Turmeric & Neuroprotective Agents Focused Research

Authors : Xing Guangwei, Lu Rongzhu, Xu Wenrong, Wang Suhua, Zhao Xiaowu, Wang Shizhong, Zhang Ye, Michael Aschner, Shrinivas K Kulkarni, Mahendra Bishnoi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemical Exposure: Acrylonitrile : CK(2) : AC(1), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Hepatoprotective : CK(2523) : AC(1099), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.

Pubmed Data : Neurochem Res. 2006 May;31(5):611-8. Epub 2006 May 23. PMID: 16770732

Article Published Date : May 01, 2006

Authors : Fadhel A Al-Omar, Mahmoud N Nagi, Mustafa M Abdulgadir, Khalda S Al Joni, Abdulhakeem A Al-Majed

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Hippocampal Damage : CK(39) : AC(18), Brain Ischemia : CK(136) : AC(52), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects 6-hydroxydopamine (6-OHDA)-induced neuronal death associated with Parkinson disease.

Pubmed Data : Biochem Pharmacol. 2009 Jul 15;78(2):178-83. Epub 2009 Apr 8. PMID: 19464433

Article Published Date : Jul 15, 2009

Authors : Jun Wang, Xi-Xun Du, Hong Jiang, Jun-Xia Xie

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin protects against chemically-induced oxidative stress in the brain.

Pubmed Data : Eur Rev Med Pharmacol Sci. 2006 Jul-Aug;10(4):157-61. PMID: 16910344

Article Published Date : Jul 01, 2006

Authors : A Rajeswari

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against colchicine-induced cognitive dysfunction and oxidative stress in rats.

Pubmed Data : Hum Exp Toxicol. 2012 Jan 19. Epub 2012 Jan 19. PMID: 22262262

Article Published Date : Jan 19, 2012

Authors : S Khurana, S Jain, P K Mediratta, B D Banerjee, K K Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive dysfunction: colchicine-induced : CK(2) : AC(1)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against ischaemia/reperfusion insult in rat forebrain.

Pubmed Data : Pharmacol Res. 2002 Sep;46(3):273-9. PMID: 12220971

Article Published Date : Sep 01, 2002

Authors : Asser I Ghoneim, Ashraf B Abdel-Naim, Amani E Khalifa, Ezzeddin S El-Denshary

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.

Pubmed Data : Methods Find Exp Clin Pharmacol. 2010 May;32(4):227-32. PMID: 20508869

Article Published Date : May 01, 2010

Authors : V Sharma, B Nehru, A Munshi, A Jyothy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperidines : CK(59) : AC(22)

Diseases : Drug-Induced Toxicity: Epilepsy Drugs : CK(2) : AC(1), Epilepsy : CK(255) : AC(66), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcumin protects astrocytes from induced oxidative stress, and reverses mitochondrial damage and dysfunction induced by oxidative stress.

Pubmed Data : Neuroscience. 2016 Jul 13. Epub 2016 Jul 13. PMID: 27423629

Article Published Date : Jul 12, 2016

Authors : Amita Daverey, Sandeep K Agrawal

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Mitochondrial Dysfunction : CK(227) : AC(92), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Cytoprotective : CK(190) : AC(94), Neuroprotective Agents : CK(2360) : AC(1099), Regenerative : CK(52) : AC(28)

Curcumin protects glial cells and promotes a microglial anti-inflammatory phenotype by a mechanism that implicates HO-1 induction.

Pubmed Data : Mol Nutr Food Res. 2015 Sep ;59(9):1690-700. Epub 2015 Jun 30. PMID: 26047311

Article Published Date : Aug 31, 2015

Authors : Esther Parada, Izaskun Buendia, Elisa Navarro, Carlos Avendaño, Javier Egea, Manuela G López

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Oxidative Stress : CK(79) : AC(46), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis.

Pubmed Data : PLoS One. 2013 ;8(8):e70565. Epub 2013 Aug 6. PMID: 23936448

Article Published Date : Dec 31, 2012

Authors : Luyan Guo, Yanyan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbing Wang, Guoyin Xiong, Jun Dong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : HIV Infections : CK(680) : AC(219), Inflammation : CK(3240) : AC(882), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin strongly induced modulator effects on oxidative stress, intracellular Ca2+ levels, and the caspase-3 and -9 values in an experimental oxidative stress model.

Pubmed Data : J Recept Signal Transduct Res. 2015 Nov 25:1-7. Epub 2015 Nov 25. PMID: 26608462

Article Published Date : Nov 24, 2015

Authors : Abdülhadi Cihangir Uğuz, Ahmi Öz, Mustafa Nazıroğlu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Oxidative Stress : CK(3871) : AC(1382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin supplementation could ameliorate cognitive deficits and reverse biochemical alterations in a ICV-streptozotocin Alzheimer's rat model.

Pubmed Data : Eur J Pharmacol. 2016 Jan 5 ;770:52-60. Epub 2015 Dec 2. PMID: 26638997

Article Published Date : Jan 04, 2016

Authors : Doaa M Samy, Cherine A Ismail, Rasha A Nassra, Teshreen M Zeitoun, Azhar M Nomair

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain: Oxidative Stress : CK(79) : AC(46), Diabetes Mellitus: Type 2 : CK(3572) : AC(624)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin supplementation to aluminum treated rats was able to normalize significantly the activities of all the three mitochondrial complexes.

Pubmed Data : Neurotox Res. 2011 Nov ;20(4):351-61. Epub 2011 Jun 9. PMID: 21656326

Article Published Date : Oct 31, 2011

Authors : Pooja Khanna Sood, Uma Nahar, Bimla Nehru

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aluminum Toxicity : CK(207) : AC(75), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Aluminum : CK(274) : AC(78)

Curcumin treatment significantly improved the neurological status evaluated during 2 weeks after brain injury.

Pubmed Data : Pharmacol Biochem Behav. 2013 Sep ;110:238-44. Epub 2013 Aug 7. PMID: 23932920

Article Published Date : Aug 31, 2013

Authors : Fariborz Samini, Saeed Samarghandian, Abasalt Borji, Gholamreza Mohammadi, Mahdi bakaian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Brain Injury: Traumatic : CK(99) : AC(30), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Significant Treatment Outcome : CK(3038) : AC(366)

Curcumin was able to significantly ameliorate ROT induced dopaminergic neuronal oxidative damage in the SNpc of rats.

Pubmed Data : Mol Med Rep. 2015 Dec 8. Epub 2015 Dec 8. PMID: 26648392

Article Published Date : Dec 07, 2015

Authors : Qunli Cui, Xin Li, Hongcan Zhu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Oxidative Stress : CK(79) : AC(46), Neurodegenerative Diseases : CK(3582) : AC(932), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin-manganese complexes have enhanced antioxidant activity.

Pubmed Data : Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID: 14680686

Article Published Date : Dec 15, 2003

Authors : Opa Vajragupta, Preecha Boonchoong, Hiroshi Watanabe, Michihisa Tohda, Naparat Kummasud, Yaowared Sumanont

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Manganese : CK(15) : AC(4)

Diseases : Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Curcuminoids positively modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.

Pubmed Data : Free Radic Res. 2008 Nov;42(11-12):999-1005. PMID: 19031318

Article Published Date : Nov 01, 2008

Authors : Manisha Rastogi, Rudra P Ojha, G V Rajamanickam, Aruna Agrawal, Abha Aggarwal, G P Dubey

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Polyphenols : CK(1109) : AC(390)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Curcuminoids protect against neuronal cell death in an Alzheimer disease model.

Pubmed Data : Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823

Article Published Date : Apr 27, 2001

Authors : D S Kim, S Y Park, J K Kim

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Demethoxycurcumin abrogates rotenone-induced dopamine depletion and motor deficits.

Pubmed Data : Pharmacogn Mag. 2018 Jan-Mar;14(53):9-16. Epub 2018 Feb 20. PMID: 29576695

Article Published Date : Dec 31, 2017

Authors : Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Saravana Babu Chidambaram, Giles J Guillemin

Study Type : Animal Study

Additional Links

Substances : Demethoxycurcumin : CK(36) : AC(21)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway.

Pubmed Data : Cell Physiol Biochem. 2013 ;32(5):1167-77. Epub 2013 Nov 11. PMID: 24335167

Article Published Date : Dec 31, 2012

Authors : Yunfei Pu, Hexuan Zhang, Peijian Wang, Yu Zhao, Qiang Li, Xing Wei, Yuanting Cui, Jing Sun, Qianhui Shang, Daoyan Liu, Zhiming Zhu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Cerebrovascular Disorders : CK(32) : AC(4), Ischemia : CK(76) : AC(38), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382), Stroke : CK(1365) : AC(168)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), Neurorestorative : CK(71) : AC(21)

EGCG and curcumin suppress Alzheimer disease associated beta amyloid production.

Pubmed Data : Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H715-21. Epub 2005 Mar 18. PMID: 18695518

Article Published Date : Aug 01, 2005

Authors : Yoshiari Shimmyo, Takeshi Kihara, Akinori Akaike, Tetsuhiro Niidome, Hachiro Sugimoto

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Herbals might play an important role in preserving the integrity of various neurotransmitters.

Pubmed Data : Adv Neurobiol. 2016;12:107-123. PMID: 27651251

Article Published Date : Dec 31, 2015

Authors : Pranay Srivastava, Rajesh Singh Yadav

Study Type : Review

Additional Links

Substances : Amla Fruit : CK(81) : AC(34), Ashwagandha : CK(169) : AC(84), Bacopa : CK(147) : AC(61), Gotu Kola : CK(51) : AC(21), Holy Basil : CK(126) : AC(52), Spikenard : CK(39) : AC(23), Turmeric : CK(5583) : AC(2569)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Neurodegenerative Diseases : CK(3582) : AC(932), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Melatonin may increase cell survival in the hippocampus via decreasing oxidative stress and SIRT2 expression and increasing Bcl-2 expression.

Pubmed Data : Brain Res Bull. 2018 Jan 8 ;137:306-310. Epub 2018 Jan 8. PMID: 29325994

Article Published Date : Jan 07, 2018

Authors : Arzu Keskin-Aktan, Kazime Gonca Akbulut, Çiğdem Yazici-Mutlu, Gizem Sonugur, Müge Ocal, Hakan Akbulut

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Melatonin : CK(1194) : AC(394)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats.

Pubmed Data : Life Sci. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29287782

Article Published Date : Dec 25, 2017

Authors : Laraib Liaquat, Zehra Batool, Sadia Sadir, Sahar Rafiq, SidrahShahzad, Tahira Perveen, Saida Haider

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Naringenin : CK(90) : AC(54), Quercetin : CK(716) : AC(335)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Antioxidants : CK(1) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1)

NPs-Cur enhance the action of curcumin on several pathways implicated in the pathophysiology of Alzheimer's disease.

Pubmed Data : Mol Pharm. 2015 Dec 23. Epub 2015 Dec 23. PMID: 26618861

Article Published Date : Dec 22, 2015

Authors : Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Polymerized nano-curcumin has significant effects on the EAE scores and myelin repair mechanisms in an animal model of multiple sclerosis.

Pubmed Data : Neuropharmacology. 2015 Dec ;99:156-67. Epub 2015 Jul 23. PMID: 26211978

Article Published Date : Nov 30, 2015

Authors : Maryam Mohajeri, Majid Sadeghizadeh, Farhood Najafi, Mohammad Javan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Demyelinating Diseases : CK(1671) : AC(332), Multiple Sclerosis : CK(964) : AC(184)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099), Remyelination : CK(2) : AC(1)

Additional Keywords : Gene Expression Regulation : CK(431) : AC(214)

Polyphenol antioxidants have properties to treat neurodegenerative diseases.

Pubmed Data : Basic Clin Neurosci. 2016 Apr ;7(2):81-90. PMID: 27303602

Article Published Date : Mar 31, 2016

Authors : Amin Ataie, Mohammad Shadifar, Ramin Ataee

Study Type : Review

Additional Links

Substances : Allicin : CK(48) : AC(25), Carnosic Acid : CK(39) : AC(27), Curcumin : CK(4417) : AC(2300), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Isothiocyanate : CK(15) : AC(4), Quercetin : CK(716) : AC(335), Resveratrol : CK(1511) : AC(865), Rosmarinic acid : CK(47) : AC(26), Sulforaphane : CK(624) : AC(303)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death.

Pubmed Data : Oxid Med Cell Longev. 2013 ;2013:801418. Epub 2013 Dec 22. PMID: 24454990

Article Published Date : Dec 31, 2012

Authors : Susana González-Reyes, Silvia Guzmán-Beltrán, Omar Noel Medina-Campos, José Pedraza-Chaverri

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Heme oxygenase-1 up-regulation : CK(73) : AC(40), Neuroprotective Agents : CK(2360) : AC(1099), Nrf2 activation : CK(177) : AC(86), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

Tetrahydrocurcumin can be a promising candidate for the prevention of chemotherapy induced peripheral neuropathy.

Pubmed Data : Chem Biol Interact. 2015 Jun 20 ;238:118-128. Epub 2015 Jun 20. PMID: 26102012

Article Published Date : Jun 19, 2015

Authors : N Greeshma, K G Prasanth, Bhaskar Balaji

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Chemotherapy-Induced Toxicity: Vincristine : CK(6) : AC(3), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Antinoceceptive : CK(193) : AC(51), Antioxidants : CK(8430) : AC(3132), Chemoprotective Agents : CK(356) : AC(146), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Tetrahydrocurcumin may be an effective therapeutic agent to treat traumatic brain injury.

Pubmed Data : Am J Transl Res. 2017 ;9(3):887-899. Epub 2017 Mar 15. PMID: 28386319

Article Published Date : Dec 31, 2016

Authors : Yongyue Gao, Zong Zhuang, Shanting Gao, Xiang Li, Zihuan Zhang, Zhennan Ye, Liwen Li, Chao Tang, Mengliang Zhou, Xiao Han, Jie Li

Study Type : In Vitro Study

Additional Links

Substances : Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Brain Injury: Traumatic : CK(99) : AC(30)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antioxidants : CK(8430) : AC(3132), Malondialdehyde Down-regulation : CK(554) : AC(152), Neuroprotective Agents : CK(2360) : AC(1099)

Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats.

Pubmed Data : J Med Food. 2007 Jun;10(2):323-9. PMID: 17651069

Article Published Date : Jun 01, 2007

Authors : Leelavinothan Pari, Pidaran Murugan

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17), Lipid Peroxidation : CK(695) : AC(255), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

These findings for the first time demonstrate that the neuromodulatory propensity of geraniol is indeed comparable to that of curcumin.

Pubmed Data : Chem Biol Interact. 2014 Nov 5 ;223:27-37. Epub 2014 Sep 6. PMID: 25199698

Article Published Date : Nov 04, 2014

Authors : Sathya N Prasad, Muralidhara

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Geraniol : CK(54) : AC(28)

Diseases : Acrylamide-induced toxicity : CK(16) : AC(9), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Acrylamide : CK(33) : AC(3)

This reviews the neuroprotective roles of these herbs and summarizes their anti-inflammatory, antioxidant, and anti-apoptotic effects in PD.

Pubmed Data : Am J Transl Res. 2015 ;7(7):1189-202. Epub 2015 Jul 15. PMID: 26328004

Article Published Date : Dec 31, 2014

Authors : Wenyu Fu, Wenxin Zhuang, Shuanhu Zhou, Xin Wang

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Ginsenosides : CK(197) : AC(84), Resveratrol : CK(1511) : AC(865)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Antioxidants : CK(8430) : AC(3132), Neuroprotective Agents : CK(2360) : AC(1099)

Turmeric oil has a neuroprotective property in transient focal ischemia in rat brain.

Pubmed Data : Neurochem Res. 2008 Sep;33(9):1672-82. Epub 2007 Oct 23. PMID: 17955367

Article Published Date : Sep 01, 2008

Authors : Priyanka Rathore, Preeti Dohare, Saurabh Varma, Aparajita Ray, Uma Sharma, N R Jagannathan, N R Jaganathanan, Madhur Ray

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(5583) : AC(2569)

Diseases : Cerebral Ischemia: Transient : CK(12) : AC(6), Middle Cerebral Artery Occlusion (MCAO) : CK(73) : AC(28), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099)

A combination of resveratrol and curcumin is effective against aluminum chloride-induced neuroinflammation in rats.

Pubmed Data : J Alzheimers Dis. 2017 Feb 7. Epub 2017 Feb 7. PMID: 28222524

Article Published Date : Feb 06, 2017

Authors : Amira Zaky, Ahmad Bassiouny, Mahitab Farghaly, Bassma M El-Sabaa

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Resveratrol : CK(1511) : AC(865)

Diseases : Aluminum Toxicity : CK(207) : AC(75), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249)

Problem Substances : Aluminum Chloride : CK(29) : AC(12)

A literature review of the neuroprotective potency of some spice herbs.

Pubmed Data : J Tradit Complement Med. 2019 Apr ;9(2):98-105. Epub 2018 Apr 30. PMID: 30963044

Article Published Date : Mar 31, 2019

Authors : Mohammad Reza Khazdair, Akbar Anaeigoudari, Milad Hashemzehi, Reza Mohebbati

Study Type : Review

Additional Links

Substances : Coriandrum sativum : CK(70) : AC(37), Saffron : CK(375) : AC(88), Thyme : CK(93) : AC(50), Turmeric : CK(5583) : AC(2569), Zataria multiflora : CK(2) : AC(1)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-6 Downregulation : CK(1137) : AC(354), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

A novel demethylated curcuminoid exhibits neuroprotective and anti-inflammatory properties.

Pubmed Data : Antioxid Redox Signal. 2009 Mar;11(3):449-68. PMID: 18724833

Article Published Date : Mar 01, 2009

Authors : Savita Khanna, Han-A Park, Chandan K Sen, Trimurtulu Golakoti, Krishanu Sengupta, Somepalli Venkateswarlu, Sashwati Roy

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin (from Turmeric) has has neuroprotective properties mostly due to its anti-inflammatory effects.

Pubmed Data : Pharmazie. 2007 Dec;62(12):937-42. PMID: 18214347

Article Published Date : Dec 01, 2007

Authors : Hae Sung Lee, Ki Kyung Jung, Jae Youl Cho, Man Hee Rhee, Sungyoul Hong, Moosik Kwon, Seung Hee Kim, Seog Youn Kang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Diseases : CK(19) : AC(8)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin and Apigenin might delay the onset of Alzheimer's disease or slow down its progression.

Pubmed Data : Neural Regen Res. 2015 Aug ;10(8):1181-5. PMID: 26487830

Article Published Date : Jul 31, 2015

Authors : Madhuri Venigalla, Erika Gyengesi, Gerald Münch

Study Type : Review

Additional Links

Substances : Apigenin : CK(199) : AC(117), Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin and piperine afforded a better neuroprotective effect compared to each of them alone.

Pubmed Data : Inflammopharmacology. 2016 Nov 16. Epub 2016 Nov 16. PMID: 27853890

Article Published Date : Nov 15, 2016

Authors : Shamsher Singh, Puneet Kumar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)

Diseases : Brain Inflammation : CK(274) : AC(145), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-6 Downregulation : CK(1137) : AC(354), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Additional Keywords : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669), CURCUMIN : CK(2) : AC(1), CURCUMIN : CK(2) : AC(1), Natural Substance Synergy : CK(540) : AC(249), Natural Substance Synergy : CK(540) : AC(249), Natural Substance Synergy : CK(540) : AC(249)

Curcumin can attenuate the downregulation of CISD2 in spinal cord injuries and LPS-treated astrocytes.

Pubmed Data : Injury. 2015 Aug 8. Epub 2015 Aug 8. PMID: 26387034

Article Published Date : Aug 07, 2015

Authors : Chai-Ching Lin, Tien-Huang Chiang, Wei-Jung Chen, Yu-Yo Sun, Yi-Hsuan Lee, Muh-Shi Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Spinal Cord Injuries : CK(155) : AC(55)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), MicroRNA modulator : CK(264) : AC(145), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-κB pathway and subsequently the expression of AQP4 and AQP9.

Pubmed Data : Acta Pharmacol Sin. 2015 Jun 29. Epub 2015 Jun 29. PMID: 26119880

Article Published Date : Jun 28, 2015

Authors : Bao-Feng Wang, Zhen-Wen Cui, Zhi-Hong Zhong, Yu-Hao Sun, Qing-Fang Sun, Guo-Yuan Yang, Liu-Guan Bian

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Edema : CK(49) : AC(13), Intracerebral Hemorrhage : CK(173) : AC(14), Stroke: Attenuation/Recovery : CK(347) : AC(75)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Additional Keywords : Dose Response : CK(1519) : AC(574), Gene Expression Regulation : CK(431) : AC(214)

Curcumin has a potential anti-inflammatory action against aluminum exposure.

Pubmed Data : Neurochem Res. 2012 Mar ;37(3):639-46. Epub 2011 Dec 1. PMID: 22130689

Article Published Date : Feb 29, 2012

Authors : Pooja Khanna Sood, Uma Nahar, Bimla Nehru

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aluminum Toxicity : CK(207) : AC(75), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Problem Substances : Aluminum : CK(274) : AC(78)

Curcumin is effective in attenuating glial activation and ameliorates cognitive deficits in chronic epilepsy.

Pubmed Data : Neurochem Int. 2015 Jul 16. Epub 2015 Jul 16. PMID: 26190183

Article Published Date : Jul 15, 2015

Authors : Harpreet Kaur, Ishan Patro, Kulbhushan Tikoo, Rajat Sandhir

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Cognitive Decline/Dysfunction : CK(1163) : AC(215), Epilepsy : CK(255) : AC(66)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may have therapeutic value in inflammatory conditions of the central nervous system.

Pubmed Data : J Neuroinflammation. 2005 Feb 25;2(1):8. Epub 2005 Feb 25. PMID: 15733321

Article Published Date : Feb 25, 2005

Authors : Michiyo Tomita, Brita J Holman, Christopher P Santoro, Thomas J Santoro

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.

Pubmed Data : J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894

Article Published Date : Jan 01, 2010

Authors : Hong-Mei Wang, Yan-Xin Zhao, Shi Zhang, Gui-Dong Liu, Wen-Yan Kang, Hui-Dong Tang, Jian-Qing Ding, Sheng-Di Chen

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Inflammation : CK(274) : AC(145), Inflammation : CK(3240) : AC(882)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against MSG-induced neurotoxicity in rats.

Pubmed Data : Neurosignals. 2016 Aug 17 ;24(1):81-87. Epub 2016 Aug 17. PMID: 27529496

Article Published Date : Aug 16, 2016

Authors : Rania M Khalil, Naglaa F Khedr

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : MSG Toxicity : CK(12) : AC(6)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Problem Substances : Monosodium Glutamate (MSG) : CK(108) : AC(36)

Curcumin protects dopaminergic neuron against lipopolysaccharide induced neurotoxicity.

Pubmed Data : Neurochem Res. 2008 Oct;33(10):2044-53. Epub 2008 Mar 27. PMID: 18368483

Article Published Date : Oct 01, 2008

Authors : Sufen Yang, Dan Zhang, Zhengqin Yang, Xiaoming Hu, Steven Qian, Jie Liu, Belinda Wilson, Michelle Block, Jau-Shyong Hong

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Microglial Activation : CK(82) : AC(53), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin protects effects against cerebral I/R injury through the activation of JAK2/STAT3 signaling pathway.

Pubmed Data : Int J Clin Exp Med. 2015;8(9):14985-14991. Epub 2015 Sep 15. PMID: 26628981

Article Published Date : Dec 31, 2014

Authors : Linlin Li, Haiyong Li, Mingming Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cerebral Ischemia : CK(229) : AC(77)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-1 beta downregulation : CK(478) : AC(205), Interleukin-8 downregulation : CK(166) : AC(61), Neuroprotective Agents : CK(2360) : AC(1099)

Effect of essential oils from ginger and turmeric rhizomes on some inflammatory biomarkers in cadmium induced neurotoxicity in rats.

Pubmed Data : J Toxicol. 2018 ;2018:4109491. Epub 2018 Oct 8. PMID: 30402094

Article Published Date : Dec 31, 2017

Authors : Ayodele Jacob Akinyemi, Philip Adeyemi Adeniyi

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(775) : AC(207), Turmeric : CK(5583) : AC(2569)

Diseases : Cadmium Poisoning : CK(131) : AC(62)

Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(37) : AC(19), Anti-Inflammatory Agents : CK(4861) : AC(1630), Interleukin-10 downregulation : CK(128) : AC(45), Interleukin-6 Downregulation : CK(1137) : AC(354), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Additional Keywords : Essential Oils : CK(181) : AC(69)

Problem Substances : Cadmium : CK(132) : AC(26)

Fermented C. longa might be a useful material for preventing impairment of learning and memory.

Pubmed Data : BMC Complement Altern Med. 2017 Jul 17 ;17(1):367. Epub 2017 Jul 17. PMID: 28716085

Article Published Date : Jul 16, 2017

Authors : Cheong-Su Eun, Jong-Soon Lim, Jihye Lee, Sam-Pin Lee, Seun-Ah Yang

Study Type : Animal Study

Additional Links

Substances : Turmeric: Fermented : CK(19) : AC(6)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Memory Disorders : CK(344) : AC(104)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Neuroprotective Agents : CK(2360) : AC(1099), Nitric Oxide Inhibitor : CK(223) : AC(108), Postaglandin PGE2 downregulation : CK(23) : AC(11)

Post-injury curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis.

Pubmed Data : J Neuroinflammation. 2014 ;11:59. Epub 2014 Mar 27. PMID: 24669820

Article Published Date : Dec 31, 2013

Authors : Hai-tao Zhu, Chen Bian, Ji-chao Yuan, Wei-hua Chu, Xin Xiang, Fei Chen, Cheng-shi Wang, Hua Feng, Jiang-Kai Lin

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Brain Injury: Traumatic : CK(99) : AC(30)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

The evidence suggests that increased consumption of these compounds might lead to a safe strategy to delay the onset of AD.

Pubmed Data : CNS Neurol Disord Drug Targets. 2014 ;13(7):1175-91. PMID: 25230232

Article Published Date : Dec 31, 2013

Authors : Nadine Apetz, Gerald Munch, Suresh Govindaraghavan, Erika Gyengesi

Study Type : Review

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300), Ginkgo biloba : CK(866) : AC(188), Green Tea : CK(2251) : AC(658), Polyunsaturated Fatty Acids (PUFAs) : CK(298) : AC(48), Turmeric : CK(5583) : AC(2569)

Diseases : Inflammation : CK(3240) : AC(882)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

This review summarizes the current knowledge on the effect of curcumin in the treatment and prevention of inflammation, neurodegenerative diseases and cancers.

Pubmed Data : Curr Pharmacol Rep. 2015 Apr ;1(2):129-139. Epub 2015 Jan 30. PMID: 26457241

Article Published Date : Mar 31, 2015

Authors : Sarandeep S S Boyanapalli, Ah-Ng Tony Kong

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cancers: All : CK(14773) : AC(4596), Inflammation : CK(3240) : AC(882), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Chemopreventive : CK(2835) : AC(787), Histone deacetylase inhibitor : CK(48) : AC(37), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Epigenetic Modification : CK(220) : AC(90)

This study provides strong evidence that at least some of the neuroprotective effects of curcumin against OGD/R are mediated by PPARγ activation.

Pubmed Data : J Neurosci Res. 2014 Nov ;92(11):1549-59. Epub 2014 Jun 26. PMID: 24975470

Article Published Date : Oct 31, 2014

Authors : Zun-Jing Liu, Hong-Qiang Liu, Cheng Xiao, Hui-Zhen Fan, Qing Huang, Yun-Hai Liu, Yu Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Hypoxia: Brain : CK(10) : AC(6)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

Turmeric extract exhibits anti-Alzheimer properties.

Pubmed Data : Curr Alzheimer Res. 2011 Aug 30. Epub 2011 Aug 30. PMID: 21875408

Article Published Date : Aug 30, 2011

Authors : R Douglas Shytle, J Tan, P C Bickford, K Rezai-Zadeh, L Hou, J Zeng, P R Sanberg, C D Sanberg, R S Alberte, R C Fink, B Roschek

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain: Microglial Activation : CK(82) : AC(53), Brain Inflammation : CK(274) : AC(145)

Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Neuroprotective Agents : CK(2360) : AC(1099)

A curcumin derivative restores membrane homeostasis disrupted after brain trauma.

Pubmed Data : Exp Neurol. 2010 Nov;226(1):191-9. Epub 2010 Sep 15. PMID: 20816821

Article Published Date : Nov 01, 2010

Authors : Sandeep Sharma, Zhe Ying, Fernando Gomez-Pinilla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Damage : CK(93) : AC(44), Brain Injury: Traumatic : CK(99) : AC(30), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), Neurorestorative : CK(71) : AC(21)

Co-administration of curcumin and piperine may provide a useful natural adjuvant in the antidepressant therapy.

Pubmed Data : PLoS One. 2013 ;8(4):e61052. Epub 2013 Apr 17. PMID: 23613781

Article Published Date : Dec 31, 2012

Authors : Puneet Rinwa, Anil Kumar, Sukant Garg

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)

Diseases : Depression : CK(2043) : AC(290), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Antidepressive Agents : CK(1115) : AC(168), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin attenuates diabetic encephalopathy in rats.

Pubmed Data : Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693

Article Published Date : Dec 08, 2007

Authors : Anurag Kuhad, Kanwaljit Chopra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17), Encephalopathies : CK(14) : AC(6), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain.

Pubmed Data : Exp Neurol. 2010 Oct;225(2):237-9. Epub 2010 Jul 11. PMID: 20553189

Article Published Date : Oct 01, 2010

Authors : Amin Ataie, Masoumeh Sabetkasaei, Abbas Haghparast, Akbar Hajizadeh Moghaddam, Ramin Ataee, Shiva Nasiraei Moghaddam

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Homocysteine: Elevated : CK(431) : AC(63), Learning disorders : CK(194) : AC(53), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a neuroprotective effect in in middle cerebral artery occlusion induced focal cerebral ischemia in rats.

Pubmed Data : Life Sci. 2004 Jan 9;74(8):969-85. PMID: 14672754

Article Published Date : Jan 09, 2004

Authors : Meenakshisundaram Thiyagarajan, Shyam S Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52), Middle Cerebral Artery Occlusion (MCAO) : CK(73) : AC(28), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a protective effect against against intracerebral streptozotocin induced impairment in memory and cerebral blood flow.

Pubmed Data : Life Sci. 2010 Jan 16;86(3-4):87-94. Epub 2009 Nov 17. PMID: 19925811

Article Published Date : Jan 16, 2010

Authors : Himani Awasthi, Santoshkumar Tota, Kashif Hanif, Chandiswar Nath, Rakesh Shukla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Dementia : CK(571) : AC(79), Memory Disorders : CK(344) : AC(104), Memory Disorders: Drug-Induced : CK(101) : AC(26), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has anti-aging and neuroprotective effects in aged rat brain regions.

Pubmed Data : Biogerontology. 2006 Apr;7(2):81-9. PMID: 16802111

Article Published Date : Apr 01, 2006

Authors : Kiran Bala, B C Tripathy, Deepak Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aging : CK(1658) : AC(438), Aging: Brain : CK(248) : AC(85), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has beneficial effects in experimental dementia.

Pubmed Data : Naunyn Schmiedebergs Arch Pharmacol. 2010 Jun;381(6):529-39. Epub 2010 Apr 6. PMID: 20369229

Article Published Date : Jun 01, 2010

Authors : Puneet Rinwa, Baljinder Kaur, Amteshwar Singh Jaggi, Nirmal Singh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Dementia : CK(571) : AC(79), Memory Disorders : CK(344) : AC(104), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has potential anti-epileptic effects.

Pubmed Data : Indian J Physiol Pharmacol. 2009 Jan-Mar;53(1):39-46. PMID: 19810575

Article Published Date : Jan 01, 2009

Authors : Yogendra K Gupta, Seema Briyal, Monisha Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Epilepsy : CK(255) : AC(66), Oxidative Stress : CK(3871) : AC(1382), Seizures : CK(208) : AC(60)

Pharmacological Actions : Anticonvulsants : CK(238) : AC(67), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats.

Pubmed Data : Brain Res. 2009 Dec 8;1301:52-60. Epub 2009 Sep 16. PMID: 19765566

Article Published Date : Dec 08, 2009

Authors : K H Reeta, Jogender Mehla, Yogendra Kumar Gupta

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Memory Disorders: Drug-Induced : CK(101) : AC(26), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anticonvulsants : CK(238) : AC(67), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Drug: Phenytoin : CK(2) : AC(1)

Curcumin prevents ethanol-induced brain damage.

Pubmed Data : Phytother Res. 1999 Nov;13(7):571-4. PMID: 10548748

Article Published Date : Nov 01, 1999

Authors : V Rajakrishnan, P Viswanathan, K N Rajasekharan, V P Menon

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alcohol Toxicity : CK(337) : AC(125), Brain Damage : CK(93) : AC(44), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents Haloperidol-induced adverse effects.

Pubmed Data : Pharmacol Biochem Behav. 2008 Feb;88(4):511-22. Epub 2007 Oct 25. PMID: 18022680

Article Published Date : Feb 01, 2008

Authors : Mahendra Bishnoi, Kanwaljit Chopra, Shrinivas K Kulkarni

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Drug-Induced Toxicity: Haloperidol : CK(4) : AC(2), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against beta-amyloid-induced toxicity.

Pubmed Data : Food Chem Toxicol. 2008 Aug;46(8):2881-7. Epub 2008 Jun 4. PMID: 18573304

Article Published Date : Aug 01, 2008

Authors : So-Young Park, Hyo-Shin Kim, Eun-Kyung Cho, Bo-Youn Kwon, Sohee Phark, Kwang-Woo Hwang, Donggeun Sul

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), DNA damage : CK(1017) : AC(387), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against cerebral ischemia-induced neuronal cell death.

Pubmed Data : J Neurosci Res. 2005 Oct 1;82(1):138-48. PMID: 16075466

Article Published Date : Oct 01, 2005

Authors : Qun Wang, Albert Y Sun, Agnes Simonyi, Michael D Jensen, Phullara B Shelat, George E Rottinghaus, Ruth S MacDonald, Dennis K Miller, Dennis E Lubahn, Gary A Weisman, Grace Y Sun

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Microglial Activation : CK(82) : AC(53), Brain Ischemia : CK(136) : AC(52), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Lectins : CK(59) : AC(37)

Curcumin protects against chemically-induced neuronal damage.

Pubmed Data : Acta Pharmacol Sin. 2004 Dec;25(12):1606-12. PMID: 15569404

Article Published Date : Dec 01, 2004

Authors : Yuan-gui Zhu, Xiao-chun Chen, Zhi-zhe Chen, Yu-qi Zeng, Guang-bin Shi, Yan-hua Su, Xu Peng

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Damage : CK(93) : AC(44), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against lead neurotoxicity in rats.

Pubmed Data : Hum Exp Toxicol. 2003 Dec;22(12):653-8. PMID: 14992327

Article Published Date : Dec 01, 2003

Authors : Pradeep K Shukla, Vinay K Khanna, Mohd Y Khan, Rikhab C Srimal

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Lead Poisoning : CK(205) : AC(60), Neurodegenerative Diseases : CK(3582) : AC(932), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.

Pubmed Data : BMC Neurosci. 2010;11:57. Epub 2010 Apr 30. PMID: 20433710

Article Published Date : Jan 01, 2010

Authors : Min S Wang, Shanta Boddapati, Sharareh Emadi, Michael R Sierks

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo, indicating its value for Parkinson disease.

Pubmed Data : Free Radic Biol Med. 2008 Mar 1;44(5):907-17. Epub 2007 Dec 4. PMID: 18166164

Article Published Date : Mar 01, 2008

Authors : Balusamy Jagatha, Rajeswara Babu Mythri, Shireen Vali, M M Srinivas Bharath

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Oxidative Stress : CK(3871) : AC(1382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Antineoplastic Agents : CK(1158) : AC(639), Glutathione Upregulation : CK(152) : AC(53), Neuroprotective Agents : CK(2360) : AC(1099)

Curcuminoids prevent experimentally induced neuronal damage in the rat hippocampus.

Pubmed Data : Life Sci. 2006 Mar 13;78(16):1884-91. Epub 2005 Nov 2. PMID: 16266725

Article Published Date : Mar 13, 2006

Authors : Yaowared Sumanont, Yukihisa Murakami, Michihisa Tohda, Opa Vajragupta, Hiroshi Watanabe, Kinzo Matsumoto

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Curcuminoids : CK(4681) : AC(2355)

Diseases : Brain Injury: Hippocampal Damage : CK(39) : AC(18), Brain Injury: Traumatic : CK(99) : AC(30), Epilepsy : CK(255) : AC(66), Oxidative Stress : CK(3871) : AC(1382), Seizures : CK(208) : AC(60), Stroke : CK(1365) : AC(168)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Excitatory Amino Acid Agonists : CK(7) : AC(4), Neuroprotective Agents : CK(2360) : AC(1099)

Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition.

Pubmed Data : Exp Neurol. 2006 Feb;197(2):309-17. Epub 2005 Dec 20. PMID: 16364299

Article Published Date : Feb 01, 2006

Authors : Aiguo Wu, Zhe Ying, Fernando Gomez-Pinilla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Traumatic : CK(99) : AC(30), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice.

Pubmed Data : Brain Res. 2012 Dec 7 ;1488:38-50. Epub 2012 Oct 23. PMID: 23099054

Article Published Date : Dec 06, 2012

Authors : Puneet Rinwa, Anil Kumar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Oxidative Stress : CK(3871) : AC(1382), Stress : CK(623) : AC(103)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Increased Bioavailability : CK(42) : AC(17), Natural Substance Synergy : CK(540) : AC(249)

Problem Substances : Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) : CK(1905) : AC(215)

The present review discusses the mitochondrial restorative mechanisms of these bioenergetics and antioxidants as a potential alternative drug strategy for effective management of AD.

Pubmed Data : Front Pharmacol. 2015 ;6:206. Epub 2015 Sep 24. PMID: 26441662

Article Published Date : Dec 31, 2014

Authors : Anil Kumar, Arti Singh

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Ginkgo biloba : CK(866) : AC(188), Omega-3 Fatty Acids : CK(3849) : AC(463)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Mitochondrial Dysfunction : CK(227) : AC(92), Oxidative Stress : CK(3871) : AC(1382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Extracts enriched in polyphenols showed promising neuroprotective effects.

Pubmed Data : Curr Top Med Chem. 2016 Feb 4. Epub 2016 Feb 4. PMID: 26845551

Article Published Date : Feb 03, 2016

Authors : Carmela Spagnuolo, Marianna Napolitano, Idolo Tedesco, Stefania Moccia, Alfonsina Milito, Gian Luigi Russo

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Elderberry : CK(102) : AC(29), Polyphenols : CK(1109) : AC(390), Quercetin : CK(716) : AC(335), Resveratrol : CK(1511) : AC(865)

Diseases : Brain Inflammation : CK(274) : AC(145), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.

Pubmed Data : Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755

Article Published Date : Feb 10, 2009

Authors : Philip Thomas, Yan-Jiang Wang, Jin-Hua Zhong, Shantha Kosaraju, Nathan J O'Callaghan, Xin-Fu Zhou, Michael Fenech

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Grapefruit Seed Extract : CK(37) : AC(14), Polyphenols : CK(1109) : AC(390)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Genoprotective : CK(270) : AC(97), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

The effects of turmeric extract at a dose of 200 mg/kg bw seem to be comparable to those of citicoline.

Pubmed Data : Drug Chem Toxicol. 2017 Apr 25:1-10. Epub 2017 Apr 25. PMID: 28440093

Article Published Date : Apr 24, 2017

Authors : Sapto Yuliani, Mustofa, Ginus Partadiredja

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(5583) : AC(2569)

Diseases : Dementia : CK(571) : AC(79), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302), Plant Extracts : CK(7645) : AC(2539)

This study investigated the neuroprotective effects of turmeric extract.

Pubmed Data : Sci Rep. 2016 Dec 22 ;6:38846. Epub 2016 Dec 22. PMID: 28004737

Article Published Date : Dec 21, 2016

Authors : Rosario Randino, Manuela Grimaldi, Marco Persico, Augusta De Santis, Elena Cini, Walter Cabri, Antonella Riva, Gerardino D'Errico, Caterina Fattorusso, Anna Maria D'Ursi, Manuela Rodriquez

Study Type : In Vitro Study

Additional Links

Substances : Curcuminoids : CK(4681) : AC(2355), Turmeric : CK(5583) : AC(2569)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Turmeric extract may exert antiapoptotic effect on the hippocampal neurons exposed to trimethyltin.

Pubmed Data : Bratisl Lek Listy. 2017 ;118(3):142-148. PMID: 28319408

Article Published Date : Dec 31, 2016

Authors : S Yuliani, S Widyarini, Mustofa, G Partadiredja

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(5583) : AC(2569)

Diseases : Dementia : CK(571) : AC(79)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Plant Extracts : CK(7645) : AC(2539)

Curcumin and tannic acid protect against glutamate-induced excitotoxicity.

Pubmed Data : J Pharmacol Exp Ther. 2006 Aug;318(2):476-83. Epub 2006 Apr 27. PMID: 17118359

Article Published Date : Aug 01, 2006

Authors : Keiko Yazawa, Takeshi Kihara, Huilian Shen, Yoshiari Shimmyo, Tetsuhiro Niidome, Hachiro Sugimoto

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Polyphenols : CK(1109) : AC(390), Tannic Acid : CK(36) : AC(28)

Diseases : Excitotoxicity : CK(58) : AC(35)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAbeta-induced cytotoxicity.

Pubmed Data : Neurosci Lett. 2010 Aug 9;480(1):21-4. PMID: 20638958

Article Published Date : Aug 09, 2010

Authors : Xiao-Yan Qin, Yong Cheng, Long-Chuan Yu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against glutamate excitotoxicity.

Pubmed Data : Brain Res. 2008 May 19;1210:84-91. Epub 2008 Apr 16. PMID: 18420184

Article Published Date : May 19, 2008

Authors : Rui Wang, Ying-Bo Li, Yu-Hua Li, Ying Xu, Hong-Li Wu, Xue-Jun Li

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Excitotoxicity : CK(58) : AC(35)

Pharmacological Actions : Antidepressive Agents : CK(1115) : AC(168), Apoptotic : CK(2958) : AC(2075), Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects pre-oligodendrocytes from activated microglia, indicating it may play a role in protecting against preterm periventricular leukomalacia (PVL).

Pubmed Data : Brain Res. 2010 Jun 21;1339:60-9. Epub 2010 Apr 24. PMID: 20403340

Article Published Date : Jun 21, 2010

Authors : Liu-fang He, Hui-Jin Chen, Long-hua Qian, Guan-yi Chen, Jeffrey S Buzby

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain: Microglial Activation : CK(82) : AC(53), Brain Inflammation : CK(274) : AC(145), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218), Preterm Periventricular Leukomalacia (PVL) : CK(2) : AC(1)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Suppression of GRASP65 phosphorylation by tetrahydrocurcumin protects against cerebral ischemia/reperfusion injury.

Pubmed Data : Mol Med Rep. 2016 Nov ;14(5):4775-4780. Epub 2016 Oct 6. PMID: 27748926

Article Published Date : Oct 31, 2016

Authors : Bin Lin, Heng Yu, Yuting Lin, Chao Cai, Huoquan Lu, Xinbo Zhu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Brain Ischemia : CK(136) : AC(52)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Malondialdehyde Down-regulation : CK(554) : AC(152), Neuroprotective Agents : CK(2360) : AC(1099), Superoxide Dismutase Up-regulation : CK(530) : AC(174)

"Curcumin protects against intracellular amyloid toxicity in rat primary neurons."

Pubmed Data : Int J Clin Exp Med. 2012 ;5(1):44-9. Epub 2012 Jan 15. PMID: 22328947

Article Published Date : Jan 01, 2012

Authors : Jelina Ye, Yan Zhang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Amyloid toxicity : CK(3) : AC(2), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

"Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain."

Pubmed Data : Nutr Neurosci. 2012 Feb 2. Epub 2012 Feb 2. PMID: 22333997

Article Published Date : Feb 02, 2012

Authors : Canales-Aguirre Alejandro A, Gomez-Pinedo Ulises A, Luquin Sonia, Ramírez-Herrera Mario A, Mendoza-Magaña María L, Feria-Velasco Alfredo

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Hippocampal Damage : CK(39) : AC(18), Pesticide Toxicity : CK(192) : AC(61)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Parathion : CK(2) : AC(1)

Adverse Pharmacological Actions : Neurotoxic : CK(1396) : AC(289)

"Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease."

Pubmed Data : Curr Pharm Des. 2012 Jan 1. Epub 2012 Jan 1. PMID: 22211691

Article Published Date : Jan 01, 2012

Authors : R B Mythri, Mm Srinivas Bharath

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.

Pubmed Data : PLoS One. 2010;5(11):e14015. Epub 2010 Nov 17. PMID: 21103342

Article Published Date : Jan 01, 2010

Authors : Anna Parachikova, Kim N Green, Curt Hendrix, Frank M LaFerla

Study Type : Animal Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(476) : AC(116), B-complex : CK(278) : AC(32), Curcumin : CK(4417) : AC(2300), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Folic Acid : CK(834) : AC(121), NAC (N-acetyl-L-cysteine) : CK(318) : AC(76), Piperine : CK(169) : AC(84), Vitamin C : CK(2484) : AC(569)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

A curcumin metabolite protects against Alzheimer disease associated amyloidβ-induced toxicity.

Pubmed Data : Neuroreport. 2010 Nov 24. Epub 2010 Nov 24. PMID: 21116204

Article Published Date : Nov 24, 2010

Authors : Shilpa Mishra, Mamata Mishra, Pankaj Seth, Shiv Kumar Sharma

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

A review of herbs and spices that could play a beneficial role as dietary aids in the treatment of Alzheimer disease.

Pubmed Data : Adv Exp Med Biol. 2015 ;863:95-116. PMID: 26092628

Article Published Date : Dec 31, 2014

Authors : Helmut M Hügel

Study Type : Review

Additional Links

Substances : Celery : CK(51) : AC(25), Green Tea : CK(2251) : AC(658), Panax Ginseng : CK(81) : AC(37), Turmeric : CK(5583) : AC(2569)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

A supplement containing huperzine A and curcumin in dementia patients and individuals with mild cognitive impairment had beneficial effects.

Pubmed Data : J Alzheimers Dis. 2018 ;63(1):75-78. PMID: 29614668

Article Published Date : Dec 31, 2017

Authors : Takeshi Tabira, Nobutoshi Kawamura

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Huperzine : CK(44) : AC(24)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Dementia with Lewy bodies (DLB) : CK(3) : AC(1)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy.

Pubmed Data : Pharm Biol. 2013 Dec ;51(12):1572-8. Epub 2013 Sep 5. PMID: 24004105

Article Published Date : Nov 30, 2013

Authors : Zahra Kiasalari, Mehrdad Roghani, Mohsen Khalili, Batool Rahmati, Tourandokht Baluchnejadmojarad

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Epileptic Seizures : CK(192) : AC(10)

Pharmacological Actions : Anticonvulsants : CK(238) : AC(67), Neuroprotective Agents : CK(2360) : AC(1099)

Aromatic turmerone constitutes a promising candidate to support regeneration in neurologic disease.

Pubmed Data : Stem Cell Res Ther. 2014 ;5(4):100. Epub 2014 Sep 26. PMID: 25928248

Article Published Date : Dec 31, 2013

Authors : Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Turmeric : CK(5583) : AC(2569), Turmerones : CK(16) : AC(13)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932), Neurologic Disorders : CK(66) : AC(30)

Pharmacological Actions : Neurogenesis : CK(59) : AC(30), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Dose Response : CK(1519) : AC(574), Neural Stem Cell : CK(6) : AC(5)

Aromatic-turmerone offers new possibilities for tackling neurodegeneration.

Pubmed Data : Stem Cell Res Ther. 2014 ;5(6):127. Epub 2014 Nov 17. PMID: 25688994

Article Published Date : Dec 31, 2013

Authors : Steven W Poser, Andreas Androutsellis-Theotokis

Study Type : Review

Additional Links

Substances : Turmeric : CK(5583) : AC(2569), Turmerones : CK(16) : AC(13)

Diseases : Brain Inflammation : CK(274) : AC(145), Neurodegenerative Diseases : CK(3582) : AC(932), Stroke: Attenuation/Recovery : CK(347) : AC(75)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Neural Stem Cell : CK(6) : AC(5)

Both curcumin and its metabolite tetrahydrocurcumin exert neuroprotection against chemically-induced neurotoxicity.

Pubmed Data : Inflammopharmacology. 2008 Apr;16(2):96-9. PMID: 18408903

Article Published Date : Apr 01, 2008

Authors : A Rajeswari, M Sabesan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Polyphenols : CK(1109) : AC(390), Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin (a special preparation) prevents dopamine-induced toxicity in rat brain synaptosomes.

Pubmed Data : Int J Pharm. 2015 Mar 31. Epub 2015 Mar 31. PMID: 25839414

Article Published Date : Mar 30, 2015

Authors : Krassimira Yoncheva, Magdalena Kondeva-Burdina, Virginia Tzankova, Petar Petrov, Mohamed Laouani, Silvia S Halacheva

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Dopamine Toxicity : CK(6) : AC(4)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin (low dose) may have a therapeutic effect in the treatment of prion diseases.

Pubmed Data : J Gen Virol. 2008 Feb;89(Pt 2):594-7. PMID: 18198391

Article Published Date : Feb 01, 2008

Authors : Constanze Riemer, Michael Burwinkel, Anja Schwarz, Sandra Gültner, Simon W F Mok, Ines Heise, Nikola Holtkamp, Michael Baier

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Prion Diseases : CK(10) : AC(7)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin ameliorates cognitive deficits and neurodegeneration in a rat model of sporadic dementia of Alzheimer's type (SDAT).

Pubmed Data : Eur Neuropsychopharmacol. 2009 Sep;19(9):636-47. Epub 2009 Mar 28. PMID: 19329286

Article Published Date : Sep 01, 2009

Authors : Tauheed Ishrat, Md Nasrul Hoda, M Badruzzaman Khan, Seema Yousuf, Muzamil Ahmad, Mohd Moshahid Khan, Ajmal Ahmad, Fakhrul Islam

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin ameliorates memory deficits associated with diabetes in the rat.

Pubmed Data : Age (Dordr). 2009 Mar;31(1):39-49. Epub 2008 Oct 8. PMID: 19234767

Article Published Date : Mar 01, 2009

Authors : Ahmet Turan Isik, Turgay Celik, Gokhan Ulusoy, Onder Ongoru, Birsen Elibol, Huseyin Doruk, Ergun Bozoglu, Hakan Kayir, Mehmet Refik Mas, Serif Akman

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17), Memory Disorders : CK(344) : AC(104)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin and curcuminoids are neuroprotective in a variety of preclinical stroke models.

Pubmed Data : Respir Med. 2008 Jun;102(6):840-4. Epub 2008 Mar 4. PMID: 21158690

Article Published Date : Jun 01, 2008

Authors : Paul A Lapchak

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Stroke : CK(1365) : AC(168)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin appears to have multiple effects on the SMN2 transcript and its splicing regulators, including the change of alternative splicing and transcript/protein level as well as phosphorylation.

Pubmed Data : Genes Nutr. 2015 Nov ;10(6):40. Epub 2015 Sep 19. PMID: 26386842

Article Published Date : Oct 31, 2015

Authors : Dairong Feng, Yi Cheng, Yan Meng, Liping Zou, Shangzhi Huang, Jiuyong Xie

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Spinal Muscular Atrophy : CK(1) : AC(2)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin attenuates aluminum-induced functional neurotoxicity in rats.

Pubmed Data : Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155

Article Published Date : Jul 01, 2009

Authors : Pallavi Sethi, Amar Jyoti, Ejaz Hussain, Deepak Sharma

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Turmeric : CK(5583) : AC(2569)

Diseases : Aluminum Toxicity : CK(207) : AC(75)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin attenuates amyloid-β aggregate toxicity and modulates amyloid-β aggregation pathway.

Pubmed Data : ACS Chem Neurosci. 2015 Nov 17. Epub 2015 Nov 17. PMID: 26529184

Article Published Date : Nov 16, 2015

Authors : Arjun Thapa, Stephen D Jett, Eva Y Chi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signalling.

Pubmed Data : Neurol Res. 2013 Oct ;35(8):857-66. Epub 2013 May 14. PMID: 23816368

Article Published Date : Sep 30, 2013

Authors : Juliana Bender Hoppe, Rudimar Luiz Frozza, Elisa Nicoloso Simões Pires, André Bevilacqua Meneghetti, Christianne Salbego

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Pharmacological Actions : Interleukin-10 upregulation : CK(105) : AC(24), Interleukin-6 Downregulation : CK(1137) : AC(354), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin attenuates cerebral edema following traumatic brain injury in mice.

Pubmed Data : J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469

Article Published Date : Feb 01, 2010

Authors : Melissa D Laird, Sangeetha Sukumari-Ramesh, Andrew E B Swift, Steffen E Meiler, John R Vender, Krishnan M Dhandapani

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Traumatic : CK(99) : AC(30)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin binding to Aβ shifts the equilibrium in the aggregation pathway by promoting the formation of non-toxic aggregates.

Pubmed Data : Chem Biol Drug Des. 2015 Mar 16. Epub 2015 Mar 16. PMID: 25776887

Article Published Date : Mar 15, 2015

Authors : Praveen P N Rao, Tarek Mohamed, Karan Teckwani, Gary Tin

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin can ameliorate cerebral pathological changes in the event of ischemic brain injury.

Pubmed Data : Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun;29(6):1153-5. PMID: 19726347

Article Published Date : Jun 01, 2009

Authors : Rong Zhuang, Meng-Xiang Lin, Qiu-Ying Song, Jun Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin can inhibit alpha-synuclein gene overexpression or mutation induced alpha-synuclein oligomers formation.

Pubmed Data : Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015 Aug 10 ;32(4):462-7. PMID: 26252085

Article Published Date : Aug 09, 2015

Authors : Tao Chen, Yidong Deng, Xiaoping Liao, Jiannong Zhao, Guoqiang Wen, Guohu Weng, Fei Ma, Yingying Zheng

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Gene Expression Regulation : CK(431) : AC(214)

Curcumin can significantly decrease cerebral ischemia reperfusions pathological damage and suppressed the expression of MMP-9 and TNF-α.

Pubmed Data : Zhong Yao Cai. 2015 Feb ;38(2):344-9. PMID: 26415414

Article Published Date : Jan 31, 2015

Authors : Ling-yan Dai, Bi-huan Cheng, Jun Li

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cerebral Ischemia : CK(229) : AC(77)

Pharmacological Actions : Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(212) : AC(128), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin can significantly protect neurons against cerebral ischemia.

Pubmed Data : Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 May;23(2):184-8. PMID: 21179765

Article Published Date : May 01, 2007

Authors : Hong Cao, Jun Li, Guang-ming Li, Yao-qi Wang, Yin-ming Zeng

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cerebral Ischemia : CK(229) : AC(77)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), NF-kappaB Inhibitor : CK(1114) : AC(694)

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

Pubmed Data : Gastroenterology. 2006 Jan;130(1):120-6. PMID: 20622013

Article Published Date : Jan 01, 2006

Authors : Can Zhang, Andrew Browne, Daniel Child, Rudolph E Tanzi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin demonstrates therapeutic properties in an animal model of Alzheimer disease.

Pubmed Data : J Pharmacol Exp Ther. 2008 Jul;326(1):196-208. Epub 2008 Apr 16. PMID: 18417733

Article Published Date : Jul 01, 2008

Authors : Aynun N Begum, Mychica R Jones, Giselle P Lim, Takashi Morihara, Peter Kim, Dennis D Heath, Cheryl L Rock, Mila A Pruitt, Fusheng Yang, Beverly Hudspeth, Shuxin Hu, Kym F Faull, Bruce Teter, Greg M Cole, Sally A Frautschy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Inflammation : CK(3240) : AC(882)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin exerts its neuroprotective function in focal cerebral ischemia by regulating the expression of γ-enolase.

Pubmed Data : Lab Anim Res. 2015 Dec ;31(4):198-203. Epub 2015 Dec 22. PMID: 26755923

Article Published Date : Nov 30, 2015

Authors : Sang-Ah Gim, So-Ra Lee, Fawad-Ali Shah, Phil-Ok Koh

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cerebral Ischemia : CK(229) : AC(77)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin exhibits a neuroprotective effect through the classical wnt signaling pathway.

Pubmed Data : J Surg Res. 2014 Dec ;192(2):298-304. Epub 2014 Jun 19. PMID: 25033705

Article Published Date : Nov 30, 2014

Authors : Fei Chen, Haoxiang Wang, Xin Xiang, Jichao Yuan, Weihua Chu, Xingsen Xue, Haitao Zhu, Hongfei Ge, Mingming Zou, Hua Feng, Jiangkai Lin

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), Wnt/β-catenin signaling pathway modulation : CK(36) : AC(24)

Curcumin exhibits inhibitory effects on Alzheimer disease associated β-amyloid proteins.

Pubmed Data : Int Dent J. 1996 Feb;46(1):22-34. PMID: 20727383

Article Published Date : Feb 01, 1996

Authors : Hongying Liu, Zhong Li, Donghai Qiu, Qiong Gu, Qingfeng Lei, Li Mao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin exhibits neuroprotective properties when given 4h post-ischemia in the rat thromboembolic stroke models.

Pubmed Data : Behav Brain Res. 2008 Nov 21;193(2):289-97. Epub 2008 Jun 19. PMID: 18611416

Article Published Date : Nov 21, 2008

Authors : Preeti Dohare, Puja Garg, Vikas Jain, Chandishwar Nath, Madhur Ray

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52), Middle Cerebral Artery Occlusion (MCAO) : CK(73) : AC(28), Stroke : CK(1365) : AC(168), Stroke: Attenuation/Recovery : CK(347) : AC(75), Thromboembolism : CK(205) : AC(16)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin exhibits protective properties against peroxynitrite-induced neurotoxicity.

Pubmed Data : Neurotoxicology. 2011 Jan;32(1):150-7. Epub 2010 Sep 24. PMID: 20869986

Article Published Date : Jan 01, 2011

Authors : Wenwen Liu, Zhaomin Fan, Yuechen Han, Sumei Lu, Daogong Zhang, Xiaohui Bai, Wei Xu, Jianfeng Li, Haibo Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Damage : CK(93) : AC(44)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a neuroprotective effect in arsenic-induced neurotoxicity in rats.

Pubmed Data : Neurotoxicology. 2010 Sep;31(5):533-9. Epub 2010 May 11. PMID: 20466022

Article Published Date : Sep 01, 2010

Authors : Rajesh S Yadav, Rajendra K Shukla, Madhu Lata Sankhwar, Devendra K Patel, Reyaz W Ansari, Aditya B Pant, Fakhrul Islam, Vinay K Khanna

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Arsenic Poisoning : CK(160) : AC(49)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a neuroprotective effect in brain trauma.

Pubmed Data : Neuroscience. 2009 Jul 21;161(4):1037-44. Epub 2009 Apr 21. PMID: 19393301

Article Published Date : Jul 21, 2009

Authors : S Sharma, Y Zhuang, Z Ying, A Wu, F Gomez-Pinilla

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Injury: Traumatic : CK(99) : AC(30)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a neuroprotective effect in hypoxia ischemia brain tissue injury.

Pubmed Data : J Nat Prod. 2009 Apr;72(4):725-31. PMID: 19397204

Article Published Date : Apr 01, 2009

Authors : Yuan-yuan Zheng, Lin-sheng Yu, Yi-gu Zhang, Guang-hua Ye, Ji-pu Yi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52), Hypoxia : CK(123) : AC(60)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a neuroprotective effect on 6-hydroxydopamine-induced Parkinsonism in rats.

Pubmed Data : Exp Neurol. 2010 Oct;225(2):237-9. Epub 2010 Jul 11. PMID: 20951685

Article Published Date : Oct 01, 2010

Authors : Gulrana Khuwaja, Mohd Moshahid Khan, Tauheed Ishrat, Ajmal Ahmad, Syed Shadab Raza, Mohammad Ashafaq, Hayate Javed, M Badruzzaman Khan, Andleeb Khan, Kumar Vaibhav, Mohammed M Safhi, Fakhrul Islam

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinsonism : CK(22) : AC(12)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a neuroprotective effect on focal cerebral ischemic rats by preventing blood-brain barrier damage.

Pubmed Data : Chemotherapy. 2010;56(1):60-5. Epub 2010 Mar 19. PMID: 17303117

Article Published Date : Jan 01, 2010

Authors : Jun Jiang, Wei Wang, Yong Jun Sun, Mei Hu, Fei Li, Dong Ya Zhu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Blood-Brain-Barrier Disorders : CK(27) : AC(16), Brain Ischemia : CK(136) : AC(52), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin has a protective effect after spinal cord injury.

Pubmed Data : J Surg Res. 2009 Aug 5. Epub 2009 Aug 5. PMID: 20018302

Article Published Date : Aug 05, 2009

Authors : Muh-Shi Lin, Yi-Hsuan Lee, Wen-Ta Chiu, Kuo-Sheng Hung

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Spinal Cord Injuries : CK(155) : AC(55)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a protective effect against neuronal damage associated with metal ions.

Pubmed Data : Neurosci Lett. 2008 Aug 8;440(3):344-7. Epub 2008 May 24. PMID: 18583042

Article Published Date : Aug 08, 2008

Authors : Raozhou Lin, Xiaohong Chen, Wenming Li, Yifan Han, Peiqing Liu, Rongbiao Pi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Heavy Metal Toxicity : CK(903) : AC(285), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has a significant role in a therapeutic application for the prevention or progression of diabetic complications in the cerebellum.

Pubmed Data : Life Sci. 2009 Nov 4;85(19-20):704-10. Epub 2009 Oct 3. PMID: 19804785

Article Published Date : Nov 04, 2009

Authors : Kumar T Peeyush, G Gireesh, Mathew Jobin, C S Paulose

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has neuroprotective effect on transient focal cerebral ischemia in rats.

Pubmed Data : Brain Res. 2008 Sep 10;1229:224-32. Epub 2008 Jul 8. PMID: 18640105

Article Published Date : Sep 10, 2008

Authors : Jing Zhao, Yong Zhao, Weiping Zheng, Yuyu Lu, Gang Feng, Shanshan Yu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52), Cerebral Ischemia: Transient : CK(12) : AC(6), Middle Cerebral Artery Occlusion (MCAO) : CK(73) : AC(28)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has neuroprotective properties against NMDA-induced toxicity.

Pubmed Data : Invest Ophthalmol Vis Sci. 2010 Sep 22. Epub 2010 Sep 22. PMID: 20861489

Article Published Date : Sep 22, 2010

Authors : Andrea Matteucci, Roberta Cammarota, Silvia Paradisi, Monica Varano, Maria Balduzzi, Lanfranco Leo, Gian C Bellenchi, Chiara De Nuccio, Giovanna Carnovale-Scalzo, Giovanni Scorcia, Claudio Frank, Cinzia Mallozzi, Annamaria M Di Stasi, Sergio Visentin, Fiorella Malchiodi-Albedi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin has neuroprotective properties.

Pubmed Data : Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):147-53. Epub 2009 Oct 29. PMID: 19879308

Article Published Date : Feb 01, 2010

Authors : Rui Wang, Yu-Hua Li, Ying Xu, Ying-Bo Li, Hong-Li Wu, Hao Guo, Jian-Zhao Zhang, Jing-Jie Zhang, Xue-Yang Pan, Xue-Jun Li

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin holds promise as an agent to prevent or treat central nervous system complications in diabetes.

Pubmed Data : J Biomed Sci. 2010;17:43. Epub 2010 May 31. PMID: 20513244

Article Published Date : Jan 01, 2010

Authors : T Peeyush Kumar, Sherin Antony, G Gireesh, Naijil George, C S Paulose

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin improves early functional results after experimental spinal cord injury.

Pubmed Data : Acta Neurochir (Wien). 2010 Sep;152(9):1583-90; discussion 1590. Epub 2010 Jun 10. PMID: 20535508

Article Published Date : Sep 01, 2010

Authors : Berker Cemil, Kivanc Topuz, Mehmet Nusret Demircan, Gokhan Kurt, Kagan Tun, Murat Kutlay, Osman Ipcioglu, Zafer Kucukodaci

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Spinal Cord Injuries : CK(155) : AC(55)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin improves learning and memory ability in a mouse Alzheimer's disease experimental model.

Pubmed Data : Chin Med J (Engl). 2008 May 5;121(9):832-9. PMID: 18701050

Article Published Date : May 05, 2008

Authors : Rui Pan, Sheng Qiu, Da-xiang Lu, Jun Dong

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Memory Disorders : CK(344) : AC(104), Memory Loss : CK(153) : AC(40)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop.

Pubmed Data : Neural Regen Res. 2015 Jun ;10(6):925-31. PMID: 26199609

Article Published Date : May 31, 2015

Authors : Ling-Ling Shen, Ming-Liang Jiang, Si-Si Liu, Min-Chun Cai, Zhong-Qiu Hong, Li-Qing Lin, Yan-Yan Xing, Gui-Lin Chen, Rui Pan, Li-Juan Yang, Ying Xu, Jun Dong

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : HIV Infections : CK(680) : AC(219)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Natural Substances Versus Drugs : CK(1698) : AC(302)

Curcumin improves the tau-induced neuronal dysfunction that is independent of insoluble aggregates of tau.

Pubmed Data : Neurobiol Aging. 2016 Mar ;39:69-81. Epub 2015 Dec 1. PMID: 26923403

Article Published Date : Feb 29, 2016

Authors : Tomohiro Miyasaka, Ce Xie, Satomi Yoshimura, Yuki Shinzaki, Sawako Yoshina, Eriko Kage-Nakadai, Shohei Mitani, Yasuo Ihara

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin induces neurogenesis and neuroprotection and may provide a novel therapeutic agent for both regenerative medicine and for the treatment of neurodegenerative diseases.

Pubmed Data : Folia Neuropathol. 2015 ;53(2):89-99. PMID: 26216111

Article Published Date : Dec 31, 2014

Authors : Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Judyta Brzozowska, Mirosław Jabłoński, Janusz Kocki

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932), Stroke: Ischemic : CK(218) : AC(31)

Pharmacological Actions : Neurogenesis : CK(59) : AC(30), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction.

Pubmed Data : Transl Neurodegener. 2012 ;1(1):16. Epub 2012 Aug 20. PMID: 23210631

Article Published Date : Dec 31, 2011

Authors : Jing Pan, Hui Li, Jian-Fang Ma, Yu-Yan Tan, Qin Xiao, Jian-Qing Ding, Sheng-Di Chen

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease.

Pubmed Data : J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263

Article Published Date : Dec 01, 2004

Authors : Ranjit K Giri, Vikram Rajagopal, Vijay K Kalra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251), Epidermal growth factor receptor (EGFR) inhibitor : CK(65) : AC(41), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin inhibits Aβ-induced neuronal damage and cell death involving the prevention from intracellular Ca2+ elevation mediated by the NMDA receptor.

Pubmed Data : J Recept Signal Transduct Res. 2015 Jun 8:1-8. Epub 2015 Jun 8. PMID: 26053510

Article Published Date : Jun 07, 2015

Authors : Han-Chang Huang, Ping Chang, Shu-Yan Lu, Bo-Wen Zheng, Zhao-Feng Jiang

Study Type : Human In Vitro

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Dose Response : CK(1519) : AC(574)

Curcumin inhibits the conversion of prion protein in vitro.

Pubmed Data : J Neurochem. 2008 Mar ;104(6):1553-64. Epub 2007 Nov 7. PMID: 17996023

Article Published Date : Feb 29, 2008

Authors : Iva Hafner-Bratkovic, Jernej Gaspersic, Lojze M Smid, Mara Bresjanac, Roman Jerala

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Creutzfeldt-Jakob disease : CK(27) : AC(9), Prion Diseases : CK(10) : AC(7)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and hypoxia-hypercapnia brain edema.

Pubmed Data : Am J Med Sci. 2015 Jun ;349(6):521-5. PMID: 25867253

Article Published Date : May 31, 2015

Authors : Linsheng Yu, Yanyan Fan, Guanghua Ye, Junli Li, Xiangping Feng, Kezhi Lin, Miuwu Dong, Zhenyuan Wang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Hypoxia : CK(24) : AC(15), Hypercapnia : CK(4) : AC(2)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin is a neuroprotective agent that prevents/delays morphological abnormalities associated with rod PR degeneration a swine model of retinitis pigmentosa.

Pubmed Data : Transl Vis Sci Technol. 2015 Sep ;4(5):5. Epub 2015 Sep 16. PMID: 26396931

Article Published Date : Aug 31, 2015

Authors : Patrick A Scott, Henry J Kaplan, Maureen A McCall

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Retinitis Pigmentosa : CK(62) : AC(7)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin is capable of promoting nerve regeneration after sciatic nerve crush injury in diabetes mellitus,

Pubmed Data : Neurosci Lett. 2015 Nov 10 ;610:139-143. Epub 2015 Nov 10. PMID: 26552010

Article Published Date : Nov 09, 2015

Authors : Junxiong Ma, Hailong Yu, Jun Liu, Yu Chen, Qi Wang, Liangbi Xiang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetic Complications : CK(1563) : AC(333), Peripheral Nerve Diseases : CK(51) : AC(14), Sciatic Nerve Crush Injury : CK(18) : AC(9)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), Regenerative : CK(52) : AC(28)

Curcumin loaded lactoferrin nanoparticles could be a promising drug delivery strategy against neurotoxicity in dopaminergic neurons.

Pubmed Data : Neurochem Int. 2016 Jan 27. Epub 2016 Jan 27. PMID: 26826319

Article Published Date : Jan 26, 2016

Authors : V Satish Bollimpelli, Prashant Kumar, Sonali Kumari, Anand K Kondapi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Rotenone : CK(5) : AC(1)

Curcumin may act as a neuroprotectant against aluminum-induced neurodegenerative and behavioural disorders.

Pubmed Data : J Environ Pathol Toxicol Oncol. 2018 ;37(2):163-172. PMID: 30055551

Article Published Date : Dec 31, 2017

Authors : Hongyuan Zhang, Wei Zhao, Anshoo Malhotra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aluminum Toxicity : CK(207) : AC(75)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Aluminum : CK(274) : AC(78)

Curcumin may be a potential therapeutic agent that can regulate the critical molecules in brain insulin signalling pathways.

Pubmed Data : Int J Immunopathol Pharmacol. 2016 Jul 27. Epub 2016 Jul 27. PMID: 27466310

Article Published Date : Jul 26, 2016

Authors : Hui-Li Feng, Hui-Zi Dang, Hui Fan, Xiao-Pei Chen, Ying-Xue Rao, Ying Ren, Jin-Duo Yang, Jing Shi, Peng-Wen Wang, Jin-Zhou Tian

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may be effective in preventing or slowing the progression of Parkinson's Disease.

Pubmed Data : J Toxicol Pathol. 2015 Oct ;28(4):197-206. Epub 2015 Jul 27. PMID: 26538809

Article Published Date : Sep 30, 2015

Authors : Xi-Jun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayama

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may contribute to preventing memory loss.

Pubmed Data : Biochem Pharmacol. 2009 Apr 1;77(7):1254-65. Epub 2008 Dec 31. PMID: 19161989

Article Published Date : Apr 01, 2009

Authors : Lisa Conboy, Andrew G Foley, Noel M O'Boyle, Marie Lawlor, Helen C Gallagher, Keith J Murphy, Ciaran M Regan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Memory Loss : CK(153) : AC(40)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may have therapeutic value in Alzheimer disease.

Pubmed Data : Brain Res. 2010 Nov 18;1361:115-23. Epub 2010 Sep 16. PMID: 20840842

Article Published Date : Nov 18, 2010

Authors : Zijian Xiao, Liming Lin, Zhonghua Liu, Fengtao Ji, Weiyan Shao, Minjuan Wang, Ling Liu, Shengliang Li, Feng Li, Xianzhang Bu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin may protect from focal cerebral ischemia reperfusion injury as well as stimulate neurogenesis.

Pubmed Data : Neurol Res. 2016 Jun ;38(6):553-9. PMID: 27320251

Article Published Date : May 31, 2016

Authors : Shuang Liu, Yungang Cao, Man Qu, Zheng Zhang, Liang Feng, Zusen Ye, Meijuan Xiao, Sheng T Hou, Rongyuan Zheng, Zhao Han

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cerebral Ischemia : CK(229) : AC(77), Stroke: Attenuation/Recovery : CK(347) : AC(75)

Pharmacological Actions : Neurogenesis : CK(59) : AC(30), Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Risk Reduction : CK(6417) : AC(686)

Curcumin micelles might be a suitable formulation for the prevention of mitochondrial dysfunction in brain aging and neurodegeneration.

Pubmed Data : Neurochem Int. 2015 Aug 5. Epub 2015 Aug 5. PMID: 26254982

Article Published Date : Aug 04, 2015

Authors : Stephanie Hagl, Alexa Kocher, Christina Schiborr, Natalie Kolesova, Jan Frank, Gunter P Eckert

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Mitochondrial Dysfunction : CK(227) : AC(92), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin might be a potential agent in post-operative cognitive dysfunction prophylaxis and treatment.

Pubmed Data : Metab Brain Dis. 2017 Feb 21. Epub 2017 Feb 21. PMID: 28224377

Article Published Date : Feb 20, 2017

Authors : Xiang Wu, Huixin Chen, Chunhui Huang, Xinmei Gu, Jialing Wang, Dilin Xu, Xin Yu, Chu Shuai, Liping Chen, Shun Li, Yiguo Xu, Tao Gao, Mingrui Ye, Wei Su, Haixiong Liu, Jinrong Zhang, Chuang Wang, Junping Chen, Qinwen Wang, Wei Cui

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), Prophylactic Agents : CK(129) : AC(31)

Curcumin might be used to prevent neuronal damage in the retina of patients with diabetes mellitus.

Pubmed Data : J Ocul Pharmacol Ther. 2015 Jul 24. Epub 2015 Jul 24. PMID: 26207889

Article Published Date : Jul 23, 2015

Authors : Jun Li, Peipei Wang, Yanxia Zhu, Zhen Chen, Tianyan Shi, Wensheng Lei, Songping Yu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301), Diabetic Complications : CK(1563) : AC(333)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin nanoparticles may offer a therapeutic approach to treating neurodegenerative diseases by enhancing brain self-repair mechanisms.

Pubmed Data : ACS Nano. 2014 Jan 28 ;8(1):76-103. Epub 2013 Dec 10. PMID: 24467380

Article Published Date : Jan 27, 2014

Authors : Shashi Kant Tiwari, Swati Agarwal, Brashket Seth, Anuradha Yadav, Saumya Nair, Priyanka Bhatnagar, Madhumita Karmakar, Manisha Kumari, Lalit Kumar Singh Chauhan, Devendra Kumar Patel, Vikas Srivastava, Dhirendra Singh, Shailendra Kumar Gupta, Anurag Tripathi, Rajnish Kumar Chaturvedi, Kailash Chand Gupta

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neurogenesis : CK(59) : AC(30), Neuroprotective Agents : CK(2360) : AC(1099), Wnt/β-catenin signaling pathway modulation : CK(36) : AC(24)

Curcumin plays an important role in the gp120 V3 loop peptide induced neuronal apoptosis by regulating HSP70.

Pubmed Data : Neurochem Res. 2015 Sep ;40(9):1996-2005. Epub 2015 Aug 21. PMID: 26294283

Article Published Date : Aug 31, 2015

Authors : Chenglai Xia, Yantao Cai, Shuhua Li, Jie Yang, Guohong Xiao

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : HIV Infections : CK(680) : AC(219)

Pharmacological Actions : Heat Shock Protein Inducer : CK(83) : AC(30), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents and/or delays diabetic complications associated with brain.

Pubmed Data : J Agric Food Chem. 2008 Nov 12;56(21):9905-10. Epub 2008 Oct 2. PMID: 20637830

Article Published Date : Nov 12, 2008

Authors : T Peeyush Kumar, Sherin Antony, Smijin Soman, Korah P Kuruvilla, Naijil George, C S Paulose

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Diabetes: Cognitive Dysfunction : CK(40) : AC(17)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents cigarette smoke extract induced cognitive impairment.

Pubmed Data : Front Biosci (Elite Ed). 2019 Jan 1 ;11:109-120. Epub 2019 Jan 1. PMID: 30468642

Article Published Date : Dec 31, 2018

Authors : Arunachalam Muthuraman, Loganathan Thilagavathi, Sara Jabeen, Shreyas Belagod Ravishankar, Syed Shakeeb Ahmed, Thomas George, Narahari Rishitha, Nallupillai Paramakrishnan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Smoking : CK(740) : AC(111)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin prevents dopaminergic neuronal death.

Pubmed Data : Rejuvenation Res. 2010 Feb;13(1):55-64. PMID: 20230279

Article Published Date : Feb 01, 2010

Authors : Song Yu, Wei Zheng, Na Xin, Zhi-Hong Chi, Nai-Qian Wang, Ying-Xue Nie, Wan-Yu Feng, Zhan-You Wang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against adverse changes associated with neuronal hypoxia.

Pubmed Data : Asia Pac J Clin Nutr. 2003;12(1):50-60. PMID: 18461445

Article Published Date : Jan 01, 2003

Authors : Yu Shen, Long-Chuan Yu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Hypoxia : CK(24) : AC(15)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against chemically-induced neurotoxicity in mice.

Pubmed Data : Anticancer Res. 1998 Sep-Oct;18(5A):3487-91. PMID: 20054649

Article Published Date : Sep 01, 1998

Authors : Neha Singla, D K Dhawan

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Damage : CK(93) : AC(44)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against chemically-induced Parkinsonism in a cell model.

Pubmed Data : Pharmacol Res. 2011 Jan 12. Epub 2011 Jan 12. PMID: 21237271

Article Published Date : Jan 12, 2011

Authors : Zhaohui Liu, Yi Yu, Xueping Li, Christopher A Ross, Wanli W Smith

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinsonism : CK(22) : AC(12)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against d-galactose-induced senescence in mice.

Pubmed Data : J Asian Nat Prod Res. 2011 Jan;13(1):42-55. PMID: 21253949

Article Published Date : Jan 01, 2011

Authors : Anil Kumar, Atish Prakash, Samrita Dogra

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Aging : CK(1658) : AC(438)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against encephalopathy in the animal model.

Pubmed Data : Mutat Res. 2008 Dec 8;657(2):105-10. Epub 2008 Aug 22. PMID: 19000058

Article Published Date : Dec 08, 2008

Authors : Diego Martín Roselló, Karina Balestrasse, Carlos Coll, Sebastian Coll, Silvina Tallis, Alberto Gurni, María Lujan Tomaro, Abraham Lemberg, Juan Carlos Perazzo

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Encephalopathies : CK(14) : AC(6)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against Haloperidol-associated neurotoxicity.

Pubmed Data : J Altern Complement Med. 2004 Dec;10(6):1015-8. PMID: 21076901

Article Published Date : Dec 01, 2004

Authors : Mahendra Bishnoi, Kanwaljit Chopra, Lu Rongzhu, Shrinivas K Kulkarni

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Drug-Induced Toxicity : CK(562) : AC(83), Drug-Induced Toxicity: Haloperidol : CK(4) : AC(2)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects against staurosporine toxicity in rat neurons.

Pubmed Data : Neurosci Bull. 2012 Oct ;28(5):606-10. Epub 2012 Oct 3. PMID: 23054638

Article Published Date : Sep 30, 2012

Authors : Xiao-Yan Qin, Ji-Hui Lv, Jia Cui, Xue Fang, Yan Zhang

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Neurotoxicity : CK(3) : AC(3), Staurosporine Toxicity : CK(1) : AC(1)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Staurosporine : CK(1) : AC(1)

Curcumin protects dopaminergic cells from Parkinson disease-associated 6-hydroxydopamine-induced neurotoxicity.

Pubmed Data : Neurosci Lett. 2011 Feb 11;489(3):192-6. Epub 2010 Dec 15. PMID: 21167259

Article Published Date : Feb 11, 2011

Authors : Yamaratee Jaisin, Anusorn Thampithak, Benjawan Meesarapee, Piyanee Ratanachamnong, Apichart Suksamrarn, Laddawal Phivthong-Ngam, Noppawan Phumala-Morales, Sukumal Chongthammakun, Piyarat Govitrapong, Yupin Sanvarinda

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects neuronal cells against status-epilepticus-induced hippocampal neuronal damage.

Pubmed Data : Can J Physiol Pharmacol. 2016 Dec 9:1-9. Epub 2016 Dec 9. PMID: 28177687

Article Published Date : Dec 08, 2016

Authors : Jin Wang, Yuan Liu, Xiao-Hui Li, Xiang-Chang Zeng, Jian Li, Jun Zhou, Bo Xiao, Kai Hu

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Epilepsy : CK(255) : AC(66)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects rat brains against focal ischemia.

Pubmed Data : Brain Res. 2009 Jul 28;1282:133-41. Epub 2009 May 13. PMID: 19445907

Article Published Date : Jul 28, 2009

Authors : Chenhui Yang, Xiangjian Zhang, Hongguang Fan, Ying Liu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52), Middle Cerebral Artery Occlusion (MCAO) : CK(73) : AC(28)

Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin protects the brain against drug-induced neurotoxicity, indicating it may have value in preventing neurological disorders such as Parkinson disease.

Pubmed Data : Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID: 17184173

Article Published Date : Mar 01, 2007

Authors : Rajeswara Babu Mythri, Balusamy Jagatha, Nityananda Pradhan, Julie Andersen, M M Srinivas Bharath

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Mitochondrial Dysfunction : CK(227) : AC(92), Neurodegenerative Diseases : CK(3582) : AC(932), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Enzyme Inhibitors : CK(473) : AC(251), Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/β-catenin signaling pathway.

Pubmed Data : Mol Neurobiol. 2015 May 12. Epub 2015 May 12. PMID: 25963729

Article Published Date : May 11, 2015

Authors : Shashi Kant Tiwari, Swati Agarwal, Anurag Tripathi, Rajnish Kumar Chaturvedi

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Bisphenol-A Toxicity : CK(185) : AC(56)

Pharmacological Actions : Neurogenesis : CK(59) : AC(30), Neuroprotective Agents : CK(2360) : AC(1099), Wnt/β-catenin signaling pathway modulation : CK(36) : AC(24)

Problem Substances : Bisphenol A : CK(685) : AC(178)

Adverse Pharmacological Actions : Neurotoxic : CK(1396) : AC(289)

Curcumin reduces cisplatin-induced neurotoxicity.

Pubmed Data : Neurotoxicology. 2012 Oct 2. Epub 2012 Oct 2. PMID: 23036615

Article Published Date : Oct 01, 2012

Authors : Leonardo Meneghin Mendonça, Carla da Silva Machado, Cristiane Cardoso Correia Teixeira, Luis Alexandre Pedro de Freitas, Maria de Lourdes Pires Bianchi, Lusânia Maria Greggi Antunes

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Chemotherapy-Induced Neurotoxicity : CK(3) : AC(3), Chemotherapy-Induced Toxicity: Cisplatin : CK(319) : AC(133)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Cisplatin : CK(30) : AC(7)

Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.

Pubmed Data : Neuropharmacology. 2009 Sep;57(4):463-71. Epub 2009 Jun 21. PMID: 19540859

Article Published Date : Sep 01, 2009

Authors : Ying Xu, Dan Lin, Shan Li, Gaowen Li, Subramaniam G Shyamala, Philip A Barish, Matthew M Vernon, Jianchun Pan, William O Ogle

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215), Memory Disorders : CK(344) : AC(104), Stress : CK(623) : AC(103)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia.

Pubmed Data : J Tradit Complement Med. 2017 Jan ;7(1):14-23. Epub 2016 Feb 11. PMID: 28053883

Article Published Date : Dec 31, 2016

Authors : Glaura Fernandes Teixeira de Alcântara, Eudes Simões-Neto, Giovany Michely Pinto da Cruz, Maria Elizabeth Pereira Nobre, Kelly Rose Tavares Neves, Geanne Matos de Andrade, Gerly Anne de Castro Brito, Glauce Socorro de Barros Viana

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Ischemia : CK(136) : AC(52)

Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(464) : AC(272), Neuroprotective Agents : CK(2360) : AC(1099), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin treatment attenuates ischemic stroke-induced brain injury via activation of SIRT1.

Pubmed Data : Brain Res Bull. 2015 Nov 27. Epub 2015 Nov 27. PMID: 26639783

Article Published Date : Nov 26, 2015

Authors : Yanping Miao, Sheng Zhao, Yang Gao, Ruijun Wang, Qiong Wu, Hui Wu, Tianyou Luo

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Inflammation : CK(274) : AC(145), Mitochondrial Dysfunction : CK(227) : AC(92), Stroke: Attenuation/Recovery : CK(347) : AC(75)

Pharmacological Actions : Interleukin-6 Downregulation : CK(1137) : AC(354), Neuroprotective Agents : CK(2360) : AC(1099), SIRT1 Activator : CK(39) : AC(23), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(1823) : AC(669)

Curcumin treatment had shown a protective effect in OCD with considerable influence on brain monoamine levels.

Pubmed Data : N Am J Med Sci. 2010 Feb ;2(2):81-6. PMID: 22624119

Article Published Date : Jan 31, 2010

Authors : Jithendra Chimakurthy, Talasila Egk Murthy

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Obsessive-Compulsive Disorder : CK(188) : AC(26)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin treatment improves motor behavior in α-synuclein transgenic mice.

Pubmed Data : PLoS One. 2015 ;10(6):e0128510. Epub 2015 Jun 2. PMID: 26035833

Article Published Date : Dec 31, 2014

Authors : Kateri J Spinelli, Valerie R Osterberg, Charles K Meshul, Amala Soumyanath, Vivek K Unni

Study Type : Transgenic Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcumin was found to increase thioredoxin protein expression and enzyme activity and to protect neurons against cell injury.

Pubmed Data : Neural Regen Res. 2015 Mar ;10(3):481-9. PMID: 25878600

Article Published Date : Feb 28, 2015

Authors : Jing-Xian Wu, Lu-Yu Zhang, Yan-Lin Chen, Shan-Shan Yu, Yong Zhao, Jing Zhao

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Ischemia : CK(76) : AC(38), Stroke: Attenuation/Recovery : CK(347) : AC(75), Stroke: Ischemic : CK(218) : AC(31)

Pharmacological Actions : Enzyme Activators : CK(4) : AC(2), Neuroprotective Agents : CK(2360) : AC(1099), Nrf2 activation : CK(177) : AC(86)

Curcumin works synergistically with the drug candesartan to reduce ischemic brain damage in rats.

Pubmed Data : J Stroke Cerebrovasc Dis. 2010 Aug 17. Epub 2010 Aug 17. PMID: 20719539

Article Published Date : Aug 17, 2010

Authors : Azza S Awad

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Brain Damage : CK(93) : AC(44), Cerebral Ischemia : CK(229) : AC(77)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Drug Synergy : CK(352) : AC(157)

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease.

Pubmed Data : Neuroscience. 2010 Sep 1;169(3):1296-306. Epub 2010 Jun 9. PMID: 20538041

Article Published Date : Sep 01, 2010

Authors : T Ahmed, S A Enam, A H Gilani

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Memory Disorders : CK(344) : AC(104)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices.

Pubmed Data : Synapse. 2010 Oct 20. Epub 2010 Oct 20. PMID: 20963814

Article Published Date : Oct 20, 2010

Authors : Touqeer Ahmed, Anwarul-Hassan Gilani, Narges Hosseinmardi, Saeed Semnanian, Syed Ather Enam, Yaghoub Fathollahi

Study Type : In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Injury: Hippocampal Damage : CK(39) : AC(18)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male rats.

Pubmed Data : J Agric Food Chem. 2007 Feb 7;55(3):1039-44. PMID: 17263510

Article Published Date : Feb 07, 2007

Authors : Amichand Dairam, Janice L Limson, Gareth M Watkins, Edith Antunes, Santy Daya

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Curcuminoids : CK(4681) : AC(2355), Demethoxycurcumin : CK(36) : AC(21)

Diseases : Lead Poisoning : CK(205) : AC(60), Memory Disorders : CK(344) : AC(104)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Curry consumption improves cognitive function in the elderly.

Pubmed Data : Am J Epidemiol. 2006 Nov 1;164(9):898-906. Epub 2006 Jul 26. PMID: 16870699

Article Published Date : Nov 01, 2006

Authors : Tze-Pin Ng, Peak-Chiang Chiam, Theresa Lee, Hong-Choon Chua, Leslie Lim, Ee-Heok Kua

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Curry Spice : CK(13) : AC(3)

Diseases : Dementia : CK(571) : AC(79)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Demethoxycurcumin ameliorates rotenone-induced toxicity.

Pubmed Data : Front Biosci (Elite Ed). 2019 01 1 ;11:1-11. Epub 2019 Jan 1. PMID: 30468633

Article Published Date : Dec 31, 2018

Authors : Muthu Ramkumar, Srinivasagam Rajasankar, William Moses Swaminathan Johnson, Kaliyaperumal Prabu, Veerappan Venkatesh Gobi

Study Type : Animal Study

Additional Links

Substances : Demethoxycurcumin : CK(36) : AC(21)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Rotenone : CK(5) : AC(1)

Demethoxycurcumin may serve as a potent therapeutic agent particularly for the treatment of neurodegenerative diseases.

Pubmed Data : BMC Complement Altern Med. 2017 Apr 18 ;17(1):217. Epub 2017 Apr 18. PMID: 28420370

Article Published Date : Apr 17, 2017

Authors : Muthu Ramkumar, Srinivasagam Rajasankar, Veerappan Venkatesh Gobi, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ameer Kalandar, Ranganathan Chidambaram

Study Type : In Vitro Study

Additional Links

Substances : Demethoxycurcumin : CK(36) : AC(21)

Diseases : Parkinson's Disease : CK(986) : AC(324), Pesticide Toxicity : CK(192) : AC(61)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Rotenone : CK(5) : AC(1)

Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases.

Pubmed Data : Curr Drug Targets. 2018 Mar 26. Epub 2018 Mar 26. PMID: 29577854

Article Published Date : Mar 25, 2018

Authors : Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh, Mohamad Fairuz Yahaya

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Flavonoids : CK(1215) : AC(379), Ginsenosides : CK(197) : AC(84), Lycopene : CK(494) : AC(108)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Ischemia : CK(136) : AC(52), Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Long-term consumption of aromatic compounds from spices could be effective in the prevention of Alzheimer's disease.

Pubmed Data : Nat Prod Commun. 2016 Apr ;11(4):507-10. PMID: 27396206

Article Published Date : Mar 31, 2016

Authors : Shinichi Matsumura, Kazuya Murata, Yuri Yoshioka, Hideaki Matsuda

Study Type : In Vitro Study

Additional Links

Substances : Cardamom : CK(42) : AC(11), Cinnamon : CK(245) : AC(89), Ginger : CK(775) : AC(207), Long Pepper : CK(15) : AC(9), Turmeric : CK(5583) : AC(2569)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), β-secretase Inhibitor : CK(1) : AC(1)

Natural phenolic compounds have anti-amyloidogenic effects on Aβ in addition to well-known anti-oxidative and anti-inflammatory effects.

Pubmed Data : Adv Exp Med Biol. 2015 ;863:79-94. PMID: 26092627

Article Published Date : Dec 31, 2014

Authors : Masahito Yamada, Kenjiro Ono, Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Ferulic acid : CK(33) : AC(21), Myricetin : CK(41) : AC(23), Nordihydroguaiaretic acid (NDGA) : CK(6) : AC(4), Rosmarinic acid : CK(47) : AC(26)

Diseases : Amyloidosis : CK(23) : AC(8)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Neuroprotective effect of curcumin against cerebral ischemia-reperfusion.

Pubmed Data : J Mol Neurosci. 2018 Jan ;64(1):129-139. Epub 2017 Dec 15. PMID: 29243061

Article Published Date : Dec 31, 2017

Authors : Lifa Huang, Chengwei Chen, Xin Zhang, Xu Li, Zupeng Chen, Chao Yang, Xiaolong Liang, Guochong Zhu, Zhen Xu

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Ischemia : CK(76) : AC(38)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Phosphatidylserine and curcumin can ameliorate scopolamine-induced amnesia and may be useful treatments for Alzheimer's disease.

Pubmed Data : Behav Pharmacol. 2016 Jul 6. Epub 2016 Jul 6. PMID: 27388114

Article Published Date : Jul 05, 2016

Authors : Teresa A Barber, Edward M Edris, Paul J Levinsky, Justin M Williams, Ari R Brouwer, Shawn A Gessay

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Phosphatidylserine : CK(134) : AC(20)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Amnesia: Drug-Induced : CK(15) : AC(9)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.

Pubmed Data : Inflammation. 2016 Jun ;39(3):1025-38. PMID: 26970969

Article Published Date : May 31, 2016

Authors : Ashok Jangra, Mohit Kwatra, Tavleen Singh, Rajat Pant, Pawan Kushwah, Yogita Sharma, Babita Saroha, Ashok Kumar Datusalia, Babul Kumar Bezbaruah

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)

Diseases : Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Piperine enhances the protective effect of curcumin against 3-Nitropropionic acid induced neurotoxicity.

Pubmed Data : Neurochem Res. 2015 Aug ;40(8):1758-66. Epub 2015 Jul 10. PMID: 26160706

Article Published Date : Jul 31, 2015

Authors : Shamsher Singh, Sumit Jamwal, Puneet Kumar

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Piperine : CK(169) : AC(84)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Review: Curcumin has a number of potential therapeutic properties for Alzheimer diseaes.

Pubmed Data : Mutat Res. 2009 Oct 13. Epub 2009 Oct 13. PMID: 19966973

Article Published Date : Oct 13, 2009

Authors : Shrikant Mishra, Kalpana Palanivelu

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Supplementation of diets with omega-3 and curcumin has been shown to have positive effects on cognitive function in healthy ageing humans and in disease states.

Pubmed Data : Nutrients. 2015 ;7(8):6719-38. Epub 2015 Aug 12. PMID: 26274972

Article Published Date : Dec 31, 2014

Authors : Jessica E Beilharz, Jayanthi Maniam, Margaret J Morris

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Omega-3 Fatty Acids : CK(3849) : AC(463)

Diseases : Cognitive Decline/Dysfunction : CK(1163) : AC(215)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer's disease.

Pubmed Data : Curr Neuropharmacol. 2018 Jan 16. Epub 2018 Jan 16. PMID: 29338678

Article Published Date : Jan 15, 2018

Authors : Ianara Mendonca da Costa, Marco Aurelio de Moura Freire, Jose Rodolfo Lopes de Paiva Cavalcanti, Dayane Pessoa de Araujo, Bianca Norrara, Isleania Maria Marques Moreira Rosa, Eduardo Pereira de Azevedo, Amalia Cinthia Meneses do Rego, Irami Araujo Filho, Fausto Pierdona Guzen

Study Type : Review

Additional Links

Substances : Turmeric : CK(5583) : AC(2569)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Neuroprotective Agents : CK(2360) : AC(1099), Neuroprotective Agents : CK(2360) : AC(1099), Neuroprotective Agents : CK(2360) : AC(1099)

Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke.

Pubmed Data : Neurochem Int. 2019 Jan ;122:120-138. Epub 2018 Nov 22. PMID: 30472160

Article Published Date : Dec 31, 2018

Authors : Nandan K Mondal, Jyotirmaya Behera, Kimberly E Kelly, Akash K George, Pranav K Tyagi, Neetu Tyagi

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Stroke: Ischemic : CK(218) : AC(31)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : Epigenetic Modification : CK(220) : AC(90)

Tetrahydrocurcumin provides neuroprotection in experimental traumatic brain injury.

Pubmed Data : Neuroimmunomodulation. 2017 ;24(6):348-355. Epub 2018 Apr 18. PMID: 29669346

Article Published Date : Dec 31, 2016

Authors : Guan Wei, Bingji Chen, Qingjiang Lin, Yasong Li, Liangqin Luo, Hefan He, Huangde Fu

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Traumatic Brain Injury : CK(88) : AC(25)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099), Nrf2 activation : CK(177) : AC(86)

The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues

Pubmed Data : Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110

Article Published Date : Jan 01, 2012

Authors : Russell L Blaylock, Joseph Maroon

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300), Green Tea : CK(2251) : AC(658), Luteolin : CK(137) : AC(98), Quercetin : CK(716) : AC(335)

Diseases : Brain: Microglial Activation : CK(82) : AC(53), Excitotoxicity : CK(58) : AC(35)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Additional Keywords : CENTRAL NERVOUS SYSTEM : CK(1) : AC(1)

The polyphenols, epigallocatechin gallate, and catechin hydrate significantly attenuate quinolinic acid-induced excitotoxicity in human neurons.

Pubmed Data : FEBS J. 2010 Jan;277(2):368-82. Epub 2009 Dec 10. PMID: 20015232

Article Published Date : Jan 01, 2010

Authors : Nady Braidy, Ross Grant, Seray Adams, Gilles J Guillemin

Study Type : In Vitro Study

Additional Links

Substances : Catechin : CK(522) : AC(170), Curcumin : CK(4417) : AC(2300)

Diseases : Excitotoxicity : CK(58) : AC(35)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

The results demonstrated a marked efficacy of curcumin in experimental model of Parkinson's disease.

Pubmed Data : BMC Complement Altern Med. 2017 Aug 17 ;17(1):412. Epub 2017 Aug 17. PMID: 28818104

Article Published Date : Aug 16, 2017

Authors : Xin-Shi Wang, Zeng-Rui Zhang, Man-Man Zhang, Miao-Xuan Sun, Wen-Wen Wang, Cheng-Long Xie

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Parkinson's Disease : CK(986) : AC(324)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

These findings confirm the neuroprotective effects of the CL extract and indicate that the cause of astrocyte loss might be partially reduced by a non-oxidative mechanism.

Pubmed Data : Acta Histochem. 2014 Oct ;116(8):1443-53. Epub 2014 Oct 16. PMID: 25440530

Article Published Date : Sep 30, 2014

Authors : Acharaporn Issuriya, Ekkasit Kumarnsit, Chatchai Wattanapiromsakul, Uraporn Vongvatcharanon

Study Type : Animal Study

Additional Links

Substances : Turmeric : CK(5583) : AC(2569)

Diseases : Steroid-Induced Toxicity : CK(24) : AC(9)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Problem Substances : Dexamethasone : CK(71) : AC(16)

These findings suggest that the L-arginine-nitric oxide pathway may be involved in the anti-epileptic properties of Curcumin.

Pubmed Data : Biomed Mater Eng. 2015 Aug 17 ;26(s1):S841-S850. PMID: 26406082

Article Published Date : Aug 16, 2015

Authors : Wenting Zhu, Jing Su, Jing Liu, Changbin Jiang

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Epilepsy : CK(255) : AC(66)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

These observations indicate that aromatic-turmerone is effective in preventing brain damage caused by neuroinflammationThese observations indicate that aromatic-turmerone is effective in preventing brain damage caused by neuroinflammation

Pubmed Data : Mol Nutr Food Res. 2018 01 ;62(2). Epub 2018 Jan 8. PMID: 28849618

Article Published Date : Dec 31, 2017

Authors : Min Chen, Yuan-Yuan Chang, Shun Huang, Li-Hang Xiao, Wei Zhou, Lan-Yue Zhang, Chun Li, Ren-Ping Zhou, Jian Tang, Li Lin, Zhi-Yun Du, Kun Zhang

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Turmerones : CK(16) : AC(13)

Diseases : Brain Inflammation : CK(274) : AC(145), Lipopolysaccharide-Induced Toxicity : CK(380) : AC(218)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

This review examines the efficacy of curcumin to treat Alzheimer's disease.

Pubmed Data : J Alzheimers Dis. 2017 May 17. Epub 2017 May 17. PMID: 28527218

Article Published Date : May 16, 2017

Authors : Mengxi Tang, Changiz Taghibiglou

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(37) : AC(19), Anticholesteremic Agents : CK(1459) : AC(264), Neuroprotective Agents : CK(2360) : AC(1099)

This review summarizes recent findings on the protective roles of redox nanoparticles both in vitro and in vivo.

Pubmed Data : Curr Drug Metab. 2016 ;17(2):142-9. PMID: 26806041

Article Published Date : Dec 31, 2015

Authors : Magisetty Obulesu, Magisetty Jhansilakshmi

Study Type : Review

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Alzheimer's Disease : CK(1292) : AC(382)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

This review will provide an overview of the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of a variety of nutraceuticals.

Pubmed Data : Neurochem Int. 2015 Oct 31. Epub 2015 Oct 31. PMID: 26529297

Article Published Date : Oct 30, 2015

Authors : Madhuri Venigalla, Erika Gyengesi, Matthew J Sharman, Gerald Münch

Study Type : Review

Additional Links

Substances : Alpha-Lipoic Acid : CK(476) : AC(116), Apigenin : CK(199) : AC(117), Curcumin : CK(4417) : AC(2300), DHA (Docosahexaenoic Acid) : CK(925) : AC(155), EGCG (Epigallocatechin gallate) : CK(721) : AC(380), Resveratrol : CK(1511) : AC(865)

Diseases : Alzheimer's Disease : CK(1292) : AC(382), Brain Inflammation : CK(274) : AC(145), Neurodegenerative Diseases : CK(3582) : AC(932)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

This study highlights the possibility of using curcumin as an adjuvant against toxicological conditions involving cadmium exposure.

Pubmed Data : Environ Toxicol. 2015 Nov 23. Epub 2015 Nov 23. PMID: 26592365

Article Published Date : Nov 22, 2015

Authors : Pauline da Costa, Jamile F Gonçalves, Jucimara Baldissarelli, Thaís R Mann, Fátima H Abdalla, Amanda M Fiorenza, Michelle M da Rosa, Fabiano B Carvalho, Jessié M Gutierres, Cinthia M de Andrade, Maribel A Rubin, Maria Rosa C Schetinger, Vera M Morsch

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Cadmium Poisoning : CK(131) : AC(62)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

This study indicates that tetrahydrocurcumin protects neurons from traumatic brain injury-induced apoptotic neuronal death.

Pubmed Data : J Surg Res. 2016 Nov ;206(1):67-76. Epub 2016 Jul 15. PMID: 27916377

Article Published Date : Oct 31, 2016

Authors : Yongyue Gao, Jie Li, Lingyun Wu, Chenhui Zhou, Qiang Wang, Xiang Li, Mengliang Zhou, Handong Wang

Study Type : Animal Study

Additional Links

Substances : Tetrahydrocurcumin : CK(80) : AC(39)

Diseases : Traumatic Brain Injury : CK(88) : AC(25)

Pharmacological Actions : Anti-Apoptotic : CK(384) : AC(212), Neuroprotective Agents : CK(2360) : AC(1099)

Treatment with curcumin during the latent period following status epilepticus is beneficial in modifying epileptogenesis.

Pubmed Data : Neuroscience. 2015 Sep 28. Epub 2015 Sep 28. PMID: 26415768

Article Published Date : Sep 27, 2015

Authors : Z Jiang, M Guo, C Shi, H Wang, L Yao, L Liu, C Xie, S Pu, G LaChaud, J Shen, M Zhu, L Mu, H Ge, Y Long, X Wang, Y Song, J Sun, X Hou, A Zarringhalam, S-H Park, C Shi, H Shen, Z Lin

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(4417) : AC(2300)

Diseases : Epilepsy : CK(255) : AC(66), Epileptic Seizures : CK(192) : AC(10)

Pharmacological Actions : Neuroprotective Agents : CK(2360) : AC(1099)

Focused Research Topics Turmeric & Neuroprotective Agents

Associated Topics included in this Focused Research