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Drug-Nutrient Depletion
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Additional Topics Details for this Page
Article Count
- 7
Cumulative Knowledge
- 52
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Quick Summary: Current access displays 2 out of 7 associated Problem Substances
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Cumulative Knowledge
Article Count
Focus Articles
Statin Drugs
23
5
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Pegylated interferon alpha
20
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Quick Summary: Current access displays 2 out of 17 associated Diseases
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Drug-Induced Nutrient Depletion: Statin Drugs
24
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Quick Summary: Current access displays 2 out of 3 associated Adverse Pharmacological Actions
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Oxidant
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Coenzyme Q10
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Quick Summary: 1 associated Pharmacological Actions
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Platelet Aggregation Inhibitors
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View the Evidence:
Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.
Click here to read the entire abstract
Pubmed Data
: Am J Cardiol. 2004 Oct 1;94(7):975-7. PMID:
15464695
Article Published Date
: Oct 01, 2004
Study Type
: Human Study
Additional Links
Diseases
:
Aspirin-Induced Toxicity : CK(83) : AC(24)
,
Drug-Induced Nutrient Depletion: Aspirin : CK(10) : AC(1)
,
Drug-Induced Nutrient Depletion: Vitamin B-12 : CK(20) : AC(2)
,
Vitamin B 12 Deficiency : CK(220) : AC(34)
Pharmacological Actions
:
Platelet Aggregation Inhibitors : CK(173) : AC(37)
Additional Keywords
:
Aspirin-Vitamin b12 Deficiency : CK(10) : AC(1)
,
Drug-Nutrient Depletion : CK(64) : AC(7)
Coq10 supplementation corrects statin-induced coq10 depletion without affecting the cholesterol lowering effect of simvastatin.
Click here to read the entire abstract
Pubmed Data
: Mol Aspects Med. 1994;15 Suppl:s187-93. PMID:
7752830
Article Published Date
: Jan 01, 1994
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10 : CK(667) : AC(104)
Diseases
:
Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords
:
Drug: Simvastatin : CK(22) : AC(3)
,
Drug-Nutrient Depletion : CK(64) : AC(7)
,
Statin-Coq10 Depletion : CK(36) : AC(5)
Statin drugs reduce coq10 levels which may result in mitochondrial dysfunction and cellular damage.
Click here to read the entire abstract
Pubmed Data
: J Clin Pharmacol. 1993 Mar;33(3):226-9. PMID:
8463436
Article Published Date
: Mar 01, 1993
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Toxicity : CK(560) : AC(78)
,
High Cholesterol : CK(1718) : AC(198)
,
Myopathies : CK(252) : AC(51)
Additional Keywords
:
Drug-Nutrient Depletion : CK(64) : AC(7)
,
Statin-Coq10 Depletion : CK(36) : AC(5)
Problem Substances
:
Lovastatin : CK(265) : AC(67)
,
Pravastatin : CK(239) : AC(40)
,
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Cytotoxic : CK(73) : AC(35)
Type 2 diabetic patients patients treated with statin drugs have decreased coq10 levels and may be associated with subclinical diabetic cardiomyopathy reversible by CoQ10 supplementation.
Click here to read the entire abstract
Pubmed Data
: Arzneimittelforschung. 1999 Apr;49(4):324-9. PMID:
10337451
Article Published Date
: Apr 01, 1999
Study Type
: Human Study
Additional Links
Diseases
:
Cardiomyopathy : CK(77) : AC(15)
,
Diabetes: Cardiovascular Illness : CK(666) : AC(104)
,
Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords
:
Drug-Nutrient Depletion : CK(64) : AC(7)
,
Statin-Coq10 Depletion : CK(36) : AC(5)
Problem Substances
:
Simvastatin : CK(713) : AC(143)
,
Statin Drugs : CK(3969) : AC(465)
Adverse Pharmacological Actions
:
Cardiotoxic : CK(638) : AC(79)
Vitamins B depletion, lower iron status and decreased antioxidative defense has been observed in patients with chronic hepatitis C treated by pegylated interferon alfa and ribavirin.
Click here to read the entire abstract
Pubmed Data
: Clin Nutr. 2009 Feb;28(1):34-8. Epub 2008 Nov 29. PMID:
19042060
Article Published Date
: Feb 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Drug-Induced Nutrient Depletion: B Complex : CK(30) : AC(3)
,
Drug-Induced Nutrient Depletion: Iron : CK(30) : AC(3)
Additional Keywords
:
Drug-Nutrient Depletion : CK(64) : AC(7)
Problem Substances
:
Pegylated interferon alpha : CK(20) : AC(2)
,
Ribavirin : CK(20) : AC(2)
Adverse Pharmacological Actions
:
Oxidant : CK(104) : AC(37)
Statin drugs result in coq10 depletion associated with congestive heart failure and which may be rectified by supplementation.
Click here to read the entire abstract
Pubmed Data
: Biofactors. 2003;18(1-4):101-11. PMID:
14695925
Article Published Date
: Jan 01, 2003
Study Type
: Review
Additional Links
Substances
:
Coenzyme Q10 : CK(667) : AC(104)
Diseases
:
Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
,
Heart Failure : CK(711) : AC(97)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords
:
Drug-Nutrient Depletion : CK(64) : AC(7)
,
Statin-Coq10 Depletion : CK(36) : AC(5)
Statins and fenofibrates may exert their wide range of adverse side effects through interfering with selenoprotein expression.
Click here to read the entire abstract
Pubmed Data
: Trends Cardiovasc Med. 2004 Oct;14(7):273-81. PMID:
15542379
Article Published Date
: Oct 01, 2004
Study Type
: Review
Additional Links
Diseases
:
Drug-Induced Nutrient Depletion: Statin Drugs : CK(104) : AC(29)
,
High Cholesterol : CK(1718) : AC(198)
,
Mineral Deficiencies: Selenium : CK(15) : AC(6)
,
Statin-Induced Pathologies : CK(1570) : AC(315)
Additional Keywords
:
Drug-Nutrient Depletion : CK(64) : AC(7)
,
Statin-Selenium Deficiency : CK(4) : AC(3)
Problem Substances
:
Fenofibrates : CK(133) : AC(19)
,
Statin Drugs : CK(3969) : AC(465)
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