic (suspected)	10	1
Carcinogenic	912	117