Topic: Statin Drugs

Focused: Coenzyme Q10 Deficiency

Statin Drugs

Topic Study Types

  • Review : 1
  • Human Study : 6
  • Human: Case Report : 2
  • Animal Study : 2
Additional Research

Coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies. - GMI Summary

Pubmed Data : Ochsner J. 2010 ;10(1):16-21. PMID: 21603349
Article Published Date : Jan 01, 2010
Authors : Richard Deichmann, Carl Lavie, Samuel Andrews
Study Type : Review
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Myopathies : CK(252) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Atorvastatin reduces serum coenzyme Q10 levels (reduced and oxidized forms) in patients with high cholesterol. - GMI Summary

Pubmed Data : J Atheroscler Thromb. 2005;12(2):111-9. PMID: 15942122
Article Published Date : Jan 01, 2005
Authors : Hiroshi Mabuchi, Toshinori Higashikata, Masaaki Kawashiri, Shoji Katsuda, Mihoko Mizuno, Atsushi Nohara, Akihiro Inazu, Junji Koizumi, Junji Kobayashi
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), High Cholesterol : CK(1718) : AC(198), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)

Atorvastatin worsens left ventricular diastolic function, which is improved through coenzyme q10 supplementation. - GMI Summary

Pubmed Data : Am J Cardiol. 2004 Nov 15 ;94(10):1306-10. PMID: 15541254
Article Published Date : Nov 15, 2004
Authors : Marc A Silver, Peter H Langsjoen, Szabolcs Szabo, Harish Patil, Allan Zelinger
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10 : CK(667) : AC(104)
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Heart Failure : CK(711) : AC(97), Hypertension : CK(2783) : AC(271), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142), Antioxidants : CK(3653) : AC(1318)
Problem Substances : Atorvastatin : CK(491) : AC(90), Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79)

Statin precipitated lactic acidosis has been reported. - GMI Summary

Pubmed Data : J Clin Pathol. 2004 Sep ;57(9):989-90. PMID: 15333664
Article Published Date : Sep 01, 2004
Authors : R Neale, T M Reynolds, W Saweirs
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Lactic Acidosis : CK(6) : AC(2), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Anticholesteremic Agents : CK(669) : AC(142)
Problem Substances : Atorvastatin : CK(491) : AC(90)

Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. - GMI Summary

Pubmed Data : Arch Neurol. 2004 Jun;61(6):889-92. PMID: 15210526
Article Published Date : Jun 01, 2004
Authors : Tatjana Rundek, Ali Naini, Ralph Sacco, Kristen Coates, Salvatore DiMauro
Study Type : Human Study
Additional Links
Diseases : Cardiovascular Diseases : CK(5138) : AC(641), Coenzyme Q10 Deficiency : CK(83) : AC(13), Statin-Induced Pathologies : CK(1570) : AC(315), Stroke : CK(540) : AC(47)
Problem Substances : Atorvastatin : CK(491) : AC(90)

Statins lower plasma and lymphocyte ubiquinol/ubiquinone (coQ10) levels. - GMI Summary

Pubmed Data : Biofactors. 2003;18(1-4):113-24. PMID: 14695926
Article Published Date : Jan 01, 2003
Authors : Siro Passi, Andrea Stancato, Enrico Aleo, Anna Dmitrieva, Gian Paolo Littarru
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Atorvastatin : CK(491) : AC(90), Pravastatin : CK(239) : AC(40), Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

Simvastatin-induced lactic acidosis has been reported. - GMI Summary

Pubmed Data : Clin Pharmacol Ther. 2002 Oct ;72(4):461-4. PMID: 12386648
Article Published Date : Oct 01, 2002
Authors : Anil K Goli, Sujatha A Goli, Ryland P Byrd, Thomas M Roy
Study Type : Human: Case Report
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Lactic Acidosis : CK(6) : AC(2), Mitochondrial Dysfunction : CK(149) : AC(51)
Problem Substances : Simvastatin : CK(713) : AC(143), Statin Drugs : CK(3969) : AC(465)

There is a dose-related decrease of serum coenzyme Q10 during treatment with statin drugs. - GMI Summary

Pubmed Data : Mol Aspects Med. 1997 ;18 Suppl:S137-44. PMID: 9266515
Article Published Date : Jan 01, 1997
Authors : S A Mortensen, A Leth, E Agner, M Rohde
Study Type : Human Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)
Problem Substances : Lovastatin : CK(265) : AC(67), Pravastatin : CK(239) : AC(40), Statin Drugs : CK(3969) : AC(465)

Statin therapy can be associated with high blood lactate/ pyruvate ratio suggestive of mitochondrial dysfunction. - GMI Summary

Pubmed Data : Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID: 8877024
Article Published Date : Sep 01, 1996
Authors : G De Pinieux, P Chariot, M Ammi-Saïd, F Louarn, J L Lejonc, A Astier, B Jacotot, R Gherardi
Study Type : Human Study
Additional Links
Diseases : Blood Lactate/ Pyruvate Ratio: Elevated : CK(10) : AC(1), Coenzyme Q10 Deficiency : CK(83) : AC(13), Mitochondrial Dysfunction : CK(149) : AC(51), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances : Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions : Myotoxicity : CK(317) : AC(79)

Simvastatin worsens the myocardial mitochondrial respiration during ischemia probably due to depletion of coenzyme Q10. - GMI Summary

Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576
Article Published Date : Sep 01, 1995
Authors : K Satoh, A Yamato, T Nakai, K Hoshi, K Ichihara
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Mitochondrial Dysfunction : CK(149) : AC(51), Myocardial Ischemia : CK(87) : AC(37), Statin-Induced Pathologies : CK(1570) : AC(315)
Pharmacological Actions : Enzyme Inhibitors : CK(372) : AC(208)
Problem Substances : Simvastatin : CK(713) : AC(143)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Myotoxicity : CK(317) : AC(79)

Lovastatin causes depletion of coenzyme Q10 levels in the cardiac muslce and mitochondria of animals. - GMI Summary

Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Article Published Date : Jul 06, 1994
Authors : B A Diebold, N V Bhagavan, R J Guillory
Study Type : Animal Study
Additional Links
Diseases : Coenzyme Q10 Deficiency : CK(83) : AC(13), Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29), Heart Failure : CK(711) : AC(97), Statin-Induced Pathologies : CK(1570) : AC(315)
Problem Substances : Lovastatin : CK(265) : AC(67)
Adverse Pharmacological Actions : Cardiotoxic : CK(638) : AC(79), Myotoxicity : CK(317) : AC(79)