Topic: Statin Drugs

Authors : Alberto Serrano-Pozo, Gloria L Vega, Dieter Lütjohann, Joseph J Locascio, Marsha K Tennis, Amy Deng, Alireza Atri, Bradley T Hyman, Michael C Irizarry, John H Growdon

Study Type : Human Study

Additional Links

Diseases : Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Severe statin-induced rhabdomyolysis mimicking Guillain-Barré syndrome in four patients with diabetes mellitus treated with fusidic acid has been reported. - GMI Summary

Pubmed Data : Diabet Med. 2010 Jun ;27(6):696-700. PMID: 20546290

Article Published Date : Jun 01, 2010

Authors : T A Collidge, S Razvi, C Nolan, M Whittle, C Stirling, A J C Russell, A C Mann, C J Deighan

Study Type : Human: Case Report

Additional Links

Diseases : Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Guillain-Barre Syndrome : CK(84) : AC(14), Rhabdomyolysis : CK(165) : AC(38), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

Problem Substances : Antibiotics : CK(180) : AC(19), Fusidic acid : CK(6) : AC(2), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin delays nerve regeneration. - GMI Summary

Pubmed Data : Folia Neuropathol. 2010;48(1):49-56. PMID: 20383811

Article Published Date : Jan 01, 2010

Authors : Ergun Daglioglu, Mustafa Berker, Mehmet Demirci, Mürvet Tuncel, Erdem Karabulut, Aykut Tuncel

Study Type : Animal Study

Additional Links

Diseases : Neuropathies : CK(450) : AC(67)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin-associated adverse cognitive effects have been reported with 90% resolving after drug discontinuation. - GMI Summary

Pubmed Data : Pharmacotherapy. 2009 Jul ;29(7):800-11. PMID: 19558254

Article Published Date : Jul 01, 2009

Authors : Marcella A Evans, Beatrice A Golomb

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(826) : AC(160), Cognitive Decline/Dysfunction : CK(522) : AC(87), Dementia : CK(225) : AC(31), Memory Disorders : CK(221) : AC(67), Memory Loss : CK(113) : AC(32)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs inhibit central nervous system remyelination. - GMI Summary

Pubmed Data : Am J Pathol. 2009 Apr 6. PMID: 19349355

Article Published Date : Apr 06, 2009

Authors : Veronique E Miron, Simone P Zehntner, Tanja Kuhlmann, Samuel K Ludwin, Trevor Owens, Timothy E Kennedy, Barry J Bedell, Jack P Antel

Study Type : Animal Study

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Statin-Induced Pathologies : CK(1570) : AC(315)

Additional Keywords : Multiple Sclerosis Contraindications : CK(2) : AC(1)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin treatment induces morphology alterations and cell death in mouse cochlear neuronal cells. - GMI Summary

Pubmed Data : Acta Otolaryngol. 2009 Feb ;129(2):166-74. PMID: 18607908

Article Published Date : Feb 01, 2009

Authors : Do-Sim Park, Hong-Seob So, Jeong-Han Lee, Hyun-Young Park, Young-Jin Lee, Ji-Hyun Cho, Kui-Hyun Yoon, Channy Park, Kijung Yun, Raekil Park

Study Type : In Vitro Study

Additional Links

Diseases : Cochlear Neuronal Damage : CK(1) : AC(1), DNA damage : CK(711) : AC(293), Hearing Disorders : CK(1) : AC(1), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs interfere with neurological healing by inhibiting myelin formation. - GMI Summary

Pubmed Data : J Neurosci. 2008 Dec 10 ;28(50):13609-14. PMID: 19074034

Article Published Date : Dec 10, 2008

Authors : Steve Klopfleisch, Doron Merkler, Matthias Schmitz, Sabine Klöppner, Mariann Schedensack, Gunnar Jeserich, Hans H Althaus, Wolfgang Brück

Study Type : Animal Study

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Multiple Sclerosis : CK(716) : AC(133)

Additional Keywords : Remyelination : CK(15) : AC(10)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Long-term treatment with statins might cause a clinically silent but still electrophysiologically definite damage to peripheral nerves. - GMI Summary

Pubmed Data : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec ;151(2):307-10. PMID: 18345269

Article Published Date : Dec 01, 2007

Authors : Pavel Otruba, Petr Kanovsky, Petr Hlustik

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxicity in the animal model. - GMI Summary

Pubmed Data : Glia. 2007 Jan 15 ;55(2):130-43. PMID: 17078030

Article Published Date : Jan 15, 2007

Authors : Veronique E Miron, Sathyanath Rajasekharan, Andrew A Jarjour, Scott S Zamvil, Timothy E Kennedy, Jack P Antel

Study Type : Animal Study

Additional Links

Diseases : Multiple Sclerosis : CK(716) : AC(133), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statins have been associated with cell death in primary neuronal culture. - GMI Summary

Pubmed Data : Glia. 2007 Jan 1 ;55(1):1-12. PMID: 16998865

Article Published Date : Jan 01, 2007

Authors : Pia März, Uwe Otten, André R Miserez

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Psychiatric adverse reactions associated with cholesterol-lowering drugs have been reported. - GMI Summary

Pubmed Data : Drug Saf. 2007 ;30(3):195-201. PMID: 17343428

Article Published Date : Jan 01, 2007

Authors : Michael Tatley, Ruth Savage

Study Type : Human Study

Additional Links

Diseases : Aggression : CK(143) : AC(15), Depression : CK(674) : AC(88), Memory Disorders: Drug-Induced : CK(77) : AC(12), Psychiatric Disorders : CK(71) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statins-induced MELAS syndrome has been reported. - GMI Summary

Pubmed Data : Eur Neurol. 2007 ;57(4):232-5. Epub 2007 Mar 26. PMID: 17389800

Article Published Date : Jan 01, 2007

Authors : Joseph E Thomas, Nora Lee, Paul D Thompson

Study Type : Human: Case Report

Additional Links

Diseases : Melas Syndrome : CK(23) : AC(3), Mitochondrial Diseases : CK(149) : AC(50)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin-induced decline in cognition has been reported. - GMI Summary

Pubmed Data : Ann Pharmacother. 2006 Oct ;40(10):1880-3. Epub 2006 Aug 29. PMID: 16940411

Article Published Date : Oct 01, 2006

Authors : Kalpana P Padala, Prasad R Padala, Jane F Potter

Study Type : Human: Case Report

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Memory Disorders : CK(221) : AC(67), Memory Loss : CK(113) : AC(32), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs have been linked to neurotoxicity. - GMI Summary

Pubmed Data : Neth J Med. 2006 Oct ;64(9):334-8. PMID: 17057271

Article Published Date : Oct 01, 2006

Authors : J J de Langen, E P van Puijenbroek

Study Type : Human Study

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Neurotoxicity : CK(37) : AC(15), Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Short-term memory loss associated with rosuvastatin has been reported. - GMI Summary

Pubmed Data : Pharmacotherapy. 2006 Aug ;26(8):1190-2. PMID: 16863497

Article Published Date : Aug 01, 2006

Authors : Laura Galatti, Giovanni Polimeni, Francesco Salvo, Marcello Romani, Aurelio Sessa, Edoardo Spina

Study Type : Human: Case Report

Additional Links

Diseases : Memory Disorders : CK(221) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Rosuvastatin : CK(68) : AC(16), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin neuropathy misdiagnosed as diabetic autoimmune polyneuropathy has been reported. - GMI Summary

Pubmed Data : Diabetes Care. 2005 Aug ;28(8):2082. PMID: 16043768

Article Published Date : Aug 01, 2005

Authors : Tom Brooks Vaughan, David S H Bell

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs have been identified to cause neuromyotoxicity. - GMI Summary

Pubmed Data : Drugs Today (Barc). 2005 Apr ;41(4):267-93. PMID: 16034491

Article Published Date : Apr 01, 2005

Authors : Steven K Baker, Mark A Tarnopolsky

Study Type : Review

Additional Links

Diseases : Neuromyotoxicity : CK(1) : AC(1)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79), Neurotoxic : CK(1076) : AC(179)

Statin drug use results in decrements in cognitive functioning. - GMI Summary

Pubmed Data : Am J Med. 2004 Dec 1 ;117(11):823-9. PMID: 15589485

Article Published Date : Dec 01, 2004

Authors : Matthew F Muldoon, Christopher M Ryan, Susan M Sereika, Janine D Flory, Stephen B Manuck

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lipid lowering drugs increase the risk of peripheral neuropathy. - GMI Summary

Pubmed Data : J Epidemiol Community Health. 2004 Dec ;58(12):1047-51. PMID: 15547071

Article Published Date : Dec 01, 2004

Authors : Giovanni Corrao, Antonella Zambon, Lorenza Bertù, Edoardo Botteri, Olivia Leoni, Paolo Contiero

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin-associated peripheral neuropathy has been recorded in the biomedical literature. - GMI Summary

Pubmed Data : Pharmacotherapy. 2004 Sep ;24(9):1194-203. PMID: 15460180

Article Published Date : Sep 01, 2004

Authors : Pang H Chong, Alexandra Boskovich, Natasa Stevkovic, Russell E Bartt

Study Type : Human Study

Additional Links

Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin-induced mononeuropathy has been reported. - GMI Summary

Pubmed Data : Arq Neuropsiquiatr. 2004 Jun ;62(2B):540-2. Epub 2004 Jul 20. PMID: 15273860

Article Published Date : Jun 01, 2004

Authors : Rosana H Scola, Ana P Trentin, Francisco M B Germiniani, Elcio J Piovesan, Lineu C Werneck

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

The statin drug atorvastatin induces adverse ultrastructural changes in muscle cells apparent through electron microscopy. - GMI Summary

Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045

Article Published Date : Jan 01, 2004

Authors : Miroslaw Lańcut, Barbara Jedrych, Marta Lis-Sochocka, Krystyna Czerny

Study Type : In Vitro Study

Additional Links

Diseases : Skeletal Muscle Changes: Ultrastructural Changes : CK(1) : AC(1), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79), Neurotoxic : CK(1076) : AC(179)

Cognitive impairment associated with statin drug use has been reported. - GMI Summary

Pubmed Data : Pharmacotherapy. 2003 Dec ;23(12):1663-7. PMID: 14695047

Article Published Date : Dec 01, 2003

Authors : Deborah S King, Amanda J Wilburn, Marion R Wofford, T Kristopher Harrell, Brent J Lindley, Daniel W Jones

Study Type : Review

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Dementia : CK(225) : AC(31), Memory Disorders : CK(221) : AC(67)

Problem Substances : Atorvastatin : CK(491) : AC(90), Cholesterol Lowering Drugs : CK(2146) : AC(349), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Atorvastatin-induced polyneuropathy has been reported. - GMI Summary

Pubmed Data : Ann Intern Med. 2003 Nov 4 ;139(9):792-3. PMID: 14597471

Article Published Date : Nov 04, 2003

Authors : Chad Silverberg

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Polyneuropathies : CK(38) : AC(7), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Atorvastatin : CK(491) : AC(90)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs show no cognitive or anti-amyloid benefits and may be associated with cognitive impairment. - GMI Summary

Pubmed Data : Pharmacotherapy. 2003 Jul ;23(7):871-80. PMID: 12885101

Article Published Date : Jul 01, 2003

Authors : Leslie R Wagstaff, Melinda W Mitton, Beth McLendon Arvik, P Murali Doraiswamy

Study Type : Human Study

Additional Links

Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Memory Disorders : CK(221) : AC(67)

Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin therapy has been associated with small fibre neuropathy. - GMI Summary

Pubmed Data : J Neurol Sci. 2003 Apr 15 ;208(1-2):105-8. PMID: 12639733

Article Published Date : Apr 15, 2003

Authors : Y L Lo, T H Leoh, L M Loh, C E Tan

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin use is associated with with neuropathy. - GMI Summary

Pubmed Data : Ann Pharmacother. 2003 Feb ;37(2):274-8. PMID: 12549960

Article Published Date : Feb 01, 2003

Authors : James M Backes, Patricia A Howard

Study Type : Human Study

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Long-term exposure to statin drugs may substantially increase the risk of polyneuropathy. - GMI Summary

Pubmed Data : Neurology. 2002 May 14 ;58(9):1333-7. PMID: 12011277

Article Published Date : May 14, 2002

Authors : D Gaist, U Jeppesen, M Andersen, L A García Rodríguez, J Hallas, S H Sindrup

Study Type : Human Study

Additional Links

Diseases : Polyneuropathies : CK(38) : AC(7), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin-induced memory loss has been reported. - GMI Summary

Pubmed Data : Pharmacotherapy. 2001 Jun ;21(6):767-9. PMID: 11401190

Article Published Date : Jun 01, 2001

Authors : A Orsi, O Sherman, Z Woldeselassie

Study Type : Human: Case Report

Additional Links

Diseases : Memory Disorders : CK(221) : AC(67)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Users of lipid-lowering drugs are at increased risk of peripheral neuropathy. - GMI Summary

Pubmed Data : Eur J Clin Pharmacol. 2001 Mar ;56(12):931-3. PMID: 11317483

Article Published Date : Mar 01, 2001

Authors : D Gaist, L A García Rodríguez, C Huerta, J Hallas, S H Sindrup

Study Type : Human Study

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin induces neuronal cell death through interacting with signal transduction pathways that cell control growth and survival. - GMI Summary

Pubmed Data : Mol Cell Neurosci. 2001 Feb ;17(2):329-41. PMID: 11178870

Article Published Date : Feb 01, 2001

Authors : N García-Román, A M Alvarez, M J Toro, A Montes, M J Lorenzo

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin may adversely affect neuropsychological tests of attention and psychomotor speed. - GMI Summary

Pubmed Data : Am J Med. 2000 May ;108(7):538-46. PMID: 10806282

Article Published Date : May 01, 2000

Authors : M F Muldoon, S D Barger, C M Ryan, J D Flory, J P Lehoczky, K A Matthews, S B Manuck

Study Type : Human Study

Additional Links

Diseases : Neuropsychological Dysfunction: Psychomotor Speed : CK(10) : AC(1), Psychological Well-Being : CK(13) : AC(2), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxic properties. - GMI Summary

Pubmed Data : Brain Res. 2000 Mar 17 ;859(1):169-72. PMID: 10720627

Article Published Date : Mar 17, 2000

Authors : T Kumano, T Mutoh, H Nakagawa, M Kuriyama

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin induces neuronal cell death. - GMI Summary

Pubmed Data : J Neurochem. 1999 Jun ;72(6):2278-85. PMID: 10349836

Article Published Date : Jun 01, 1999

Authors : M Michikawa, K Yanagisawa

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Long-term statin treatment may be associated with chronic peripheral neuropathy. - GMI Summary

Pubmed Data : Eur J Clin Pharmacol. 1999 Jan ;54(11):835-8. PMID: 10027656

Article Published Date : Jan 01, 1999

Authors : U Jeppesen, D Gaist, T Smith, S H Sindrup

Study Type : Human: Case Report

Additional Links

Diseases : Neuropathies : CK(450) : AC(67), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Peripheral neuropathy induced by lipid-lowering therapy has been reported. - GMI Summary

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841

Article Published Date : Jul 01, 1998

Authors : P E Ziajka, T Wehmeier

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies : CK(394) : AC(31)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Atorvastatin : CK(491) : AC(90), Cholesterol Lowering Drugs : CK(2146) : AC(349), Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs are associated with adverse mental effects. - GMI Summary

Pubmed Data : Tidsskr Nor Laegeforen. 1997 Sep 20 ;117(22):3210-3. PMID: 9411859

Article Published Date : Sep 20, 1997

Authors : I Buajordet, S Madsen, H Olsen

Study Type : Human Study

Additional Links

Diseases : Aggression : CK(143) : AC(15), Anxiety Disorders : CK(659) : AC(82), Depression : CK(674) : AC(88), Impotence : CK(13) : AC(2), Sleep Disorders : CK(168) : AC(17), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Simvastatin exhibits neurotoxicity in a neuronal cell model. - GMI Summary

Pubmed Data : Neurosci Lett. 1996 Dec 6 ;220(1):21-4. PMID: 8977139

Article Published Date : Dec 06, 1996

Authors : I Sato-Suzuki, S Murota

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775), Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin drugs exhibit myotoxic, neurotoxic, hepatotoxic and testicule damaging properties in the anima model. - GMI Summary

Pubmed Data : Toxicol Pathol. 1996 Jul-Aug;24(4):468-76. PMID: 8864188

Article Published Date : Jul 01, 1996

Authors : K M Walsh, M A Albassam, D E Clarke

Study Type : Animal Study

Additional Links

Diseases : Brain Damage : CK(89) : AC(41), Liver Damage: Drug-Induced : CK(46) : AC(10), Statin-Induced Pathologies : CK(1570) : AC(315), Testicular Diseases : CK(38) : AC(15)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Hepatotoxic : CK(283) : AC(80), Myotoxicity : CK(317) : AC(79), Neurotoxic : CK(1076) : AC(179)

Lovastatin exhibits neurotoxic properties. - GMI Summary

Pubmed Data : J Submicrosc Cytol Pathol. 1995 Oct ;27(4):435-44. PMID: 7585443

Article Published Date : Oct 01, 1995

Authors : Y V Bobryshev, O V Pavlov, Y V Balabanov, K Ashwell

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Peripheral neuropathy associated with simvastatin has been reported. - GMI Summary

Pubmed Data : J Neurol Neurosurg Psychiatry. 1995 May ;58(5):625-8. PMID: 7745415

Article Published Date : May 01, 1995

Authors : T Phan, J G McLeod, J D Pollard, O Peiris, A Rohan, J P Halpern

Study Type : Human: Case Report

Additional Links

Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Lovastatin : CK(265) : AC(67), Simvastatin : CK(713) : AC(143)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lovastatin exhibits toxicity in human fetal brain cells. - GMI Summary

Pubmed Data : Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9. PMID: 7708017

Article Published Date : Jan 01, 1995

Authors : O V Pavlov, Bobryshev YuV, Balabanov YuV, K Ashwell

Study Type : Human In Vitro

Additional Links

Diseases : Abortion: Spontaneous : CK(204) : AC(29), Birth Defects : CK(196) : AC(37), Neurotoxicity : CK(37) : AC(15), Prenatal Chemical Exposures : CK(322) : AC(86)

Pharmacological Actions : Antiproliferative : CK(1052) : AC(775)

Problem Substances : Lovastatin : CK(265) : AC(67)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179), Teratogenic : CK(304) : AC(59)

Lovastatin may adversely affect myelin formation and the remyelination process. - GMI Summary

Pubmed Data : J Neurochem. 1994 Apr ;62(4):1539-45. PMID: 8133281

Article Published Date : Apr 01, 1994

Authors : L Sepp-Lorenzino, P S Coleman, J N Larocca

Study Type : In Vitro Study

Additional Links

Diseases : Demyelinating Diseases : CK(1278) : AC(250), Statin-Induced Pathologies : CK(1570) : AC(315)

Additional Keywords : Remyelination : CK(15) : AC(10)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Some statin drugs are may cause neurological problems due to their ability to cross the blood-brain barrier. - GMI Summary

Pubmed Data : Pharm Res. 1994 Feb ;11(2):305-11. PMID: 8165193

Article Published Date : Feb 01, 1994

Authors : A Saheki, T Terasaki, I Tamai, A Tsuji

Study Type : Animal Study

Additional Links

Diseases : Blood-Brain-Barrier Disorders : CK(25) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Psychiatric disorders with use of simvastatin have been reported. - GMI Summary

Pubmed Data : Ned Tijdschr Geneeskd. 1993 Jun 26 ;137(26):1312-5. PMID: 8345888

Article Published Date : Jun 26, 1993

Authors : N Duits, F M Bos

Study Type : Human: Case Report

Additional Links

Diseases : Mood Disorders : CK(123) : AC(13), Psychiatric Disorders : CK(71) : AC(10), Psychological Well-Being : CK(13) : AC(2), Statin-Induced Pathologies : CK(1570) : AC(315)

Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)

Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statins have been associated with arrest of DNA synthesis and proliferation in glial cells. - GMI Summary

Pubmed Data : J Neurochem. 1986 Apr ;46(4):1283-91. PMID: 3633306

Article Published Date : Apr 01, 1986

Authors : T J Langan, J J Volpe

Study Type : In Vitro Study

Additional Links

Diseases : Neurotoxicity : CK(37) : AC(15), Statin-Induced Pathologies : CK(1570) : AC(315)

Problem Substances : Lovastatin : CK(265) : AC(67), Statin Drugs : CK(3969) : AC(465)

Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

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