Topic: Statin Drugs

Focused: Peripheral Neuropathies

Statin Drugs

Topic Study Types

  • Human Study : 6
  • Human: Case Report : 3
Additional Research

The prevalence of peripheral neuropathy is significantly higher among those who used statins. - GMI Summary

Pubmed Data : J Diabetes. 2012 Nov 1. Epub 2012 Nov 1. PMID: 23121724
Article Published Date : Oct 31, 2012
Authors : Edward F Tierney, David J Thurman, Gloria L Beckles, Betsy L Cadwell
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Long-term treatment with statins caused a clinically silent but still definite damage to peripheral nerves when the treatment lasts longer than 2 years. - GMI Summary

Pubmed Data : Neuro Endocrinol Lett. 2011 Sep 3 ;32(5):688-690. Epub 2011 Sep 3. PMID: 22167150
Article Published Date : Sep 03, 2011
Authors : Pavel Otruba, Petr Kanovsky, Petr Hlustik
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Long-term treatment with statins might cause a clinically silent but still electrophysiologically definite damage to peripheral nerves. - GMI Summary

Pubmed Data : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007 Dec ;151(2):307-10. PMID: 18345269
Article Published Date : Dec 01, 2007
Authors : Pavel Otruba, Petr Kanovsky, Petr Hlustik
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Multiple mononeuropathy caused by treatment with pravastatin has been reporeted. - GMI Summary

Pubmed Data : Rev Neurol. 2006 Dec 1-15;43(11):659-61. PMID: 17133326
Article Published Date : Dec 01, 2006
Authors : I Abellán-Miralles, R M Sánchez-Pérez, N Pérez-Carmona, C Díaz-Marín, J Mallada-Frechín
Study Type : Human: Case Report
Additional Links
Diseases : Multiple Mononeuropathy : CK(3) : AC(1), Peripheral Neuropathies : CK(394) : AC(31)
Problem Substances : Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)

Statin drugs have been linked to neurotoxicity. - GMI Summary

Pubmed Data : Neth J Med. 2006 Oct ;64(9):334-8. PMID: 17057271
Article Published Date : Oct 01, 2006
Authors : J J de Langen, E P van Puijenbroek
Study Type : Human Study
Additional Links
Diseases : Neuropathies : CK(450) : AC(67), Neurotoxicity : CK(37) : AC(15), Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Lipid lowering drugs increase the risk of peripheral neuropathy. - GMI Summary

Pubmed Data : J Epidemiol Community Health. 2004 Dec ;58(12):1047-51. PMID: 15547071
Article Published Date : Dec 01, 2004
Authors : Giovanni Corrao, Antonella Zambon, Lorenza Bertù, Edoardo Botteri, Olivia Leoni, Paolo Contiero
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Cholesterol Lowering Drugs : CK(2146) : AC(349), Fenofibrates : CK(133) : AC(19), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Statin-associated peripheral neuropathy has been recorded in the biomedical literature. - GMI Summary

Pubmed Data : Pharmacotherapy. 2004 Sep ;24(9):1194-203. PMID: 15460180
Article Published Date : Sep 01, 2004
Authors : Pang H Chong, Alexandra Boskovich, Natasa Stevkovic, Russell E Bartt
Study Type : Human Study
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Peripheral neuropathy induced by lipid-lowering therapy has been reported. - GMI Summary

Pubmed Data : South Med J. 1998 Jul ;91(7):667-8. PMID: 9671841
Article Published Date : Jul 01, 1998
Authors : P E Ziajka, T Wehmeier
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90), Cholesterol Lowering Drugs : CK(2146) : AC(349), Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Peripheral neuropathy associated with simvastatin has been reported. - GMI Summary

Pubmed Data : J Neurol Neurosurg Psychiatry. 1995 May ;58(5):625-8. PMID: 7745415
Article Published Date : May 01, 1995
Authors : T Phan, J G McLeod, J D Pollard, O Peiris, A Rohan, J P Halpern
Study Type : Human: Case Report
Additional Links
Diseases : Peripheral Neuropathies : CK(394) : AC(31), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Lovastatin : CK(265) : AC(67), Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)