Focused Research Topics Demyelinating Diseases & Vaccination: All

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Associated Topics included in this Focused Research

Amyotrophic Lateral Sclerosis Charcot-Marie-Tooth Disease Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Demyelinating Diseases Guillain-Barre Syndrome Multiple Sclerosis

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View the Evidence
24 Research Articles in Total

Hepatitis B vaccination may contribute to autoimmune demyelinating complications due to immunological cross-reactivity between Hepatitis B virus surface antigen and myelin basic protein.

Pubmed Data : Clin Dev Immunol. 2005 Sep;12(3):217-24. PMID: 16295528
Article Published Date : Sep 01, 2005
Authors : Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani
Study Type : Human Study
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Demyelinating Diseases : CK(1671) : AC(332), Vaccine-induced Toxicity : CK(1325) : AC(194)
Additional Keywords : Hepatitis B Vaccine : CK(30) : AC(2), Molecular Mimicry : CK(67) : AC(15)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Hepatitis B : CK(429) : AC(54)

Swine and influenza vaccines induce anti-ganglioside antibodies associated with autoimmune neuropathies such as Guillain-Barre syndrome.

Pubmed Data : J Infect Dis. 2008 Jul 15;198(2):226-33. PMID: 18522505
Article Published Date : Jul 15, 2008
Authors : Irving Nachamkin, Sean V Shadomy, Anthony P Moran, Nancy Cox, Collette Fitzgerald, Huong Ung, Adrian T Corcoran, John K Iskander, Lawrence B Schonberger, Robert T Chen
Study Type : Human Study
Additional Links
Diseases : Acute Autoimmune Neuropathy : CK(20) : AC(2), Autoimmune Diseases : CK(6629) : AC(1128), Guillain-Barre Syndrome : CK(110) : AC(18), Influenza : CK(789) : AC(123), Swine Flu Associated Virus : CK(182) : AC(40), Vaccine-induced Toxicity : CK(1325) : AC(194)
Additional Keywords : Influenza Vaccine : CK(10) : AC(1), Swine Flu Vaccine : CK(10) : AC(1)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431)

Swine flu vaccine adjuvants may cause harm in patients with autoimmune diseases such as multiple sclerosis.

Pubmed Data : Med Hypotheses. 2010 Feb 18. Epub 2010 Feb 18. PMID: 20171793
Article Published Date : Feb 18, 2010
Authors : Serefnur Oztürk
Study Type : Commentary
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Multiple Sclerosis : CK(964) : AC(184)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Influenza : CK(435) : AC(50)

Vaccination may be contributing to autoimmune disease.

Pubmed Data : J Autoimmun. 2000 Feb;14(1):1-10. PMID: 10648110
Article Published Date : Feb 01, 2000
Authors : Y Shoenfeld, A Aron-Maor
Study Type : Commentary
Additional Links
Diseases : Autism Spectrum Disorders : CK(1493) : AC(159), Autoimmune Diseases : CK(6629) : AC(1128), Multiple Sclerosis : CK(964) : AC(184), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431)

Viruses (wild-type or recombinant vaccine-type) can silently prime for and trigger central nervous system autoimmune disease.

Pubmed Data : J Neurovirol. 2001 Jun;7(3):220-7. PMID: 11517396
Article Published Date : Jun 01, 2001
Authors : D J Theil, I Tsunoda, F Rodriguez, J L Whitton, R S Fujinami
Study Type : Commentary
Additional Links
Diseases : Autoimmune Diseases : CK(6629) : AC(1128), Multiple Sclerosis : CK(964) : AC(184)
Additional Keywords : Diseases that are Linked : CK(2335) : AC(304)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Varicella (Chicken pox) : CK(177) : AC(22)

Vaccination of any type was associated with an increased risk of CNS ADS onset within the first 30 days after vaccination only in younger (<50 years) individuals (OR, 2.32; 95% CI, 1.18-4.57).

Pubmed Data : JAMA Neurol. 2014 Dec ;71(12):1506-13. PMID: 25329096
Article Published Date : Nov 30, 2014
Authors : Annette Langer-Gould, Lei Qian, Sara Y Tartof, Sonu M Brara, Steve J Jacobsen, Brandon E Beaber, Lina S Sy, Chun Chao, Rulin Hechter, Hung Fu Tseng
Study Type : Human Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Multiple Sclerosis : CK(964) : AC(184), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431)
Adverse Pharmacological Actions : Immunotoxic : CK(294) : AC(52), Neurotoxic : CK(1251) : AC(224)

Acute disseminated encephalomyelitis (ADEM) may be caused by vaccination.

Pubmed Data : J Clin Neurosci. 2008 Dec;15(12):1315-22. Epub 2008 Oct 30. PMID: 18976924
Article Published Date : Dec 01, 2008
Authors : William Huynh, Dennis J Cordato, Elias Kehdi, Lynette T Masters, Chris Dedousis
Study Type : Commentary
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Encephalomyelitis : CK(24) : AC(15), Neuromyelitis Optica : CK(22) : AC(5), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431)

Children vaccinated with MMR before age 10 are at significantly higher risk of multiple sclerosis.

Pubmed Data : Eur J Epidemiol. 2009;24(9):541-52. Epub 2009 Jul 26. PMID: 19633994
Article Published Date : Jan 01, 2009
Authors : Cecilia Ahlgren, Kjell Torén, Anders Odén, Oluf Andersen
Study Type : Human Study
Additional Links
Diseases : Multiple Sclerosis : CK(964) : AC(184), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Mumps-Measles-Rubella (MMR) : CK(276) : AC(37)

Guillain-Barré syndrome following H1N1 immunization in a pediatric patient has been reported.

Pubmed Data : Ann Pharmacother. 2010 Jul-Aug;44(7-8):1330-3. Epub 2010 May 18. PMID: 20484170
Article Published Date : Jul 01, 2010
Authors : Marie-Eve Tremblay, Aurélie Closon, Guy D'Anjou, Jean-François Bussières
Study Type : Human: Case Report
Additional Links
Diseases : Childhood Infections : CK(275) : AC(29), Guillain-Barre Syndrome : CK(110) : AC(18), Influenza : CK(789) : AC(123), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Influenza : CK(435) : AC(50)

Guillain-Barré syndrome following hepatitis B vaccination has been reported.

Pubmed Data : Clin Exp Rheumatol. 2004 Nov-Dec;22(6):767-70. PMID: 15638054
Article Published Date : Nov 01, 2004
Authors : M Khamaisi, Y Shoenfeld, H Orbach
Study Type : Human: Case Report
Additional Links
Diseases : Guillain-Barre Syndrome : CK(110) : AC(18)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Hepatitis B : CK(429) : AC(54)

Hepatitis B vaccination coverage has fallen to beneath 30% in France due to concerns over safety.

Pubmed Data : J Clin Virol. 2009 Nov;46(3):202-5. Epub 2009 Aug 28. PMID: 19716764
Article Published Date : Nov 01, 2009
Authors : Marta A Balinska
Study Type : Human Study
Additional Links
Diseases : Multiple Sclerosis : CK(964) : AC(184)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Hepatitis B : CK(429) : AC(54)

Hepatitis B vaccination is associated with an increased risk of CNS inflammatory demyelination after 3 years of age.

Pubmed Data : Reprod Toxicol. 2002 May-Jun;16(3):237-43. PMID: 18843097
Article Published Date : May 01, 2002
Authors : Yann Mikaeloff, Guillaume Caridade, Samy Suissa, Marc Tardieu
Study Type : Human Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Inflammation : CK(3240) : AC(882), Multiple Sclerosis : CK(964) : AC(184)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Hepatitis B : CK(429) : AC(54)

Hepatitis B vaccine is associated with an increased risk of multiple sclerosis.

Pubmed Data : Neurology. 2004 Sep 14;63(5):838-42. PMID: 15365133
Article Published Date : Sep 14, 2004
Authors : Miguel A Hernán, Susan S Jick, Michael J Olek, Hershel Jick
Study Type : Human Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), Hepatitis B : CK(241) : AC(46), Multiple Sclerosis : CK(964) : AC(184), Vaccine-induced Toxicity : CK(1325) : AC(194)
Additional Keywords : Hepatitis B Vaccine : CK(30) : AC(2)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431)

HPV vaccination has been linked to demyelination.

Pubmed Data : J Child Neurol. 2010 Mar;25(3):321-7. PMID: 20189933
Article Published Date : Mar 01, 2010
Authors : Francis J DiMario, Mirna Hajjar, Thomas Ciesielski
Study Type : Human Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: HPV (Gardisil) : CK(150) : AC(22)

Human Papilloma Virus (HPV) vaccine is associated with demyelinating events.

Pubmed Data : Mult Scler. 2009 Jan;15(1):116-9. Epub 2008 Sep 19. PMID: 18805844
Article Published Date : Jan 01, 2009
Authors : I Sutton, R Lahoria, Il Tan, P Clouston, Mh Barnett
Study Type : Human Study
Additional Links
Diseases : Demyelinating Diseases : CK(1671) : AC(332), HPV : CK(31) : AC(4), Human Papillomavirus (HPV) : CK(212) : AC(35), Vaccine-induced Toxicity : CK(1325) : AC(194)
Additional Keywords : HPV Vaccine : CK(10) : AC(1)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: HPV (Gardisil) : CK(150) : AC(22)

In the US the highest number of cases of Guillain-Barre sundrome are associated with influenza and hepatitis B vaccines.

Pubmed Data : J Clin Neuromuscul Dis. 2009 Sep;11(1):1-6. PMID: 19730016
Article Published Date : Sep 01, 2009
Authors : Nizar Souayah, Abu Nasar, M Fareed K Suri, Adnan I Qureshi
Study Type : Human Study
Additional Links
Diseases : Guillain-Barre Syndrome : CK(110) : AC(18), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: Hepatitis B : CK(429) : AC(54), Vaccination: Influenza : CK(435) : AC(50)

There were 69 reports of Guillain-Barré Syndrome (GBS) after Gardasil vaccination that occurred in the United States between 2006 and 2009.

Pubmed Data : Vaccine. 2010 Sep 23. Epub 2010 Sep 23. PMID: 20869467
Article Published Date : Sep 23, 2010
Authors : Nizar Souayah, P A Michas-Martin, Abu Nasar, Nataliya Krivitskaya, Hussam A Yacoub, Hafiz Khan, Adnan I Qureshi
Study Type : Human Study
Additional Links
Diseases : Guillain-Barre Syndrome : CK(110) : AC(18), Vaccine-induced Toxicity : CK(1325) : AC(194)
Anti Therapeutic Actions : Vaccination: All : CK(5117) : AC(431), Vaccination: HPV (Gardisil) : CK(150) : AC(22)

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