| Excitatory Amino Acid Agonists | 7 | 4 | |
| Expectorants | 1 | 1 | |
| Extracellular Signal-Regulated Kinases Modulator | 5 | 4 | |
| Fatty Acid Synthesis Inhibitors | 1 | 1 | |
| Fibrinolytic Agents | 28 | 6 | |
| Follicle-stimulating hormone receptor (FSHR) up-regulation | 2 | 1 | |
| Forkhead Transcription Factor Family O (FOXO) Modulator | 3 | 2 | |
| GABA Modulators | 11 | 7 | |
| Galactogogue | 13 | 3 | |
| Gastric Inhibitory Polypeptide Up-Regulation | 10 | 1 | |
| Gastroprotective | 62 | 31 | |
| Gene Protective | 2 | 1 | |
| Genoprotective | 116 | 48 | |
| Ghrelin Down-Regulation | 36 | 6 | |
| Ghrelin Up-regulation | 4 | 2 | |
| Glucagon Like Peptide 1 (GLP-1) Down-Regulation | 35 | 6 | |
| Glucagon Like peptide 1 (GLP-1) Up-regulation | 118 | 30 | |
| Gluconeogenesis Inhibitor | 20 | 14 | |
| Glucose transporter-2 (GLUT2) expression up-regulation | 10 | 1 | |
| Glucose Uptake Optimization | 2 | 1 | |
| Glutathione Peroxidase 1 (GPx1) Up-Regulation | 3 | 2 | |
| Glutathione S-transferase Inhibitor | 3 | 2 | |
| Glutathione Upregulation | 144 | 48 |  |
| Glycine Agents | 2 | 1 | |
| Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor | 4 | 4 | |
| Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhibitor | 1 | 1 | |
| Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Upregulation | 4 | 2 | |
| GSH-Px Up-Regulation | 2 | 1 | |
| Heat Shock Protein Down-Regulation | 1 | 1 | |
| Heat Shock Protein Inducer | 51 | 17 | |
| Hematologic Agents | 1 | 1 | |
| Hematopoietic | 20 | 9 | |
| Hepatocyte growth factor (HGF) inhibitor | 15 | 4 | |
| Hepatoprotective | 557 | 272 | |
| HER-2 oncoprotein down-regulation | 2 | 1 | |
| High-mobility group box-1 (HMGB1) inhibitor | 2 | 1 | |
| Histamine Agonists | 2 | 1 | |
| Histamine Antagonists | 46 | 18 | |
| Histamine Antagonists | 46 | 18 | |
| Histamine down-regulation | 2 | 1 | |
| Histamine H2 Antagonists | 2 | 2 | |
| Histamine up-regulation | 1 | 1 | |
| Histone deacetylase inhibitor | 26 | 16 | |
| HIV Fusion Inhibitors | 5 | 4 | |
| HIV Protease Inhibitors | 26 | 15 | |
| HIV-1 Integrase Inhibitor | 3 | 3 | |
| HMG-CoA reductase inhibitor | 3 | 2 | |
| Human androgen receptor (AR) antagonist | 2 | 2 | |
| Human Polymorphonuclear Leukocyte Degranulation Inhibitor | 1 | 1 | |
| Hydroperoxidase Inhibitor | 2 | 1 | |
| Hydroxyheptadecatrienoate (HHT) Inhibitor | 1 | 1 | |
| Hypnotics and Sedatives | 20 | 6 | |
| Hypoglycemic Agents | 563 | 156 | |
| Hypolipidemic | 370 | 80 | |
| Hypomethylating | 1 | 1 | |
| Hypotensive | 383 | 53 | |
| Hypoxia-inducible factor-1 (HIF-1) inhibitor | 1 | 1 | |
| IGF-1R expression down-regulation | 1 | 1 | |
| Immunomodulatory | 536 | 142 | |
| Immunomodulatory: CD23+ Mature Macrophage Down-Regulation | 10 | 1 | |
| Immunomodulatory: CD8+ Up-regulation | 2 | 1 | |
| Immunomodulatory: Immunoglobulin G up-regulation | 10 | 1 | |
| Immunomodulatory: Immunoglobulin M Up-Regulation | 10 | 1 | |
| Immunomodulatory: Innate Immunity Up-Regulation | 2 | 1 | |
| Immunomodulatory: Regulatory T Cell Up-Regulation | 4 | 2 | |
| Immunomodulatory: T-Cell down-regulation | 12 | 2 | |
| Immunomodulatory: Th17 downregulation | 3 | 2 | |
| Immunostimulatory | 143 | 33 | |
| Immunostimulatory: IgA Production Up-Regulation | 10 | 1 | |
| Immunosuppressive Agents | 26 | 19 | |
| Incretin Modulator | 2 | 1 | |
| Inhibitor of Nuclear Factor Kappa-B Kinase (IKK) | 2 | 2 | |
| Insulin Antagonists | 10 | 1 | |
| Insulin Down-Regulation | 12 | 2 | |
| Insulin Receptor Modulator | 12 | 2 | |
| Insulin Sensitizers | 167 | 36 | |
| Insulin-Like Growth Factor Enhancer/Upregulation | 5 | 3 | |
| Insulin-Like Growth Factor Inhibition/Downregulation | 66 | 16 | |
| Insulin-mimetic | 9 | 6 | |
| Insulin-releasing | 26 | 15 | |
| Insulinotrophic | 11 | 7 | |
| Intercellular adhesion molecule 3 down-regulation | 3 | 2 | |
| Interferon Gamma Reducer | 8 | 5 | |
| Interferon Inducers | 31 | 9 | |
| Interferon-gamma (IFN-gamma) inducer | 12 | 6 | |
| Interleukin 1 receptor antagonist (IL-1Ra) up-regulation | 10 | 1 | |
| Interleukin-1 alpha downregulation | 34 | 12 | |
| Interleukin-1 alpha upregulation | 3 | 2 | |
| Interleukin-1 beta downregulation | 177 | 70 | |
| Interleukin-1 beta upregulation | 1 | 1 | |
| Interleukin-1 receptor antagonist | 11 | 2 | |
| Interleukin-10 downregulation | 73 | 21 | |
| Interleukin-10 upregulation | 30 | 8 | |
| Interleukin-12 downregulation | 9 | 5 | |
| Interleukin-12 upregulation | 17 | 5 | |
| Interleukin-13 Up-Regulation | 10 | 1 | |
| Interleukin-15 downregulation | 1 | 1 | |
| Interleukin-17 downregulation | 16 | 4 | |
| Interleukin-17 upregulation | 4 | 2 | |
| Interleukin-18 down-regulation | 2 | 1 | |
