Chemothapeutic Synergy: Paclitaxel

Name	AC	CK
Breast Cancer	11	13
Breast Cancer: Triple Negative	7	8
Lung Cancer	5	6
Cervical Cancer	4	5
Carcinoma: Non-Small-Cell Lung	3	4
Glioma	2	4
Cancers: All	3	3
Gastric Cancer	2	3
Kidney Cancer	3	3
Ovarian Cancer	2	3
Prostate Cancer	2	3
Bladder Cancer	1	2
Cancers: Multi-Drug Resistant	2	2
Chemotherapy-Induced Toxicity: Tamoxifen	1	2
Colon Cancer	2	2
Ehrlich carcinoma	1	2
Liver Cancer	2	2
Pancreatic Cancer	2	2
Thyroid Cancer	1	2
Acute Myeloid Leukemia	1	1
Bone Cancer	1	1
Breast Cancer Stem Cells	1	1
Cancer Metastasis	1	1
Cancers: Drug Resistant	1	1
Choriocarcinoma	1	1
Colorectal Cancer	1	1
Glioblastoma	1	1
Non-Small-Cell Lung Carcinoma	1	1
Oral Cancer	1	1
Skin Cancer	1	1

Name	AC	CK
Curcumin	7	8
Ginsenosides	2	3
Modified Arabinoxylan Rice Bran (MGN-3)	2	3
Nobiletin	2	3
Bamboo	1	2
Berbamine	1	2
Cannabinoids	1	2
Cannabinoids: Synthetic	1	2
Flavonoids	1	2
Ginseng (Korean)	1	2
Honokiol	2	2
Mulberry	1	2
Thymoquinone	2	2
Tomato	1	2
Vitamin C	1	2
Wogonin	1	2
Alpha-Lipoic Acid	1	1
Berberine	1	1
Crocin	1	1
Cucurbitacin B	1	1
Ellagic Acid	1	1
Fermented Foods and Beverages	1	1
Fisetin	1	1
Folic Acid	1	1
Geraniol	1	1
Gingerol	1	1
Luteolin	1	1
Nettle	1	1
Panax Ginseng	1	1
Sulforaphane	1	1

Name	AC	CK	Focus
Heat Therapy	1	1
Ultrasound therapy	1	1

Name	AC	CK
Apoptotic	20	28
Antiproliferative	14	19
Chemosensitizer	16	19
Chemotherapeutic	8	10
NF-kappaB Inhibitor	5	7
Cell cycle arrest	4	6
Antineoplastic Agents	3	5
Bcl-2 protein down-regulation	2	4
Anti-metastatic	3	3
Chemopreventive	2	3
Anti-Inflammatory Agents	2	2
Cannabinoid Receptor Antagonist/Inverse Agonist	1	2
Multidrug Resistance Gene Modulators	2	2
PI3K-AKT inhibitor	1	2
Radiosensitizer	2	2
Bax/Bcl2 ratio: Increase	1	1
Caspase-3 Activation	1	1
Cyclooxygenase 2 Inhibitors	1	1
Heat Shock Protein Down-Regulation	1	1
Matrix metalloproteinase-9 (MMP-9) inhibitor	1	1
P21 Activation	1	1
Tumor Necrosis Factor (TNF) Alpha Inhibitor	1	1
Tumor Suppressor Protein p53 Upregulation	1	1
Vascular Endothelial Growth Factor Inhibitors	1	1

[+]

Bamboo concentrate enhances the bioavailability of the chemotherapy agent paclitaxel. Nov 01, 2010

Click here to read the entire abstract

Pubmed Data : Radiat Res. 2010 Nov;174(5):624-36. Epub 2010 Sep 13. PMID: 15918522

Article Published Date : Nov 01, 2010

Study Type : Animal Study

Additional Links

Substances : Bamboo

Diseases : Chemotherapy-Induced Toxicity: Tamoxifen

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Berbamine has synergistic antitumor effects with paclitaxel in glioma cells.Dec 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Evid Based Complement Alternat Med. 2017 ;2017:8152526. Epub 2017 Aug 13. PMID: 28883885

Article Published Date : Dec 31, 2016

Study Type : Animal Study

Additional Links

Substances : Berbamine

Diseases : Glioma

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Click here to read the entire abstract

Pubmed Data : Planta Med. 2014 Apr ;80(6):452-7. Epub 2014 Mar 31. PMID: 24687742

Article Published Date : Mar 31, 2014

Study Type : Animal Study

Additional Links

Substances : Nobiletin

Diseases : Carcinoma: Non-Small-Cell Lung, Lung Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Drug: Carboplatin, Natural Substance/Drug Synergy, Plant Extracts

[+]

Curcumin is a potent chemosensitizer to improve the therapeutic index of paclitaxel.Jul 13, 2011

Click here to read the entire abstract

Pubmed Data : Oncogene. 2011 Jul 14 ;30(28):3139-52. Epub 2011 Feb 14. PMID: 21317920

Article Published Date : Jul 13, 2011

Study Type : Animal Study

Additional Links

Substances : Curcumin

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo.Feb 01, 2017

Click here to read the entire abstract

Pubmed Data : J Control Release. 2017 Feb 2. Epub 2017 Feb 2. PMID: 28163212

Article Published Date : Feb 01, 2017

Study Type : Animal Study

Additional Links

Substances : Vitamin C

Diseases : Breast Cancer, Glioma

Additional Keywords : Breast Cancer, Chemothapeutic Synergy: Paclitaxel, Glioma, Vitamin C

[+]

Flavopiridol and paclitaxel exerted synergistic cytotoxic activities against SKOV3 cells in vitro and significantly suppress the tumor growth of mice bearing SKOV3 cells.Dec 31, 2014

Click here to read the entire abstract

Pubmed Data : Arch Gynecol Obstet. 2015 Jan ;291(1):143-50. Epub 2014 Aug 14. PMID: 25118834

Article Published Date : Dec 31, 2014

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Flavonoids

Diseases : Ovarian Cancer

Pharmacological Actions : Antineoplastic Agents, Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Ginsenoside Rg3 promotes cytotoxicity and apoptosis of Paclitaxel by inhibiting NF-κB signalling.Feb 19, 2017

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2017 Feb 20 ;89:227-232. Epub 2017 Feb 20. PMID: 28231544

Article Published Date : Feb 19, 2017

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Bcl-2 protein down-regulation, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Korean red ginseng extract enhances paclitaxel distribution to mammary tumors.May 16, 2016

Click here to read the entire abstract

Pubmed Data : Xenobiotica. 2016 May 17:1-10. Epub 2016 May 17. PMID: 27189791

Article Published Date : May 16, 2016

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Ginseng (Korean)

Diseases : Breast Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Bioavailability, Chemothapeutic Synergy: Paclitaxel, Plant Extracts

[+]

MGN-3 supplementation enhances tumor cell demise in the presence of a low dose of paclitaxel.Jun 30, 2016

Click here to read the entire abstract

Pubmed Data : Nutr Cancer. 2016 Jul 1:1-11. Epub 2016 Jul 1. PMID: 27367621

Article Published Date : Jun 30, 2016

Study Type : Animal Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3)

Diseases : Ehrlich carcinoma

Pharmacological Actions : Apoptotic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Mulberry water extract enhanced the cytotoxicity of paclitaxel and induced severe G2/M arrest, mitotic catastrophe and subsequent apoptosis.Dec 31, 2015

Click here to read the entire abstract

Pubmed Data : Sci Rep. 2016 ;6:20417. Epub 2016 Feb 3. PMID: 26838546

Article Published Date : Dec 31, 2015

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Mulberry

Diseases : Bladder Cancer

Pharmacological Actions : Apoptotic, Cell cycle arrest, Chemopreventive

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts

[+]

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Cancer Gene Ther. 2008 Feb ;15(2):101-7. Epub 2007 Dec 21. PMID: 18197164

Article Published Date : Jan 31, 2008

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Cannabinoids , Cannabinoids: Synthetic

Diseases : Thyroid Cancer

Pharmacological Actions : Apoptotic, Cannabinoid Receptor Antagonist/Inverse Agonist, Chemosensitizer

Additional Keywords : Cannabinoid Receptors, Chemothapeutic Synergy: Paclitaxel

[+]

The synergistic anti cancer effects of paclitaxel and α-tomatine may be beneficial for refractory prostate cancer treatment.Nov 14, 2013

Click here to read the entire abstract

Pubmed Data : Phytomedicine. 2013 Nov 15 ;20(14):1297-305. Epub 2013 Aug 4. PMID: 23920276

Article Published Date : Nov 14, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Tomato

Diseases : Prostate Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bcl-2 protein down-regulation, PI3K-AKT inhibitor

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts, Significant Treatment Outcome

[+]

Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Chin J Cancer Res. 2013 Oct ;25(5):505-13. PMID: 24255573

Article Published Date : Sep 30, 2013

Study Type : Animal Study, In Vitro Study

Additional Links

Substances : Wogonin

Diseases : Gastric Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Natural Substance/Drug Synergy

[+]

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

Click here to read the entire abstract

Pubmed Data : Food Chem Toxicol. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28249781

Article Published Date : Feb 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Gingerol

Diseases : Cervical Cancer

Pharmacological Actions : Antiproliferative , Apoptotic, Bax/Bcl2 ratio: Increase, Cell cycle arrest

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel

[+]

A combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells.Jun 24, 2015

Click here to read the entire abstract

Pubmed Data : J Recept Signal Transduct Res. 2015 Jun 25:1-8. Epub 2015 Jun 25. PMID: 26108226

Article Published Date : Jun 24, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Kidney Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antiproliferative , Apoptotic, Chemosensitizer, NF-kappaB Inhibitor

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Co-delivery of paclitaxel and honokiol suppressed multidrug resistance and metastasis of breast cancer.Aug 27, 2017

Click here to read the entire abstract

Pubmed Data : Acta Biomater. 2017 Aug 28. Epub 2017 Aug 28. PMID: 28842335

Article Published Date : Aug 27, 2017

Study Type : In Vitro Study

Additional Links

Substances : Honokiol

Diseases : Breast Cancer, Cancers: Multi-Drug Resistant

Pharmacological Actions : Anti-metastatic, Multidrug Resistance Gene Modulators

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(9):e0139298. Epub 2015 Sep 30. PMID: 26421434

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Berberine

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Colon Cancer

Pharmacological Actions : Antiproliferative

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Dose Response, Natural Substance/Drug Synergy

[+]

Combined ultrasonic treatment and chemotherapy with paclitaxel showed a significantly increased killing of MCF7 cells compared to both monotherapies.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015;10(8):e0134999. Epub 2015 Aug 4. PMID: 26241649

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Diseases : Breast Cancer, Breast Cancer: Triple Negative

Therapeutic Actions : Ultrasound therapy

Pharmacological Actions : Apoptotic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Selective Cytotoxicity

[+]

Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Breast Cancer. 2015 ;2015:139349. Epub 2015 Nov 26. PMID: 26693354

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Crocin

Diseases : Breast Cancer

Pharmacological Actions : Apoptotic, Radiosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Cucurbitacin B, showed potential in vitro synergistic antiproliferative effects combined with paclitaxel in A549 cells.Jun 09, 2017

Click here to read the entire abstract

Pubmed Data : Toxicol Appl Pharmacol. 2017 Jun 10 ;329:272-281. Epub 2017 Jun 10. PMID: 28610991

Article Published Date : Jun 09, 2017

Study Type : In Vitro Study

Additional Links

Substances : Cucurbitacin B

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Antiproliferative , Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Curcumin by itself was as good as carboplatin or paclitaxel in inducing apoptosis in the primary ovarian cancer cells.Mar 31, 2016

Click here to read the entire abstract

Pubmed Data : J Cancer Res Ther. 2016 Apr-Jun;12(2):1050-5. PMID: 27461697

Article Published Date : Mar 31, 2016

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Ovarian Cancer

Pharmacological Actions : Apoptotic, Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Carboplatin, Natural Substances Versus Drugs

[+]

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Exp Ther Med. 2015 Apr ;9(4):1470-1476. Epub 2015 Jan 29. PMID: 25780454

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Cervical Cancer

Pharmacological Actions : Apoptotic, Caspase-3 Activation, NF-kappaB Inhibitor, Tumor Suppressor Protein p53 Upregulation

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.Mar 31, 2017

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2017 Apr ;39(4):1010428317698353. PMID: 28443468

Article Published Date : Mar 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Carcinoma: Non-Small-Cell Lung

Pharmacological Actions : Chemosensitizer

Additional Keywords : Carcinoma: Non-Small-Cell Lung, Chemosensitizer, Chemothapeutic Synergy: Paclitaxel, CURCUMIN

[+]

Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2.Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : PLoS One. 2015 ;10(8):e0136694. Epub 2015 Aug 25. PMID: 26305906

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Curcumin

Diseases : Breast Cancer, Breast Cancer: Triple Negative , Breast Cancer Stem Cells

Pharmacological Actions : Apoptotic, Chemopreventive, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Mitomycin C

[+]

Effect of ginseng rare ginsenoside components combined with paclitaxel on A549 lung cancer.Mar 31, 2018

Click here to read the entire abstract

Pubmed Data : Zhongguo Zhong Yao Za Zhi. 2018 Apr ;43(7):1446-1452. PMID: 29728035

Article Published Date : Mar 31, 2018

Study Type : In Vitro Study

Additional Links

Substances : Ginsenosides

Diseases : Lung Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Fermented red ginseng extract may be more effective for decreasing cancer cell survival by inducing apoptotic cell death.Mar 31, 2015

Click here to read the entire abstract

Pubmed Data : J Med Food. 2015 Apr ;18(4):421-8. Epub 2015 Feb 6. PMID: 25658580

Article Published Date : Mar 31, 2015

Study Type : In Vitro Study

Additional Links

Substances : Fermented Foods and Beverages, Ginsenosides, Panax Ginseng

Diseases : Breast Cancer, Liver Cancer

Pharmacological Actions : Antiproliferative , Apoptotic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Folic acid significantly enhanced the efficacy of curcumin in down-regulating various survival signals induced by paclitaxel in cervical cancer.Dec 07, 2017

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Oncotarget. 2017 Dec 8 ;8(64):107374-107389. Epub 2017 Nov 10. PMID: 29296172

Article Published Date : Dec 07, 2017

Study Type : In Vitro Study

Additional Links

Substances : Curcumin, Folic Acid

Diseases : Cervical Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Geraniol can constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs.Apr 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Oncol. 2016 May ;48(5):1772-82. Epub 2016 Mar 9. PMID: 26983575

Article Published Date : Apr 30, 2016

Study Type : Review

Additional Links

Substances : Geraniol

Diseases : Breast Cancer, Cancers: All, Cancers: Drug Resistant, Colon Cancer, Kidney Cancer, Liver Cancer, Lung Cancer, Oral Cancer, Pancreatic Cancer, Prostate Cancer, Skin Cancer

Pharmacological Actions : Anti-Inflammatory Agents, Antineoplastic Agents, Antiproliferative , Apoptotic, Chemosensitizer, Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: 5-flourouracil, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin

[+]

Honokiol targets mitochondria to halt cancer progression and metastasis.May 31, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Nutr Food Res. 2016 Jun ;60(6):1383-95. Epub 2016 May 6. PMID: 27276215

Article Published Date : May 31, 2016

Study Type : Review

Additional Links

Substances : Honokiol

Diseases : Bone Cancer, Breast Cancer, Gastric Cancer, Glioblastoma, Kidney Cancer, Lung Cancer

Pharmacological Actions : Anti-metastatic, Antiproliferative , Chemosensitizer, Radiosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Chemotherapeutic Synergy: Doxorubicin, Chemotherapeutic Synergy: Gemcitabine, Chemotherapeutic Synergy: Oxaliplatin, Natural Substance/Drug Synergy

[+]

Liposomal codelivery of HSA-paclitaxel and HSA-ellagic acid complexes for enhanced drug perfusion and efficacy against pancreatic cancer.Aug 01, 2017

Click here to read the entire abstract

Pubmed Data : ACS Appl Mater Interfaces. 2017 Aug 2 ;9(30):25138-25151. Epub 2017 Jul 24. PMID: 28696100

Article Published Date : Aug 01, 2017

Study Type : In Vitro Study

Additional Links

Substances : Ellagic Acid

Diseases : Pancreatic Cancer

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Luteolin plays an important role in the treatment of human choriocarcinoma cells.Aug 30, 2016

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Biol Reprod. 2016 Aug 31. Epub 2016 Aug 31. PMID: 27580988

Article Published Date : Aug 30, 2016

Study Type : In Vitro Study

Additional Links

Substances : Luteolin

Diseases : Choriocarcinoma

Pharmacological Actions : Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin, Natural Substance/Drug Synergy

[+]

MGN-3 is an effective chemosensitizer and may represent a novel adjuvant for the treatment of metastatic breast cancer.Dec 31, 2013

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Anticancer Res. 2014 Jan ;34(1):81-7. PMID: 24403447

Article Published Date : Dec 31, 2013

Study Type : In Vitro Study

Additional Links

Substances : Modified Arabinoxylan Rice Bran (MGN-3)

Diseases : Breast Cancer, Cancer Metastasis

Pharmacological Actions : Antiproliferative , Apoptotic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer.Feb 20, 2018

Click here to read the entire abstract

Pubmed Data : Eur J Nutr. 2018 Feb 21. Epub 2018 Feb 21. PMID: 29468462

Article Published Date : Feb 20, 2018

Study Type : In Vitro Study

Additional Links

Substances : Hydroxytyrosol

Diseases : Breast Cancer

Pharmacological Actions : Chemotherapeutic

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Nettle extract substantially increased sensitivity of breast cancer cells to paclitaxel.Aug 04, 2016

Click here to read the entire abstract

Pubmed Data : Biomed Pharmacother. 2016 Aug 5 ;83:835-842. Epub 2016 Aug 5. PMID: 27501501

Article Published Date : Aug 04, 2016

Study Type : In Vitro Study

Additional Links

Substances : Nettle

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Cell cycle arrest, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Plant Extracts

[+]

Nobiletin significantly reversed ABCB1 mediated multidrug resistance in cancer cells. Dec 31, 2014

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Sci Rep. 2015 ;5:18789. Epub 2015 Dec 22. PMID: 26689156

Article Published Date : Dec 31, 2014

Study Type : In Vitro Study

Additional Links

Substances : Nobiletin

Diseases : Cancers: All, Cancers: Multi-Drug Resistant, Colorectal Cancer

Pharmacological Actions : Chemosensitizer, Chemotherapeutic, Multidrug Resistance Gene Modulators

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Doxorubicin

[+]

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.Feb 26, 2017

Click here to read the entire abstract

Pubmed Data : Cancer Lett. 2017 Feb 27. Epub 2017 Feb 27. PMID: 28254410

Article Published Date : Feb 26, 2017

Study Type : In Vitro Study

Additional Links

Substances : Sulforaphane

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Chemosensitizer, Chemotherapeutic

Additional Keywords : Cancer Stem Cells, Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Docetaxel

[+]

The combination of fisetin and paclitaxel is expected to have a synergistic anticancer efficacy and a significant potential for the treatment of NSCLC.Feb 26, 2018

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Int J Mol Sci. 2018 Feb 27 ;19(3). Epub 2018 Feb 27. PMID: 29495431

Article Published Date : Feb 26, 2018

Study Type : In Vitro Study

Additional Links

Substances : Fisetin

Diseases : Non-Small-Cell Lung Carcinoma

Additional Keywords : Chemothapeutic Synergy: Paclitaxel

[+]

Thermotherapy in combination with chemotherapy showed more strong inhibitory effect than those of thermotherapy or chemotherapy alone.Aug 31, 2008

Click here to read the entire abstract

Pubmed Data : Wei Sheng Yan Jiu. 2008 Sep ;37(5):529-32. PMID: 19069644

Article Published Date : Aug 31, 2008

Study Type : In Vitro Study

Additional Links

Diseases : Lung Cancer

Therapeutic Actions : Heat Therapy

Pharmacological Actions : Heat Shock Protein Down-Regulation

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Therapeutic Action Synergy with Drugs

[+]

Thymoquinone and paclitaxel combined act in synergy against triple negative breast cancer cells.Oct 25, 2015

Click here to read the entire abstract

Pubmed Data : Tumour Biol. 2015 Oct 26. Epub 2015 Oct 26. PMID: 26500095

Article Published Date : Oct 25, 2015

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Breast Cancer: Triple Negative

Pharmacological Actions : Apoptotic, P21 Activation

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Gene Expression Regulation

[+]

Thymoquinone is a potentially effective suppressor of inflammation, tumor cell survival, proliferation, invasion, and angiogenesis.May 31, 2008

Click here to read the entire abstract

Article Publish Status : This is a free article. Click here to read the complete article.

Pubmed Data : Mol Cancer Res. 2008 Jun ;6(6):1059-70. PMID: 18567808

Article Published Date : May 31, 2008

Study Type : In Vitro Study

Additional Links

Substances : Thymoquinone

Diseases : Acute Myeloid Leukemia, Cancers: All

Pharmacological Actions : Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors, Matrix metalloproteinase-9 (MMP-9) inhibitor, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor, Vascular Endothelial Growth Factor Inhibitors

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Doxorubicin

[+]

α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents.Jul 17, 2016

Click here to read the entire abstract

Pubmed Data : Int J Oncol. 2016 Jul 18. Epub 2016 Jul 18. PMID: 27431988

Article Published Date : Jul 17, 2016

Study Type : In Vitro Study

Additional Links

Substances : Alpha-Lipoic Acid

Diseases : Lung Cancer

Pharmacological Actions : Anti-metastatic, Chemosensitizer

Additional Keywords : Chemothapeutic Synergy: Paclitaxel, Chemotherapeutic Synergy: Cisplatin

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View the Evidence: 41 Abstracts with Chemothapeutic Synergy: Paclitaxel Research

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Bamboo concentrate enhances the bioavailability of the chemotherapy agent paclitaxel. Nov 01, 2010

Berbamine has synergistic antitumor effects with paclitaxel in glioma cells.Dec 31, 2016

Combinations of nobiletin with paclitaxel and carboplatin significantly suppressed the growth of subcutaneous A549 tumors xenografts in nude mice.Mar 31, 2014

Curcumin is a potent chemosensitizer to improve the therapeutic index of paclitaxel.Jul 13, 2011

Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo.Feb 01, 2017

Flavopiridol and paclitaxel exerted synergistic cytotoxic activities against SKOV3 cells in vitro and significantly suppress the tumor growth of mice bearing SKOV3 cells.Dec 31, 2014

Ginsenoside Rg3 promotes cytotoxicity and apoptosis of Paclitaxel by inhibiting NF-κB signalling.Feb 19, 2017

Korean red ginseng extract enhances paclitaxel distribution to mammary tumors.May 16, 2016

MGN-3 supplementation enhances tumor cell demise in the presence of a low dose of paclitaxel.Jun 30, 2016

Mulberry water extract enhanced the cytotoxicity of paclitaxel and induced severe G2/M arrest, mitotic catastrophe and subsequent apoptosis.Dec 31, 2015

The discovery of IL-12-induced CB2 overexpression in thyroid cancer cells may offer a new target for anaplastic thyroid cancer treatmentJan 31, 2008

The synergistic anti cancer effects of paclitaxel and α-tomatine may be beneficial for refractory prostate cancer treatment.Nov 14, 2013

Wogonin combined with low-dose paclitaxel obtained the same efficacy as with high dose Paclitaxel reducing tumor burden by 61%.Sep 30, 2013

6-Gingerol with 5-flourouracil and paclitaxel resulted in 83.2% and 52% inhibition of cervical cancer cells. Feb 26, 2017

A combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells.Jun 24, 2015

Co-delivery of paclitaxel and honokiol suppressed multidrug resistance and metastasis of breast cancer.Aug 27, 2017

Co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents.Dec 31, 2014

Combined ultrasonic treatment and chemotherapy with paclitaxel showed a significantly increased killing of MCF7 cells compared to both monotherapies.Dec 31, 2014

Crocin and paclitaxel and crocin and gamma radiation had synergistic effect on MCF-7 cell line to get more significant apoptosis.Dec 31, 2014

Cucurbitacin B, showed potential in vitro synergistic antiproliferative effects combined with paclitaxel in A549 cells.Jun 09, 2017

Curcumin by itself was as good as carboplatin or paclitaxel in inducing apoptosis in the primary ovarian cancer cells.Mar 31, 2016

Curcumin has the ability to improve the paclitaxel induced apoptosis of HPV positive human cervical cancer cell lines via the NF-κB-p53-caspase-3 pathway.Mar 31, 2015

Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.Mar 31, 2017

Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2.Dec 31, 2014

Effect of ginseng rare ginsenoside components combined with paclitaxel on A549 lung cancer.Mar 31, 2018

Fermented red ginseng extract may be more effective for decreasing cancer cell survival by inducing apoptotic cell death.Mar 31, 2015

Folic acid significantly enhanced the efficacy of curcumin in down-regulating various survival signals induced by paclitaxel in cervical cancer.Dec 07, 2017

Geraniol can constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs.Apr 30, 2016

Honokiol targets mitochondria to halt cancer progression and metastasis.May 31, 2016

Liposomal codelivery of HSA-paclitaxel and HSA-ellagic acid complexes for enhanced drug perfusion and efficacy against pancreatic cancer.Aug 01, 2017

Luteolin plays an important role in the treatment of human choriocarcinoma cells.Aug 30, 2016

MGN-3 is an effective chemosensitizer and may represent a novel adjuvant for the treatment of metastatic breast cancer.Dec 31, 2013

Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer.Feb 20, 2018

Nettle extract substantially increased sensitivity of breast cancer cells to paclitaxel.Aug 04, 2016

Nobiletin significantly reversed ABCB1 mediated multidrug resistance in cancer cells. Dec 31, 2014

Sulforaphane enhances the anticancer activity of taxanes against triple negative breast cancer by killing cancer stem cells.Feb 26, 2017

The combination of fisetin and paclitaxel is expected to have a synergistic anticancer efficacy and a significant potential for the treatment of NSCLC.Feb 26, 2018

Thermotherapy in combination with chemotherapy showed more strong inhibitory effect than those of thermotherapy or chemotherapy alone.Aug 31, 2008

Thymoquinone and paclitaxel combined act in synergy against triple negative breast cancer cells.Oct 25, 2015

Thymoquinone is a potentially effective suppressor of inflammation, tumor cell survival, proliferation, invasion, and angiogenesis.May 31, 2008

α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents.Jul 17, 2016

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Chemothapeutic Synergy: Paclitaxel

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41 Abstracts with Chemothapeutic Synergy: Paclitaxel Research