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Drug: Indomethacin
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Additional Topics Details for this Page
Article Count
- 17
Cumulative Knowledge
- 32
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Quick Summary: 2 associated Problem Substances
Name
Cumulative Knowledge
Article Count
Focus Articles
Alendronate (trade name Fosamax)
2
1
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Freund adjuvant
2
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Quick Summary: Current access displays 2 out of 17 associated Diseases
Name
Cumulative Knowledge
Article Count
Focus Articles
Gastric Ulcer
14
7
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Drug-Induced Toxicity: Indomethacin
13
7
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Quick Summary: 1 associated Adverse Pharmacological Actions
Name
Cumulative Knowledge
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Inflammatory
2
1
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Quick Summary: Current access displays 2 out of 18 associated Substances
Name
Cumulative Knowledge
Article Count
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Curcumin
10
5
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Mussel: Green-lipped (Perna canaliculus)
3
2
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Quick Summary: Current access displays 2 out of 14 associated Pharmacological Actions
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Gastroprotective
12
6
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Anti-Ulcer Agents
6
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View the Evidence:
Alendronate impairs the healing of gastric ulcers in rats.
Click here to read the entire abstract
Pubmed Data
: Dig Dis Sci. 2007 Aug;52(8):1879-89. Epub 2007 Apr 5. PMID:
17410434
Article Published Date
: Aug 01, 2007
Study Type
: Animal Study
Additional Links
Diseases
:
Gastric Ulcer : CK(246) : AC(91)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Problem Substances
:
Alendronate (trade name Fosamax) : CK(166) : AC(27)
Analgesic and anti-inflammatory activity of saponins of Argania spinoza
Click here to read the entire abstract
Pubmed Data
: Ann Pharm Fr. 1998 ;56(5):220-8. PMID:
9805822
Article Published Date
: Dec 31, 1997
Study Type
: Animal Study
Additional Links
Substances
:
Argania spinosa (Argan) : CK(13) : AC(8)
Diseases
:
Inflammation : CK(1077) : AC(363)
,
Pain : CK(616) : AC(91)
Pharmacological Actions
:
Analgesics : CK(372) : AC(78)
,
Anti-Inflammatory Agents : CK(1230) : AC(433)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Click here to read the entire abstract
Pubmed Data
: Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID:
18060385
Article Published Date
: Jul 01, 2008
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2923) : AC(1482)
Diseases
:
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
,
Mitochondrial Diseases : CK(149) : AC(50)
,
Mitochondrial Dysfunction : CK(149) : AC(51)
,
NSAID-induced toxicity : CK(230) : AC(50)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Curcumin protects against indomethacin-induced gastric injury.
Click here to read the entire abstract
Pubmed Data
: Anticancer Drugs. 2009 Oct;20(9):757-69. PMID:
16631530
Article Published Date
: Oct 01, 2009
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2923) : AC(1482)
Diseases
:
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Gastroprotective : CK(62) : AC(31)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Curcumin reduces indomethacin-induced damage in the rat small intestine.
Click here to read the entire abstract
Pubmed Data
: Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID:
17351913
Article Published Date
: Nov 15, 2010
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2923) : AC(1482)
Diseases
:
Duodenal Ulcer : CK(89) : AC(26)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Antioxidants : CK(3653) : AC(1318)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Curcumin's antiulcer activity is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.
Click here to read the entire abstract
Pubmed Data
: J Biol Chem. 2005 Mar 11;280(10):9409-15. Epub 2004 Dec 22. PMID:
15615723
Article Published Date
: Mar 11, 2005
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2923) : AC(1482)
Diseases
:
Gastric Ulcer : CK(246) : AC(91)
,
Oxidative Stress : CK(1945) : AC(710)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
,
Gastroprotective : CK(62) : AC(31)
,
Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
,
Matrix metalloproteinase-9 (MMP-9) inhibitor : CK(49) : AC(30)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Green mussel extract exhibits anti-inflammatory and gastroprotective properties.
Click here to read the entire abstract
Pubmed Data
: Arzneimittelforschung. 1980;30(12):2128-32. PMID:
7194074
Article Published Date
: Jan 01, 1980
Study Type
: Animal Study
Additional Links
Substances
:
Mussel: Green-lipped (Perna canaliculus) : CK(48) : AC(20)
Diseases
:
Aspirin-Induced Toxicity : CK(83) : AC(24)
,
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
,
Gastric Ulcer : CK(246) : AC(91)
,
NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions
:
Anti-Inflammatory Agents : CK(1230) : AC(433)
,
Gastroprotective : CK(62) : AC(31)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Honey and a glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.
Click here to read the entire abstract
Pubmed Data
: Exp Toxicol Pathol. 2002 Nov;54(3):217-21. PMID:
12484559
Article Published Date
: Nov 01, 2002
Study Type
: Animal Study
Additional Links
Substances
:
Fructose : CK(4) : AC(2)
,
Glucose : CK(12) : AC(2)
,
Honey : CK(251) : AC(50)
,
Maltose : CK(2) : AC(1)
,
Sucrose : CK(12) : AC(2)
Diseases
:
Alcohol Toxicity : CK(212) : AC(85)
,
Aspirin-Induced Toxicity : CK(83) : AC(24)
,
Gastric Ulcer : CK(246) : AC(91)
,
NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions
:
Gastroprotective : CK(62) : AC(31)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Loquat seed extract and deep sea water protect against NSAID-induced gastric injury in rats.
Click here to read the entire abstract
Pubmed Data
: J Nat Med. 2011 Jan;65(1):9-17. Epub 2010 Jul 17. PMID:
20640522
Article Published Date
: Jan 01, 2011
Study Type
: Animal Study
Additional Links
Substances
:
Loquat Seeds : CK(11) : AC(6)
,
Water: Deep Sea : CK(21) : AC(7)
Diseases
:
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
,
NSAID-induced toxicity : CK(230) : AC(50)
Pharmacological Actions
:
Gastroprotective : CK(62) : AC(31)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
,
Plant Extracts : CK(3616) : AC(1226)
Mangifera indica exhibits ant-inflammatory properties.
Click here to read the entire abstract
Pubmed Data
: Pharmacol Res. 2004 Aug;50(2):143-9. PMID:
15177302
Article Published Date
: Aug 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Mangiferin : CK(42) : AC(27)
Diseases
:
Inflammation : CK(1077) : AC(363)
,
Lipopolysaccharide-Induced Toxicity : CK(227) : AC(128)
,
Pain : CK(616) : AC(91)
Pharmacological Actions
:
Analgesics : CK(372) : AC(78)
,
Anti-Inflammatory Agents : CK(1230) : AC(433)
,
Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
,
Plant Extracts : CK(3616) : AC(1226)
,
Xanthones : CK(50) : AC(28)
Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.
Click here to read the entire abstract
Pubmed Data
: Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID:
16934674
Article Published Date
: Sep 15, 2006
Study Type
: Animal Study
Additional Links
Substances
:
Curcumin : CK(2923) : AC(1482)
,
Melatonin : CK(470) : AC(131)
Diseases
:
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Gastroprotective : CK(62) : AC(31)
,
Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Oral glutamine attenuates indomethacin-induced small intestinal damage.
Click here to read the entire abstract
Pubmed Data
: Clin Sci (Lond). 2004 Sep;107(3):281-9. PMID:
15128285
Article Published Date
: Sep 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Glutamine : CK(98) : AC(19)
Diseases
:
Duodenal Ulcer : CK(89) : AC(26)
,
Gastroduodenal Ulcer : CK(82) : AC(9)
,
Oxidative Stress : CK(1945) : AC(710)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
The vaccine ingredient Freund's adjuvant is used to induce arthritis in rat experiments - Article 2.
Click here to read the entire abstract
Pubmed Data
: J Physiol Pharmacol. 2009 Dec;60(4):147-55. PMID:
20065509
Article Published Date
: Dec 01, 2009
Study Type
: Animal Study
Additional Links
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
,
Vaccine Adjuvant : CK(15) : AC(4)
Problem Substances
:
Freund adjuvant : CK(21) : AC(11)
Adverse Pharmacological Actions
:
Inflammatory : CK(150) : AC(37)
Whey protein concentrate protects against ulcerative lesions caused by subcutaneous administration of indomethacin.
Click here to read the entire abstract
Pubmed Data
: J Med Food. 2004;7(3):309-14. PMID:
15383224
Article Published Date
: Jan 01, 2004
Study Type
: Animal Study
Additional Links
Substances
:
Whey : CK(323) : AC(72)
Diseases
:
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
,
Gastric Ulcer : CK(246) : AC(91)
Pharmacological Actions
:
Anti-Ulcer Agents : CK(162) : AC(57)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Green mussel lipid extracts have anti-cyclooxygenase activity superior to fish oil.
Click here to read the entire abstract
Pubmed Data
: Comp Biochem Physiol B Biochem Mol Biol. 2007 Mar;146(3):346-56. Epub 2006 Nov 17. PMID:
17197217
Article Published Date
: Mar 01, 2007
Study Type
: In Vitro Study
Additional Links
Substances
:
Fish Oil : CK(615) : AC(95)
,
Mussel: Green-lipped (Perna canaliculus) : CK(48) : AC(20)
Diseases
:
Inflammation : CK(1077) : AC(363)
Pharmacological Actions
:
Anti-Inflammatory Agents : CK(1230) : AC(433)
,
Cyclooxygenase 1 Inhibitor : CK(22) : AC(18)
,
Cyclooxygenase 2 Inhibitors : CK(269) : AC(169)
,
Cyclooxygenase Inhibitors : CK(64) : AC(32)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
,
Green Muscle Lipids Superior to Fish Oil Lipids : CK(1) : AC(1)
Resveratrol inhibits PGHS-1 and upregulates PGHS-2 synthesis.
Click here to read the entire abstract
Pubmed Data
: Prostaglandins Other Lipid Mediat. 1998 Jun;56(2-3):131-43. PMID:
9785383
Article Published Date
: Jun 01, 1998
Study Type
: In Vitro Study
Additional Links
Substances
:
Resveratrol : CK(977) : AC(590)
,
Stilbenes : CK(128) : AC(92)
Pharmacological Actions
:
Cyclooxygenase Inhibitors : CK(64) : AC(32)
,
Prostaglandin H Synthase-1 (PGHS-1) Inhibits : CK(1) : AC(1)
,
Prostaglandin H Synthase-2 (PGHS-2) Up-Regulation : CK(1) : AC(1)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
Resveratrol or a combination of resveratrol and quercetin, in concentrations equivalent to that present in red wines, are effective inhibitors of oral squamous carcinoma cell (SCC-25) growth and proliferation.
Click here to read the entire abstract
Pubmed Data
: Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):32-7. PMID:
10211549
Article Published Date
: Jan 01, 2006
Study Type
: In Vitro Study
Additional Links
Substances
:
Quercetin : CK(318) : AC(136)
,
Resveratrol : CK(977) : AC(590)
,
Stilbenes : CK(128) : AC(92)
Diseases
:
Oral Cancer : CK(66) : AC(43)
,
Squamous cell carcinoma : CK(79) : AC(36)
,
Tongue Cancer : CK(14) : AC(10)
Pharmacological Actions
:
Antiproliferative : CK(1058) : AC(775)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
,
Natural Substance Synergy : CK(144) : AC(81)
Sulforaphane has protective effect on indomethacin-induced cytoxicity in human intestinal cells.
Click here to read the entire abstract
Pubmed Data
: Mol Nutr Food Res. 2009 Sep;53(9):1166-76. PMID:
19653226
Article Published Date
: Sep 01, 2009
Study Type
: In Vitro Study
Additional Links
Substances
:
Sulforaphane : CK(520) : AC(171)
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
Drug-Induced Toxicity: Indomethacin : CK(15) : AC(7)
Additional Keywords
:
Drug: Indomethacin : CK(30) : AC(17)
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