Topic: Roundup (herbicide)

Focused: Endocrine Disruptor

Roundup (herbicide)

Topic Study Types

  • Animal Study : 6
  • Human Study : 1
  • In Vitro Study : 3

Both the general health condition and reproductive success of J. multidenatata (fish) could be seriously affected by Roundup. - GMI Summary

Pubmed Data : Arch Environ Contam Toxicol. 2012 Jan ;62(1):107-17. Epub 2011 Jun 4. PMID: 21643816
Article Published Date : Dec 31, 2011
Authors : Andrea Cecilia Hued, Sabrina Oberhofer, María de losÁngeles Bistoni
Study Type : Animal Study
Additional Links
Problem Substances : Glyphosate formulations : CK(356) : AC(107), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Aquacidal : CK(2) : AC(1), Endocrine Disruptor : CK(478) : AC(81), Genotoxic : CK(146) : AC(61)

Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology. - GMI Summary

Pubmed Data : Arch Toxicol. 2010 Apr;84(4):309-17. Epub 2009 Dec 12. PMID: 20012598
Article Published Date : Apr 01, 2010
Authors : R M Romano, M A Romano, M M Bernardi, P V Furtado, C A Oliveira
Study Type : Human Study
Additional Links
Diseases : Hormonal Disorders: Children : CK(14) : AC(3), Pesticide Toxicity : CK(147) : AC(45), Testosterone: Too Low : CK(369) : AC(70)
Additional Keywords : Environmental Pollutant : CK(32) : AC(15)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines at exceedingly small concentrations (.5 ppm to 10 ppm). - GMI Summary

Pubmed Data : Toxicology. 2009 Aug 21;262(3):184-91. Epub 2009 Jun 17. PMID: 19539684
Article Published Date : Aug 21, 2009
Authors : Céline Gasnier, Coralie Dumont, Nora Benachour, Emilie Clair, Marie-Christine Chagnon, Gilles-Eric Séralini
Study Type : In Vitro Study
Additional Links
Diseases : DNA damage : CK(711) : AC(293)
Additional Keywords : Estrogen Receptor Beta : CK(24) : AC(11)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Cytotoxic : CK(73) : AC(35), Endocrine Disruptor : CK(478) : AC(81), Mutagenic : CK(22) : AC(11)

Glyphosate herbicides (Roundup) exhibit pre- and postnatal toxicity in rats. - GMI Summary

Pubmed Data : Arch Toxicol. 2007 Sep;81(9):665-73. Epub 2007 Jul 19. PMID: 17634926
Article Published Date : Sep 01, 2007
Authors : Eliane Dallegrave, Fabiana D Mantese, Rosemari T Oliveira, Anderson J M Andrade, Paulo R Dalsenter, Augusto Langeloh
Study Type : Animal Study
Additional Links
Diseases : Postnatal Care: Breastfeeding : CK(209) : AC(25), Pregnancy: Environmental Exposures : CK(29) : AC(6), Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Glyphosate : CK(365) : AC(116), Polyoxyethylene amine : CK(12) : AC(7), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Glyphosate pesticide (Roundup) exposure may adversely alter estrogen-related gene expression. - GMI Summary

Pubmed Data : Hum Exp Toxicol. 2007 Sep;26(9):747-52. PMID: 17984146
Article Published Date : Sep 01, 2007
Authors : R Hokanson, R Fudge, R Chowdhary, D Busbee
Study Type : In Vitro Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Genotoxic : CK(146) : AC(61)

Roundup exposure may adversely affect human reproduction and fetal development in case of contamination. - GMI Summary

Pubmed Data : Arch Environ Contam Toxicol. 2007 Jul;53(1):126-33. Epub 2007 May 4. PMID: 17486286
Article Published Date : Jul 01, 2007
Authors : N Benachour, H Sipahutar, S Moslemi, C Gasnier, C Travert, G E Séralini
Study Type : In Vitro Study
Additional Links
Diseases : Endocrine Diseases : CK(13) : AC(3), Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Aromatase Disruptor : CK(1) : AC(1), Endocrine Disruptor : CK(478) : AC(81)

The herbicide Roundup may cause disorder in the morphophysiology of the male genital system of animals. - GMI Summary

Pubmed Data : Reprod Toxicol. 2007 Feb;23(2):182-91. Epub 2006 Nov 11. PMID: 17166697
Article Published Date : Feb 01, 2007
Authors : André G Oliveira, Luiz F Telles, Rex A Hess, Germán A B Mahecha, Cleida A Oliveira
Study Type : Animal Study
Additional Links
Diseases : Endocrine Diseases : CK(13) : AC(3), Hormonal Disorders: Children : CK(14) : AC(3)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81)

Endocrine and toxic effects of Roundup, not just glyphosate, can be observed in mammals, and Roundup adjuvants enhance glyphosate bioavailability and/or bioaccumulation. - GMI Summary

Pubmed Data : Environ Health Perspect. 2005 Jun;113(6):716-20. PMID: 15929894
Article Published Date : Jun 01, 2005
Authors : Sophie Richard, Safa Moslemi, Herbert Sipahutar, Nora Benachour, Gilles-Eric Seralini
Study Type : Animal Study
Additional Links
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(1011) : AC(268)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Bioaccumulator : CK(104) : AC(23), Cytotoxic : CK(73) : AC(35), Endocrine Disruptor : CK(478) : AC(81)

The glyphosate herbicide Roundup exhibits teratogenic potential in rats. - GMI Summary

Pubmed Data : Toxicol Lett. 2003 Apr 30;142(1-2):45-52. PMID: 12765238
Article Published Date : Apr 30, 2003
Authors : Eliane Dallegrave, Fabiana DiGiorgio Mantese, Ricardo Soares Coelho, Janaina Drawans Pereira, Paulo Roberto Dalsenter, Augusto Langeloh
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Glyphosate : CK(365) : AC(116), Roundup (herbicide) : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Teratogenic : CK(304) : AC(59)

Maternal exposure to agrochemicals (such as glyphosate) during pregnancy induces a variety of functional abnormalities in the specific activity of the enzymes in the studied organs of the pregnant rats and their fetuses. - GMI Summary

Pubmed Data : Environ Res. 2001 Mar ;85(3):226-31. PMID: 11237511
Article Published Date : Mar 01, 2001
Authors : J Daruich, F Zirulnik, M S Gimenez
Study Type : Animal Study
Additional Links
Diseases : Prenatal Chemical Exposures : CK(322) : AC(86)
Problem Substances : Glyphosate : CK(365) : AC(116)
Adverse Pharmacological Actions : Endocrine Disruptor : CK(478) : AC(81), Teratogenic : CK(304) : AC(59)