Topic: Aspartame

Focused: Neurotoxic

Aspartame

Topic Study Types

  • Animal Study : 3
  • In Vitro Study : 1

Chronic exposure to aspartame results in oxidative stress in the brain of albino rats, as well as methanol formation. - GMI Summary

Pubmed Data : J Biosci. 2012 Sep ;37(4):679-88. PMID: 22922192
Article Published Date : Aug 31, 2012
Authors : Ashok Iyyaswamy, Sheeladevi Rathinasamy
Study Type : Animal Study
Additional Links
Diseases : Brain Inflammation : CK(79) : AC(35), Excitotoxicity : CK(56) : AC(33), Lipid Peroxidation : CK(403) : AC(127)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Aspartame induces brain oxidative stress and vascular congestion in the animal model. - GMI Summary

Pubmed Data : Drug Chem Toxicol. 2012 Mar 2. Epub 2012 Mar 2. PMID: 22385158
Article Published Date : Mar 02, 2012
Authors : M Abhilash, M V Sauganth Paul, Mathews V Varghese, R Harikumaran Nair
Study Type : Animal Study
Additional Links
Diseases : Brain: Oxidative Stress : CK(2) : AC(1), Brain: Vascular Congestion : CK(2) : AC(1)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)

Aspartame appears to adversely affect spatial cognition and insulin sensitivity, especially in males. - GMI Summary

Pubmed Data : PLoS One. 2012 ;7(4):e31570. Epub 2012 Apr 3. PMID: 22509243
Article Published Date : Jan 01, 2012
Authors : Kate S Collison, Nadine J Makhoul, Marya Z Zaidi, Soad M Saleh, Bernard Andres, Angela Inglis, Rana Al-Rabiah, Futwan A Al-Mohanna
Study Type : Animal Study
Additional Links
Diseases : Cognitive Decline/Dysfunction : CK(522) : AC(87), Insulin Resistance : CK(1034) : AC(221)
Problem Substances : Aspartame : CK(103) : AC(30)
Adverse Pharmacological Actions : Endocrine Disruptor: Insulin Resistance : CK(152) : AC(31), Neurotoxic : CK(1076) : AC(179)

Aspartame and L-glutamic acid work synergistically with food coloring agents to induce neurotoxicity. - GMI Summary

Pubmed Data : Toxicol Sci. 2006 Mar;90(1):178-87. Epub 2005 Dec 13. PMID: 16352620
Article Published Date : Mar 01, 2006
Authors : Karen Lau, W Graham McLean, Dominic P Williams, C Vyvyan Howard
Study Type : In Vitro Study
Additional Links
Diseases : Attention Deficit Disorder with Hyperactivity : CK(240) : AC(30), Excitotoxicity : CK(56) : AC(33), Neurodevelopmental Disorders : CK(163) : AC(13)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Problem Substances : Aspartame : CK(103) : AC(30), Brilliant Blue FCF : CK(4) : AC(3), L-glutamic Acid : CK(11) : AC(2), Quinoline Yellow : CK(1) : AC(1)
Adverse Pharmacological Actions : Neurotoxic : CK(1076) : AC(179)