Topic: Roundup (herbicide)

Focused: Genotoxic

Roundup (herbicide)

Topic Study Types

  • Animal Study : 8
  • In Vitro Study : 5
  • Human In Vitro : 2
  • Human Study : 1

Genotoxic effects of the herbicide Roundup(®) have been observed in the fish species Corydoras paleatus after short-term, environmentally low concentration exposure. - GMI Summary

Pubmed Data : Environ Monit Assess. 2012 Jul 22. Epub 2012 Jul 22. PMID: 22821326
Article Published Date : Jul 21, 2012
Authors : Nédia de Castilhos Ghisi, Marta Margarete Cestari
Study Type : Animal Study, Environmental
Additional Links
Diseases : Glyphosate Toxicity : CK(22) : AC(12)
Problem Substances : Glyphosate : CK(365) : AC(116), Glyphosate formulations : CK(356) : AC(107), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Roundup(®) formulation exhibits genotoxicity in blood cells of fish (Anguilla anguilla). - GMI Summary

Pubmed Data : Ecotoxicology. 2012 Jul ;21(5):1381-90. Epub 2012 Apr 8. PMID: 22526921
Article Published Date : Jun 30, 2012
Authors : S Guilherme, M A Santos, C Barroso, I Gaivão, M Pacheco
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Components of the original formulation of Roundup exhibit significant toxicity in five North American anurans (frogs; keystone species). - GMI Summary

Pubmed Data : Ecotoxicol Environ Saf. 2012 Apr ;78:128-33. Epub 2011 Dec 3. PMID: 22137360
Article Published Date : Mar 31, 2012
Authors : Lindsay J Moore, Latice Fuentes, John H Rodgers, William W Bowerman, Greg K Yarrow, Wayne Y Chao, William C Bridges
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Fish exposed to a glyphosate-based herbicide undergo DNA damage. - GMI Summary

Pubmed Data : Mutat Res. 2012 Mar 18 ;743(1-2):1-9. Epub 2012 Jan 14. PMID: 22266476
Article Published Date : Mar 17, 2012
Authors : S Guilherme, I Gaivão, M A Santos, M Pacheco
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

Roundup herbicide is more toxic than its constituent parts and is genotoxic in concentrations that concentrations that correspond to a 450-fold dilution of spraying used in agriculture. - GMI Summary

Pubmed Data : Arch Toxicol. 2012 Feb 14. Epub 2012 Feb 14. PMID: 22331240
Article Published Date : Feb 14, 2012
Authors : Verena J Koller, Maria Fürhacker, Armen Nersesyan, Miroslav Mišík, Maria Eisenbauer, Siegfried Knasmueller
Study Type : In Vitro Study
Additional Links
Diseases : Cancers: All : CK(9062) : AC(2869), DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Both the general health condition and reproductive success of J. multidenatata (fish) could be seriously affected by Roundup. - GMI Summary

Pubmed Data : Arch Environ Contam Toxicol. 2012 Jan ;62(1):107-17. Epub 2011 Jun 4. PMID: 21643816
Article Published Date : Dec 31, 2011
Authors : Andrea Cecilia Hued, Sabrina Oberhofer, María de losÁngeles Bistoni
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate formulations : CK(356) : AC(107), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Endocrine Disruptor : CK(478) : AC(81), Genotoxic : CK(146) : AC(61)

Environmentally relevant concentrations of Roundup can pose a health risk for fish populations. - GMI Summary

Pubmed Data : Mutagenesis. 2010 Sep ;25(5):523-30. Epub 2010 Jul 19. PMID: 20643706
Article Published Date : Aug 31, 2010
Authors : S Guilherme, I Gaivão, M A Santos, M Pacheco
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293), Lipid Peroxidation : CK(403) : AC(127)
Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Genotoxic : CK(146) : AC(61)

The environmental metabolite of glyphosate, Aminomethylphosphonic acid, exhibits genotoxicity. - GMI Summary

Pubmed Data : Ecotoxicol Environ Saf. 2009 Mar ;72(3):834-7. Epub 2008 Nov 14. PMID: 19013644
Article Published Date : Mar 01, 2009
Authors : F Mañas, L Peralta, J Raviolo, H García Ovando, A Weyers, L Ugnia, M Gonzalez Cid, I Larripa, N Gorla
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage : CK(711) : AC(293), Liver Cancer : CK(1641) : AC(266)
Problem Substances : Aminomethylphosphonic acid : CK(12) : AC(5), Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Clastogenic : CK(6) : AC(2), Genotoxic : CK(146) : AC(61)

There is evidence that there is a genotoxic risk potential associated with exposure to glyphosate in areas where the herbicide is applied. - GMI Summary

Pubmed Data : J Toxicol Environ Health A. 2009;72(15-16):986-97. PMID: 19672767
Article Published Date : Jan 01, 2009
Authors : C Bolognesi, G Carrasquilla, S Volpi, K R Solomon, E J P Marshall
Study Type : Human Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Glyphosate pesticide (Roundup) exposure may adversely alter estrogen-related gene expression. - GMI Summary

Pubmed Data : Hum Exp Toxicol. 2007 Sep;26(9):747-52. PMID: 17984146
Article Published Date : Sep 01, 2007
Authors : R Hokanson, R Fudge, R Chowdhary, D Busbee
Study Type : In Vitro Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Genotoxic : CK(146) : AC(61)

Commercial glyphosate herbicides exhibit genotoxicity in fish. - GMI Summary

Pubmed Data : Mutagenesis. 2007 Jul;22(4):263-8. Epub 2007 Apr 10. PMID: 17426049
Article Published Date : Jul 01, 2007
Authors : Tolga Cavaş, Serpil Könen
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Glyphosate has genotoxic properties. - GMI Summary

Pubmed Data : Int J Hyg Environ Health. 2006 Jan ;209(1):15-20. Epub 2005 Aug 29. PMID: 16373198
Article Published Date : Jan 01, 2006
Authors : Katarína Siviková, Ján Dianovskỳ
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Glyphosphate exhibits genotoxicity in human cells. - GMI Summary

Pubmed Data : Biomedica. 2005 Sep;25(3):335-45. PMID: 16276681
Article Published Date : Sep 01, 2005
Authors : Claudia Milena Monroy, Andrea Carolina Cortés, Diana Mercedes Sicard, Helena Groot de Restrepo
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Glyphosate-based pesticides adversely affect cell cycle regulation at concentrations 500 to 4000 times lower than used in agriculatural applications. - GMI Summary

Pubmed Data : Biol Cell. 2004 Apr ;96(3):245-9. PMID: 15182708
Article Published Date : Apr 01, 2004
Authors : Julie Marc, Odile Mulner-Lorillon, Robert Bellé
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Cell Cycle Inhibitor : CK(3) : AC(1), Cytotoxic : CK(73) : AC(35), Genotoxic : CK(146) : AC(61)

Roundup is able to induce a dose-dependent formation of DNA adducts in the kidneys and liver of mice. - GMI Summary

Pubmed Data : Environ Mol Mutagen. 1998 ;31(1):55-9. PMID: 9464316
Article Published Date : Jan 01, 1998
Authors : M Peluso, A Munnia, C Bolognesi, S Parodi
Study Type : Animal Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)

Cytogenetic damage and induction of pro-oxidant state has been observed in human lymphocytes exposed in vitro to glyphosate. - GMI Summary

Pubmed Data : Environ Mol Mutagen. 1998 ;32(1):39-46. PMID: 9707097
Article Published Date : Jan 01, 1998
Authors : M B Lioi, M R Scarfi, A Santoro, R Barbieri, O Zeni, F Salvemini, D Di Berardino, M V Ursini
Study Type : Human In Vitro
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Genotoxic : CK(146) : AC(61)